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1. 发明申请

WO2005037848A2 GLYCEROPHOSPHOLIPIDS CONTAINING OMEGA-3 AND OMEGA-6 FATTY ACIDS 审中-公开
标题翻译：含有OMEGA-3和OMEGA-6脂肪酸的甘油磷脂
公开(公告)号：WO2005037848A2
公开(公告)日：2005-04-28
申请号：PCT/IL2004000957
申请日：2004-10-21
申请人： ENZYMOTEC LTD , BEN DROR GAI , PLATT DORIT , FARKASH ORLY , ZUABI RASSAN , BAR-ON ZOHAR , SHULMAN AVIDOR , PELLED DORI
发明人： BEN DROR GAI , PLATT DORIT , FARKASH ORLY , ZUABI RASSAN , BAR-ON ZOHAR , SHULMAN AVIDOR , PELLED DORI
IPC分类号： A61K31/683 , A61K31/685 , C07F9/10
CPC分类号： A61K31/685 , A61K31/683
摘要： Disclosed is a lipid preparation comprising a glycerophospholipid or salt, conjugate and derivatives thereof, particularly phosphatidylserine (PS), phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidyl-inositol (PI), phosphatidylglycerol (PG) and phosphatidic acid (PA), and poly-unsaturated fatty acid (PUFA) acyl groups, particularly long-chain poly-unsaturated fatty acid (LC-PUFA) acyl groups such as omega-3 and/or omega-6 acyl groups, wherein said PUFA is covalently bound to said glycerophospholipid. The disclosed preparations possess an improved bioactivity, and are useful in the treatment of various cognitive and mental conditions and disorders and for maintenance of normal functions of brain-related systems and processes, for example ADHD.
摘要翻译：公开了包含甘油磷脂或其盐，缀合物及其衍生物，特别是磷脂酰丝氨酸（PS），磷脂酰胆碱（PC），磷脂酰乙醇胺（PE），磷脂酰肌醇（PI），磷脂酰甘油（PG）和磷脂酸（PA）和多不饱和脂肪酸（PUFA）酰基，特别是长链多不饱和脂肪酸（LC-PUFA）酰基如ω-3和/或ω-6酰基，其中所述PUFA共价结合到所述甘油。所公开的制剂具有改善的生物活性，并且可用于治疗各种认知和精神状况和障碍，并且用于维持脑相关系统和过程（例如ADHD）的正常功能。

2. 发明申请

WO2009156991A3 GLYCEROPHOSPHOLIPIDS FOR THE IMPROVEMENT OF COGNITIVE FUNCTIONS 审中-公开
标题翻译：用于改善认知功能的甘油磷脂
公开(公告)号：WO2009156991A3
公开(公告)日：2010-05-14
申请号：PCT/IL2009000626
申请日：2009-06-24
申请人： ENZYMOTEC LTD , BEN DROR GAI , PLATT DORIT , FARKASH ORLY , ZUABI RASSAN , BAR-ON ZOHAR , SHULMAN AVIDOR , PELLED DORI , RICHTER YAEL
发明人： BEN DROR GAI , PLATT DORIT , FARKASH ORLY , ZUABI RASSAN , BAR-ON ZOHAR , SHULMAN AVIDOR , PELLED DORI , RICHTER YAEL
IPC分类号： A61K47/48 , A23L1/30 , A61P25/28 , C07F9/10
CPC分类号： A61K47/544 , A21D2/32 , A23D7/013 , A23D9/013 , A23L33/12 , A23L33/30 , A23L33/40 , A23V2002/00 , A61K31/201 , A61K31/202 , A61K31/66 , A61K31/685 , A61K47/48053 , A61K47/481 , C07F9/10 , A23V2200/322 , A23V2250/1882 , A23V2250/1942 , A23V2250/1842
摘要： The invention described herein provides a preparation comprising a non-mammalian derived mixture of serine glycerophospholipid conjugates with a specific content and specific conjugation patterns of LA, linolenic acid (alpha-linolenic acid, gamma-linolenic acid) DHA and eicosapentaenoyl (EPA), e.g. utilizing different sources of lipids, and uses thereof.
摘要翻译：本文描述的本发明提供了包含具有特异性含量和LA，亚麻酸（α-亚麻酸，γ-亚麻酸）DHA和二十碳五烯酰（EPA）的特异性缀合模式的丝氨酸甘油磷脂缀合物的非哺乳动物衍生的混合物的制剂，例如，利用不同的脂质来源及其用途。

