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1. 发明申请

US20050207983A1 Formulations decreasing particle exhalation 审中-公开
标题翻译：减少颗粒呼气的配方
公开(公告)号：US20050207983A1
公开(公告)日：2005-09-22
申请号：US10990996
申请日：2004-11-17
申请人： David Edwards , Jonathan Man , Jeffrey Katstra , Robert Clarke
发明人： David Edwards , Jonathan Man , Jeffrey Katstra , Robert Clarke
IPC分类号： A61K9/00 , A61K47/02 , A61L9/04 , A61K31/70 , A61K31/715 , A61K38/17 , A61K48/00
CPC分类号： A61K47/02 , A61K9/0078 , A61K9/14 , A61K9/141 , A61K9/16 , A61M15/00
摘要： Formulations have been developed for pulmonary delivery to treat or reduce the infectivity of diseases such as viral infections, especially tuberculosis, SARS, influenza and respiratory synticial virus in humans and hoof and mouth disease in animals, or to reduce the symptoms of allergy or other pulmonary disease. Formulations for pulmonary administration include a material that significantly alters physical properties such as surface tension and surface elasticity of lung mucus lining fluid, which may be isotonic saline and, optionally, a carrier. The formulation may be administered as a liquid solution, suspension, aerosol, or powder where the particles consist basically of an osmotically active solute. Drugs, especially antivirals or antibiotics, may optionally be included with the formulation. These may be administered with or incorporated into the formulation.
摘要翻译：已经开发了用于肺部输送以治疗或降低人类感染病毒感染，特别是结核病，SARS，流感和呼吸道合成病毒以及动物蹄和口蹄疫等疾病或减轻过敏或其他肺部疾病症状的传染性的制剂疾病。用于肺部给药的制剂包括显着改变诸如等渗盐水和任选的载体的肺粘液衬里液体的表面张力和表面弹性的物理性质的材料。制剂可以作为液体溶液，悬浮液，气雾剂或粉末施用，其中颗粒基本上由渗透活性的溶质组成。药物，特别是抗病毒剂或抗生素，可以任选地包括在制剂中。这些可以与制剂一起施用或掺入制剂中。

2. 发明申请

US20070270502A1 Formulations decreasing particle exhalation 有权
标题翻译：减少颗粒呼气的配方
公开(公告)号：US20070270502A1
公开(公告)日：2007-11-22
申请号：US11714999
申请日：2007-03-06
申请人： David Edwards , Jonathan Man , Jeffrey Katstra , Robert Clarke
发明人： David Edwards , Jonathan Man , Jeffrey Katstra , Robert Clarke
IPC分类号： A61K47/00
CPC分类号： A61K47/02 , A61K9/0078 , A61K9/14 , A61K9/141 , A61K9/16 , A61M15/00
摘要： Formulations have been developed for pulmonary delivery to treat or reduce the infectivity of diseases such as viral infections, especially tuberculosis, SARS, influenza and respiratory synticial virus in humans and hoof and mouth disease in animals, or to reduce the symptoms of allergy or other pulmonary disease. Formulations for pulmonary administration include a material that significantly alters physical properties such as surface tension and surface elasticity of lung mucus lining fluid, which may be isotonic saline and, optionally, a carrier. The formulation may be administered as a liquid solution, suspension, aerosol, or powder where the particles consist basically of an osmotically active solute. Drugs, especially antivirals or antibiotics, may optionally be included with the formulation. These may be administered with or incorporated into the formulation.
摘要翻译：已经开发了用于肺部输送以治疗或降低人类感染病毒感染，特别是结核病，SARS，流感和呼吸道合成病毒以及动物蹄和口蹄疫等疾病或减轻过敏或其他肺部疾病症状的传染性的制剂疾病。用于肺部给药的制剂包括显着改变诸如等渗盐水和任选的载体的肺粘液衬里液体的表面张力和表面弹性的物理性质的材料。制剂可以作为液体溶液，悬浮液，气雾剂或粉末施用，其中颗粒基本上由渗透活性的溶质组成。药物，特别是抗病毒剂或抗生素，可以任选地包括在制剂中。这些可以与制剂一起施用或掺入制剂中。

