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1. 发明专利

CA3061201A1 SPHINGOSINE PATHWAY MODULATING COMPOUNDS FOR THE TREATMENT OF CANCERS 未知
公开(公告)号：CA3061201A1
公开(公告)日：2018-12-27
申请号：CA3061201
申请日：2018-06-25
申请人： ENZO BIOCHEM INC , ELAZAR RABBANI , DONEGAN JAMES J , DIAMOND PAUL
发明人： ELAZAR RABBANI , DONEGAN JAMES J , DIAMOND PAUL
IPC分类号： A61K31/135 , A61K31/4245 , A61K45/06 , A61P35/00 , A61P35/02
摘要： The invention provides methods and compositions for treating cancers and myeloproliferative disorders using sphingosine kinase-1 inhibitors, such as SK1-I, and selective sphingosine- 1 -phosphate receptor agonists, such as ozanimod.

2. 发明专利

CA3124986A1 SPHINGOSINE PATHWAY MODULATING COMPOUNDS FOR THE TREATMENT OF CANCERS 未知
公开(公告)号：CA3124986A1
公开(公告)日：2020-01-02
申请号：CA3124986
申请日：2018-12-21
申请人： ENZO BIOCHEM INC , RABBANI ELAZAR , DONEGAN JAMES J , DIAMOND PAUL
发明人： RABBANI ELAZAR , DONEGAN JAMES J , DIAMOND PAUL
IPC分类号： A61K31/4245 , A61K31/137 , A61P35/00 , A61P35/02
摘要： The invention provides methods and compositions for treating cancers and myeloproliferative disorders using sphingosine kinase-1 inhibitors, such as SK1-I, and selective sphingosine-1-phosphate receptor agonists, such as ozanimod.

3. 发明申请

WO2011156252A3 SULFATION OF WNT PATHWAY PROTEINS 审中-公开
标题翻译： WNT途径蛋白质的硫化
公开(公告)号：WO2011156252A3
公开(公告)日：2012-02-02
申请号：PCT/US2011039223
申请日：2011-06-06
申请人： ENZO BIOCHEM INC , RABBANI JOSHUA , DONEGAN JAMES J
发明人： RABBANI JOSHUA , DONEGAN JAMES J
IPC分类号： C07K14/51 , C07K14/47 , C07K14/705 , C07K14/71 , C07K16/18 , C07K16/22 , C07K16/28
CPC分类号： C07K16/22 , C07K14/47 , C07K14/51 , C07K14/705 , C07K14/71 , C07K2317/54 , C07K2317/55 , C07K2317/76
摘要： Provided is a protein comprising an antibody binding site that binds to a sulfated epitope of a Wnt pathway protein that is not Wnt5A, Wnt11, or Wnt3a. Also provided is a composition comprising an isolated, and purified Wnt pathway protein, where the protein is sulfated but not glycosylated. Additionally provided is a preparation of a Wnt pathway protein comprising at least one sulfation site and at least one glycosylation site, where all of the Wnt pathway protein in the preparation is glycosylated but not sulfated. Further provided is a composition comprising a peptide less than 75 amino acids or amino acid analogs, the peptide consisting of a fragment of a Wnt pathway protein, wherein the fragment is sulfated. A modified Wnt pathway protein comprising a sulfation site that, is not present, in the native Wnt pathway protein is also provided. Also provided is a method of detecting or quantifying a sulfated Wnt pathway protein in a preparation. Additionally, a modified Wnt pathway protein, lacking a sulfation site that, is present in the native Wnt pathway protein is provided. Also provided, is methods of treating a subject having a disease exacerbated by Wnt activation. Additionally, a method of treating a subject having a disease exacerbated by Wnt inhibition is provided.
摘要翻译：提供了包含结合不是Wnt5A，Wnt11或Wnt3a的Wnt途径蛋白的硫酸化表位的抗体结合位点的蛋白质。还提供了包含分离的和纯化的Wnt途径蛋白质的组合物，其中蛋白质被硫酸化但不被糖基化。另外提供了包含至少一个硫酸化位点和至少一个糖基化位点的Wnt途径蛋白质的制剂，其中所述制剂中的所有Wnt途径蛋白质被糖基化但不硫酸化。还提供了包含小于75个氨基酸或氨基酸类似物的肽的组合物，所述肽由Wnt途径蛋白质的片段组成，其中所述片段被硫酸化。还提供了包含未存在于天然Wnt途径蛋白中的硫酸化位点的修饰的Wnt途径蛋白。还提供了在制剂中检测或定量硫酸化Wnt途径蛋白的方法。另外，提供了在天然Wnt途径蛋白中存在缺乏硫酸化位点的修饰的Wnt途径蛋白。还提供了治疗患有由Wnt活化加重的疾病的受试者的方法。另外，提供了治疗由Wnt抑制加剧的疾病的受试者的方法。

