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1. 发明申请

WO2023079401A1 PLUG FOR LUNG TISSUE TRACT SEALING 审中-公开
公开(公告)号：WO2023079401A1
公开(公告)日：2023-05-11
申请号：PCT/IB2022/060146
申请日：2022-10-21
申请人： ETHICON, INC.
发明人： GHODBANE, Salim , DHANARAJ, Sridevi , DEANGLIS, Ashley , ZHANG, Guanghui
IPC分类号： A61L24/06 , A61L24/10 , A61L24/00
摘要： The present invention provides a tissue sealing plug comprising a substrate comprising foamed gelatin impregnated with polyethylene glycol that is liquid at room temperature, wherein the weight ratio of polyethylene glycol to foamed gelatin in the substrate is about 4:1 to about 6.8:1 and the substrate is substantially free of air, along with methods of using the plug for closing tissue punctures in the lung.

2. 发明申请

WO2017192438A1 SURGICAL STAPLER/CUTTER AND EXTENDED BUTTRESS 审中-公开
标题翻译：手术装订器/刀具和延伸扣件
公开(公告)号：WO2017192438A1
公开(公告)日：2017-11-09
申请号：PCT/US2017/030383
申请日：2017-05-01
申请人： ETHICON, INC. , ETHICON LLC
发明人： NATIV, Nir I. , DHANARAJ, Sridevi , KRIKSUNOV, Leo B. , SCHEIB, Charles J.
IPC分类号： A61B17/072
摘要： The present invention is directed to surgical staplers stapling and resecting tissue comprising a surgical buttress at least partially disposed on a tissue facing surface of at least one of the cartridge or the anvil, said buttress having width substantially larger than width of said tissue facing surfaces; said buttress comprising a first portion positioned over the deployable staples or over the staple forming pockets, and at least one flap portion not positioned over the deployable staples or over the staple forming pockets; said flap portion folded or rolled on itself and configured to be unfurlable and wrappable about the resected tissue. The present invention is also directed to methods of use of such stapler assembly devices.
摘要翻译：本发明涉及外科缝合器缝合和切除组织，其包括至少部分地设置在药筒或砧座中的至少一个的面向组织的表面上的手术支撑件，所述支撑件具有基本上更大的宽度超过所述面向组织的表面的宽度; 所述支撑件包括位于所述可展开钉上方或所述钉成形凹坑上方的第一部分以及未定位在所述可展开钉上方或所述钉成形凹坑上方的至少一个折翼部分; 所述折翼部分自身折叠或卷起并且构造成不可展开并且可围绕切除的组织卷绕。本发明还涉及这种缝合器组件装置的使用方法。

3. 发明申请

WO2023042146A1 KIT FOR COMPOSITION FOR TISSUE TRACT SEALING 审中-公开
公开(公告)号：WO2023042146A1
公开(公告)日：2023-03-23
申请号：PCT/IB2022/058770
申请日：2022-09-16
申请人： ETHICON, INC.
发明人： GHODBANE, Salim , DEANGLIS, Ashley , DHANARAJ, Sridevi , ZHANG, Guanghui
IPC分类号： A61L24/00 , A61L24/10
摘要： The present invention provides a kit for preparing a composition for sealing a lung tract, comprising: (a) a first component comprising: (i) a fibrinogen solution, and (ii) prewet gelatin particles in an aqueous solution; and (b) a second component comprising: (i) a thrombin solution, and (ii) a dry gelatin powder; wherein the first and second components are stored separately and configured for mixing together to form a composition that is flowable and cross-linkable. The composition may be used to seal tissue tracts such as lung tissue tracts.

4. 发明申请

WO2022137002A1 BLEEDING DETECTION METHOD 审中-公开
公开(公告)号：WO2022137002A1
公开(公告)日：2022-06-30
申请号：PCT/IB2021/061520
申请日：2021-12-09
申请人： ETHICON, INC.
发明人： DEANGLIS, Ashley , GHODBANE, Salim A. , DHANARAJ, Sridevi , AITKEN, Brian
IPC分类号： A61K49/00 , C12Q1/56
摘要： Disclosed are devices for detection of bleeding during surgical procedures and uses thereof. Also disclosed are methods of localizing a bleeding site during surgical procedures, and methods for evaluating an intensity of bleeding during the surgical procedures. The detection of bleeding is based, inter alia, on the presence of thrombin activity in a bleeding site.

5. 发明申请

WO2022043795A1 LYOPHILIZED CURED POLYMERIC FOAM PLUG 审中-公开
公开(公告)号：WO2022043795A1
公开(公告)日：2022-03-03
申请号：PCT/IB2021/057060
申请日：2021-08-02
申请人： ETHICON, INC.
发明人： GHODBANE, Salim A. , DEANGLIS, Ashley , DHANARAJ, Sridevi
IPC分类号： A61L24/00 , A61L24/04 , A61L24/10
摘要： The present invention is directed to dry lyophilized foam plugs that are a polymeric reaction product of at least a pair of co-reactive polyethylene glycol having reactive moieties in which substantially all of reactive moieties have reacted prior to lyophilization or blend of biomaterial and a reactive polyethylene glycol or plasma derived biomaterial reaction product and wherein the plug has an overall pore void content of about 30-45%, and a microporous structure with an average pore generally between 20 and 95 µm.

