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1. 发明授权

US09745374B2 Fusion proteins containing recombinant cytotoxic RNAses 有权
公开(公告)号：US09745374B2
公开(公告)日：2017-08-29
申请号：US13402480
申请日：2012-02-22
申请人： David M. Goldenberg , Hans J. Hansen , Chien-Hsing Ken Chang , Sailaja S. Vanama , Edmund A. Rossi
发明人： David M. Goldenberg , Hans J. Hansen , Chien-Hsing Ken Chang , Sailaja S. Vanama , Edmund A. Rossi
IPC分类号： A61K47/48 , C07K16/28 , C07K16/30 , C12N9/12 , C12N9/22
CPC分类号： C07K16/2803 , A61K47/6817 , A61K47/6877 , C07K16/2833 , C07K2317/24 , C07K2317/41 , C07K2319/00 , C07K2319/33 , C12N9/22 , C12N2510/02
摘要： Recombinant immunotoxins containing a cytotoxic RNAse fused to an antibody or antibody fragment may be produced in mammalian cell culture. Surprisingly, immunotoxins containing a cytotoxic RNAse fused to the N-terminus of one antibody variable domain can be prepared and retain the ability to specifically bind antigen. The immunotoxins may be used in a variety of therapeutic methods for treating diseases or syndromes associated with unwanted or inappropriate cell proliferation or activation.

2. 发明授权

US08613903B2 Humanized L243 antibodies 有权
公开(公告)号：US08613903B2
公开(公告)日：2013-12-24
申请号：US12556718
申请日：2009-09-10
申请人： David M. Goldenberg , Hans J. Hansen , Zhengxing Qu , Chien-Hsing Chang
发明人： David M. Goldenberg , Hans J. Hansen , Zhengxing Qu , Chien-Hsing Chang
IPC分类号： A61K38/43 , A61K45/00 , A61K51/00 , A61K39/00 , A61K39/395 , C07K16/30
CPC分类号： C07K16/2833 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K47/6849 , A61K47/6867 , A61K51/1027 , A61K51/1093 , A61K2039/505 , A61K2039/507 , C07K16/28 , C07K16/2887 , C07K16/4241 , C07K19/00 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/75 , C07K2317/92
摘要： Humanized antibodies are provided that specifically bind HLA-DR. The antibodies recognize the epitope recognized by the murine monoclonal antibody L243. Processes for preparing such antibodies, pharmaceutical compositions containing such antibodies, and clinical therapeutic and diagnostic, as well as research-related uses for such antibodies, are provided.

3. 发明授权

US08343496B2 Anti-CD74 immunoconjugates and methods 有权
公开(公告)号：US08343496B2
公开(公告)日：2013-01-01
申请号：US12891169
申请日：2010-09-27
申请人： Gary L. Griffiths , Hans J. Hansen , David M. Goldenberg , Bo B. Lundberg
发明人： Gary L. Griffiths , Hans J. Hansen , David M. Goldenberg , Bo B. Lundberg
IPC分类号： A61K51/10 , A61K51/12 , A61K39/44 , C07K16/28 , C07K16/30
CPC分类号： A61K39/395 , A61K45/00 , A61K47/6913 , A61K51/1234 , A61K2039/505 , C07K16/2803 , C07K16/2833 , C07K16/2896 , C07K2317/24 , G01N33/574 , G01N2333/70596 , G01N2800/245 , A61K2300/00
摘要： Disclosed are compositions that include anti-CD74 immunoconjugates and a therapeutic and/or diagnostic agent. Also disclosed are methods for preparing the immunoconjugates and using the immunoconjugates in diagnostic and therapeutic procedures. The compositions may be part of a kit for administering the anti-CD74 immunoconjugate compositions in therapeutic and/or diagnostic methods.