3. 发明申请

WO2005051091A8 MIMETIC LIPIDS AND DIETARY SUPPLEMENTS COMPRISING THE SAME 审中-公开
标题翻译： MIMETIC LIPIDS和包含它们的膳食补充剂
公开(公告)号：WO2005051091A8
公开(公告)日：2005-08-04
申请号：PCT/IL2004000959
申请日：2004-10-21
申请人： ENZYMOTEC LTD , SHULMAN AVIDOR , BEN DROR GAI , PELLED DORI , BAR-ON ZOHAR
发明人： SHULMAN AVIDOR , BEN DROR GAI , PELLED DORI , BAR-ON ZOHAR
IPC分类号： A23D9/013 , A23J7/00 , A23L1/29 , A23L1/30
CPC分类号： A23D9/013 , A23J7/00 , A23L33/115 , A23L33/40 , A23V2002/00 , A23V2250/1846 , A23V2250/1852 , A23V2250/185
摘要： Disclosed is substantially homogenous lipid preparation comprising a combination of glycerophospholipids being phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS) and phosphatidylinositol (PI), wherein the quantitative ratio between said glycerophospholipids essentially mimics their corresponding ratio in naturally occurring human milk fat (HMF), optionally further comprising sphingomyelin (SM) and/or cholesterol, wherein the quantitative ratio between the glycerophospholipids in said combination and the sphingomyelin and/or cholesterol essentially mimics their corresponding ratio in said naturally occurring HMF. Further disclosed is the lipid combination which upon dispersion or emulsification in an essentially aqueous medium with other ingredients of infant formula, especially protein and fat under suitable conditions, forms a substantially homogenous dispersion or emulsion having a fat, globule-containing microstructure which is essentially mimetic of the corresponding globular microstructure of naturally occurring HMF, said globules having a membrane which is essentially mimetic of naturally occurring human milk fat globule membrane (HMFGM). Further disclosed are methods for preparing the lipid combination, and various uses thereof, particularly uses related to the preparation of infant formulas.
摘要翻译：公开了包含甘油磷脂是磷脂酰胆碱（PC），磷脂酰乙醇胺（PE），磷脂酰丝氨酸（PS）和磷脂酰肌醇（PI），其中所述的数量比率的组合基本上均匀的脂质制备甘油磷脂基本上模仿在天然存在的人乳脂肪它们相应的比（HMF），任选还包含鞘磷脂（SM）和/或胆固醇，其中所述组合中甘油磷脂与鞘磷脂和/或胆固醇之间的数量比基本上模拟它们在所述天然存在的HMF中的相应比例。进一步公开的是这样的脂质组合，其在基本上含水的介质中与婴儿配方的其它成分（特别是蛋白质和脂肪）在合适的条件下分散或乳化时形成基本上均匀的分散体或乳液，其具有基本上模拟的含脂肪球的微观结构的天然存在的HMF的相应球状微观结构，所述小球具有基本上与天然存在的人乳脂肪球膜（HMFGM）模拟的膜。还公开了用于制备脂质组合的方法及其各种用途，特别是涉及制备婴儿配方食品的用途。