4. 发明申请

WO2014176235A2 TOLERIZING TREATMENTS FOR AUTOIMMUNE DISEASE 审中-公开
标题翻译：治疗自身免疫疾病的治疗
公开(公告)号：WO2014176235A2
公开(公告)日：2014-10-30
申请号：PCT/US2014034948
申请日：2014-04-22
申请人： ENZO BIOCHEM INC , NUSSENBLATT RICHARD , LIU BAOYING , WEI LAI , RABBANI ELAZAR , DONEGAN JAMES J
发明人： NUSSENBLATT RICHARD , LIU BAOYING , WEI LAI , RABBANI ELAZAR , DONEGAN JAMES J
IPC分类号： A61K35/14 , G01N33/50
CPC分类号： A61K35/17 , C12N5/0636 , C12N2501/998 , G01N33/505
摘要： The disclosure relates to methods of identifying a compound that comprises an epitope that induces immune tolerance in a patient suffering from an autoimmune disease. The disclosure further relates to methods of treating an autoimmune disease by administering (i) a compound identified by the methods described herein, (ii) regulatory T-cells from the patient or a compatible donor, or (iii) a combination of regulatory T-cells and a compound identified by the methods described herein. The disclosure further relates to methods of treating age-related macular degeneration and uveitis.
摘要翻译：本公开涉及鉴定包含在患有自身免疫疾病的患者中诱导免疫耐受的表位的化合物的方法。本公开还涉及通过施用（i）通过本文所述的方法鉴定的化合物，（ii）来自患者或相容供体的调节性T细胞，或（iii）调节性T细胞的组合来治疗自身免疫性疾病的方法，细胞和通过本文所述方法鉴定的化合物。本发明还涉及治疗年龄相关性黄斑变性和葡萄膜炎的方法。

5. 发明申请

WO2014176555A2 IMMUNE MODULATION FOR TREATMENT OF AUTOIMMUNE DISEASE 审中-公开
标题翻译：免疫调节治疗自身免疫性疾病
公开(公告)号：WO2014176555A2
公开(公告)日：2014-10-30
申请号：PCT/US2014035549
申请日：2014-04-25
申请人： ENZO BIOCHEM INC , NUSSENBLATT RICHARD , LIU BAOYING , WEI LAI , RABBANI ELAZAR , DONEGAN JAMES J
发明人： NUSSENBLATT RICHARD , LIU BAOYING , WEI LAI , RABBANI ELAZAR , DONEGAN JAMES J
IPC分类号： A61K35/14 , G01N33/50
CPC分类号： A61K35/17 , C12N5/0636 , C12N2501/998 , G01N33/505
摘要： The disclosure relates to methods of identifying a compound that comprises an epitope that induces immune tolerance in a patient suffering from an autoimmune disease. The disclosure further relates to methods of treating an autoimmune disease by administering (i) a compound identified by the methods described herein, (ii) regulatory T-cells from the patient or a compatible donor, or (iii) a combination of regulatory T-cells and a compound identified by the methods described herein. The disclosure further relates to methods of treating age- related macular degeneration and uveitis. The disclosure also relates to methods of monitoring, diagnosing and/or prognosticating an autoimmune disease in a patient.
摘要翻译：本公开涉及鉴定包含在患有自身免疫性疾病的患者中诱导免疫耐受性的表位的化合物的方法。本公开还涉及通过施用（i）通过本文所述方法鉴定的化合物，（ii）来自患者或相容供体的调节性T细胞，或（iii）调节性T细胞的组合来治疗自身免疫性疾病的方法，细胞和通过本文所述方法鉴定的化合物。本公开还涉及治疗年龄相关性黄斑变性和葡萄膜炎的方法。本公开还涉及监测，诊断和/或预测患者中的自身免疫疾病的方法。

6. 发明申请

WO2009086125A2 AFFINITY TAG NUCLEIC ACID AND PROTEIN COMPOSITIONS, AND PROCESSES FOR USING SAME 审中-公开
标题翻译：亲和标记核酸和蛋白质组合物，以及使用相同的方法
公开(公告)号：WO2009086125A2
公开(公告)日：2009-07-09
申请号：PCT/US2008087713
申请日：2008-12-19
申请人： ENZO BIOCHEM INC , RABBANI ELAZAR , STAVRIANOPOULOS JANNIS G , DONEGAN JAMES J , PATTON WAYNE , CARCAMO JUAN
发明人： RABBANI ELAZAR , STAVRIANOPOULOS JANNIS G , DONEGAN JAMES J , PATTON WAYNE , CARCAMO JUAN
IPC分类号： G01N33/566 , C07H1/00 , C07K7/00 , C07K16/18 , C12P21/04 , C12Q1/68
CPC分类号： C12Q1/6804 , C12Q1/6806 , C12Q1/6818 , C12Q1/6834 , G01N33/5308 , G01N33/58 , G01N33/6854 , G01N2458/10 , C12Q2565/518 , C12Q2563/119 , C12Q2565/101
摘要： The present invention concerns compositions and processes that use affinity tags for isolating, and detecting or quantifying analytes, including nucleic acids, proteins and polypeptides. Compositions include nucleic acid compositions and protein compositions with affinity binding pairs, including metal binding peptides and immobilized metals, or peptide affinity groups.
摘要翻译：本发明涉及使用亲和标签分离，检测或定量分析物（包括核酸，蛋白质和多肽）的组合物和方法。组合物包括具有亲和结合对的核酸组合物和蛋白质组合物，包括金属结合肽和固定金属或肽亲和基团。