4. 发明授权

US08216572B2 Antibody therapy 有权
标题翻译：抗体治疗
公开(公告)号：US08216572B2
公开(公告)日：2012-07-10
申请号：US13245330
申请日：2011-09-26
申请人： David M. Goldenberg , Hans J. Hansen
发明人： David M. Goldenberg , Hans J. Hansen
IPC分类号： A61K39/395
CPC分类号： A61K39/39558 , A61K31/437 , A61K31/4545 , A61K31/4745 , A61K31/475 , A61K31/513 , A61K31/519 , A61K31/555 , A61K31/655 , A61K31/675 , A61K31/704 , A61K38/164 , A61K38/168 , A61K38/1816 , A61K38/191 , A61K38/193 , A61K38/196 , A61K38/20 , A61K38/217 , A61K51/1045 , A61K51/1048 , A61K51/1096 , A61K2039/505 , C07K16/3007 , C07K2317/24 , A61K2300/00
摘要： The present invention provides a composition comprising naked humanized, chimeric, and human anti-CEA antibodies and a therapeutic agent, which is useful for treatment of CEA expressing cancers and other diseases, and methods of use in treatment using this composition.
摘要翻译：本发明提供了包含裸体人源化，嵌合和人抗CEA抗体和治疗剂的组合物，其可用于治疗表达CEA的癌症和其它疾病，以及使用该组合物的治疗方法。

5. 发明授权

US08192739B2 Fusion proteins containing recombinant cytotoxic RNAses 有权
标题翻译：含有重组细胞毒性RNA酶的融合蛋白
公开(公告)号：US08192739B2
公开(公告)日：2012-06-05
申请号：US12479250
申请日：2009-06-05
申请人： David M. Goldenberg , Hans J. Hansen , Chien-Hsing Ken Chang , Sailaja S. Vanama , Edmund A. Rossi
发明人： David M. Goldenberg , Hans J. Hansen , Chien-Hsing Ken Chang , Sailaja S. Vanama , Edmund A. Rossi
IPC分类号： C07K16/46 , C07K16/28 , C07K16/30 , C12P21/08 , A61K39/00 , A61K39/395 , C12N9/22
CPC分类号： C07K16/2803 , A61K47/6817 , A61K47/6877 , C07K16/2833 , C07K2317/24 , C07K2317/41 , C07K2319/00 , C07K2319/33 , C12N9/22 , C12N2510/02
摘要： Recombinant immunotoxins containing a cytotoxic RNAse fused to an antibody or antibody fragment may be produced in mammalian cell culture. Surprisingly, immunotoxins containing a cytotoxic RNAse fused to the N-terminus of one antibody variable domain can be prepared and retain the ability to specifically bind antigen. The immunotoxins may be used in a variety of therapeutic methods for treating diseases or syndromes associated with unwanted or inappropriate cell proliferation or activation.
摘要翻译：可以在哺乳动物细胞培养物中产生含有与抗体或抗体片段融合的细胞毒性RNA的重组免疫毒素。令人惊讶的是，可以制备含有与一个抗体可变结构域的N末端融合的细胞毒性RNA的免疫毒素，并保留特异性结合抗原的能力。免疫毒素可以用于治疗与不想要的或不适当的细胞增殖或活化相关的疾病或综合征的各种治疗方法。

