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1. 发明申请

WO2012143798A1 METHOD AND SYSTEM FOR OPTICALLY EVALUATING PROXIMITY TO THE INFERIOR ALVEOLAR NERVE IN SITU 审中-公开
标题翻译：用于光学评估临床中对于传统神经内分泌神经的方法和系统
公开(公告)号：WO2012143798A1
公开(公告)日：2012-10-26
申请号：PCT/IB2012/050045
申请日：2012-01-04
申请人： DR. HASSAN GHADERI MOGHADDAM , MOGHADDAM, Hassan, Ghaderi , GALLANT, Pascal , MERMUT, Ozzy , VEILLEUX, Israël
发明人： MOGHADDAM, Hassan, Ghaderi , GALLANT, Pascal , MERMUT, Ozzy , VEILLEUX, Israël
IPC分类号： A61B6/14 , A61C8/00
CPC分类号： A61B17/1703 , A61B5/0066 , A61B5/0075 , A61B5/0261 , A61B5/14551 , A61B5/4542 , A61B5/489 , A61B5/4893 , A61B17/1673 , A61B2034/2057 , A61B2090/306 , A61C1/084 , A61C1/088 , A61C8/0089 , A61C19/04
摘要： A low coherence interferometry probe system for evaluating proximity to a tissue layer, comprising a low coherence light source for generating low coherence excitation light, an excitation optical fiber to bring the low coherence excitation light near the tissue layer and a collection optical fiber for capturing back-scattered light from the tissue layer. The probe system comprises a low coherence interferometry sub-system and a digital signal processor for evaluating a distance to the tissue layer based on the back- scattered light received by the collection optical fiber. There is also provided a spectral absorption probe system for evaluating proximity to an artery, comprising a light source for generating excitation light having a wavelength adapted for absorption by blood chromophores, an excitation optical fiber to bring the excitation light near the artery and a collection optical fiber for capturing back-scattered light from the artery. The probe system comprises a light detector and a signal processor for determining a distance to the artery based on the back-scattered light and on Beer-Lambert law of light absorption using a value for surrounding tissue attenuation coefficient (μείί). A spectral absorption and low coherence interferometry probe system combining low coherence interferometry and spectral absorption is also provided.
摘要翻译：用于评估与组织层的接近度的低相干干涉测量探针系统，包括用于产生低相干激发光的低相干光源，在组织层附近带来低相干激发光的激发光纤和用于捕获的收集光纤来自组织层的散射光。探针系统包括低相干干涉测量子系统和数字信号处理器，用于基于由收集光纤接收的反向散射光来评估到组织层的距离。还提供了一种用于评估与动脉接近度的光谱吸收探针系统，其包括用于产生具有适于由血液发色团吸收的波长的激发光的光源，将激发光引导到动脉附近的激发光纤和收集光用于从动脉捕获背散射光的纤维。探针系统包括光检测器和信号处理器，用于基于背散射光确定到动脉的距离，并且使用用于周围组织衰减系数（μeθ）的值的Beer-Lambert光吸收定律。还提供了组合低相干干涉测量和光谱吸收的光谱吸收和低相干干涉测量系统。

2. 发明申请

WO2010139071A1 HYBRIDIZED OPTICAL-MRI METHOD AND DEVICE FOR MOLECULAR DYNAMIC MONITORING OF IN VIVO RESPONSE TO DISEASE TREATMENT 审中-公开
标题翻译：混合光学MRI方法和用于疾病反应的分子动态监测的装置
公开(公告)号：WO2010139071A1
公开(公告)日：2010-12-09
申请号：PCT/CA2010/000851
申请日：2010-06-04
申请人： INSTITUT NATIONAL D'OPTIQUE , GALLANT, Pascal , MERMUT, Ozzy
发明人： GALLANT, Pascal , MERMUT, Ozzy
IPC分类号： A61B5/055
CPC分类号： A61B5/055
摘要： An apparatus for providing physiological information from an organism in disease diagnosis and treatment monitoring, for use in an MRI instrument. The apparatus operates on the concept of hybridized magneto-optical sensitivity. The MRI includes an MRI scanner and a controller for controlling the MRI scanner. The MRI scanner provides a magnetic field of at least 0.5T. The apparatus further includes a front end built of non-magnetic components, comprising light guides for illuminating a region of interest (ROI) and for collecting light emitted at said ROI; and a back-end comprising a light source for injecting light into said light guides; a light detector for receiving light collected at said ROI; and a processing and control unit for processing said light collected at said ROI.
摘要翻译：一种用于在用于MRI仪器的疾病诊断和治疗监测中从生物体提供生理信息的装置。该装置基于杂波磁光灵敏度的概念。 MRI包括MRI扫描器和用于控制MRI扫描仪的控制器。 MRI扫描仪提供至少0.5T的磁场。该装置还包括由非磁性部件构成的前端，包括用于照亮感兴趣区域（ROI）的光导和用于收集在所述ROI处发射的光; 以及后端，其包括用于将光注入所述光导中的光源; 用于接收在所述ROI处收集的光的光检测器; 以及处理和控制单元，用于处理在所述ROI处收集的所述光。