3. 发明申请

US20080038207A1 Method and device for decreasing contamination 有权
公开(公告)号：US20080038207A1
公开(公告)日：2008-02-14
申请号：US11827031
申请日：2007-07-10
申请人： David Edwards , Mark Gabrielson , Robert Clarke , Wesley Dehaan , Matthew Brande , Jonathan Man
发明人： David Edwards , Mark Gabrielson , Robert Clarke , Wesley Dehaan , Matthew Brande , Jonathan Man
IPC分类号： A61K31/70 , A01N37/18
CPC分类号： A61B5/097 , G01N33/497
摘要： Methods and devices to determine rate of particle production and the size range for the particles produced for an individual are described herein. The device (10) contains a mouthpiece (12), a filter (14), a low resistance one-way valve (16), a particle counter (20) and a computer (30). Optionally, the device also contains a gas flow meter (22). The data obtained using the device can be used to determine if a formulation for reducing particle exhalation should be administered to an individual. This device is particularly useful prior to and/or following entry in a cleanroom to ensure that the cleanroom standards are maintained. The device can also be used to identify animals and humans who have an enhanced propensity to exhale aerosols (referred to herein as “over producers”, “super-producers”, or “superspreaders”). Formulations to reduce particle production are also described herein. The formulation is administered in an amount sufficient to alter biophysical properties in the mucosal linings of the body. When applied to mucosal lining fluids, the formulation alters the physical properties such as the gel characteristics at the air/liquid interface, surface elasticity, surface viscosity, surface tension and bulk viscoelasticity of the mucosal lining. The formulation is administered in an effective amount to minimize ambient contamination due to particle formation during breathing, coughing, sneezing, or talking, which is particularly important in cleanroom applications. In one embodiment, the formulation for administration is a non-surfactant solution. In one embodiment, the formulations are conductive formulations containing conductive agents, such as salts, ionic surfactants, or other substances that are in an ionized state or easily ionized in an aqueous or organic solvent environment. Preferably the formulation is administered in the form of an aerosol.

4. 发明申请

US20070053844A1 FORMULATIONS FOR ALTERATION OF BIOPHYSICAL PROPERTIES OF MUCOSAL LINING 审中-公开
标题翻译：用于改变粘膜内衬生物学特性的配方
公开(公告)号：US20070053844A1
公开(公告)日：2007-03-08
申请号：US11419165
申请日：2006-05-18
申请人： Wiwik Watanabe , Matthew Thomas , Jeffrey Katstra , Robert Clarke
发明人： Wiwik Watanabe , Matthew Thomas , Jeffrey Katstra , Robert Clarke
IPC分类号： A61K48/00 , A61K9/14 , A61L9/04
CPC分类号： A61K33/14 , A61K9/0014 , A61K9/0034 , A61K9/0043 , A61K9/0048 , A61K9/007 , A61K9/0078 , A61K31/255 , A61K31/721 , A61K47/02 , A61K47/12 , Y02A50/475
摘要： Conductive formulations containing conductive agents, such as salts, ionic surfactants, or other substances that are in an ionized state or easily ionized in an aqueous or organic solvent environment, and methods of use, have been developed. One or more active agents, such as antivirals, antimicrobials, anti-inflammatories, proteins or peptides, may optionally be included with the formulation. The active agent may be administered with or incorporated into the formulation, or may be administered after the conductive formulation is administered. When applied to mucosal lining fluids, the formulation alters the physical properties such as the surface tension, surface elasticity, and bulk viscosity of the mucosal lining. The formulation is administered in an amount sufficient to alter biophysical properties in the mucosal linings of the body. The formulations may be administered for several different purposes: reducing the spreading of infectious diseases, both viral and bacterial, such as SARS, influenza, tuberculosis, and RSV in humans and hoof and mouth disease in cloven-tooted animals; minimizing ambient contamination due to particle formation during breathing, coughing, sneezing, or talking which is particularly important in the clean room applications; decreasing or preventing the occurrence of obstructive sleep apnea and some cases of irritable bowel syndrome; and controlling the uptake kinetics of drug molecules and pathogens.
摘要翻译：已经开发了含有导电剂，例如盐，离子表面活性剂或处于电离状态或容易在水溶液或有机溶剂环境中离子化的其它物质的导电配方，以及使用方法。制剂中可以任选地包括一种或多种活性剂，例如抗病毒剂，抗微生物剂，抗炎剂，蛋白质或肽。活性剂可以与制剂一起施用或掺入制剂中，或者可以在施用导电制剂后施用。当施用于粘膜衬里液时，制剂会改变物理性质，如粘膜内衬的表面张力，表面弹性和体积粘度。该制剂的施用量足以改变身体粘膜内衬的生物物理性质。制剂可以用于几种不同的目的：减少感染性疾病，包括病毒和细菌，如SARS，流行性感冒，结核病和RSV在人类和蹄和口腔疾病的蔓延的动物; 在洁净室应用中特别重要的是在呼吸，咳嗽，打喷嚏或说话期间由于颗粒形成造成的环境污染最小化; 减少或预防阻塞性睡眠呼吸暂停和一些肠易激综合征的发生; 并控制药物分子和病原体的吸收动力学。

