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1. 发明申请

WO2012085814A2 ELECTRONIC CONTROL METHOD AND SYSTEM FOR A PIEZO-ELECTRIC PUMP 审中-公开
标题翻译：电动泵的电子控制方法和系统
公开(公告)号：WO2012085814A2
公开(公告)日：2012-06-28
申请号：PCT/IB2011/055771
申请日：2011-12-19
申请人： DEBIOTECH S.A. , NOTH, André , CHAPPEL, Eric
发明人： NOTH, André , CHAPPEL, Eric
IPC分类号： F04B43/04 , F04B49/06
CPC分类号： F04B49/00 , F04B43/0081 , F04B43/046 , F04B49/065
摘要： The method for actuating a pumping device with an optimal driving voltage, wherein the pumping device comprises at least a pumping chamber (4) having a pumping membrane (1), an inlet chamber (3) and an outlet chamber (5), a voltage controlled actuator (6) connected to said pumping membrane (1 ), said pumping membrane reaching at least one stop position defined by a mechanical stop (2) during a pumping stroke, at least one sensor for determining whether the pumping membrane has reached said at least one mechanical stop (2); said method comprising a learning phase and a working phase, wherein the learning phase comprises at least the following steps -) actuation of the pumping membrane (1 ) by applying a predetermined actuation voltage V act to the actuator (6), said voltage being either high enough for said pumping membrane (1 ) to reach said position in an over-actuation step or low enough for said pumping membrane (1 ) not to reach said mechanical stop (2) position in an under-actuation process; -) after the over-actuation step, decreasing the applied actuation voltage until it is determined that the pumping membrane (1 ) has left said mechanical stop (2) position and storing as the optimal voltage V act optimal the lowest applied voltage value before the pumping membrane (1 ) has left said mechanical stop (2) position; or -) in the under-actuation step, increasing the applied voltage until it is determined that the pumping membrane (1 ) has reached said mechanical stop (2) position and storing as the optimal voltage V act optimal the lowest applied voltage value when the pumping membrane (1 ) has reached said mechanical stop (2) position; -) actuating the pumping device in the working phase with the determined optimal voltage value V act optimal .
摘要翻译：用于以最佳驱动电压致动泵送装置的方法，其中所述泵送装置至少包括具有泵送膜（1），入口室（3）和出口室（5）的泵送室（4），电压连接到所述泵送膜（1）的所述控制致动器（6），所述泵送膜在泵送冲程期间达到由机械止挡（2）限定的至少一个停止位置，至少一个传感器，用于确定泵送膜是否达到至少一个机械停止（2）; 所述方法包括学习阶段和工作阶段，其中所述学习阶段至少包括以下步骤： - 通过向所述致动器（6）施加预定的致动电压Vact来致动所述泵送膜（1），所述电压高足以使所述泵送膜（1）在过度致动步骤中达到所述位置或足够低以使所述泵送膜（1）在致动不足的过程中不到达所述机械停止（2）位置; - ）在过度致动步骤之后，减小所施加的致动电压，直到确定泵送膜（1）已经离开所述机械停止（2）位置并且存储为泵送之前的最低施加电压值为最佳电压Vact 膜（1）已经离开了机械停止位置（2）; 或 - ）在增加施加的电压，直到确定泵送膜（1）已经达到所述机械停止（2）位置并且存储为最佳电压Vact时最佳施加的电压值，当泵送膜（1）已达到所述机械停止位置（2）; - ）在确定的最佳电压值Vact最优的情况下在工作阶段致动泵送装置。

2. 发明申请

WO2011098946A1 MICROMECHANIC PASSIVE FLOW REGULATOR 审中-公开
标题翻译：微生物被动流量调节器
公开(公告)号：WO2011098946A1
公开(公告)日：2011-08-18
申请号：PCT/IB2011/050514
申请日：2011-02-07
申请人： DEBIOTECH S.A. , CHAPPEL, Eric
发明人： CHAPPEL, Eric
IPC分类号： A61M5/168 , A61M27/00 , F15C3/04 , F15C5/00 , F16K11/00 , G05D7/01 , F16K99/00
CPC分类号： A61M5/16881 , A61M5/14276 , A61M5/145 , A61M5/16813 , A61M27/006 , A61M2039/2413 , A61M2205/0244 , F16K99/0001 , F16K99/0015 , F16K99/0057 , F16K2099/008 , F16K2099/0088 , G05D7/0635 , G05D7/0694 , Y10T137/7791 , Y10T137/86734
摘要： The invention concerns a flow regulator, made of a stack of 3 plates, respectively a top plate including a flexible membrane (1), a middle plate (2) with pillars and through holes and a bottom plate ( 3 ) with fluidic ports, micro channels and through holes (8,9,12). The principle is based on the deformation of the membrane due to the pressure of the liquid. The membrane goes in contact with the pillars of the middle plate, obstructing gradually the through holes of the pillars. The device is designed to keep the flow constant in a predefined range of pressure. The device is dedicated to ultra low flow rate up to 1 ml per day or below, typically for drug infusion. Plastic flow regulators comprise preferably several independent valves coupled in parallel. The membrane plate is therefore made of several flexible membranes obstructing gradually the flow by increasing the pressure. Stress limiters are used to avoid plastic deformation of the membrane. For implanted pump, the use of a flow regulator instead of a flow restrictor has several advantages, including the possibility to reduce significantly the reservoir pressure and to generate directly the pressure during the pump filling by using an elastic drug reservoir.
摘要翻译：本发明涉及一种流量调节器，由三个板组成，分别是包括柔性膜（1），具有支柱和通孔的中间板（2）和具有流体端口的底板（3）的顶板，微板通道和通孔（8,9,12）。该原理是基于液体由于压力引起的膜的变形。膜与中间板的支柱接触，逐渐阻塞柱的通孔。设备旨在使流量保持在预定的压力范围内。该设备专用于每天或以下超过1毫升的超低流速，通常用于药物输注。塑料流量调节器优选并联连接多个独立的阀。因此，膜片由几个柔性膜制成，通过增加压力逐渐阻塞流动。应力限制器用于避免膜的塑性变形。对于植入式泵，使用流量调节器代替限流器具有若干优点，包括显着降低储层压力并通过使用弹性药物储存器在泵填充期间直接产生压力的可能性。

