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1. 发明授权

US06709814B1 Peptides causing formation of compact structures 有权
标题翻译：引起紧密结构形成的肽
公开(公告)号：US06709814B1
公开(公告)日：2004-03-23
申请号：US09285912
申请日：1999-04-02
申请人： David Anderson , Tarikere Gururaja
发明人： David Anderson , Tarikere Gururaja
IPC分类号： C12N1563
CPC分类号： C07K7/06 , C07K1/047 , C07K14/47
摘要： The present invention is directed to compositions and methods including peptides which have a high affinity for each other and, when linked to a protein, are used to help fold the protein into a compact structure. By virtue of its stability and constraints, this scaffold can prolong the activity of any embedded protein sequences in the presence of cellular and other proteases. The compact structure can have other functional sequences embedded, and is preferable to linear and less constrained peptides for library screening, for creating structurally-biased peptide libraries and for targeting to specific intracellular and extracellular compartments. Compositions of the present invention can be displayed on the surface of viruses, archaebacteria, prokaryotic and eukaryotic cells for library screening, drug screening and display. Methods of the present invention are useful for screening in vivo for intracellular effector proteins modulating signaling pathways and to identify interacting proteins in vitro. Thus, the present invention is useful as a scaffold for gene therapy, for the isolation of new therapeutic drug leads and for potential use as a therapeutic in physiological fluids.
摘要翻译：本发明涉及组合物和方法，包括彼此具有高亲和力的肽，当与蛋白质连接时，用于帮助将蛋白质折叠成紧密结构。由于其稳定性和约束，该支架可以延长任何嵌入的蛋白质序列在细胞和其它蛋白酶存在下的活性。紧密结构可以具有嵌入的其它功能序列，并且优选用于文库筛选的线性和较不受约束的肽，用于产生结构偏向肽文库并靶向特定的细胞内和细胞外区室。本发明的组合物可以显示在病毒，古细菌，原核和真核细胞的表面上，用于文库筛选，药物筛选和显示。本发明的方法可用于体内筛选调节信号传导途径的细胞内效应蛋白，并在体外鉴定相互作用蛋白。因此，本发明可用作基因治疗的支架，用于分离新的治疗药物引线和潜在用作生理液体中的治疗剂。

2. 发明授权

US11027382B1 Instantly removable self-aligning high-accuracy mount for mounting a calibration instrument to a CNC work table 有权
公开(公告)号：US11027382B1
公开(公告)日：2021-06-08
申请号：US16188242
申请日：2018-11-12
申请人： David Anderson
发明人： David Anderson
IPC分类号： B23Q3/10 , B23Q1/42 , B23Q3/18
摘要： The instant-mount aspect of the present invention allows a user to rapidly accurately dismount a mounted CNC calibration device from a CNC work table, and rapidly replace the CNC calibration device to its previously mounted position within 0.0001, in seconds. The alignment aspect of the present invention allows faster and more robust high-accuracy alignment of a CNC calibration device once it is mounted on a CNC work table. The remote nest aspect of the present invention allows rapid re-positioning of a CNC calibration device within a CNC milling machine cabinet in a way that does not disrupt the data connection between the CNC control computer and the CNC calibration device, and allows for utilization of more of the worktable surface during milling operations.

3. 发明申请

US20200235513A1 ANGLED POWER PIN ALIGNMENT AND CRIMPING FIXTURE 审中-公开
公开(公告)号：US20200235513A1
公开(公告)日：2020-07-23
申请号：US16745701
申请日：2020-01-17
申请人： David Anderson , Myles Keefer , Larry Le
发明人： David Anderson , Myles Keefer , Larry Le
IPC分类号： H01R13/207 , H01R13/58 , E21B43/12
摘要： A power pin alignment and crimping fixture having a fixture body. The fixture body includes a plurality of channels each having a first open end and a second open end. The plurality of channels are disposed at an angle diverging away from one another in a direction from the first open end to the second open end such that each of the plurality of channels are disposed along a corresponding side edge of a symmetrical shape.

4. 发明申请

US20170361813A1 Hitch Receiver Stand 审中-公开
公开(公告)号：US20170361813A1
公开(公告)日：2017-12-21
申请号：US15626772
申请日：2017-06-19
申请人： David Anderson
发明人： David Anderson
IPC分类号： B60S9/04 , F16M11/16 , B60S9/02
CPC分类号： B60S9/04 , B60D1/58 , B60S9/02 , F16M11/16
摘要： A hitch receiver stand comprises a hitch receiver assembly having a hitch receiver than can removably mount a device having a standard hitch and is removably attached to a framework. The framework may include a number of releasably coupled components.