6. 发明申请

US20120100068A1 Anti-CD74 Immunoconjugates and Methods of Use 有权
标题翻译：抗CD74免疫缀合物及其使用方法
公开(公告)号：US20120100068A1
公开(公告)日：2012-04-26
申请号：US13347934
申请日：2012-01-11
申请人： John C. Byrd , David M. Goldenberg , Hans J. Hansen
发明人： John C. Byrd , David M. Goldenberg , Hans J. Hansen
IPC分类号： A61K39/395 , C07K17/00 , A61K51/00 , A61P35/02 , A61K38/20 , A61K38/21 , A61P37/00 , A61P35/00 , A61K9/127 , A61K38/19
CPC分类号： A61K47/48823 , A61K39/395 , A61K47/6907 , A61K47/6913 , A61K51/1234 , A61K2039/505 , C07K16/2803 , C07K16/2833 , C07K16/2896 , C07K2317/24 , C07K2317/565 , C07K2317/73 , G01N33/574 , G01N2333/70596 , G01N2800/245 , A61K2300/00
摘要： Disclosed are compositions that include anti-CD74 immunoconjugates and optionally a therapeutic and/or diagnostic agent. In preferred embodiments, the immunoconjugates comprise one or more anti-CD74 antibodies or antigen-binding fragments thereof, conjugated to a liposome or micelle. Also disclosed are methods for preparing the immunoconjugates and using the immunoconjugates in diagnostic and therapeutic procedures. In certain preferred embodiments, the therapeutic methods comprise administering to a subject with a CD74-expressing disease an anti-CD74 immunoconjugate and thereby inducing apoptosis of CD74-expressing cells. In more preferred embodiments, the CD74 immunoconjugate is capable of inducing cell death in the absence of any other therapeutic agent, although such agents may be optionally administered prior to, together with or subsequent to administration of the anti-CD74 immunoconjugate. The compositions may be part of a kit for administering the anti-CD74 immunoconjugates or compositions.
摘要翻译：公开了包含抗CD74免疫缀合物和任选的治疗和/或诊断剂的组合物。在优选的实施方案中，免疫偶联物包含缀合至脂质体或胶束的一种或多种抗CD74抗体或其抗原结合片段。还公开了在诊断和治疗过程中制备免疫缀合物和使用免疫缀合物的方法。在某些优选实施方案中，治疗方法包括向具有表达CD74的疾病的受试者施用抗CD74免疫偶联物，从而诱导表达CD74的细胞的凋亡。在更优选的实施方案中，CD74免疫缀合物能够在不存在任何其它治疗剂的情况下诱导细胞死亡，尽管可以任选地在施用抗CD74免疫缀合物之前，之后或之后施用这些试剂。组合物可以是用于施用抗CD74免疫缀合物或组合物的试剂盒的一部分。

7. 发明授权

US08097252B2 Methods and compositions for administering therapeutic and diagnostic agents 有权
标题翻译：用于治疗和诊断药物的方法和组合物
公开(公告)号：US08097252B2
公开(公告)日：2012-01-17
申请号：US12985775
申请日：2011-01-06
申请人： William J. McBride , Chien-Hsing Chang , David M. Goldenberg , Hans J. Hansen
发明人： William J. McBride , Chien-Hsing Chang , David M. Goldenberg , Hans J. Hansen
IPC分类号： A61K39/00 , A61K39/44 , A61K38/08 , A61K39/395 , A61K49/06 , C12P21/08 , C07K16/18 , C07K16/22 , C07K16/24
CPC分类号： B82Y5/00 , A61K47/6891 , Y10S435/975
摘要： Methods and compositions are described for targeting therapeutic and diagnostic molecules to particular types of cells using targeting antibodies or other targeting moeities.
摘要翻译：描述了使用靶向抗体或其他靶向动物将治疗和诊断分子靶向特定类型的细胞的方法和组合物。