3. 发明申请

WO2009098314A1 REGULATEUR DE FLUX PASSIF POUR INFUSION DE MEDICAMENTS 审中-公开
标题翻译：被动流量调节器用于输注药物
公开(公告)号：WO2009098314A1
公开(公告)日：2009-08-13
申请号：PCT/EP2009/051414
申请日：2009-02-06
申请人： DEBIOTECH S.A. , CHAPPEL, Eric , GAMPER, Stephan
发明人： CHAPPEL, Eric , GAMPER, Stephan
IPC分类号： A61M5/168 , F16K99/00
CPC分类号： A61M5/16881 , A61M2205/0244 , G05D7/0113 , Y10T29/494
摘要： Régulateur de flux pour l'infusion de médicaments comprenant successivement un substrat (1 ), un canal (5), une entretoise (3) et une membrane (4), cette dernière comportant au moins un trou (6) communiquant avec le canal (5), caractérisé par le fait que le régulateur est réalisé à partir d'au moins deux éléments distincts (1 -4), le premier élément comportant la membrane (4) et le deuxième élément comportant l'entretoise (3).
摘要翻译：用于输注药物的流量调节器，包括依次包括基底（1），通道（5），间隔物（3）和膜（4），后者具有至少一个孔（6），与孔通道（5），其特征在于，所述调节器由至少两个分离的元件（1-4）制成，所述第一元件包括所述膜（4），所述第二元件包括所述间隔物（3）。

4. 发明申请

WO2013018011A3 METHOD FOR ACCURATE AND LOW-CONSUMPTION MEMS MICROPUMP ACTUATION AND DEVICE FOR CARRYING OUT SAID METHOD 审中-公开
公开(公告)号：WO2013018011A3
公开(公告)日：2013-02-07
申请号：PCT/IB2012/053847
申请日：2012-07-27
申请人： DEBIOTECH S.A. , CHAPPEL, Eric
发明人： CHAPPEL, Eric
IPC分类号： F04B43/02 , F04B43/04 , A61M5/142
摘要： The present invention describes the improvements due to alternated actuation cycles to reduce the delivery errors related to the pumping chamber elasticity, the actuator relaxation or hysteresis. The method actuates a pumping device with an optimal driving voltage profile, wherein the pumping device comprises a pumping chamber including a pumping membrane and a voltage controlled actuator connected to said membrane; the movement of said membrane being defined by three positions, namely a rest, a bottom and a top position. The method includes the actuation of the membrane with a pumping pattern including at least two different cycles : Cycle A : rest-bottom-rest-top-rest Cycle B : rest-top-rest-bottom-rest. The invention also relates to a device to carry out the method.