4. 发明专利

IL186927A Enzymatically-prepared fat base compostions, human milk fat substitutes and infant formulas comprising the same and processes for the preparation thereof 未知
公开(公告)号：IL186927A
公开(公告)日：2013-10-31
申请号：IL18692707
申请日：2007-10-25
申请人： SHULMAN AVIDOR , ENZYMOTEC LTD , DROR GAI BEN , HERZOG YAEL , LAOUZ HALA , YAAKOBI DOV , BAR-ON ZOHAR , BLINDER GREGORY , MEIRI-BENDEK IRIS
发明人： SHULMAN AVIDOR , DROR GAI BEN , HERZOG YAEL , LAOUZ HALA , YAAKOBI DOV , BAR-ON ZOHAR , BLINDER GREGORY , MEIRI-BENDEK IRIS
IPC分类号： A23L20060101 , A23L33/00
摘要： Disclosed are human milk fat (HMF) substitutes, processes for preparation thereof, uses thereof, and fat blends and formula containing the HMF substitutes. A fat base composition of the invention includes a mixture of vegetable-derived triglycerides, with less than 50% of the fatty acid residues bonded at the sn-2 position being saturated; and/or with the amount of saturated fatty acid residues bonded at the sn-2 position of the glycerol backbone less than about 43.5% of the total amount of the fatty acid residues. Typically, substantially all of the saturated fatty acids bonded at the sn-2 position of the glycerol backbone are palmitic acid residues. Also disclosed are substitute HMF compositions including a blend of at least 25% or at least 30% of the fat base composition of the invention with up to 75%, or respectively up to 70%, of at least one vegetable oil. Processes for preparing the fat base compositions and blend are also disclosed. Further disclosed are infant formulas including the fat base composition or substitute human milk fat composition.

5. 发明专利

JP2012211168A Glycerophospholipid containing omega-3 and pmega-6 fatty acid 有权
标题翻译：含有OMEGA-3和PMEGA-6脂肪酸的甘油磷脂
公开(公告)号：JP2012211168A
公开(公告)日：2012-11-01
申请号：JP2012141384
申请日：2012-06-06
申请人： Enzymotec Ltd , エンジィモテックリミテッド
发明人： BEN DROR GAI , PLATT DORIT , FARKASH ORLY , ZUABI RASSAN , BAR-ON ZOHAR , SHULMAN AVIDOR , PELLED DORI
IPC分类号： A61K31/683 , A23L1/30 , A61K9/10 , A61K9/20 , A61K9/48 , A61K31/685 , A61P25/18 , A61P25/28
CPC分类号： A61K31/685 , A61K31/683
摘要： PROBLEM TO BE SOLVED: To provide lipid a preparation having improved biological activity.SOLUTION: There is disclosed the lipid preparation which contains a long-chain apolyunsaturated fatty acid (LC-PUFA) acyl group such as phosphatidylserine (PS), particularly, an eicosatetraenoic penta enoyl (EPA) group and/or a docosahexaenoic acid (DHA) group, and here, the PUFA is commonly coupled to glycerophospholipid. The preparation has the improved biological activity, and is useful for curing a variety of states and troubles related to recognition ability and mentality, and for maintaining normal states of a system and a process to which a brain is related.
摘要翻译：要解决的问题：提供具有改善的生物活性的脂质制剂。解决方案：公开了含有长链多不饱和脂肪酸（LC-PUFA）酰基如磷脂酰丝氨酸（PS），特别是二十碳四烯五烯酰（EPA）和/或二十二碳六烯酸的脂质制剂（DHA）组，这里，PUFA通常与甘油磷脂偶联。该制剂具有改善的生物活性，并且可用于治疗与识别能力和心理相关的各种状态和麻烦，并且用于维持与脑相关的系统和过程的正常状态。版权所有（C）2013，JPO＆INPIT

7. 发明专利

DE602004031750D1 FRAUENMILCH-LIPID-MIMITIKUM ALS NAHRUNGSMITTELZUSATZ 未知
公开(公告)号：DE602004031750D1
公开(公告)日：2011-04-21
申请号：DE602004031750
申请日：2004-10-21
申请人： ENZYMOTEC LTD
发明人： MEIRI-BENDEK IRIS , BEN DROR GAI , LAOUZ HALA , YAAKOBI DOV , BAR-ON ZOHAR , SHULMAN AVIDOR
IPC分类号： A21D2/16 , A23C11/00 , A23C11/04 , A23D7/00 , A23D9/00 , A23G3/34 , A23L1/30 , A23L33/00 , A23L33/15 , C11C3/08 , C11C3/10