3. 发明申请

WO2005043138A1 A TIME-DOMAIN METHOD AND APPARATUS FOR DETERMINING THE DEPTH AND CONCENTRATION OF A FLUOROPHORE IN A TURBID MEDIUM 审中-公开
标题翻译：用于确定涡轮介质中氟的深度和浓度的时域方法和装置
公开(公告)号：WO2005043138A1
公开(公告)日：2005-05-12
申请号：PCT/IB2004/003559
申请日：2004-10-29
申请人： ART ADVANCED RESEARCH TECHNOLOGIES INC. , HALL, David, Jonathan , MA, Guobin , LESAGE, Frederic , GALLANT, Pascal
发明人： HALL, David, Jonathan , MA, Guobin , LESAGE, Frederic , GALLANT, Pascal
IPC分类号： G01N21/64
CPC分类号： G01N21/4795 , A61B5/0059 , A61B5/0073 , G01N21/49 , G01N21/6408 , G01N21/6428 , G01N21/6456 , G01N2021/1787 , G01N2021/6491
摘要： Methods and apparatuses for determining the depth and concentration of fluorophores in a turbid medium are disclosed. The method advantageously provides for a rapid estimation of the depth of the flurophore using characteristics of a temporal point spread function. The concentration of the flurophore can be determined using the method of the present invention by combining a calculated depth of the flurophore with a measurement of the intensity of the emitted fluorescence. The intensity can be accurately measured by the apparatus disclosed herein which combine back-reflection and trans-illumination geometries for the source of light injecting and detection.
摘要翻译：公开了用于确定混浊介质中荧光团的深度和浓度的方法和装置。该方法有利地提供使用时间点扩散函数的特征来快速估计荧光的深度。可以使用本发明的方法通过将计算的荧光深度与所发射的荧光的强度的测量结合来确定荧光的浓度。可以通过本文公开的装置精确地测量强度，其结合用于光注入和检测的源的背反射和反照射几何形状。

4. 发明申请

WO2007071032A1 OBJECT-DETECTING LIGHTING SYSTEM AND METHOD 审中-公开
标题翻译：目标检测照明系统和方法
公开(公告)号：WO2007071032A1
公开(公告)日：2007-06-28
申请号：PCT/CA2006/002067
申请日：2006-12-19
申请人： INSTITUT NATIONAL D'OPTIQUE , CANTIN, Daniel , MIMEAULT, Yvan , GALLANT, Pascal
发明人： CANTIN, Daniel , MIMEAULT, Yvan , GALLANT, Pascal
IPC分类号： G01S17/06 , B60W40/04 , F21S2/00 , G01S17/08 , G01S17/10 , G08G1/052 , G08G1/095 , G01P13/00
CPC分类号： G08G1/095 , B60W40/04 , G01P13/00 , G01S7/481 , G01S7/4814 , G01S17/06 , G01S17/42 , G01S17/936 , G08G1/04
摘要： An object-detecting lighting system (10) comprises a light source (12) emitting visible light. A source controller (14) is connected to the light source (12) to drive the light source (12) into emitting the visible light in a predetermined mode. An optical detector (16) is positioned with respect to the light source (12) and is adapted to detect the visible light as reflected/backscattered by an object (A). A data/signal processor (18) is connected to the source controller (14) and the optical detector (16) to receive detection data from the optical detector (16). The data/signal processor (18) produces a data output associated to the object (A) as a function of the predetermined mode and the detection data.
摘要翻译：物体检测照明系统（10）包括发射可见光的光源（12）。源控制器（14）连接到光源（12）以驱动光源（12）以预定模式发射可见光。光检测器（16）相对于光源（12）定位，并且适于检测被物体（A）反射/反向散射的可见光。数据/信号处理器（18）连接到源控制器（14）和光检测器（16）以接收来自光检测器（16）的检测数据。数据/信号处理器（18）根据预定模式和检测数据产生与对象（A）相关联的数据输出。

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