8. 发明授权

US08084583B2 RS7 antibodies 有权
标题翻译： RS7抗体
公开(公告)号：US08084583B2
公开(公告)日：2011-12-27
申请号：US12389503
申请日：2009-02-20
申请人： Serengulam V. Govindan , Zhengxing Qu , Hans J. Hansen , David M. Goldenberg
发明人： Serengulam V. Govindan , Zhengxing Qu , Hans J. Hansen , David M. Goldenberg
IPC分类号： C07K16/00
CPC分类号： A61K45/06 , A61K39/39558 , A61K51/1045 , A61K51/1051 , A61K2039/505 , C07K16/30 , C07K16/3015 , C07K2317/21 , C07K2317/24
摘要： This invention relates to monovalent and multivalent, monospecific binding proteins and to multivalent, multispecific binding proteins. One embodiment of these binding proteins has one or more binding sites where each binding site binds with a target antigen or an epitope on a target antigen. Another embodiment of these binding proteins has two or more binding sites where each binding site has affinity towards different epitopes on a target antigen or has affinity towards either a target antigen or a hapten. The present invention further relates to recombinant vectors useful for the expression of these functional binding proteins in a host. More specifically, the present invention relates to the tumor-associated antigen binding protein designated RS7, and other EGP-1 binding-proteins. The invention further relates to humanized, human and chimeric RS7 antigen binding proteins, and the use of such binding proteins in diagnosis and therapy.
摘要翻译：本发明涉及单价和多价单特异性结合蛋白和多价多特异性结合蛋白。这些结合蛋白的一个实施方案具有一个或多个结合位点，其中每个结合位点与靶抗原或靶抗原上的表位结合。这些结合蛋白的另一个实施方案具有两个或更多个结合位点，其中每个结合位点对靶抗原上的不同表位具有亲和力，或对靶抗原或半抗原具有亲和力。本发明还涉及可用于在宿主中表达这些功能性结合蛋白的重组载体。更具体地，本发明涉及称为RS7的肿瘤相关抗原结合蛋白和其它EGP-1结合蛋白。本发明还涉及人源化，人和嵌合RS7抗原结合蛋白，以及这种结合蛋白在诊断和治疗中的用途。

9. 发明授权

US08084029B2 Alpha-fetoprotein Immu31 antibodies and fusion proteins and methods of use thereof 有权
公开(公告)号：US08084029B2
公开(公告)日：2011-12-27
申请号：US13090391
申请日：2011-04-20
申请人： Hans J. Hansen , Zhengxing Qu , David M. Goldenberg
发明人： Hans J. Hansen , Zhengxing Qu , David M. Goldenberg
IPC分类号： A61K39/395
CPC分类号： C07K16/30 , A61K41/0095 , A61K47/6843 , A61K49/0002 , A61K51/1018 , A61K2039/505 , C07K16/18 , C07K16/3076 , C07K2317/24 , C07K2317/56 , G01N33/57484 , G01N33/689
摘要： The present invention provides humanized, chimeric and human anti-alpha-fetoprotein antibodies, fusion proteins, and fragments thereof. The antibodies, fusion proteins, and fragments thereof, as well as combinations with other suitable antibodies, are useful for the treatment and diagnosis of hepatocellular carcinoma, hepatoblastoma, germ cell tumors carcinoma and other AFP-producing tumors.

10. 发明授权

US08017736B2 Alpha-fetoprotein Immu31 antibodies and fusion proteins and methods of use thereof 有权
标题翻译：甲胎蛋白Immu31抗体和融合蛋白及其使用方法
公开(公告)号：US08017736B2
公开(公告)日：2011-09-13
申请号：US12359745
申请日：2009-01-26
申请人： Hans J. Hansen , Zhengxing Qu , David M. Goldenberg
发明人： Hans J. Hansen , Zhengxing Qu , David M. Goldenberg
IPC分类号： C12P21/08
CPC分类号： C07K16/30 , A61K41/0095 , A61K47/6843 , A61K49/0002 , A61K51/1018 , A61K2039/505 , C07K16/18 , C07K16/3076 , C07K2317/24 , C07K2317/56 , G01N33/57484 , G01N33/689
摘要： The present invention provides humanized, chimeric and human anti-alpha-fetoprotein antibodies, fusion proteins, and fragments thereof. The antibodies, fusion proteins, and fragments thereof, as well as combinations with other suitable antibodies, are useful for the treatment and diagnosis of hepatocellular carcinoma, hepatoblastoma, germ cell tumors carcinoma and other AFP-producing tumors.
摘要翻译：本发明提供人源化，嵌合和人抗甲胎蛋白抗体，融合蛋白及其片段。抗体，融合蛋白及其片段以及与其它合适抗体的组合可用于治疗和诊断肝细胞癌，肝母细胞瘤，生殖细胞肿瘤癌和其他产生AFP的肿瘤。

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