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1. 发明申请

US20080161303A1 Imidazo- and triazolo-pyridine compounds and methods of use thereof 失效
标题翻译：咪唑并 - 三唑并吡啶化合物及其使用方法
公开(公告)号：US20080161303A1
公开(公告)日：2008-07-03
申请号：US11973076
申请日：2007-10-05
申请人： Dawei Zhang , Andrew Tasker , Kelvin K.C. Sham , Partha Pratim Chakrabarti , James Richard Falsey , Bradley J. Herberich , Liping H. Pettus , Robert M. Rzasa
发明人： Dawei Zhang , Andrew Tasker , Kelvin K.C. Sham , Partha Pratim Chakrabarti , James Richard Falsey , Bradley J. Herberich , Liping H. Pettus , Robert M. Rzasa
IPC分类号： A61K31/5377 , C07D221/02 , A61K31/496 , A61P29/00 , C07D295/00 , A61K31/437
CPC分类号： C07D471/04
摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A, B, R1, R2, R3 and R4 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of P38 map kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammation disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.
摘要翻译：本发明包括一类新的可用于预防和治疗蛋白激酶介导的疾病，包括炎症和相关病症的化合物。化合物具有通式I，其中A，B，R 1，R 2，R 3和R 4， >在本文中定义。本发明还包括包含一种或多种式I化合物的药物组合物，这些化合物和组合物用于治疗P38地图激酶介导的疾病（包括类风湿性关节炎，牛皮癣和其它炎症疾病）的用途，以及可用于制备式Ⅰ的化合物。

2. 发明授权

US07700593B2 Imidazo- and triazolo-pyridine compounds and methods of use thereof 失效
标题翻译：咪唑并 - 三唑并吡啶化合物及其使用方法
公开(公告)号：US07700593B2
公开(公告)日：2010-04-20
申请号：US11973076
申请日：2007-10-05
申请人： Dawei Zhang , Andrew Tasker , Kelvin K. C. Sham , Partha Pratim Chakrabarti , James Richard Falsey , Bradley J. Herberich , Liping H. Pettus , Robert M. Rzasa
发明人： Dawei Zhang , Andrew Tasker , Kelvin K. C. Sham , Partha Pratim Chakrabarti , James Richard Falsey , Bradley J. Herberich , Liping H. Pettus , Robert M. Rzasa
IPC分类号： A61K31/5377 , C07D221/02 , A61K31/496 , A61P29/00 , C07D295/00 , A61K31/437
CPC分类号： C07D471/04
摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A, B, R1, R2, R3 and R4 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of P38 map kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammation disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.
摘要翻译：本发明包括一类新的可用于预防和治疗蛋白激酶介导的疾病，包括炎症和相关病症的化合物。该化合物具有通式I，其中A，B，R 1，R 2，R 3和R 4在本文中定义。本发明还包括包含一种或多种式I化合物的药物组合物，这些化合物和组合物用于治疗P38地图激酶介导的疾病（包括类风湿性关节炎，牛皮癣和其他炎症疾病）的用途，以及可用于制备式Ⅰ的化合物。

3. 发明授权

US07759337B2 Phthalazine compounds and methods of use 有权
标题翻译：酞嗪化合物及其使用方法
公开(公告)号：US07759337B2
公开(公告)日：2010-07-20
申请号：US11367123
申请日：2006-03-02
申请人： Andrew Tasker , Dawei Zhang , Guo-Qiang Cao , Partha Pratim Chakrabarti , James Richard Falsey , Bradley J. Herberich , Randall W. Hungate , Liping H. Pettus , Anthony Reed , Robert M. Rzasa , Kelvin K. C. Sham , Maya C. Thaman , Shimin Xu
发明人： Andrew Tasker , Dawei Zhang , Guo-Qiang Cao , Partha Pratim Chakrabarti , James Richard Falsey , Bradley J. Herberich , Randall W. Hungate , Liping H. Pettus , Anthony Reed , Robert M. Rzasa , Kelvin K. C. Sham , Maya C. Thaman , Shimin Xu
IPC分类号： C07D237/34 , C07D413/12 , C07D498/08 , C07D279/12 , C07D243/08 , A61K31/498 , A61K31/5355 , A61K31/537 , A61K31/541 , A61K31/551 , A61P29/00 , A61P23/00 , C07D487/04 , A61K31/4985
CPC分类号： C07D409/04 , C07D237/30 , C07D237/32 , C07D237/34 , C07D403/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D487/08 , C07D491/10
摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein B, R1, R2, R3, R4 and R5 are d.efined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammation disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.
摘要翻译：本发明包括一类新的可用于预防和治疗蛋白激酶介导的疾病，包括炎症和相关病症的化合物。该化合物具有通式I，其中B，R 1，R 2，R 3，R 4和R 5在本文中定义。本发明还包括药物组合物，其包含一种或多种式I化合物，这些化合物和组合物用于治疗激酶介导的疾病包括类风湿性关节炎，牛皮癣和其它炎症疾病的用途，以及可用于制备一级方程式

