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1. 发明授权

US5840008A Radiation emitting sleeve catheter and methods 失效
标题翻译：辐射套管导管及方法
公开(公告)号：US5840008A
公开(公告)日：1998-11-24
申请号：US555457
申请日：1995-11-13
申请人： Enrique J. Klein , Aaron V. Kaplan
发明人： Enrique J. Klein , Aaron V. Kaplan
IPC分类号： A61M25/00 , A61B17/22 , A61M36/04 , A61N5/10 , A61N5/00
CPC分类号： A61N5/1002 , A61B2017/22068 , A61M2025/1047 , A61N2005/1004 , A61N2005/1005 , A61N2005/1018 , A61N2005/1023 , A61N2005/1025
摘要： The invention provides methods and devices for delivering low level radiation to inhibit neointimal hyperplasia following angioplasty or other intravascular procedures. In an exemplary method, a balloon is inflated within a stenosed region of a blood vessel to produce a treated region. The balloon is then deflated and a radioactive source within a sleeve is aligned over the deflated balloon. The balloon is again inflated at the treated region to engage the sleeve having the radioactive source against the blood vessel within the treated region for from 1 to 40 minutes to deliver a sufficient dosage of radiation to inhibit neointimal hyperplasia.
摘要翻译：本发明提供用于在血管成形术或其他血管内手术之后递送低水平辐射以抑制新内膜增生的方法和装置。在示例性方法中，气球在血管的狭窄区域内充气以产生治疗区域。气球然后放气，套筒内的放射源在放气气球上对准。气囊在处理区域再次膨胀，以将具有放射源的套筒与处理区域内的血管接合1至40分钟以递送足够剂量的辐射以抑制新生内膜增生。

2. 发明授权

US5713860A Intravascular catheter with infusion array 失效
标题翻译：输液阵列血管内导管
公开(公告)号：US5713860A
公开(公告)日：1998-02-03
申请号：US464153
申请日：1995-06-05
申请人： Aaron V. Kaplan , James R. Kermode , Enrique J. Klein
发明人： Aaron V. Kaplan , James R. Kermode , Enrique J. Klein
IPC分类号： A61M25/00 , A61B8/12 , A61F2/00 , A61F2/06 , A61F2/84 , A61M29/02 , A61M37/00 , A61M29/00
CPC分类号： A61M25/104 , A61B8/12 , A61B8/4488 , A61F2/958 , A61M29/02 , A61F2250/0067 , A61M2025/0057 , A61M2025/0063 , A61M2025/09183 , A61M2025/105 , A61M2025/1075 , A61M2025/1079 , A61M2025/1081 , A61M2025/1084 , A61M25/0054 , A61M25/1002 , A61M37/0092
摘要： An intravascular catheter provides means for infusing an agent into a treatment site in a body lumen and means for deploying the infusing means adjacent the treatment site which operate independently of one another. In a first embodiment, a flexible catheter body has an expansion member attached to its distal end in communication with an inflation passage, and an infusion array disposed about the expansion member in communication with one or more delivery passages. In a second embodiment, the infusion array is a separate component and slidably received over the expansion member, which may be a balloon dilatation catheter. In both embodiments, the infusion array includes a plurality of delivery conduits having laterally oriented orifices. The delivery conduits may be extended radially from the catheter body to contact a treatment site by expanding the expansion member with an inflation fluid. An agent may be introduced into the delivery passages and infused into the treatment site through orifices in the delivery conduits. The expansion member may be expanded for dilatation of the lumen before, during, or after infusion.
摘要翻译：血管内导管提供用于将药剂注入体腔内的治疗部位的装置，以及用于在邻近治疗部位部署相互独立操作的输注装置的装置。在第一实施例中，柔性导管主体具有连接到其远端的膨胀构件与膨胀通道连通，以及设置在与一个或多个输送通道连通的膨胀构件周围的输注排列。在第二实施例中，输注阵列是单独的部件，并且可滑动地容纳在膨胀部件上，膨胀部件可以是球囊扩张导管。在两个实施例中，输注阵列包括具有侧向定向孔的多个输送管道。输送管道可以从导管主体径向延伸，以通过用膨胀流体膨胀膨胀构件来接触治疗部位。可以将药剂引入输送通道并通过输送管道中的孔注入治疗部位。膨胀构件可以在输液之前，期间或之后膨胀以扩张内腔。

