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1. 发明申请

US20060222645A1 Monoclonal antibodies against ANGPTL4 有权
公开(公告)号：US20060222645A1
公开(公告)日：2006-10-05
申请号：US11327844
申请日：2006-01-06
申请人： E-Chiang Lee , Gregory Landes , Kyu Chung , Ling Chen , Urvi Desai , David Powell , Seokjoo Hong
发明人： E-Chiang Lee , Gregory Landes , Kyu Chung , Ling Chen , Urvi Desai , David Powell , Seokjoo Hong
IPC分类号： A61K39/395 , C07K16/22
CPC分类号： C07K16/22 , A61K2039/505 , C07K14/515 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/76 , C07K2317/92
摘要： Monoclonal antibodies that specifically bind to ANGPTL4 are provided. Monoclonal antibodies that neutralize at least one activity of ANGPTL4 are provided. Methods of treating a disorder of lipid metabolism using neutralizing monoclonal antibodies are provided.

2. 发明授权

US07935796B2 Monoclonal antibodies against ANGPTL3 有权
标题翻译：针对ANGPTL3的单克隆抗体
公开(公告)号：US07935796B2
公开(公告)日：2011-05-03
申请号：US12001012
申请日：2007-12-06
申请人： E-Chiang Lee , Gregory Landes , Seokjoo Hong , Urvi Desai , David Powell , Xiao Feng
发明人： E-Chiang Lee , Gregory Landes , Seokjoo Hong , Urvi Desai , David Powell , Xiao Feng
IPC分类号： C07K16/26 , C07K16/00 , C07K16/46
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2317/92
摘要： Monoclonal antibodies that specifically bind to ANGPTL3 are provided. Monoclonal antibodies that neutralize at least one activity of ANGPTL3 are provided. Methods of treating a disorder of lipid metabolism using neutralizing monoclonal antibodies are provided.
摘要翻译：提供特异性结合ANGPTL3的单克隆抗体。提供中和至少一种ANGPTL3活性的单克隆抗体。提供了使用中和单克隆抗体治疗脂质代谢紊乱的方法。

3. 发明申请

US20080177045A1 Monoclonal antibodies against ANGPTL3 有权
标题翻译：针对ANGPTL3的单克隆抗体
公开(公告)号：US20080177045A1
公开(公告)日：2008-07-24
申请号：US12001012
申请日：2007-12-06
申请人： E-Chiang Lee , Gregory Landes , Seokjoo Hong , Urvi Desai , David Powell
发明人： E-Chiang Lee , Gregory Landes , Seokjoo Hong , Urvi Desai , David Powell
IPC分类号： C07K16/00
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2317/92
摘要： Monoclonal antibodies that specifically bind to ANGPTL3 are provided. Monoclonal antibodies that neutralize at least one activity of ANGPTL3 are provided. Methods of treating a disorder of lipid metabolism using neutralizing monoclonal antibodies are provided.
摘要翻译：提供特异性结合ANGPTL3的单克隆抗体。提供中和至少一种ANGPTL3活性的单克隆抗体。提供了使用中和单克隆抗体治疗脂质代谢紊乱的方法。

4. 发明授权

US08742075B2 Monoclonal antibodies against ANGPTL3 有权
标题翻译：针对ANGPTL3的单克隆抗体
公开(公告)号：US08742075B2
公开(公告)日：2014-06-03
申请号：US13073617
申请日：2011-03-28
申请人： E-Chiang Lee , Gregory Landes , Seokjoo Hong , Urvi Desai , David Powell , Xiao Feng
发明人： E-Chiang Lee , Gregory Landes , Seokjoo Hong , Urvi Desai , David Powell , Xiao Feng
IPC分类号： C07K16/26 , C07K16/00 , A61K39/395
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2317/92
摘要： Monoclonal antibodies that specifically bind to ANGPTL3 are provided. Monoclonal antibodies that neutralize at least one activity of ANGPTL3 are provided. Methods of treating a disorder of lipid metabolism using neutralizing monoclonal antibodies are provided.
摘要翻译：提供特异性结合ANGPTL3的单克隆抗体。提供中和至少一种ANGPTL3活性的单克隆抗体。提供了使用中和单克隆抗体治疗脂质代谢紊乱的方法。