6. 发明申请

WO2021250548A1 TWO COMPONENT SEALING SYSTEMS INCLUDING SYNTHETIC MATRICES AND BIOSYNTHETIC ADHESIVES FOR SEALING RESECTED SURFACES OF ORGANS TO CONTROL BLEEDING, FLUID LEAKS AND AIR LEAKS 审中-公开
公开(公告)号：WO2021250548A1
公开(公告)日：2021-12-16
申请号：PCT/IB2021/054988
申请日：2021-06-07
申请人： ETHICON, INC.
发明人： NATIV, Nir , DHANARAJ, Sridevi , DEANGLIS, Ashley , GHODBANE, Salim
IPC分类号： A61L31/06 , A61L31/14 , A61L24/04 , A61L24/10 , A61B17/00 , A61B17/00491 , A61B17/0057 , A61B2017/00004 , A61B2017/00495 , A61B2017/0065 , A61L24/046 , A61L24/108 , A61L2400/04 , A61L31/005 , A61L31/047 , A61L31/125 , A61L31/146 , A61L31/148 , D04H1/435
摘要： A method of sealing a resected surface of an organ includes applying a synthetic matrix to a resected surface of an organ, and applying an adhesive on the synthetic matrix so that the adhesive penetrates through interstices of the synthetic matrix for contacting an interface between the synthetic matrix and the resected surface of the organ. The method includes curing the adhesive for bonding the synthetic matrix to the resected surface of the organ. The synthetic matrix is a non-woven mesh made of polyglactin 910 or any other synthetic or non-synthetic fabric having a similar porosity or density. The adhesive is a biosynthetic or a synthetic adhesive. After penetrating through the pores of the synthetic matrix and curing, the cured biosynthetic or synthetic adhesive mechanically interlocks with the synthetic matrix for adhering the synthetic matrix to the tissue for creating a sealing barrier.

7. 发明申请

WO2018034922A1 SPRAY TIPS FOR SIMULTANEOUS MULTI-DIRECTIONAL DELIVERY OF DISSIMILAR FLUIDS 审中-公开
标题翻译：喷雾提示可以同时多方向输送异构流体
公开(公告)号：WO2018034922A1
公开(公告)日：2018-02-22
申请号：PCT/US2017/046210
申请日：2017-08-10
申请人： ETHICON, INC.
发明人： DHANARAJ, Sridevi , DEANGLIS, Ashley , GOODMAN, John F.
IPC分类号： A61B17/00
摘要： The present inventions are directed to spray tips for multidirectional or three-dimensional spraying of an unmixed two-part sealant and/or hemostat comprising a first biocompatible component and a biocompatible second component onto a tissue or wound comprising: a hollow body having inside a first component distribution compartment and a second component distribution compartment, said compartments not in fluid communication with each other. The first component can contain one or more biologic components, preferably fibrinogen and the second component can contain one or more biologic component different from the first biologic component, preferably thrombin and/or thrombin precursors. The present inventions are also directed to methods of spraying the unmixed two-part sealant or hemostat using the spray tip and associated components described above by simultaneously expressing the first component and the second component from the syringes.
摘要翻译：本发明涉及用于将包括第一生物相容性组分和生物相容性第二组分的未混合的两部分密封剂和/或止血剂多向或三维喷雾到组织或伤口上的喷雾尖端，其包括：在第一组分分配隔室和第二组分分配隔室内具有中空体，所述隔室彼此不流体连通。第一组分可含有一种或多种生物组分，优选纤维蛋白原，第二组分可含有不同于第一生物组分的一种或多种生物组分，优选凝血酶和/或凝血酶前体。本发明还涉及通过从注射器同时表达第一组分和第二组分而使用上述喷嘴和相关组分喷雾未混合的两部分密封剂或止血剂的方法。

8. 发明申请

WO2015142509A1 DECELLULARIZED PLEURAL MATRIX 审中-公开
标题翻译：细致的PLEURAL MATRIX
公开(公告)号：WO2015142509A1
公开(公告)日：2015-09-24
申请号：PCT/US2015/018421
申请日：2015-03-03
申请人： ETHICON, INC.
发明人： DHANARAJ, Sridevi , VALMIKINATHAN, Chandra M. , BUENSUCESO, Charito , SEYDA, Agnieszka
IPC分类号： A61L27/36
CPC分类号： A61K35/12 , A61L27/3633
摘要： The present invention pertains to the development of biologically derived extracellular matrices (ECM) derived from decellularized pleura tissue. Such matrices are useful in many clinical and therapeutic applications, including the repair, reconstruction, sealing, or joining of tissue, tendons, bones, and/or ligaments. In addition, the present invention features methods of making a biologically derived ECM derived from decellularized pleura tissue. The invention further features laminated ECM matrices.
摘要翻译：本发明涉及衍生自脱细胞化胸膜组织的生物衍生的细胞外基质（ECM）的开发。这些基质在许多临床和治疗应用中是有用的，包括组织，腱，骨骼和/或韧带的修复，重建，密封或连接。此外，本发明的特征在于制备衍生自脱细胞化胸膜组织的生物衍生ECM的方法。本发明进一步具有层叠的ECM矩阵。