4. 发明申请

US20080119468A1 Phthalazine, aza-and diaza-phthalazine compounds and methods of use 失效
标题翻译：酞嗪，氮杂和二氮杂 - 酞嗪化合物及其使用方法
公开(公告)号：US20080119468A1
公开(公告)日：2008-05-22
申请号：US11899363
申请日：2007-09-04
申请人： Andrew Tasker , Dawei Zhang , Liping H. Pettus , Rob M. Rzasa , Kelvin K.C. Sham , Shimin Xu , Partha Chakrabarti
发明人： Andrew Tasker , Dawei Zhang , Liping H. Pettus , Rob M. Rzasa , Kelvin K.C. Sham , Shimin Xu , Partha Chakrabarti
IPC分类号： A61K31/502 , C07D403/12 , C07D237/34 , C07D413/02 , C07D471/04 , A61P19/10 , A61P11/00 , A61P9/00 , A61P25/00 , A61P21/00 , A61P35/02 , A61K31/496 , C07D413/14 , A61K31/5377 , C07D237/30
CPC分类号： C07D403/12 , C07D237/30 , C07D237/34 , C07D403/10 , C07D413/12 , C07D417/10 , C07D471/04
摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A1, A2, B, R1, R2, R3 and R4 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammation disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.
摘要翻译：本发明包括一类新的可用于预防和治疗蛋白激酶介导的疾病，包括炎症和相关病症的化合物。化合物具有通式I，其中A 1，A 2，B，R 1，R 2， R 3和R 4在本文中定义。本发明还包括药物组合物，其包含一种或多种式I化合物，这些化合物和组合物用于治疗激酶介导的疾病包括类风湿性关节炎，牛皮癣和其它炎症疾病的用途，以及可用于制备一级方程式

5. 发明授权

US08497269B2 Phthalazine compounds as p38 map kinase modulators and methods of use thereof 有权
标题翻译：酞嗪化合物作为p38映射激酶调节剂及其使用方法
公开(公告)号：US08497269B2
公开(公告)日：2013-07-30
申请号：US13123889
申请日：2009-10-07
申请人： Andrew Tasker , James R. Falsey , Robert M. Rzasa , Bradley J. Herberich , Dawei Zhang
发明人： Andrew Tasker , James R. Falsey , Robert M. Rzasa , Bradley J. Herberich , Dawei Zhang
IPC分类号： C07D487/04 , A61K31/50 , A01N43/58
CPC分类号： C07D401/12 , C07D237/30 , C07D237/32 , C07D237/34 , C07D401/04 , C07D403/04 , C07D413/04
摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A4, L, R1, R2, R3, R5 and m are as defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of p38 map kinase mediated diseases including rheumatoid arthritis, psoriasis, chronic obstructive pulmonary disease, ankylosing spondylitis, pain and other inflammatory disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.
摘要翻译：本发明包括一类新的可用于预防和治疗蛋白激酶介导的疾病，包括炎症和相关病症的化合物。该化合物具有通式I，其中A4，L，R1，R2，R3，R5和m如本文所定义。本发明还包括药物组合物，其包含一种或多种式I化合物，用于治疗p38地图激酶介导的疾病包括类风湿性关节炎，牛皮癣，慢性阻塞性肺病，强直性脊柱炎，疼痛和其它炎症性疾病的化合物和组合物的用途，如以及可用于制备式I化合物的中间体和方法。