5. 发明申请

US20110243948A1 Monoclonal Antibodies Against ANGPTL3 有权
标题翻译：针对ANGPTL3的单克隆抗体
公开(公告)号：US20110243948A1
公开(公告)日：2011-10-06
申请号：US13073617
申请日：2011-03-28
申请人： E-Chiang Lee , Gregory Landes , Seokjoo Hong , Urvi Desai , David Powell , Xiao Feng
发明人： E-Chiang Lee , Gregory Landes , Seokjoo Hong , Urvi Desai , David Powell , Xiao Feng
IPC分类号： A61K39/395 , C07K16/18 , A61P3/10 , A61P3/06 , A61P9/10 , A61P3/00 , A61P3/04
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2317/92
摘要： Monoclonal antibodies that specifically bind to ANGPTL3 are provided. Monoclonal antibodies that neutralize at least one activity of ANGPTL3 are provided. Methods of treating a disorder of lipid metabolism using neutralizing monoclonal antibodies are provided.
摘要翻译：提供特异性结合ANGPTL3的单克隆抗体。提供中和至少一种ANGPTL3活性的单克隆抗体。提供了使用中和单克隆抗体治疗脂质代谢紊乱的方法。

6. 发明申请

US20120094555A1 ELECTRIC MARINE PROPULSION DEVICE WITH INTEGRAL MAGNETIC GEARING 有权
标题翻译：具有整体磁力传动的电动海洋推进装置
公开(公告)号：US20120094555A1
公开(公告)日：2012-04-19
申请号：US13260428
申请日：2010-03-26
申请人： Stuart Calverley , David Powell
发明人： Stuart Calverley , David Powell
IPC分类号： B63H23/24 , H02K51/00
CPC分类号： B63H23/24 , B63H2005/1258 , B63H2021/202 , H02K7/11 , H02K51/00 , Y02T70/5236
摘要： A propulsion device for a marine vessel, the propulsion device comprising an electrical machine with integral magnetic gearing, which comprises three members, namely a first or inner rotor comprising a first plurality of permanent magnets, a second rotor in the form of a plurality of ferromagnetic pole pieces, and a stator which is associated with a plurality of 3-phase windings and to the periphery of which a plurality of second permanent magnets are fixed. The magnetic pole piece rotor is connected to a drive shaft provided with a propulsion means for providing propulsion to the marine vessel. The first or inner rotor is free to rotate about the drive shaft. The pole pieces of the second rotor are arranged to magnetically couple the permanent magnets of the first or inner rotor to the second permanent magnets on the stator.
摘要翻译：一种用于海洋船舶的推进装置，该推进装置包括具有整体磁力传动装置的电机，其包括三个构件，即包括第一多个永磁体的第一或第二转子，包括多个铁磁体形式的第二转子极片和与多个三相绕组相关联的定子，并且固定有多个第二永磁体的周边。磁极片转子连接到设置有用于向船舶提供推进的推进装置的驱动轴上。第一或内转子围绕驱动轴自由旋转。第二转子的极片布置成将第一或内转子的永磁体磁耦合到定子上的第二永磁体。