5. 发明授权

US07297437B2 Battery with gelled electrolyte 有权
标题翻译：电池用凝胶电解液
公开(公告)号：US07297437B2
公开(公告)日：2007-11-20
申请号：US10483953
申请日：2002-02-12
申请人： Robert Clarke , Brian Dougherty , Stephen Harrison , J. Peter Millington , Samaresh Mohanta
发明人： Robert Clarke , Brian Dougherty , Stephen Harrison , J. Peter Millington , Samaresh Mohanta
IPC分类号： H01M4/36
CPC分类号： H01M6/182 , H01M6/22 , H01M2300/008 , H01M2300/0085 , H01M2300/0091
摘要： An electric device comprises a gelled acid electrolyte (142A) in complex with a lanthanide that forms a redox pair with a second element. Preferred electric devices include batteries and especially primary batteries, while preferred acid electrolytes (124A) have a sulfonic acid group. Contemplated lanthanides especially include cerium, and preferred second elements particularly include zinc. Alternatively, contemplated electric devices may comprise a gelled electrolyte (142A) in which with a lanthanide forms a redox pair with zinc.
摘要翻译：电气装置包括与与第二元素形成氧化还原对的镧系元素复合的凝胶酸电解质（142A）。优选的电气装置包括电池，特别是初级电池，而优选的酸性电解质（124A）具有磺酸基。考虑的镧系元素特别包括铈，优选的第二元素尤其包括锌。或者，预期的电气装置可以包括凝胶电解质（142A），其中镧系元素与锌形成氧化还原对。

6. 发明申请

US20050145743A1 Method and apparatus for transporting a sheet from a dryer to a reel 有权
标题翻译：将片材从干燥器输送到卷轴的方法和装置
公开(公告)号：US20050145743A1
公开(公告)日：2005-07-07
申请号：US11054026
申请日：2005-02-09
申请人： Robert Clarke , Thomas Neal
发明人： Robert Clarke , Thomas Neal
IPC分类号： D21F7/00 , B65H20/06 , D21G9/00 , B65H20/10
CPC分类号： B65H20/12 , B65H20/06 , B65H2301/511 , B65H2301/517 , B65H2301/522 , B65H2406/323 , B65H2801/84 , D21G9/0063
摘要： A system and method for transferring a continuously advancing paper web from a dryer to a reel section is provided. The system includes a first fabric defining a first moving conveyor. The first fabric may be a permeable fabric, which is positioned downstream from the dryer. A second fabric, which may also be permeable and defines a second moving conveyor, is also included. The first moving conveyor overlaps the second moving conveyor for a predetermined distance, and the first and second moving conveyors are configured to receive the paper web between the conveyors. A vacuum device is rotatably disposed against the first moving conveyor, and the dryer and the vacuum device are disposed relative to each other to form an open draw. The vacuum device is configured to produce a vacuum to attract the web to the first fabric for transferring the advancing web into the predetermined distance where the first and second conveyors overlap.
摘要翻译：提供了一种用于将连续推进的纸幅从干燥器转移到卷轴部分的系统和方法。该系统包括限定第一移动输送机的第一织物。第一织物可以是位于干燥器下游的可渗透织物。还可以包括也可渗透并限定第二移动输送机的第二织物。第一移动输送机与第二移动输送机重叠预定距离，并且第一和第二移动输送机构造成在输送机之间接收纸幅。真空装置可旋转地设置在第一移动输送机上，并且干燥器和真空装置相对于彼此设置以形成开放式抽出。真空装置被配置为产生真空以将幅材吸引到第一织物，以将前进幅材传送到第一和第二输送机重叠的预定距离。

7. 发明授权

US5625767A Method and system for two-dimensional visualization of an information taxonomy and of text documents based on topical content of the documents 失效
标题翻译：基于文献专题内容的信息分类法和文本文档的二维可视化方法和系统
公开(公告)号：US5625767A
公开(公告)日：1997-04-29
申请号：US402839
申请日：1995-03-13
申请人： Brian Bartell , Robert Clarke
发明人： Brian Bartell , Robert Clarke
IPC分类号： G06F17/30 , G06T11/00
CPC分类号： G06F17/30572 , Y10S707/99935
摘要： A method and system for aiding users in visualizing the relatedness of retrieved text documents and the topics to which they relate comprises training a classifier by semantically analyzing an initial group of manually-classified documents, positioning the classes and documents in two-dimensional space in response to semantic associations between the classes, and displaying the classes and documents. The displayed documents may be retrieved by an information storage and retrieval subsystem in any suitable manner.
摘要翻译：用于帮助用户可视化所检索的文本文档及其相关主题的相关性的方法和系统包括：通过语义分析手动分类文档的初始组来对分类器进行训练，将类和文档定位在二维空间中以作出响应到类之间的语义关联，并显示类和文档。显示的文件可以以任何合适的方式由信息存储和检索子系统检索。