3. 发明授权

US5599306A Method and apparatus for providing external perfusion lumens on balloon catheters 失效
标题翻译：用于在气囊导管上提供外部灌注腔的方法和装置
公开(公告)号：US5599306A
公开(公告)日：1997-02-04
申请号：US536555
申请日：1995-09-29
申请人： Enrique J. Klein , Jordan Bajor , Paul Alba , Aaron V. Kaplan
发明人： Enrique J. Klein , Jordan Bajor , Paul Alba , Aaron V. Kaplan
IPC分类号： A61F2/958 , A61M25/00 , A61M29/02
CPC分类号： A61M25/104 , A61M2025/0025 , A61M2025/0063 , A61M2025/0183 , A61M2025/1004 , A61M2025/1072 , A61M2025/1079 , A61M2025/1081 , A61M2025/1095 , A61M25/0023 , A61M25/1002
摘要： A catheter sleeve includes a radially expansible distal region having a plurality of axial blood perfusion lumens or channels formed thereon. The catheter sleeve may be introduced over a conventional angioplasty balloon catheter with the expansible region lying over the balloon. When the balloon of the angioplasty catheter is expanded, the perfusion lumens will provide a flow path for blood around the expanded balloon. Optionally, the catheter sleeve may further include drug infusion lumens over the radially expansible region. In this way, drugs can be delivered over prolonged periods while the underlying angioplasty balloon is inflated and blood flows through the lumens or channels to perfuse the distal myocardium.
摘要翻译：导管套管包括具有多个轴向血液灌注腔或形成在其上的通道的可径向扩张的远端区域。可以将导管套管引入常规的血管成形术球囊导管，其中可膨胀区域位于气囊上。当血管成形术导管的气囊膨胀时，灌注内腔将为扩张的气囊周围的血液提供流路。任选地，导管套筒还可包括在径向可膨胀区域上的药物输注腔。以这种方式，药物可以在长时间内递送，而下面的血管成形术球囊被充气并且血液流过腔或通道以灌注远端心肌。

4. 发明授权

US5658248A Double-blind infusion device and method 失效
标题翻译：双盲输液装置及方法
公开(公告)号：US5658248A
公开(公告)日：1997-08-19
申请号：US511567
申请日：1995-08-04
申请人： Enrique J. Klein , Aaron V. Kaplan
发明人： Enrique J. Klein , Aaron V. Kaplan
IPC分类号： A61M5/14 , A61M5/00 , A61M5/168 , A61M39/00 , A61M1/00
CPC分类号： A61M5/00
摘要： Type-A (operational) and type-B (non-operational) syringes (2A, 2B), used for double-blind clinical tests, are constructed so the type-B syringe mimics the operation of the type-A syringe while avoiding the delivery of anything into the patient. Each syringe includes an injector (4), a fluid connector (12) coupling the exit port (10) of the injector to a discharge port (14) to which a catheter or needle cannula is connected, a valve (18) positioned along the fluid connector, and a dumping reservoir (24) mounted to the valve. The type-A valve fluidly couples the exit port to the discharge port in both purging and infusion positions. The type-B valve couples the exit port to the discharge port in the purging position, but couples the exit port to the dumping reservoir in the infusion position. The infusate is directed through the catheter and into the patient when in the infusion position with the type-A valve but is directed into the dumping reservoir with the type-B valve.
摘要翻译：构建用于双盲临床试验的A型（可操作）和B型（非操作型）注射器（2A，2B），因此B型注射器模拟A型注射器的操作，同时避免将任何东西交付给患者。每个注射器包括注射器（4），将注射器的出口（10）连接到导管或针插管所连接的排出口（14）的流体连接器（12），沿着流体连接器和安装到阀的倾倒储存器（24）。 A型阀在清洗和排液位置都将出口流体地连接到排出口。 B型阀将出口连接到排气位置的排出口，但将输出端口连接到倾倒储存器的输液位置。当使用A型阀的输液位置时，输注物通过导管引导进入患者，但是用B型阀引导到倾倒储存器中。