7. 发明申请

US20100105639A1 MESALAMINE SUPPOSITORY 有权
标题翻译：木脂素支架
公开(公告)号：US20100105639A1
公开(公告)日：2010-04-29
申请号：US12639645
申请日：2009-12-16
申请人： Yves Dumoulin , Carl Gauthier , David Powell , Hugues Moreau
发明人： Yves Dumoulin , Carl Gauthier , David Powell , Hugues Moreau
IPC分类号： A61K31/606 , A61P1/00
CPC分类号： A61K9/14 , A61K9/0031 , A61K9/02 , A61K31/136 , A61K31/195 , A61K31/606 , A61K47/44
摘要： The present invention relates to a mesalamine rectal suppository designed to provide improved comfort of use. One embodiment of the invention is a mesalamine rectal suppository comprising mesalamine and one or more pharmaceutically acceptable excipients, wherein the drug load of the suppository ranges from 35% to 50%. Yet another embodiment of the invention is a mesalamine rectal suppository comprising mesalamine having a tap density ranging from about 600 to about 800 g/L (as measured by USP ) and a hard fat having an ascending melting point of 32 to 35.5° C. Yet another embodiment is a mesalamine rectal suppository comprising mesalamine particles and one or more pharmaceutically acceptable excipients, where the mesalamine particles have a surface area of from about 0.1 m2/g to about 2.8 m2/g (e.g., from about 0.1 m2/g to about 1.3 m2/g). Methods of preparing and methods of treatment with mesalamine suppositories are also provided. The invention further provides a method of determining a dissolution parameter (such as dissolution rate) of a mesalamine rectal suppository, such as a 1 g mesalamine suppository, by measuring its dissolution with USP Apparatus #2 at 40° C. and a paddle rotation speed of 125 rpm in 0.2 M phosphate buffer at a pH of 7.5.
摘要翻译：本发明涉及美沙拉坦直肠栓剂，其旨在提供改善的使用舒适性。本发明的一个实施方案是美沙拉坦直肠栓剂，其包含美沙拉嗪和一种或多种药学上可接受的赋形剂，其中栓剂的药物负载范围为35％至50％。本发明的另一个实施方案是美沙拉坦直肠栓剂，其包含振荡密度范围为约600至约800g / L的美沙拉嗪（通过USP <616>测量）和具有上升熔点为32至35.5°的硬脂肪 C.另一个实施方案是美沙拉坦直肠栓剂，其包含美沙拉嗪颗粒和一种或多种药学上可接受的赋形剂，其中美沙拉嗪颗粒的表面积为约0.1m 2 / g至约2.8m 2 / g（例如，约0.1m 2 / g至约1.3m 2 / g）。还提供了制备方法和美沙拉坦栓剂的治疗方法。本发明还提供了一种通过用USP装置＃2在40℃下测量溶解参数（例如溶解度）来测定美沙拉嗪直肠栓剂如1g美沙胺栓剂的溶出参数（如溶出速率），并且桨叶转速在pH 7.5的0.2M磷酸盐缓冲液中的125rpm。

8. 发明申请

US20100057855A1 TRACKING SUBJECT MATTER IN AN E-MAIL DISCUSSION 审中-公开
标题翻译：跟踪电子邮件讨论中的主题
公开(公告)号：US20100057855A1
公开(公告)日：2010-03-04
申请号：US12199235
申请日：2008-08-27
申请人： Al Chakra , Brian Hussey , Simon P. O'Doherty , David Powell
发明人： Al Chakra , Brian Hussey , Simon P. O'Doherty , David Powell
IPC分类号： G06F15/16 , G06F17/30
CPC分类号： H04L51/00
摘要： Methods, systems, and computer readable media for tracking subject matter of an e-mail discussion are described. A query e-mail is received, wherein the query e-mail includes an initial request and wherein the query e-mail commences the e-mail discussion. At least one marked response e-mail is received, wherein the at least one marked response e-mail includes information responsive to the query e-mail and is marked with an indication that the initial request has been resolved, and wherein the at least one marked response e-mail is appended to the e-mail discussion. At least one visual indicator in the e-mail discussion is provided that distinguishes at least one of the query e-mail and the at least one marked response e-mail when the e-mail discussion is opened at a later time.
摘要翻译：描述用于跟踪电子邮件讨论主题的方法，系统和计算机可读介质。接收查询电子邮件，其中查询电子邮件包括初始请求，其中查询电子邮件开始电子邮件讨论。接收至少一个标记的响应电子邮件，其中所述至少一个标记的响应电子邮件包括响应于查询电子邮件的信息，并且标记有初始请求已被解析的指示，并且其中所述至少一个标有回应的电子邮件附加到电子邮件讨论中。提供了电子邮件讨论中的至少一个视觉指示符，其在稍后打开电子邮件讨论时区分查询电子邮件和至少一个标记的回复电子邮件中的至少一个。