9. 发明申请

WO2005032461A2 NOVEL PEPTIDE WITH OSTEOGENIC ACTIVITY 审中-公开
标题翻译：新的具有造血活性的肽
公开(公告)号：WO2005032461A2
公开(公告)日：2005-04-14
申请号：PCT/US2004/029649
申请日：2004-09-10
申请人： ETHICON, INC. , DHANARAJ, Sridevi , GOSIEWSKA, Anna , REZANIA, Ali , HEAVNER, George, A. , LIN, Xuanhan , YI, Chin-Feng
发明人： DHANARAJ, Sridevi , GOSIEWSKA, Anna , REZANIA, Ali , HEAVNER, George, A. , LIN, Xuanhan , YI, Chin-Feng
IPC分类号： A61K
CPC分类号： A61K38/08 , A61K31/375 , A61K31/573 , A61K31/661 , A61K35/32 , A61K38/18 , A61K45/06 , A61L27/227 , A61K2300/00
摘要： The present invention provides a composition including an isolated or recombinant peptide component that has osteogenic cell proliferative activity. The peptide, which promotes proliferation of osteoblasts, is useful for treatment of fractures, as a filler in deficient sites of bone, for inhibition of decrease in bone substance related to osteoporosis and periodontic diseases, and for prevention of fractures associated with osteoporosis and rheumatoid arthritis. The peptide, or cells that have been genetically engineered to produce the peptide, can be combined with a bone-compatible matrix to facilitate slow release of the peptide to a treatment site and/or provide a structure for developing bone.
摘要翻译：本发明提供了包含具有成骨细胞增殖活性的分离或重组肽组分的组合物。促进成骨细胞增殖的肽可用于治疗骨折，作为骨骼缺陷部位的填充物，抑制与骨质疏松症和牙周病有关的骨质减少，以及用于预防与骨质疏松症和类风湿性关节炎相关的骨折。已经基因工程改造以产生肽的肽或细胞可以与骨相容性基质组合以促进肽缓慢释放至治疗部位和/或提供用于发展骨的结构。

10. 发明申请

WO2022175840A1 SYSTEMS AND DEVICES FOR DISPENSING BIOCOMPATIBLE REACTIVE FORMULATIONS AND CONTROLLING CROSS-LINKING OF THE REACTIVE COMPONENTS OF THE BIOCOMPATIBLE REACTIVE FORMULATIONS 审中-公开
公开(公告)号：WO2022175840A1
公开(公告)日：2022-08-25
申请号：PCT/IB2022/051382
申请日：2022-02-16
申请人： ETHICON, INC.
发明人： GUO, Jianxin , GHODBANE, Salim A. , DHANARAJ, Sridevi
IPC分类号： A61B17/00 , A61M5/19 , A61M11/00 , B05C17/005 , A61M15/00 , B05B7/04 , B05B11/00 , B05B11/02 , B01F25/313 , B01F25/434 , B01F25/441 , B01F33/501 , B01F35/71 , A61M5/31 , B05B1/34 , B01F101/22 , B01F101/00
摘要： A system for dispensing a biocompatible reactive formulation includes a first chamber containing a first fluid having a first reactive component, a second chamber containing a second fluid having a second reactive component, and a third chamber containing a third fluid. A spray tip assembly is configured for spraying a final mixture of the first, second and third fluids. The spray tip assembly has a spray tip housing, a mixing element disposed within the spray tip housing, a mixing chamber located between the mixing element and an inner surface of the spray tip housing. The mixing element has a proximal end adjacent the proximal end of the spray tip housing and a distal end adjacent the distal end of the spray tip housing, a third fluid inlet opening at the proximal end of the mixing element, and one or more third fluid exit openings formed in the outer surface of the mixing element that are in fluid communication with the third fluid inlet opening and that extend laterally to the outer surface of the mixing element for being in fluid communication with the mixing chamber. A fluid connector is secured to the proximal end of the spray tip housing and opposes the proximal end of the mixing element. The fluid connector has first and second fluid channels in fluid communication with the mixing chamber, and a third fluid channel in fluid communication with the third fluid inlet opening of the mixing element. A pump assembly is coupled with the first, second and third chambers for simultaneously forcing the first, second and third fluids to flow through the first, second and third fluid channels of the fluid connector and into the proximal end of the spray tip housing.

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