5. 发明授权

US09435749B2 System and method for inspection of roll surface 有权
标题翻译：轧辊表面检查的系统和方法
公开(公告)号：US09435749B2
公开(公告)日：2016-09-06
申请号：US14208990
申请日：2014-03-13
申请人： Wade A. Winchip , David Anderson , Kelly Pepper , Neville Whittle
发明人： Wade A. Winchip , David Anderson , Kelly Pepper , Neville Whittle
IPC分类号： H04N5/235 , G01N21/952
CPC分类号： B21B28/04 , B24B5/37 , B24B49/12 , B24B55/02 , G01N21/8851 , G01N21/952
摘要： A system and method that includes, in an embodiment, a prism, a camera, a light source, and a plate. The system, in an embodiment, is configured for scanning a roll and generating an image of the roll surface. The prism, in an embodiment, is positioned below the camera and above the plate. In an embodiment, the plate is positioned below the prism and above the roll surface. In an embodiment, the light source is positioned above the prism. In an embodiment, the light source and the prism are positioned to provide light to the roll surface at an angle of at least 75 degrees measured from a line normal to the roll surface. In an embodiment, the prism is configured to refract light from the light source, the camera is a line scan camera that includes a row of pixel sensors, and the light source includes light emitting diodes.
摘要翻译：在一个实施例中包括棱镜，照相机，光源和板的系统和方法。在一个实施例中，该系统被配置用于扫描辊并产生辊表面的图像。在一个实施例中，棱镜位于照相机下方和板的上方。在一个实施例中，板位于棱镜下方并在辊表面上方。在一个实施例中，光源位于棱镜上方。在一个实施例中，光源和棱镜被定位成以与垂直于辊表面的线测量的至少75度的角度向辊表面提供光。在一个实施例中，棱镜被配置为折射来自光源的光，照相机是包括一排像素传感器的行扫描照相机，并且光源包括发光二极管。

6. 发明授权

US08954144B2 Hybrid clustered neural interface system 有权
标题翻译：混合聚类神经接口系统
公开(公告)号：US08954144B2
公开(公告)日：2015-02-10
申请号：US13524989
申请日：2012-06-15
申请人： David Anderson , Daryl R. Kipke , Jamille Hetke , Rio J. Vetter , Kc Kong , John Seymour
发明人： David Anderson , Daryl R. Kipke , Jamille Hetke , Rio J. Vetter , Kc Kong , John Seymour
IPC分类号： A61N1/00 , A61N1/05
CPC分类号： A61N1/0531 , Y10T29/49147
摘要： An apparatus comprises a flexible substrate. The flexible substrate includes a first substrate surface, a surface electrode array that includes a plurality of electrodes disposed on the first substrate surface, one or more flexible neural probes substantially orthogonal to the first substrate surface and insertable into biological tissue, and a penetrating electrode array that includes a plurality of electrodes formed on the one or more flexible neural probes, wherein electrodes of the surface electrode array and the penetrating electrode array are configured to one or both of receive a neural signal from a neural signal source and provide electrical stimulation energy to a neural stimulation target.
摘要翻译：一种装置包括柔性基板。柔性基板包括第一基板表面，包括设置在第一基板表面上的多个电极的表面电极阵列，基本上与第一基板表面正交并可插入到生物组织中的一个或多个柔性神经探针，以及穿透电极阵列其包括形成在所述一个或多个柔性神经探针上的多个电极，其中所述表面电极阵列和所述穿透电极阵列的电极被配置为接收来自神经信号源的神经信号中的一个或两个，并将电刺激能量提供给神经刺激目标。

7. 发明授权

US08700649B2 Analyzing administrative healthcare claims data and other data sources 有权
标题翻译：分析行政医疗索赔数据和其他数据来源
公开(公告)号：US08700649B2
公开(公告)日：2014-04-15
申请号：US13073573
申请日：2011-03-28
申请人： Jean Rawlings , David Anderson , Carl Kraus , Andrew Paris
发明人： Jean Rawlings , David Anderson , Carl Kraus , Andrew Paris
IPC分类号： G06F7/00 , G06F17/30
CPC分类号： G06F19/36 , G06F19/00 , G06Q40/08 , G06Q50/22 , G16H10/20 , G16H15/00 , Y02A90/22 , Y02A90/26 , Y10S707/941
摘要： Techniques suitable for identifying potential subjects for a clinical trial and other applications are disclosed. One or more exclusion or inclusion criteria are defined for the clinical trial. One or more specialized searching tables are pre-generated using administrative healthcare claims data and the one or more exclusion or inclusion criteria. The specialized searching tables are searched. Through the searching step, subjects are identified within the administrative healthcare claims data who match the one or more exclusion or inclusion criteria. Through the searching step, a geographical area is identified corresponding to the subjects who match the one or more exclusion or inclusion criteria. A customized report is generated using the identified subjects and geographical area.
摘要翻译：公开了适用于鉴定临床试验和其他应用的潜在受试者的技术。为临床试验定义了一个或多个排除或纳入标准。使用管理医疗保健索赔数据和一个或多个排除或纳入标准预先生成一个或多个专门的搜索表。搜索专门的搜索表。通过搜索步骤，在与一个或多个排除或纳入标准相匹配的行政医疗保健索赔数据内确定受试者。通过搜索步骤，识别与匹配一个或多个排除或包含标准的受试者相对应的地理区域。使用识别的主题和地理区域生成定制报告。