6. 发明申请

US20120040983A1 Phthalazine Compounds as P38 Map Kinase Modulators and Methods of Use Thereof 有权
标题翻译：酞嗪化合物作为P38映射激酶调节剂及其使用方法
公开(公告)号：US20120040983A1
公开(公告)日：2012-02-16
申请号：US13123889
申请日：2009-10-07
申请人： Andrew Tasker , James R. Falsey , Robert M. Rzasa , Bradley J. Herberich , Dawei Zhang
发明人： Andrew Tasker , James R. Falsey , Robert M. Rzasa , Bradley J. Herberich , Dawei Zhang
IPC分类号： C07D401/04 , A61K31/50 , C07D413/02 , A61P25/28 , A61P3/10 , A61P11/06 , A61P31/12 , A61P1/04 , A61P19/02 , A61P11/00 , A61P9/10 , A61P31/18 , A61P25/00 , A61P37/08 , A61P17/00 , A61P19/00 , A61P31/22 , A61P17/06 , A61K31/501
CPC分类号： C07D401/12 , C07D237/30 , C07D237/32 , C07D237/34 , C07D401/04 , C07D403/04 , C07D413/04
摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A4, L, R1, R2, R3, R5 and m are as defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of p38 map kinase mediated diseases including rheumatoid arthritis, psoriasis, chronic obstructive pulmonary disease, ankylosing spondylitis, pain and other inflammatory disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.
摘要翻译：本发明包括一类新的可用于预防和治疗蛋白激酶介导的疾病，包括炎症和相关病症的化合物。该化合物具有通式I，其中A4，L，R1，R2，R3，R5和m如本文所定义。本发明还包括药物组合物，其包含一种或多种式I化合物，用于治疗p38地图激酶介导的疾病包括类风湿性关节炎，牛皮癣，慢性阻塞性肺病，强直性脊柱炎，疼痛和其它炎症性疾病的化合物和组合物的用途，如以及可用于制备式I化合物的中间体和方法。

7. 发明申请

US20090149468A1 Substituted heterocyclic compounds and methods of use 审中-公开
标题翻译：取代的杂环化合物及其使用方法
公开(公告)号：US20090149468A1
公开(公告)日：2009-06-11
申请号：US12322671
申请日：2009-02-04
申请人： Guo-Qiang Cao , Jian J. Chen , Celia Dominguez , Anthony Reed , Kelvin K.C. Sham , Maya C. Thaman , Dawei Zhang , Bradley J. Herberich
发明人： Guo-Qiang Cao , Jian J. Chen , Celia Dominguez , Anthony Reed , Kelvin K.C. Sham , Maya C. Thaman , Dawei Zhang , Bradley J. Herberich
IPC分类号： A61K31/497 , C07D401/14 , A61K31/496
CPC分类号： C07D487/06 , C07D213/56 , C07D239/95 , C07D401/04 , C07D401/14 , C07D417/14
摘要： The present invention relates to therapeutic diazobicyclo pyridines and their use in the treatment of arthritis, rheumatoid arthritis, psoriatic arthritis or osteoarthritis, organ transplant, acute transplant or heterograft and homograft rejection, ischemic and reperfusion injury, transplantation tolerance induction, multiple sclerosis, inflammatory bowel disease, ulcerative colitis, Crohn's disease, lupus, graft vs. host diseases, T-cell mediated hypersensitivity diseases, contact hypersensitivity, delayed-type hypersensitivity, gluten-sensitive enteropathy, Type 1 diabetes, psoriasis, contact dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism, Graves' Disease, Addison's disease, autoimmune polyglandular disease, autoimmune alopecia, pernicious anemia, vitiligo, autoimmune hypopituatarism, Guillain-Barre syndrome, autoimmune diseases, glomerulonephritis, serum sickness, uticaria, respiratory allergies, asthma, hayfever, allergic rhinitis, skin allergies, scleracielma, mycosis fungoides, acute inflammatory responses, acute respiratory distress syndrome, dermatomyositis, alopecia areata, chronic actinic dermatitis, eczema, Behcet's disease, Pustulosis palmoplanteris, Pyoderma gangrenum, Sezary's syndrome, atopic dermatitis, systemic schlerosis, morphea, Type II diabetes and cancers where PKC theta or other PKC-family kinases are activated, overexpressed or facilitate tumor growth or survival of tumor cells, T cell leukemia, thymoma, T and B cell lymphoma, colon carcinoma, breast carcinoma and lung carcinoma or provides resistance to chemotherapeutic drugs.
摘要翻译：本发明涉及治疗性重氮二环吡啶及其在治疗关节炎，类风湿性关节炎，银屑病关节炎或骨关节炎，器官移植，急性移植或异种移植和同种异体移植排斥，缺血和再灌注损伤，移植耐受诱导，多发性硬化，炎性肠中的用途疾病，溃疡性结肠炎，克罗恩病，狼疮，移植物抗宿主病，T细胞介导的超敏反应疾病，接触性超敏反应，延迟型超敏反应，麸质敏感性肠病，1型糖尿病，牛皮癣，接触性皮炎，桥本氏甲状腺炎，干燥综合征，自身免疫性甲状腺功能亢进症，格雷夫斯病，艾迪生病，自身免疫性多腺病，自身免疫性脱发，恶性贫血，白癜风，自身免疫性低分化症，吉兰巴利综合征，自身免疫性疾病，肾小球肾炎，血清病，荨麻疹，呼吸道过敏，哮喘，过敏性鼻炎，过敏性鼻炎，皮肤过敏 s，scleracielma，蕈样真菌病，急性炎症反应，急性呼吸窘迫综合征，皮肌炎，斑秃，慢性光化性皮炎，湿疹，白塞病，脓疱疮，疱疹性坏疽，Sezary综合征，特应性皮炎，全身性硬化症，morphea，II型糖尿病和PKCθ或其他PKC家族激酶被激活，过度表达或促进肿瘤细胞，T细胞白血病，胸腺瘤，T细胞和B细胞淋巴瘤，结肠癌，乳腺癌和肺癌的肿瘤生长或存活的癌症，或提供对化学治疗的抗性药物

