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1. 发明申请

US20080241961A1 DROSOPHILA G PROTEIN COUPLED RECEPTORS, NUCLEIC ACIDS, AND MEHTODS RELATED TO THE SAME 审中-公开
标题翻译： DROSOPHILA G蛋白偶联受体，核酸和与其相关的酶
公开(公告)号：US20080241961A1
公开(公告)日：2008-10-02
申请号：US12032029
申请日：2008-02-15
申请人： David E. Lowery , Valdin G. Smith , Teresa M. Kubiak , Martha J. Larsen
发明人： David E. Lowery , Valdin G. Smith , Teresa M. Kubiak , Martha J. Larsen
IPC分类号： G01N33/566
CPC分类号： C07K14/705 , C12N2799/021
摘要： The present invention provides a Drosophila melanogaster GPCR (DmGPCR) polypeptides and polynucleotides which identify and encode such a DmGPCR. In addition, the invention provides expression vectors, host cells and methods for its production. The invention also provides methods for the identification of homologs in other animals, and of DmGPCR agonists/antagonists, useful for the treatment of diseases in animals and for the control of insects that are injurious or harmful to plants or animals.
摘要翻译：本发明提供了一种果蝇黑腹果蝇GPCR（DmGPCR）多肽和鉴定和编码这种DmGPCR的多核苷酸。此外，本发明提供表达载体，宿主细胞及其生产方法。本发明还提供了用于鉴定其他动物和DmGPCR激动剂/拮抗剂的同系物的方法，其用于治疗动物疾病和控制对植物或动物有害或有害的昆虫。

2. 发明授权

US06835546B1 Drosophila G protein coupled receptors, nucleic acids, and methods related to the same 失效
公开(公告)号：US06835546B1
公开(公告)日：2004-12-28
申请号：US09693746
申请日：2000-10-20
申请人： David E. Lowery , Valdin G. Smith , Teresa M. Kubiak , Martha J. Larsen
发明人： David E. Lowery , Valdin G. Smith , Teresa M. Kubiak , Martha J. Larsen
IPC分类号： G01N33566
CPC分类号： C07K14/705 , C12N2799/021
摘要： The present invention provides a Drosophila melanogaster GPCR (DmGPCR) polypeptides and polynucleotides which identify and encode such a DmGPCR. In addition, the invention provides expression vectors, host cells and methods for its production. The invention also provides methods for the identification of homologs in other animals, and of DmGPCR agonists/antagonists, useful for the treatment of diseases in animals and for the control of insects that are injurious or harmful to plants or animals.

3. 发明授权

US07364866B2 Drosophila G protein coupled receptors, nucleic acids, and methods related to the same 失效
标题翻译：果蝇G蛋白偶联受体，核酸和与之相关的方法
公开(公告)号：US07364866B2
公开(公告)日：2008-04-29
申请号：US10213821
申请日：2002-08-06
申请人： David E. Lowery , Valdin G. Smith , Teresa M. Kubiak , Martha J. Larsen
发明人： David E. Lowery , Valdin G. Smith , Teresa M. Kubiak , Martha J. Larsen
IPC分类号： G01N33/53 , C12N5/06 , C12N5/00 , C07K1/00 , C07K5/00
CPC分类号： C07K14/705 , C12N2799/021
摘要： The present invention provides Drosophila melanogaster GPCR (DmGPCR) polypeptides and polynucleotides which identify and encode such a DmGPCR. In addition, the invention provides expression vectors, host cells, and methods for its production. The invention also provides methods for the identification of homologs in other species and of DmGPCR agonists/antagonists useful as potential insecticides. The invention further provides methods for binding a DmGPCR, methods for identifying modulators of DmGPCR expression and activity, methods for controlling a population of insects with a DmGPCR antibody, a DmGPCR antisense polynucleotide, a DmGPCR binding partner or modulator, and methods of preventing or treating a disease or condition associated with an ectoparasite. Specifically, this invention discloses the matching of the orphan Drosophila drotachykinin, droleucokinin, and drostatin-C receptors with their cognate peptide ligands.
摘要翻译：本发明提供了果蝇黑腹果蝇GPCR（DmGPCR）多肽和鉴定和编码这种DmGPCR的多核苷酸。此外，本发明提供表达载体，宿主细胞及其生产方法。本发明还提供了用于鉴定其他物种中的同源物的方法和用作潜在杀虫剂的DmGPCR激动剂/拮抗剂。本发明还提供了用于结合DmGPCR的方法，用于鉴定DmGPCR表达和活性的调节剂的方法，用DmGPCR抗体，DmGPCR反义多核苷酸，DmGPCR结合配偶体或调节剂控制昆虫群体的方法，以及预防或治疗方法与外寄生物相关的疾病或病症。具体地说，本发明公开了孤儿果蝇的洛匹心碱，泪果状蛋白和抑制素-C受体与其同源肽配体的匹配。

4. 发明授权

US07354724B2 Drosophila G protein coupled receptors, nucleic acids, and methods related to the same 失效
标题翻译：果蝇G蛋白偶联受体，核酸和与之相关的方法
公开(公告)号：US07354724B2
公开(公告)日：2008-04-08
申请号：US10736048
申请日：2003-12-15
申请人： David E. Lowery , Valdin G. Smith , Teresa M. Kubiak , Martha J. Larsen
发明人： David E. Lowery , Valdin G. Smith , Teresa M. Kubiak , Martha J. Larsen
IPC分类号： G01N33/53 , G01N33/566
CPC分类号： C07K14/705 , C12N2799/021
摘要： The present invention provides a Drosophila melanogaster GPCR (DmGPCR) polypeptides and polynucleotides which identify and encode such a DmGPCR. In addition, the invention provides expression vectors, host cells and methods for its production. The invention also provides methods for the identification of homologs in other animals, and of DmGPCR agonists/antagonists, useful for the treatment of diseases in animals and for the control of insects that are injurious or harmful to plants or animals.
摘要翻译：本发明提供了一种果蝇黑腹果蝇GPCR（DmGPCR）多肽和鉴定和编码这种DmGPCR的多核苷酸。此外，本发明提供表达载体，宿主细胞及其生产方法。本发明还提供了用于鉴定其他动物和DmGPCR激动剂/拮抗剂的同系物的方法，其用于治疗动物疾病和控制对植物或动物有害或有害的昆虫。

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