8. 发明授权

US08643772B2 Electromagnetically shielded video camera and shielded enclosure for image capture devices 有权
标题翻译：电磁屏蔽摄像机和屏蔽外壳，用于图像捕获设备
公开(公告)号：US08643772B2
公开(公告)日：2014-02-04
申请号：US13289849
申请日：2011-11-04
申请人： David Anderson
发明人： David Anderson
IPC分类号： H04N5/225
CPC分类号： H04N5/2252
摘要： Camera arrangements that can include electromagnetic protection, such as from EMP/IEMI events, is disclosed. One example camera arrangement includes a camera including a viewfinder having a lens, and an electromagnetically shielded enclosure defining an interior volume containing the camera and configured to include at least one opening aligned with the lens. The camera arrangement includes a waveguide beyond cutoff disposed across the at least one opening, the waveguide beyond cutoff including a plurality of cells sized and oriented to shield the interior volume of the enclosure from electromagnetic signals while exposing an optical path between the lens and objects external to the enclosure.
摘要翻译：公开了可以包括诸如来自EMP / IEMI事件的电磁保护的照相机布置。一个示例性相机布置包括包括具有透镜的取景器的照相机和限定包含照相机的内部空间的电磁屏蔽外壳，并且被配置为包括与透镜对准的至少一个开口。照相机装置包括跨越至少一个开口的超越截止的波导，超越切除的波导包括多个单元，其大小和取向以将外壳的内部空间屏蔽电磁信号，同时暴露在透镜和对象外部之间的光路到外壳。

9. 发明申请

US20130144365A1 NEURAL DEVICE WITH MODULAR ELECTRODE ARRAY 有权
标题翻译：具有模块电极阵列的神经器件
公开(公告)号：US20130144365A1
公开(公告)日：2013-06-06
申请号：US13556715
申请日：2012-07-24
申请人： Daryl R. Kipke , Rio J. Vetter , Kc Kong , Jamille Hetke , David Anderson
发明人： Daryl R. Kipke , Rio J. Vetter , Kc Kong , Jamille Hetke , David Anderson
IPC分类号： A61N1/04 , A61N1/05 , A61N5/06
CPC分类号： A61N1/0476 , A61B5/0059 , A61B5/04001 , A61B5/0478 , A61B5/4064 , A61B5/4094 , A61B2562/0209 , A61B2562/046 , A61N1/0502 , A61N1/0531 , A61N1/36064 , A61N5/06 , A61N5/0622 , Y10T29/49117
摘要： An apparatus comprises a flexible substrate including a modular electrode array disposed on the flexible substrate. The modular electrode array includes a plurality of electrode modules, where an electrode module includes a plurality of electrodes. The flexible substrate also includes a spatial separation between the electrode modules of the modular electrode array, and conductive interconnect coupled to the electrodes of the plurality of electrodes.
摘要翻译：一种装置包括柔性基板，其包括设置在柔性基板上的模块化电极阵列。模块化电极阵列包括多个电极模块，其中电极模块包括多个电极。柔性基板还包括模块化电极阵列的电极模块与耦合到多个电极的电极的导电互连之间的空间间隔。

10. 发明申请

US20120317288A1 SYSTEM AND METHOD FOR PUBLISHING CONTENT ON THE INTERNET 审中-公开
标题翻译：在互联网上发布内容的系统和方法
公开(公告)号：US20120317288A1
公开(公告)日：2012-12-13
申请号：US13579706
申请日：2010-12-08
申请人： David Anthony Campana , Shemimon Manlikudy Anthru , Ishan Mandrekar , Jens Cahnbley , Saurabh Mathur , David Anderson
发明人： David Anthony Campana , Shemimon Manlikudy Anthru , Ishan Mandrekar , Jens Cahnbley , Saurabh Mathur , David Anderson
IPC分类号： G06F15/173
CPC分类号： H04N21/6581 , G06F16/40 , G06Q10/10 , H04L63/102 , H04N7/17318 , H04N21/25875 , H04N21/2743
摘要： A method and system enables sharing content between a plurality of users over a communications network. A link to content that has been shared by a user is selected, the link includes at least one access characteristic defining a set of users able to access the content. A request signal including the at least one access characteristic associated with the content and at least one user characteristic associated with a requesting user over the communications network is transmitted for receipt by an authorization processor. A level of access available is determined for the content by comparing the at least one access characteristic and the at least one user characteristic in the request signal with a source of content specific authentication information including data representing content-specific access levels. Access to the requested content is provided via an internet interface to an output device in accordance with the determined level of access.
摘要翻译：一种方法和系统使得能够通过通信网络在多个用户之间共享内容。选择已经被用户共享的内容的链接，该链接包括定义能够访问内容的一组用户的至少一个访问特征。发送包括与内容相关联的至少一个访问特性的请求信号和通过通信网络与请求用户相关联的至少一个用户特征，以供授权处理器接收。通过将请求信号中的至少一个访问特征和至少一个用户特征与包含表示内容特定访问级别的数据的内容特定认证信息的源进行比较来确定内容的可用访问级别。根据确定的访问级别，通过因特网接口向输出设备提供对所请求内容的访问。

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