8. 发明专利

AU2004282006C1 Glycerophospholipids containing omega-3 and omega-6 fatty acids 未知
公开(公告)号：AU2004282006C1
公开(公告)日：2010-10-21
申请号：AU2004282006
申请日：2004-10-21
申请人： ENZYMOTEC LTD
发明人： DROR GAI BEN , BAR-ON ZOHAR , PELLED DORI , FARKASH ORLY , PLATT DORIT , ZUABI RASSAN , SHULMAN AVIDOR
IPC分类号： A61K31/683 , A23L17/20 , A23L33/00 , A61K31/685
摘要： Disclosed is a lipid preparation comprising a glycerophospholipid or salt, conjugate and derivatives thereof, particularly phosphatidylserine (PS), phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylinositol (PI), phosphatidylglycerol (PG) and phosphatidic acid (PA), and poly-unsaturated fatty acid (PUFA) acyl groups, particularly long-chain poly-unsaturated fatty acid (LC-PUFA) acyl groups such as omega-3 and/or omega-6 acyl groups, wherein said PUFA is covalently bound to said glycerophospholipid. The disclosed preparations possess an improved bioactivity, and are useful in the treatment of various cognitive and mental conditions and disorders and for maintenance of normal functions of brain-related systems and processes, for example ADHD.

9. 发明专利

BRPI0609904A2 未知
公开(公告)号：BRPI0609904A2
公开(公告)日：2010-05-11
申请号：BRPI0609904
申请日：2006-04-27
申请人： ENZYMOTEC LTD
发明人： SHULMAN AVIDOR , DROR GAI BEN , LAOUZ HALA , YAAKOBI DOV , BAR-ON ZOHAR , BLINDER GREGORY , MEIRI-BENDEK IRIS , HERZOG YAEL
IPC分类号： A23L33/00 , A23D9/00 , C11C3/08 , C11C3/10
摘要： Disclosed are human milk fat (HMF) substitutes, processes for preparation thereof, uses thereof, and fat blends and formula containing the HMF substitutes. A fat base composition of the invention includes a mixture of vegetable-derived triglycerides, with less than 50% of the fatty acid residues bonded at the sn-2 position being saturated; and/or with the amount of saturated fatty acid residues bonded at the sn-2 position of the glycerol backbone less than about 43.5% of the total amount of the fatty acid residues. Typically, substantially all of the saturated fatty acids bonded at the sn-2 position of the glycerol backbone are palmitic acid residues. Also disclosed are substitute HMF compositions including a blend of at least 25% or at least 30% of the fat base composition of the invention with up to 75%, or respectively up to 70%, of at least one vegetable oil. Processes for preparing the fat base compositions and blend are also disclosed. Further disclosed are infant formulas including the fat base composition or substitute human milk fat composition.

10. 发明专利

HK1117350A1 HUMAN MILK FAT SUBSTITUTES 未知
公开(公告)号：HK1117350A1
公开(公告)日：2009-01-16
申请号：HK08112260
申请日：2008-11-07
申请人： ENZYMOTEC LTD
发明人： SHULMAN AVIDOR , DROR GAI BEN , LAOUZ HALA , YAAKOBI DOV , BAR-ON ZOHAR , BLINDER GREGORY , MEIRI-BENDEK IRIS , HERZOG YAEL
IPC分类号： A23L20060101 , A23L33/00 , A23D20060101 , C11C20060101
摘要： Disclosed are human milk fat (HMF) substitutes, processes for preparation thereof, uses thereof, and fat blends and formula containing the HMF substitutes. A fat base composition of the invention includes a mixture of vegetable-derived triglycerides, with less than 50% of the fatty acid residues bonded at the sn-2 position being saturated; and/or with the amount of saturated fatty acid residues bonded at the sn-2 position of the glycerol backbone less than about 43.5% of the total amount of the fatty acid residues. Typically, substantially all of the saturated fatty acids bonded at the sn-2 position of the glycerol backbone are palmitic acid residues. Also disclosed are substitute HMF compositions including a blend of at least 25% or at least 30% of the fat base composition of the invention with up to 75%, or respectively up to 70%, of at least one vegetable oil. Processes for preparing the fat base compositions and blend are also disclosed. Further disclosed are infant formulas including the fat base composition or substitute human milk fat composition.

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