5. 发明授权

US5571086A Method and apparatus for sequentially performing multiple intraluminal procedures 失效
公开(公告)号：US5571086A
公开(公告)日：1996-11-05
申请号：US222143
申请日：1994-04-01
申请人： Aaron V. Kaplan , James R. Kermode , Enrique J. Klein
发明人： Aaron V. Kaplan , James R. Kermode , Enrique J. Klein
IPC分类号： A61M25/00 , A61B8/12 , A61F2/00 , A61F2/06 , A61F2/84 , A61M29/02 , A61M37/00 , A61M29/00
CPC分类号： A61M25/104 , A61B8/12 , A61B8/4488 , A61F2/958 , A61M29/02 , A61F2250/0067 , A61M2025/0057 , A61M2025/0063 , A61M2025/09183 , A61M2025/105 , A61M2025/1075 , A61M2025/1079 , A61M2025/1081 , A61M2025/1084 , A61M25/0054 , A61M25/1002 , A61M37/0092
摘要： Sleeve catheters having an interactive device near their distal ends are provided for introduction while disposed over conventional interventional and imaging catheters. Exemplary interactive devices on the sleeve catheters include ultrasonic imaging arrays, drug delivery lumens, and the like. The sleeve catheters are most commonly used with angioplasty catheters, stent placement catheters, atherectomy catheters, and the like.

6. 发明授权

US5609574A Intravascular catheter with infusion array 失效
标题翻译：输液阵列血管内导管
公开(公告)号：US5609574A
公开(公告)日：1997-03-11
申请号：US241428
申请日：1994-05-11
申请人： Aaron V. Kaplan , James R. Kermode , Enrique J. Klein
发明人： Aaron V. Kaplan , James R. Kermode , Enrique J. Klein
IPC分类号： A61M25/00 , A61B8/12 , A61F2/00 , A61F2/06 , A61F2/84 , A61M29/02 , A61M37/00 , A61M31/00
CPC分类号： A61M25/104 , A61B8/12 , A61B8/4488 , A61F2/958 , A61M29/02 , A61F2250/0067 , A61M2025/0057 , A61M2025/0063 , A61M2025/09183 , A61M2025/105 , A61M2025/1075 , A61M2025/1079 , A61M2025/1081 , A61M2025/1084 , A61M25/0054 , A61M25/1002 , A61M37/0092
摘要： An intravascular catheter provides means for infusing an agent into a treatment site in a body lumen and means for deploying the infusing means adjacent the treatment site which operate independently of one another. In a first embodiment, a flexible catheter body has an expansion member attached to its distal end in communication with an inflation passage, and an infusion array disposed about the expansion member in communication with one or more delivery passages. In a second embodiment, the infusion array is a separate component and slidably received over the expansion member, which may be a balloon dilatation catheter. In both embodiments, the infusion array includes a plurality of delivery conduits having laterally oriented orifices. The delivery conduits may be extended radially from the catheter body to contact a treatment site by expanding the expansion member with an inflation fluid. An agent may be introduced into the delivery passages and infused into the treatment site through orifices in the delivery conduits. The expansion member may be expanded for dilatation of the lumen before, during, or after infusion.
摘要翻译：血管内导管提供用于将药剂注入体腔内的治疗部位的装置，以及用于在邻近治疗部位部署相互独立操作的输注装置的装置。在第一实施例中，柔性导管主体具有连接到其远端的膨胀构件与膨胀通道连通，以及设置在与一个或多个输送通道连通的膨胀构件周围的输注排列。在第二实施例中，输注阵列是单独的部件，并且可滑动地容纳在膨胀部件上，膨胀部件可以是球囊扩张导管。在两个实施例中，输注阵列包括具有侧向定向孔的多个输送管道。输送管道可以从导管主体径向延伸，以通过用膨胀流体膨胀膨胀构件来接触治疗部位。可以将药剂引入输送通道并通过输送管道中的孔注入治疗部位。膨胀构件可以在输液之前，期间或之后膨胀以扩张内腔。

