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1. 发明公开

EP2684878A1 DIPYRIDYLAMINE DERIVATIVE 审中-公开
标题翻译： DIPYRIDYLAMINDERIVAT ALS GLUCOKINASE ACTIVATOR
公开(公告)号：EP2684878A1
公开(公告)日：2014-01-15
申请号：EP12754741.2
申请日：2012-03-08
申请人： Daiichi Sankyo Company, Limited
发明人： KANEKO, Satoru , TSURUOKA, Hiroyuki , HONZUMI, Masatoshi , ABE, Manabu , YOSHIDA, Taishi
IPC分类号： C07D401/14 , A61K31/444 , A61K31/506 , A61P3/10 , A61P9/00 , A61P9/10 , A61P13/12 , A61P25/02 , A61P27/02 , A61P43/00 , C07D413/14
CPC分类号： C07D413/14 , A61K31/444 , A61K31/506 , C07D401/14
摘要： The present invention relates to a compound or a pharmacologically acceptable salt thereof having superior glucokinase activating activity, and is a compound represented by general formula (I), or pharmacologically acceptable salt thereof:

[wherein,
R 2 represents a C 6 -C 10 aryl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group A, a C 1 -C 6 alkyl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group B, or the like; X represents a single bond, an oxygen atom, a sulfur atom, or the like; R 2 represents a C 6 -C 10 aryl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group A, or the like; R 3 represents a 1H-tetrazol-5-yl group or a 5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl group; Substituent Group A represents the group of substituents selected from a halogen atom, a C 1 -C 6 alkyl group, a C 1 -C 6 halogenated alkyl group, a hydroxy group, a C 1 -C 6 hydroxyalkyl group, or the like; and, Substituent Group B represents the group of substituents selected from a halogen atom, a C 3 -C 6 cycloalkyl group that may be substituted with one C 1 -C 6 hydroxyalkyl group, a hydroxy group, a C 1 -C 6 alkoxy group, a C 2 -C 7 alkylcarbonyl group, a C 2 -C 7 alkoxycarbonyl group, or the like].
摘要翻译：本发明涉及具有优异的葡糖激酶活化活性的化合物或其药理学上可接受的盐，是由通式（I）表示的化合物或其药理学上可接受的盐：[其中，R 2表示C 6 -C 10芳基可以被独立地选自取代基组A的1至5个基团取代的基团，可以被独立地选自取代基组B的1至5个基团取代的C 1 -C 6烷基等 ; X表示单键，氧原子，硫原子等; R 2表示可以被独立地选自取代基组A的1至5个基团取代的C 6 -C 10芳基等; R 3表示1H-四唑-5-基或5-氧代-4,5-二氢 - [1,2,4]恶二唑-3-基; 取代基组A表示选自卤素原子，C 1 -C 6烷基，C 1 -C 6卤代烷基，羟基，C 1 -C 6羟烷基等的取代基; 并且取代基B代表选自卤素原子，可以被一个C 1 -C 6羟烷基取代的C 3 -C 6环烷基，羟基，C 1 -C 6烷氧基，C 2 -C 7烷基羰基，C 2 -C 7烷氧基羰基等〕。

2. 发明公开

EP1857118A1 MEDICINAL COMPOSITION FOR TREATING DIABETES 审中-公开
标题翻译： MEDIZINISCHE ZUSAMMENSETZUNG ZUR BEHANDLUNG馄饨
公开(公告)号：EP1857118A1
公开(公告)日：2007-11-21
申请号：EP05814764.6
申请日：2005-12-12
申请人： Daiichi Sankyo Company, Limited
发明人： YOSHIDA, Taishi , OKUNO, Akira
IPC分类号： A61K45/00 , A61K31/155 , A61K31/427 , A61P3/10
CPC分类号： A61K31/155 , A61K31/427
摘要： To provide a therapeutic procedure for diabetes mellitus with an excellent efficacy and high safety by possibly reducing side effects.
To administer a pharmaceutical composition comprising an FBPase inhibitor at a specified timing.
摘要翻译：通过可能减少副作用为糖尿病提供优异疗效和高安全性的治疗方法。在规定的时间给药包含FBPase抑制剂的药物组合物。

3. 发明公开

EP1825854A1 MEDICINAL COMPOSITION CONTAINING FBPase INHIBITOR 审中-公开
标题翻译： EINEN FBPase INHIBITOR ENTHALTENDE MEDISINISCHE ZUSAMMENSETZUNG
公开(公告)号：EP1825854A1
公开(公告)日：2007-08-29
申请号：EP05816808.9
申请日：2005-12-14
申请人： Daiichi Sankyo Company, Limited
发明人： YOSHIDA, Taishi , OKUNO, Akira
IPC分类号： A61K31/427 , A61K31/664 , A61K45/00 , A61P3/10 , A61P43/00
CPC分类号： A61K31/427 , A61K31/664 , A61K45/06 , A61K2300/00
摘要： To provide a method of treatment for diabetes mellitus having excellent decreasing activity in blood glucose levels and improving effects for dysfunction of β-cells in the pancreas of patients with diabetes mellitus.
A pharmaceutical composition comprising an FBPase inhibitor and an insulin sensitizer
5-[4-(6-methoxy-1-methyl-1H-benzimidazol-2-ylmethoxy)benzyl]thia zolidine-2,4-dione or a pharmacologically acceptable salt thereof.
摘要翻译：提供一种糖尿病治疗方法，其具有优异的降低血糖水平的活性和改善对糖尿病患者胰腺中2型细胞功能障碍的作用。一种药物组合物，其包含FBP酶抑制剂和胰岛素敏化剂5- [4-（6-甲氧基-1-甲基-1H-苯并咪唑-2-基甲氧基）苄基]硫唑烷-2,4-二酮或其药理学上可接受的盐。

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