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1. 发明授权

US06479639B1 Monoclonal antibody to a human MDR1 multidrug resistance gene product and uses 有权
标题翻译：单克隆抗体对人MDR1多药耐药基因产物及用途
公开(公告)号：US06479639B1
公开(公告)日：2002-11-12
申请号：US09515232
申请日：2000-02-29
申请人： Eugene Metchetner , Igor B. Roninson
发明人： Eugene Metchetner , Igor B. Roninson
IPC分类号： C07K1600
CPC分类号： C07K16/28 , A61K38/00 , C07K2317/73 , C07K2319/00
摘要： A hybridoma (termed “UIC2 hybridoma”, ATCC Accession No. HB11027) producing monoclonal antibodies (termed “UIC2 mAb”) directed against an extracellular domain of a cell surface P-glycoprotein antigen associated with multidrug resistance in primate cells was produced by fusing a human myeloma cell with a spleen cell derived from a BALB/c mouse immunized with syngeneic 3T3 fibroblasts previously transfected with the isolated human mdrl cDNA. UIC2 mAb, thus produced, as well as fragments and recombinant derivatives thereof, may be used to detect and isolate multidrug resistant primate cells and human mdrl gene products, and to reverse multidrug resistance in primate cells, including cells of multidrug resistant human tumors.
摘要翻译：产生针对细胞表面的细胞外结构域的单克隆抗体（称为“UIC2杂交瘤”，ATCC登录号HB11027）的杂交瘤（称为“UIC2杂交瘤”），通过融合a 人骨髓瘤细胞与来自用先前用分离的人mdr1 cDNA转染的同源3T3成纤维细胞免疫的BALB / c小鼠的脾细胞。由此产生的UIC2mAb以及其片段和重组衍生物可用于检测和分离多药耐药的灵长类动物细胞和人mdr1基因产物，并且在灵长动物细胞（包括多重耐药性人肿瘤的细胞）中逆转多药耐药性。

2. 发明授权

US07598340B2 Monoclonal antibody to a human MDR1 multidrug resistance gene product, and uses 失效
标题翻译：人MDR1多药耐药基因产物的单克隆抗体及其用途
公开(公告)号：US07598340B2
公开(公告)日：2009-10-06
申请号：US10292541
申请日：2002-11-12
申请人： Eugene Metchetner , Igor B. Roninson
发明人： Eugene Metchetner , Igor B. Roninson
IPC分类号： C07K5/00
CPC分类号： C07K16/28 , A61K38/00 , C07K2317/73 , C07K2319/00
摘要： A hybridoma (termed “UIC2 hybridoma”, ATCC Accession No. HB11027) producing monoclonal antibodies (termed “UIC2 mAb”) directed against an extracellular domain of a cell surface P-glycoprotein antigen associated with multidrug resistance in primate cells was produced by fusing a human myeloma cell with a spleen cell derived from a BALB/c mouse immunized with syngeneic 3T3 fibroblasts previously transfected with the isolated human mdr1 cDNA. UIC2 mAb, thus produced, as well as fragments and recombinant derivatives thereof, may be used to detect and isolate multidrug resistant primate cells and human mdr1 gene products, and to reverse multidrug resistance in primate cells, including cells of multidrug resistant human tumors.
摘要翻译：产生针对细胞表面的细胞外结构域的单克隆抗体（称为“UIC2杂交瘤”，ATCC登录号HB11027）的杂交瘤（称为“UIC2杂交瘤”），通过融合a 人骨髓瘤细胞与来自用先前用分离的人mdr1 cDNA转染的同源3T3成纤维细胞免疫的BALB / c小鼠的脾细胞。由此产生的UIC2mAb以及其片段和重组衍生物可用于检测和分离多药耐药的灵长类动物细胞和人类mdr1基因产物，并且在灵长动物细胞（包括多重耐药性人肿瘤的细胞）中逆转多药耐药性。

3. 发明授权

US06030796A Monoclonal antibody to a human MDR1 multidrug resistance gene product, and uses 失效
公开(公告)号：US06030796A
公开(公告)日：2000-02-29
申请号：US482670
申请日：1995-06-07
申请人： Eugene Metchetner , Igor B. Roninson
发明人： Eugene Metchetner , Igor B. Roninson
IPC分类号： A61K38/00 , C07K16/28 , C12P21/08 , G01N33/574 , A61K39/395 , C07H21/04
CPC分类号： C07K16/28 , A61K38/00 , C07K2317/73 , C07K2319/00
摘要： A hybridoma (termed "UIC2 hybridoma", ATCC Accession No. HB11027) producing monoclonal antibodies (termed "UIC2 mAb") directed against an extracellular domain of a cell surface P-glycoprotein antigen associated with multidrug resistance in primate cells was produced by fusing a human myeloma cell with a spleen cell derived from a BALB/c mouse immunized with syngeneic 3T3 fibroblasts previously transfected with the isolated human mdr1 cDNA. UIC2 mAb, thus produced, as well as fragments and recombinant derivatives thereof, may be used to detect and isolate multidrug resistant primate cells and human mdr1 gene products, and to reverse multidrug resistance in primate cells, including cells of multidrug resistant human tumors.

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