8. 发明授权

US08101612B2 Phthalazine compounds and methods of use 失效
标题翻译：酞嗪化合物及其使用方法
公开(公告)号：US08101612B2
公开(公告)日：2012-01-24
申请号：US11899363
申请日：2007-09-04
申请人： Andrew Tasker , Dawei Zhang , Liping H. Pettus , Rob M. Rzasa , Kelvin K. C. Sham , Shimin Xu , Partha Chakrabarti
发明人： Andrew Tasker , Dawei Zhang , Liping H. Pettus , Rob M. Rzasa , Kelvin K. C. Sham , Shimin Xu , Partha Chakrabarti
IPC分类号： C07D237/30 , C07D413/04 , A61K31/502 , A61K31/5355 , A61P29/00 , A61P19/02 , A61P19/10 , A61P17/06 , A61P17/00 , A61P31/00 , A61P31/16 , A61P31/22 , A61P37/08 , A61P21/00 , A61P3/10 , A61P9/10 , A61P33/06
CPC分类号： C07D403/12 , C07D237/30 , C07D237/34 , C07D403/10 , C07D413/12 , C07D417/10 , C07D471/04
摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of p38 kinase mediated diseases and related inflammatory conditions. The compounds have a general Formula II wherein L1, L2, R1a, R1b, R1c, R2, R3, R3a, R4, R5 and p are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of p38 kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammation disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.
摘要翻译：本发明包括一类新的可用于预防和治疗p38激酶介导的疾病和相关炎性病症的化合物。该化合物具有通式II，其中本文定义了L1，L2，R1a，R1b，R1c，R2，R3，R3a，R4，R5和p。本发明还包括包含一种或多种式I化合物的药物组合物，用于治疗p38激酶介导的疾病（包括类风湿性关节炎，牛皮癣和其它炎症疾病）的这些化合物和组合物的用途，以及可用于制备化合物的中间体和方法的式