7. 发明专利

CA2914614C TOLERIZING TREATMENTS FOR AUTOIMMUNE DISEASE 未知
公开(公告)号：CA2914614C
公开(公告)日：2021-07-06
申请号：CA2914614
申请日：2014-04-22
申请人： ENZO BIOCHEM INC , NUSSENBLATT RICHARD , LIU BAOYING , WEI LAI , RABBANI ELAZAR , DONEGAN JAMES J
发明人： NUSSENBLATT RICHARD , LIU BAOYING , WEI LAI , RABBANI ELAZAR , DONEGAN JAMES J
IPC分类号： A61K35/17 , A61P37/06 , C12Q1/02 , C40B30/04 , C40B30/06 , G01N33/48
摘要： The disclosure relates to methods of identifying a compound that comprises an epitope that induces immune tolerance in a patient suffering from an autoimmune disease. The disclosure further relates to methods of treating an autoimmune disease by administering (i) a compound identified by the methods described herein, (ii) regulatory T-cells from the patient or a compatible donor, or (iii) a combination of regulatory T-cells and a compound identified by the methods described herein. The disclosure further relates to methods of treating age-related macular degeneration and uveitis.

8. 发明专利

AU2014256884B2 Immune modulation for treatment of autoimmune disease 未知
公开(公告)号：AU2014256884B2
公开(公告)日：2018-12-13
申请号：AU2014256884
申请日：2014-04-25
申请人： DONEGAN JAMES J , ENZO BIOCHEM INC , LIU BAOYING , NUSSENBLATT ROBERT , RABBANI ELAZAR , WEI LAI
发明人： NUSSENBLATT RICHARD , LIU BAOYING , WEI LAI , RABBANI ELAZAR , DONEGAN JAMES J
IPC分类号： A61K35/14 , A61K39/00 , A61K39/38 , C40B30/04 , G01N33/00 , G01N33/50
摘要： The disclosure relates to methods of identifying a compound that comprises an epitope that induces immune tolerance in a patient suffering from an autoimmune disease. The disclosure further relates to methods of treating an autoimmune disease by administering (i) a compound identified by the methods described herein, (ii) regulatory T-cells from the patient or a compatible donor, or (iii) a combination of regulatory T-cells and a compound identified by the methods described herein. The disclosure further relates to methods of treating age- related macular degeneration and uveitis. The disclosure also relates to methods of monitoring, diagnosing and/or prognosticating an autoimmune disease in a patient.

9. 发明专利

CA2914614A1 TOLERIZING TREATMENTS FOR AUTOIMMUNE DISEASE 未知
公开(公告)号：CA2914614A1
公开(公告)日：2014-10-30
申请号：CA2914614
申请日：2014-04-22
申请人： ENZO BIOCHEM INC , NUSSENBLATT RICHARD , LIU BAOYING , WEI LAI , RABBANI ELAZAR , DONEGAN JAMES J
发明人： NUSSENBLATT RICHARD , LIU BAOYING , WEI LAI , RABBANI ELAZAR , DONEGAN JAMES J
IPC分类号： A61K35/17 , A61P37/06 , C40B30/04 , G01N33/48
摘要： The disclosure relates to methods of identifying a compound that comprises an epitope that induces immune tolerance in a patient suffering from an autoimmune disease. The disclosure further relates to methods of treating an autoimmune disease by administering (i) a compound identified by the methods described herein, (ii) regulatory T-cells from the patient or a compatible donor, or (iii) a combination of regulatory T-cells and a compound identified by the methods described herein. The disclosure further relates to methods of treating age-related macular degeneration and uveitis.

10. 发明专利

JP2002330756A POLYNUCLEOTIDE COMPOSITION AND METHOD 审中-公开
公开(公告)号：JP2002330756A
公开(公告)日：2002-11-19
申请号：JP2002114026
申请日：2002-04-16
申请人： ENZO BIOCHEM INC
发明人： YANG HUEY-LANG , DONEGAN JAMES J
IPC分类号： C12N15/09 , A61K31/7088 , A61K48/00 , A61P31/00 , C12N15/10 , C12N15/70 , C12Q1/68 , C12Q1/689
摘要： PROBLEM TO BE SOLVED: To obtain a composition comprising a specific oligo- or polynucleotide of interest and free of non-specific oligo- or polynucleotide. SOLUTION: This composition is prepared by a method comprising the steps of: (I) forming a vector containing the oligo- or polynucleotide insert of interest, (II) replicating the insert in a suitable cell or cell free system, (III) rendering any oligo- or polynucleotide not associated with the insert without annealing and (IV) recovering the insert as the specific oligo- or polynucleotide composition.

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