7. 发明授权

US5336178A Intravascular catheter with infusion array 失效
标题翻译：输液阵列血管内导管
公开(公告)号：US5336178A
公开(公告)日：1994-08-09
申请号：US47737
申请日：1993-04-15
申请人： Aaron V. Kaplan , James R. Kermode , Enrique J. Klein
发明人： Aaron V. Kaplan , James R. Kermode , Enrique J. Klein
IPC分类号： A61M25/00 , A61B8/12 , A61F2/00 , A61F2/06 , A61F2/84 , A61M29/02 , A61M37/00 , A61M31/00
CPC分类号： A61M25/104 , A61B8/12 , A61B8/4488 , A61F2/958 , A61M29/02 , A61F2250/0067 , A61M2025/0057 , A61M2025/0063 , A61M2025/09183 , A61M2025/105 , A61M2025/1075 , A61M2025/1079 , A61M2025/1081 , A61M2025/1084 , A61M25/0054 , A61M25/1002 , A61M37/0092
摘要： An intravascular catheter provides means for infusing an agent into a treatment site in a body lumen and means for deploying the infusing means adjacent the treatment site which operate independently of one another. In a preferred embodiment, a flexible catheter body has an expansion member attached to its distal end in communication with an inflation passage, and an infusion array disposed about the expansion member in communication with one or more delivery passages. The infusion array includes a plurality of delivery conduits having laterally oriented orifices. The delivery conduits may be extended radially from the catheter body to contact a treatment site by expanding the expansion member with an inflation fluid. An agent may be introduced into the delivery passages and infused into the treatment site through orifices in the delivery conduits. The expansion member may be expanded for dilatation of the lumen before, during, or after infusion.
摘要翻译：血管内导管提供用于将药剂注入体腔内的治疗部位的装置，以及用于在邻近治疗部位部署相互独立操作的输注装置的装置。在优选实施例中，柔性导管主体具有连接到其远端的膨胀构件，其与充气通道连通，以及设置在与一个或多个输送通道连通的膨胀构件周围的输液阵列。输液阵列包括具有侧向定向孔的多个输送管道。输送管道可以从导管主体径向延伸，以通过用膨胀流体膨胀膨胀构件来接触治疗部位。可以将药剂引入输送通道并通过输送管道中的孔注入治疗部位。膨胀构件可以在输液之前，期间或之后膨胀以扩张内腔。

8. 发明授权

US5810869A Methods for loading coaxial catheters 失效
标题翻译：同轴导管装载方法
公开(公告)号：US5810869A
公开(公告)日：1998-09-22
申请号：US751780
申请日：1996-11-18
申请人： Aaron V. Kaplan , Enrique J. Klein
发明人： Aaron V. Kaplan , Enrique J. Klein
IPC分类号： A61M25/00 , A61M25/18
CPC分类号： A61M25/0097 , A61M25/0014 , A61M2025/0076
摘要： The catheter system comprises a balloon catheter having a removable hub. The hub is removed to permit loading of a sleeve catheter over the proximal end of the balloon catheter. The removable hub includes both a circumferential seal for preventing leakage of inflation medium from the hub and a mechanical interlock for axially securing the hub to the balloon catheter.
摘要翻译：导管系统包括具有可拆卸毂的球囊导管。轮毂被移除以允许将套管导管装载在球囊导管的近端上。可拆卸轮毂包括用于防止充气介质从轮毂泄漏的圆周密封件和用于将轮毂轴向固定到球囊导管的机械互锁件。