8. 发明授权

US5549675A Method for implanting tissue in a host 失效
标题翻译：在组织中植入组织的方法
公开(公告)号：US5549675A
公开(公告)日：1996-08-27
申请号：US180018
申请日：1994-01-11
申请人： Steven Neuenfeldt , James Brauker , Robert Clarke , Victoria Carr-Brendel
发明人： Steven Neuenfeldt , James Brauker , Robert Clarke , Victoria Carr-Brendel
IPC分类号： C12M1/00 , A61F2/02 , A61K9/00 , A61L27/00 , A61L27/38 , C12N5/06
CPC分类号： A61K9/0024 , A61F2/022 , A61L27/38 , Y10S623/902
摘要： A method for implanting cells into a host tissue is provided. The method comprises the steps of: creating an implant assembly for holding cells including wall means for forming a porous boundary between the host tissue and the implanted cells in the device, the pore size of the boundary being sufficient to isolate the implanted cells from the immune response; implanting the assembly without the cells into a host tissue; and accessing an interior of the assembly to add the cells thereto.
摘要翻译：提供了将细胞植入宿主组织的方法。该方法包括以下步骤：创建用于保持细胞的植入物组件，其包括用于在所述装置中的宿主组织和植入细胞之间形成多孔边界的壁装置，边界的孔径足以将植入的细胞与免疫响应; 将没有细胞的组件植入宿主组织中; 以及访问组件的内部以将单元格添加到其中。

9. 发明申请

US20140088148A1 SMALL MOLECULE INHIBITORS OF XBP1 SPLICING 有权
标题翻译： XBP1分离小分子抑制剂
公开(公告)号：US20140088148A1
公开(公告)日：2014-03-27
申请号：US14009969
申请日：2012-04-04
申请人： Sivanesan Dakshanamurthy , Milton L. Brown , Robert Clarke , Ayesha N. Shahjahan , Jaqueline Smith
发明人： Sivanesan Dakshanamurthy , Milton L. Brown , Robert Clarke , Ayesha N. Shahjahan , Jaqueline Smith
IPC分类号： C07D213/32 , A61K31/4439 , A61K45/06 , C07D417/14 , C07D401/14 , C07D405/14 , A61K31/444 , C07D401/04 , C07D417/04
CPC分类号： A61K31/4439 , A61K31/41 , A61K31/426 , A61K31/427 , A61K31/444 , A61K45/06 , C07D213/32 , C07D401/04 , C07D401/14 , C07D405/14 , C07D417/04 , C07D417/14
摘要： Small molecule inhibitors of XBP1 splicing by IRE1 are provided, as well as methods for their use in treating or preventing cancer (e.g., endocrine resistant breast cancer), diabetes, and obesity.
摘要翻译：提供了通过IRE1剪接XBP1的小分子抑制剂，以及它们用于治疗或预防癌症（例如内分泌耐药性乳腺癌），糖尿病和肥胖症的方法。

10. 发明申请

US20070041912A1 Trospium containing compositions 审中-公开
标题翻译：含有Trospium的组合物
公开(公告)号：US20070041912A1
公开(公告)日：2007-02-22
申请号：US10550471
申请日：2003-09-04
申请人： Elliot Ehrich , Daniel Deaver , Robert Clarke , Michael Lipp
发明人： Elliot Ehrich , Daniel Deaver , Robert Clarke , Michael Lipp
IPC分类号： A61K31/4747 , A61L9/04
CPC分类号： A61K9/0078 , A61K9/0075 , A61K9/1617 , A61K31/40 , A61K31/438 , A61K31/46 , A61K45/06
摘要： The invention relates to a method for treating a disease characterized by a constrictive airway comprising administering to a patient in need thereof via inhalation a pharmaceutical composition comprising trospium, wherein said patient achieves an effective therapy for at least 10 hours. The trospium composition is preferably a particulate formulation useful for administration via a dry powder inhaler. In a preferred embodiment, the composition further comprises a second active agent, such as a beta-2 agonist. A particularly preferred second active agent is formoterol, wherein the trospium, formoterol composition is manufactured by spray drying a mixture comprising trospium and formoterol.
摘要翻译：本发明涉及用于治疗特征在于缩窄性气道的疾病的方法，其包括通过吸入给予有需要的患者包含trospium的药物组合物，其中所述患者达到有效治疗至少10小时。 ium组合物优选是可用于通过干粉吸入器施用的颗粒制剂。在优选的实施方案中，组合物还包含第二活性剂，例如β-2激动剂。特别优选的第二活性剂是福莫特罗，其中通过将包含trospium和福莫特罗的混合物喷雾干燥来制备tro石福莫特罗组合物。

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