9. 发明授权

US08193199B2 Heterocyclic compounds and their uses 有权
标题翻译：杂环化合物及其用途
公开(公告)号：US08193199B2
公开(公告)日：2012-06-05
申请号：US12079406
申请日：2008-03-24
申请人： Yi Chen , Timothy D. Cushing , Jason A. Duquette , Felix Gonzalez Lopez De Turiso , Xiaolin Hao , Xiao He , Brian Lucas , Lawrence R. McGee , Andreas Reichelt , Robert M. Rzasa , Jennifer Seganish , Youngsook Shin , Dawei Zhang
发明人： Yi Chen , Timothy D. Cushing , Jason A. Duquette , Felix Gonzalez Lopez De Turiso , Xiaolin Hao , Xiao He , Brian Lucas , Lawrence R. McGee , Andreas Reichelt , Robert M. Rzasa , Jennifer Seganish , Youngsook Shin , Dawei Zhang
IPC分类号： C07D473/34 , A61K31/52 , A61P35/00 , A61P19/02 , A61P37/06 , A61P19/08 , C07D487/04 , C07D241/40 , C07D241/44 , C07D215/14 , C07D215/26 , C07D215/22 , C07D417/14 , C07D417/04
CPC分类号： C07D487/04 , C07D471/04 , C07D473/30 , C07D473/34
摘要： Substituted bicyclic heteroaryls having the structures: and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.
摘要翻译：具有以下结构的取代的双环杂芳基：和含有它们的组合物，用于治疗一般炎症，关节炎，风湿性疾病，骨关节炎，炎性肠病，炎症性眼病，炎性或不稳定性膀胱病，牛皮癣，皮肤炎症成分的投诉，慢性炎症包括但不限于自身免疫疾病如系统性红斑狼疮（SLE），重症肌无力，类风湿性关节炎，急性播散性脑脊髓炎，特发性血小板减少性紫癜，多发性硬化症，Sjoegren综合征和自身免疫性溶血性贫血，包括所有形式的超敏反应的过敏性疾病，本发明还使得能够治疗依赖于p110δ活性或与p110δ活性相关的癌症的方法，包括但不限于白血病，例如急性骨髓性白血病（AML）Myelo-dysplastic综合征（MDS）骨髓增殖性疾病（MPD） Ch 骨髓性白血病（CML）T细胞急性淋巴细胞白血病（T-ALL）B细胞急性淋巴细胞白血病（B-ALL）非霍奇金淋巴瘤（NHL）B细胞淋巴瘤和实体瘤如乳腺癌。

10. 发明申请

US20090030002A1 Heterocyclic compounds and their uses 失效
标题翻译：杂环化合物及其用途
公开(公告)号：US20090030002A1
公开(公告)日：2009-01-29
申请号：US12079281
申请日：2008-03-24
申请人： Yi Chen , Timothy D. Cushing , Xiaolin Hao , Xiao He , Andreas Reichelt , Robert M. Rzasa , Jennifer Seganish , Youngsook Shin , Dawei Zhang
发明人： Yi Chen , Timothy D. Cushing , Xiaolin Hao , Xiao He , Andreas Reichelt , Robert M. Rzasa , Jennifer Seganish , Youngsook Shin , Dawei Zhang
IPC分类号： A61K31/498 , C07D473/34 , A61K31/52 , C07D471/02 , A61P29/00 , A61P19/02 , A61P37/02 , A61P35/00 , A61K31/519 , C07D487/02
CPC分类号： C07D487/04 , C07D471/04 , C07D519/00
摘要： Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelodysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.
摘要翻译：取代的双环杂芳基和含有它们的组合物，用于治疗一般炎症，关节炎，风湿性疾病，骨关节炎，炎性肠病，炎症性眼病，炎症性或不稳定性膀胱病，牛皮癣，皮肤炎症成分的投诉，慢性炎性病症不限于自身免疫性疾病如系统性红斑狼疮（SLE），重症肌无力，类风湿性关节炎，急性播散性脑脊髓炎，特发性血小板减少性紫癜，多发性硬化症，Sjoegren综合征和自身免疫性溶血性贫血，包括所有形式的超敏反应的过敏症状包括但不限于白血病，例如急性骨髓性白血病（AML）骨髓增生异常综合征（MDS）骨髓增生性疾病（MPD）慢性骨髓性白血病（Myeloid Leukemi）的介导，依赖或与p110delta活性相关的癌症的方法（CML）T细胞急性淋巴细胞白血病（T-ALL）B细胞急性淋巴细胞白血病（B-ALL）非霍奇金淋巴瘤（NHL）B细胞淋巴瘤和实体瘤如乳腺癌。

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