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1. 发明授权

US5939252A Detachable-element assay device 失效
标题翻译：可拆分元素测定装置
公开(公告)号：US5939252A
公开(公告)日：1999-08-17
申请号：US853760
申请日：1997-05-09
申请人： Donald J. Lennon , Roger N. Piasio
发明人： Donald J. Lennon , Roger N. Piasio
IPC分类号： G01N21/01 , G01N21/27 , G01N30/00 , G01N30/88 , G01N33/543 , C12Q1/00
CPC分类号： G01N33/54386 , Y10S435/97 , Y10S435/975 , Y10S436/807 , Y10S436/808 , Y10S436/825
摘要： An assay device for detection or determination of an analyte in a sample uses either removably attachable components or hinged panels to provide greater flexibility and reduce manufacturing and storage costs. In one embodiment of the device, the device comprises: (1) a first opposable component including:(a) a first panel; (b) a second panel mounted on the first panel generally parallel to the first panel with space between the first and second panel, the second panel having an opening forming a first receptacle for a sample collection device; and (c) a second receptacle for a test strip formed by the first panel and the second panel; and (2) a second opposable component hingedly attached to the first opposable component. In this device, the first and second opposable components can be brought into operable contact so that fluid is expressed from the sample collection device and applied to the test strip for detection or determination of an analyte by a test performed on the test strip. Other embodiments of devices are included, as well as test kits and method of use of the devices.
摘要翻译：用于检测或确定样品中分析物的测定装置使用可拆卸地附接的部件或铰接板来提供更大的灵活性并降低制造和存储成本。在该设备的一个实施例中，该装置包括：（1）第一可反对组件，包括：（a）第一面板; （b）安装在所述第一面板上的大致平行于所述第一面板的第二面板，所述第一面板具有位于所述第一面板与所述第二面板之间的空间，所述第二面板具有形成用于样品收集装置的第一容器的开口; 和（c）由第一面板和第二面板形成的用于测试条的第二容器; 和（2）铰接地附接到第一可反涂组分的第二可反涂组分。在该装置中，可以使第一和第二可反映部件可操作地接触，使得流体从样品收集装置表达并施加到测试条上，以通过在试纸上进行的测试来检测或确定分析物。包括设备的其他实施例，以及测试套件和设备的使用方法。

2. 发明授权

US4999163A Disposable, pre-packaged device for conducting immunoassay procedures 失效
标题翻译：用于进行免疫测定程序的一次性预包装设备
公开(公告)号：US4999163A
公开(公告)日：1991-03-12
申请号：US404061
申请日：1989-09-08
申请人： Donald J. Lennon , Timothy C. Murphy, Jr.
发明人： Donald J. Lennon , Timothy C. Murphy, Jr.
IPC分类号： G01N33/53 , G01N33/543
CPC分类号： G01N33/5302 , G01N33/54366 , Y10S436/81
摘要： A disposable, pre-packaged device for conducting an immunoassay procedure that results in the production of separable liquid and solid phases. The device includes a cup having an inlet and presenting a liquid phase receiving chamber. An absorbent for liquid phase materials is in the chamber and a series of ribs hold the absorbent away from the walls of the chamber providing a breathing space extending around the absorbent. A porous capture media element for capturing and displaying solid phase products of the procedure is disposed adjacent the inlet of the device in fluid communication with the absorbent so that in operation the absorbent promotes flow of liquid phase through the capture element. A lid element is mounted on the cup adjacent the inlet and the lid and the cup are held together by welding of annular flanges. The lid element includes an elongated cylindrical member extending through the inlet and defining a throat for directing flow of liquid phase onto the capture media. The cylindrical member has an annular surface at its inner end for contacting the porous capture media and holding it in tight fluid communication with the absorbent. A vent hole is provided in the lid flange to facilitate venting of the breathing space. The vent hole and the throat opening are disposed in a single plane so that a single planar coil element may be used to keep out contamination during storage and shipment.
摘要翻译：用于进行免疫测定程序的一次性预先包装的装置，其导致可分离的液体和固相的生产。该装置包括具有入口并呈现液相接收室的杯。用于液相材料的吸收剂在腔室中，并且一系列肋将吸收剂保持离开室的壁，从而提供围绕吸收体延伸的呼吸空间。用于捕获和显示该过程的固相产物的多孔捕获介质元件设置在与吸收剂流体连通的装置的入口附近，使得在操作中吸收剂促进液相流过捕获元件。盖元件安装在靠近入口的杯子上，并且通过环形凸缘的焊接将杯子保持在一起。盖元件包括延伸穿过入口的细长圆柱形构件，并且限定了用于将液相流引导到捕获介质上的喉部。圆柱形构件在其内端具有环形表面，用于接触多孔捕获介质并将其保持与吸收剂紧密流体连通。盖法兰上设有通风孔，以便呼吸空间排出。通气孔和喉部开口设置在单个平面中，使得可以使用单个平面线圈元件来防止在储存和运输期间的污染。