9. 发明授权

US5478331A Multi-function proximal end adapter for catheter 失效
标题翻译：导管多功能近端适配器
公开(公告)号：US5478331A
公开(公告)日：1995-12-26
申请号：US241104
申请日：1994-05-11
申请人： Ernest W. Heflin , Enrique J. Klein , Aaron V. Kaplan
发明人： Ernest W. Heflin , Enrique J. Klein , Aaron V. Kaplan
IPC分类号： A61M25/00 , A61M29/02 , A61M39/06 , A61M5/178 , A61M31/00
CPC分类号： A61M39/0613 , A61M25/00 , A61M25/104
摘要： A multi-function proximal end adapter (70, 86, 100) for a catheter (22) includes a hollow body (6) defining an axial lumen (8) extending between its proximal and distal ends (12, 10). An annular radially compressible seal (48) is positioned within the body along the axial lumen. A seal driver (58) is threadably mounted to the body and has a hollow extension (60) with a distal end adapted to axially compress the seal causing a radially inward deflection of the seal when the seal driver is threaded onto the body thereby providing a good seal against and securement for an object (such as a catheter or guide wire) passing through the axial lumen of the body. At least a portion of the proximal end of the axial lumen is defined by an internal tapered surface (36) sized to matingly and sealingly engage an external tapered surface (44) of a Luer lock connector (40) after the seal driver has been removed from the proximal end of the body.
摘要翻译：用于导管（22）的多功能近端适配器（70,86,100）包括限定在其近端和远端（12,10）之间延伸的轴向内腔（8）的空心体（6）。环形可径向压缩的密封件（48）沿轴向内腔定位在主体内。密封件驱动器（58）螺纹地安装到主体上并且具有中空延伸部（60），其远端适于轴向地压缩密封件，当密封件驱动器被拧到主体上时导致密封的径向向内偏转，从而提供对通过身体的轴向内腔的物体（例如导管或导丝）的良好的密封和固定。轴向内腔的近端的至少一部分由内部锥形表面（36）限定，该内部锥形表面（36）在密封驱动器已经被移除之后尺寸设定成匹配并密封地接合鲁尔锁定连接器（40）的外部锥形表面（44）从身体的近端。

10. 发明授权

US5855563A Method and apparatus for sequentially performing multiple intraluminal procedures 失效
标题翻译：顺序执行多个腔内手术的方法和装置
公开(公告)号：US5855563A
公开(公告)日：1999-01-05
申请号：US666778
申请日：1996-06-19
申请人： Aaron V. Kaplan , James R. Kermode , Enrique J. Klein
发明人： Aaron V. Kaplan , James R. Kermode , Enrique J. Klein
IPC分类号： A61M25/00 , A61B8/12 , A61F2/00 , A61F2/06 , A61F2/84 , A61M29/02 , A61M37/00 , A61M31/00
CPC分类号： A61M25/104 , A61B8/12 , A61B8/4488 , A61F2/958 , A61M29/02 , A61F2250/0067 , A61M2025/0057 , A61M2025/0063 , A61M2025/09183 , A61M2025/105 , A61M2025/1075 , A61M2025/1079 , A61M2025/1081 , A61M2025/1084 , A61M25/0054 , A61M25/1002 , A61M37/0092
摘要： Sleeve catheters having an interactive device near their distal ends are provided for introduction while disposed over conventional interventional and imaging catheters. Exemplary interactive devices on the sleeve catheters include ultrasonic imaging arrays, drug delivery lumens, and the like. The sleeve catheters are most commonly used with angioplasty catheters, stent placement catheters, atherectomy catheters, and the like.
摘要翻译：在其远端附近具有交互式装置的套管设置用于引入，同时设置在常规介入和成像导管之上。套管导管上的示例性交互设备包括超声波成像阵列，药物输送腔等。套管导管最常用于血管成形术导管，支架置入导管，粥样斑块切除术导管等。

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