9. 发明申请

US20090264386A1 MESALAMINE SUPPOSITORY 有权
标题翻译：木脂素支架
公开(公告)号：US20090264386A1
公开(公告)日：2009-10-22
申请号：US12476185
申请日：2009-06-01
申请人： Carl Gauthier , Yves Dumoulin , David Powell
发明人： Carl Gauthier , Yves Dumoulin , David Powell
IPC分类号： A61K31/606 , A61P1/00
CPC分类号： A61K9/02 , A61K31/137 , A61K47/44 , Y10S514/953
摘要： The present invention relates to a mesalamine rectal suppository designed to provide improved comfort of use. One embodiment of the invention is a mesalamine rectal suppository comprising mesalamine and one or more pharmaceutically acceptable excipients, wherein the drug load of the suppository ranges from 35% to 50%. Another embodiment of the invention is a mesalamine rectal suppository comprising from about 850 to about 1150 mg mesalamine and one or more pharmaceutically acceptable excipients, wherein the total weight of the suppository ranges from about 2250 to about 2700 mg. Another embodiment of the invention is a mesalamine rectal suppository comprising from about 400 to about 600 mg mesalamine and one or more pharmaceutically acceptable excipients, wherein the total weight of the suppository ranges from about 870 to about 1715 mg. Yet another embodiment of the invention is a mesalamine rectal suppository comprising mesalamine having a tap density ranging from about 600 to about 800 g/L (as measured by USP ) and a hard fat having an ascending melting point of 32 to 35.5° C. Methods of preparing and methods of treatment with mesalamine suppositories are also provided. The invention further provides a method of determining a dissolution parameter (such as dissolution rate) of a mesalamine rectal suppository, such as a 1 g mesalamine suppository, by measuring its dissolution with USP Apparatus #2 at 40° C. and a paddle rotation speed of 125 rpm in 0.2 M phosphate buffer at a pH of 7.5.
摘要翻译：本发明涉及美沙拉坦直肠栓剂，其旨在提供改善的使用舒适性。本发明的一个实施方案是美沙拉坦直肠栓剂，其包含美沙拉嗪和一种或多种药学上可接受的赋形剂，其中栓剂的药物负载范围为35％至50％。本发明的另一个实施方案是美沙拉坦直肠栓剂，其包含约850至约1150mg美沙拉嗪和一种或多种药学上可接受的赋形剂，其中栓剂的总重量为约2250至约2700mg。本发明的另一个实施方案是美沙拉坦直肠栓剂，其包含约400至约600mg的美沙拉嗪和一种或多种药学上可接受的赋形剂，其中栓剂的总重量为约870至约1715mg。本发明的另一个实施方案是美沙拉坦直肠栓剂，其包含振荡密度范围为约600至约800g / L的美沙拉嗪（通过USP <616>测量）和具有上升熔点为32至35.5°的硬脂肪 C.还提供了制备方法和美沙拉嗪栓剂的治疗方法。本发明还提供了一种通过用USP装置＃2在40℃下测量溶解参数（例如溶解度）来测定美沙拉嗪直肠栓剂如1g美沙胺栓剂的溶出参数（如溶出速率），并且桨叶转速在pH 7.5的0.2M磷酸盐缓冲液中的125rpm。

10. 发明申请

US20090056095A1 Rail Fence Retractor 有权
标题翻译：铁栅栏牵引器
公开(公告)号：US20090056095A1
公开(公告)日：2009-03-05
申请号：US12263931
申请日：2008-11-03
申请人： David Powell , Steven R. Watts
发明人： David Powell , Steven R. Watts
IPC分类号： E04H17/26 , E04H17/24 , B25B27/00
CPC分类号： E04H17/26 , E04H17/1413 , E04H2017/1469 , Y10T29/53683 , Y10T29/53909 , Y10T29/53943
摘要： A rail fence retractor allowing removal of a fence rail engaged with a fence post comprising a blade having a first and second end. The first end of the blade has a thickness and width allowing insertion into a fence post slot having a rail inserted therein. The rail has self-locking tabs which must be depressed for removal of the rail from the fence post slot. The fence rail retractor also has a handle which is attached to the second end of the blade. The handle allows the application of force against handle to fix the position of the handle against the fence post during removal of said rail from said fence post slot. The handle is also useful in carrying the rail fence retractor when not in use. The handles of the rail fence retractor may be configured to allow integration with the blade. The handles may be also be configured to allow a pair of rail fence retractors to fit or snap together when not in use.
摘要翻译：轨道牵引器，其允许移除与栅栏柱接合的围栏栏杆，所述围栏栏杆包括具有第一端和第二端的叶片。叶片的第一端具有允许插入到其中插入有导轨的栅栏柱槽中的厚度和宽度。导轨具有自锁片，必须按下以将轨从栅栏柱槽中取出。围栏轨道牵开器还具有附接到叶片第二端的把手。在从所述围栏柱槽移除所述导轨期间，所述手柄允许施加抵抗手柄的力将所述把手的位置固定在所述挡板柱上。当不使用时，手柄也可用于承载轨道牵引器。轨道牵引器的手柄可以被配置成允许与叶片的一体化。手柄也可以被配置成允许一对轨道护栏卷收器在不使用时装配或卡扣在一起。

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