3. 发明授权

US4963325A Swab expressor immunoassay device 失效
标题翻译：拭子表达免疫测定装置
公开(公告)号：US4963325A
公开(公告)日：1990-10-16
申请号：US191158
申请日：1988-05-06
申请人： Donald J. Lennon , Paul B. Foster
发明人： Donald J. Lennon , Paul B. Foster
IPC分类号： B01L3/00 , G01N1/02 , G01N33/543
CPC分类号： B01L3/508 , G01N1/02 , G01N33/54366 , B01L2300/043 , G01N2001/028 , Y10S435/81 , Y10S436/808 , Y10S436/81
摘要： A disposable, pre-packaged device is particularly suitable for conducting diagnostic procedures based on immunological reactions using specimens gathered in the absorbent tip of a swab. The device is made up of an elongated holder member which includes structure for supporting and positioning a swab, another holder member hingedly mounted at one end of the swab holder member and which carries a capture media element assemblage suitable for conducting an immunoassay test. The device also includes a cover member hingedly mounted on the opposite end of the swab holder member. The cover member includes structure positioned for pressing the swab tip against the capture element when the device is operated. Thus, the light in the swab tip is squeezed and the test fluid is expressed therefrom and brought into intimate contact with the capture element. The results of the test are visually observable by simply swinging the member which carries the capture element away from the swab holder member.
摘要翻译：一次性预包装的装置特别适用于使用聚集在拭子的吸收尖端中的样本进行基于免疫反应的诊断程序。该装置由细长的保持器构件组成，其包括用于支撑和定位拭子的结构，另一保持构件铰接地安装在拭子保持器构件的一端并且携带适于进行免疫测定试验的捕获介质元件组合。该装置还包括铰链地安装在拭子保持器构件的相对端上的盖构件。所述盖构件包括定位成当所述装置被操作时将所述拭子尖端压靠在所述捕获元件上的结构。因此，拭子尖端的光被挤压并且测试流体由其表达并与捕获元件紧密接触。通过将携带捕获元件的构件远离拭子保持器构件简单地摆动，可以目测观察测试结果。

4. 发明授权

US4496236A Anodized electrostatic imaging surface 失效
标题翻译：阳极氧化静电成像表面
公开(公告)号：US4496236A
公开(公告)日：1985-01-29
申请号：US529195
申请日：1983-09-06
申请人： Leo A. Beaudet , Donald J. Lennon
发明人： Leo A. Beaudet , Donald J. Lennon
IPC分类号： C25D11/24 , G03G15/08 , G03G15/22
CPC分类号： C25D11/246 , G03G15/0849
摘要： Dielectric sealing of porous anodized aluminum, in which moisture in the pores of the coating formed by hardcoat anodizing is removed, and the porous anodized surface then impregnated with a water insoluble metallic salt. The impregnant material is a compound of a Group II or III metal with a long chain fatty acid containing between 8 and 32 carbon atoms, saturated or unsaturated. The impregnant material may be applied as a hot melt or in solution; in the former case, any excess material is removed from the surface. The resulting product has excellent resistivity and dielectric properties, and maintains these properties at elevated humidities. As a final step the surface may be polished to provide favorable toner release characteristics during pressure transfer.
摘要翻译：多孔阳极氧化铝的电介质密封，其中除去由硬涂层阳极氧化形成的涂层的孔中的水分，然后用水不溶性金属盐浸渍多孔阳极氧化表面。浸渍剂材料是具有饱和或不饱和的含有8至32个碳原子的长链脂肪酸的II或III族金属的化合物。浸渍剂材料可以作为热熔体或溶液使用; 在前一种情况下，从表面去除任何多余的材料。所得产品具有优异的电阻率和介电性能，并且在升高的湿度下保持这些性能。作为最终步骤，可以抛光表面以在压力传递期间提供有利的调色剂释放特性。

5. 发明授权

US5084245A Assay device for swab borne analytes 失效
标题翻译：用于拭子分析物的测定装置
公开(公告)号：US5084245A
公开(公告)日：1992-01-28
申请号：US630432
申请日：1990-12-20
申请人： Carl M. Berke , Donald J. Lennon , Paul B. Foster , Gary W. Boys
发明人： Carl M. Berke , Donald J. Lennon , Paul B. Foster , Gary W. Boys
IPC分类号： B01L3/00 , G01N33/53 , G01N33/543
CPC分类号： B01L3/502 , G01N33/5302 , G01N33/54366 , Y10S435/81 , Y10S436/808 , Y10S436/81
摘要： A disposable, pre-packaged device as particularly suitable for conducting diagnostic procedures based on immunological reactions using specimens gathered up in the absorbent tip of a swab. The device is made up of a base component upon which a sample sensitive element is mounted and a guide member that is normally mounted on the base component in covering relationship to the reactive element. The guide member includes structure which defines an elongated passageway extending therethrough. One end of the passageway is positioned in close proximity to the sensitive element when the member is mounted on the base component. The other end of the passageway opens outwardly of the guide member. In using the device, the swab tip is pushed through the passageway and toward the sensitive element using the stick of the swab. A number of ribs are positioned in the passageway adjacent the sensitive element to squeeze the tip and express fluid therefrom as the tip is pushed toward the sensitive element. Thus, the liquid in the swab tip is expressed therefrom and brought into intimate contact with the sensitive element. The results of the test are visually observable by removing the guide member from the base component to uncover the sensitive element.
摘要翻译：一种一次性的预先包装的装置，特别适用于使用收集在拭子的吸收尖端中的样本进行基于免疫反应的诊断程序。该装置由安装有样品敏感元件的基础部件和通常安装在基部部件上的与反应元件覆盖关系的引导部件组成。引导构件包括限定延伸穿过其中的细长通道的结构。当构件安装在基座部件上时，通道的一端位于紧邻敏感元件的位置。通道的另一端通向导向件的外部。在使用该装置时，拭子尖被推动通过通道并且使用拭子的棒朝向敏感元件。多个肋条定位在靠近敏感元件的通道中，以挤压尖端并且当尖端被推向敏感元件时从其表达流体。因此，拭子尖端中的液体由其表示并与敏感元件紧密接触。通过从基部组件移除引导构件以露出敏感元件，目视观察测试结果。

6. 发明授权

US3964832A Gel composition and adhesive stick 失效
标题翻译：凝胶成分和胶粘剂
公开(公告)号：US3964832A
公开(公告)日：1976-06-22
申请号：US479801
申请日：1974-06-17
申请人： Norman B. Cohen , Donald J. Lennon
发明人： Norman B. Cohen , Donald J. Lennon
IPC分类号： A45D40/04 , B01J13/00 , B65D83/00 , C09J5/00 , B43K21/08
CPC分类号： A45D40/04 , B01J13/0065 , B65D83/0011 , C09J9/005
摘要： A gel composition suitable for use as a carrier for adhesives, dyes, pigments or the like is formed from a Group II metal salt or Group III metal salt of an aliphatic carboxylic acid having from 8 to 36 carbon atoms and a chelating agent for the metal, dispersed or dissolved in a liquid dispersant that can be water, a water-miscible organic solvent or a mixture of water and at least one water-miscible organic solvent. The gel contains from about 80 to 96 percent by weight of the liquid and the mole ratio of the salt to chelating agent employed is between about 0.5 to 1 and 2 to 1. When employed as an adhesive carrier, the gel contains from 5 to 45 weight percent, based upon the total weight of the adhesive composition, of a water soluble or water dispersible film-forming adhesive such as polyvinylpyrrolidone.
摘要翻译：适合用作粘合剂，染料，颜料等的载体的凝胶组合物由具有8至36个碳原子的脂族羧酸的第II族金属盐或III族金属盐和金属螯合剂形成分散或溶解在可以是水，水混溶性有机溶剂或水与至少一种水混溶性有机溶剂的混合物的液体分散剂中。该凝胶含有约80至96重量％的液体，并且所用的盐与螯合剂的摩尔比为约0.5至1至2:1。当用作粘合剂载体时，凝胶含有5至45 基于粘合剂组合物的总重量的水溶性或水分散性成膜粘合剂如聚乙烯吡咯烷酮的重量百分数。

7. 发明授权

US4413049A Anodized electrostatic imaging surface 失效
公开(公告)号：US4413049A
公开(公告)日：1983-11-01
申请号：US346349
申请日：1982-02-05
申请人： Leo A. Beaudet , Donald J. Lennon
发明人： Leo A. Beaudet , Donald J. Lennon
IPC分类号： C25D11/24 , G03G15/00 , G03G13/22
CPC分类号： G03G15/751 , C25D11/246
摘要： Dielectric sealing of porous anodized aluminum, in which moisture in the pores of the coating formed by hardcoat anodizing is removed, and the porous anodized surface then impregnated with a water insoluble metallic salt. The impregnant material is a compound of a Group II or III metal with a long chain fatty acid containing between 8 and 32 carbon atoms, saturated or unsaturated. The impregnant material may be applied as a hot melt or in solution; in the former case, any excess material is removed from the surface. The resulting product has excellent resistivity and dielectric properties, and maintains these properties at elevated humidities. As a final step the surface may be polished to provide favorable toner release characteristics during pressure transfer.

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