5. 发明申请

WO2012176171A1 VENTED RESERVOIR FOR MEDICAL PUMP 审中-公开
标题翻译：用于医用泵的通风储罐
公开(公告)号：WO2012176171A1
公开(公告)日：2012-12-27
申请号：PCT/IB2012/053177
申请日：2012-06-22
申请人： DEBIOTECH S.A. , CHAPPEL, Eric , ALLENDES, Ricardo , NEFTEL, Frédéric
发明人： CHAPPEL, Eric , ALLENDES, Ricardo , NEFTEL, Frédéric
IPC分类号： A61M5/142 , A61M5/168 , A61M5/145
CPC分类号： A61M5/14244 , A61M5/14593 , A61M5/16859 , A61M5/16881 , A61M5/5086 , F04D15/0005
摘要： The present invention concerns a medical pump comprising: a. A hard housing comprising a top (24) and bottom (1 ) hard shells, within which a rigid wall (3) and a movable membrane (2) create three distinct chambers; wherein i. said movable membrane tightly separates said second (29) and third (22) chambers ii. said first and third chambers have a watertight interface iii. said second chamber (29) is designed to contain a fluid iv. said first chamber (23) comprises a first venting mean (20) which is arranged to provide a fluidic communication between said first chamber (23) and the external environment; v. said third chamber (22) comprises a second venting mean which is arranged to provide a fluidic communication between said third chamber (22) and the external environment b. A pumping element (4) located in the first chamber (23) c. A least one pressure sensor which measure the pressure gradient between the first chamber (23) and the second chamber (29) d. A fluid pathway which permits: i. a first fluid connection (27) between said second chamber (29) and said pumping element ii. a second fluid connection (28) between said pumping element and a patient line (30).
摘要翻译：本发明涉及一种医用泵，包括：a。一种硬壳体，包括顶部（24）和底部（1）硬壳，刚性壁（3）和活动膜（2）形成三个不同的腔室; 其中i。所述活动膜将所述第二（29）和第三（22）腔室紧密分离。所述第一和第三室具有不透水的界面。所述第二室（29）被设计成容纳流体iv。所述第一腔室（23）包括第一通气装置（20），其被布置成在所述第一腔室（23）和外部环境之间提供流体连通; v。所述第三室（22）包括第二排气装置，其被布置成在所述第三室（22）和外部环境b之间提供流体连通。位于第一室（23）中的泵送元件（4）至少一个压力传感器，其测量第一室（23）和第二室（29）之间的压力梯度。流体通道，允许：i。所述第二室（29）和所述泵送元件（ii）之间的第一流体连接（27）。在所述泵送元件和患者管线（30）之间的第二流体连接（28）。

6. 发明申请

WO2011098867A1 PASSIVE FLUID FLOW REGULATOR 审中-公开
标题翻译：被动流体流量调节器
公开(公告)号：WO2011098867A1
公开(公告)日：2011-08-18
申请号：PCT/IB2010/052250
申请日：2010-05-20
申请人： DEBIOTECH S.A. , CHAPPEL, Eric , NEFTEL, Frédéric
发明人： CHAPPEL, Eric , NEFTEL, Frédéric
IPC分类号： A61M27/00 , F16K15/02 , F16K15/06
CPC分类号： A61M27/006 , A61M5/16881 , A61M2205/3344 , F16K15/026 , F16K15/063 , Y10T137/7792 , Y10T137/7933
摘要： The regulator comprises at least a cylinder (2) with a fluid inlet connector (1 ) for receiving fluid at an inlet pressure and a fluid outlet connector (4) for delivering fluid, at least one chamber (3), a rod (5) in said cylinder with one side submitted to the inlet pressure and the other side submitted to the outlet pressure generating a net force counter-balanced by at least one spring means (7) acting on one side of said rod (5) against said inlet pressure, wherein a fluidic pathway is formed between said rod (5) and said cylinder (2) as the major fluidic resistance of the device, wherein a change of the inlet pressure induces a move of the rod along the axis of the cylinder thereby modifying the fluidic resistance of said fluidic pathway, wherein the fluidic resistance of said pathway varies with the applied pressure at the inlet in a predefined range of pressure, inducing a regulated flow rate in the considered range of pressure.
摘要翻译：所述调节器至少包括具有用于接收入口压力的流体的流体入口连接器（1）和用于输送流体的流体出口连接器（4）的至少一个气缸（2），至少一个腔室（3），杆（5）在所述气缸中，一侧承受入口压力，另一侧承受出口压力，产生由至少一个弹簧装置（7）反平衡的净力，所述弹簧装置（7）抵抗所述入口压力作用在所述杆（5）的一侧上，其中在所述杆（5）和所述气缸（2）之间形成流体通道作为所述装置的主要流体阻力，其中所述入口压力的变化引起所述杆沿着所述气缸的轴线的移动，从而改变所述流体路径的流体阻力，其中所述通路的流体阻力随预定压力范围内入口处的施加压力而变化，从而在所考虑的压力范围内引起调节流量。

7. 发明申请

WO2011070468A1 ELEMENT FLEXIBLE POUR MICRO-POMPE 审中-公开
标题翻译： MICROPUMP柔性元件
公开(公告)号：WO2011070468A1
公开(公告)日：2011-06-16
申请号：PCT/IB2010/055310
申请日：2010-11-19
申请人： DEBIOTECH S.A. , SCHNEEBERGER, Niklaus , CHAPPEL, Eric
发明人： SCHNEEBERGER, Niklaus , CHAPPEL, Eric
IPC分类号： F04B43/04
CPC分类号： F04B43/046 , F04B19/006 , F04B43/043
摘要： Micro-pompe se présentant sous forme d'un empilement comprenant successivement, une membrane flexible (2), une chambre de pompage (4) et une plaque de fermeture (3), ladite chambre de pompage (4) communiquant avec l'extérieur, p.ex. au travers de la membrane flexible (2); ladite membrane (2) étant par ailleurs rendue solidaire d'un actuateur (5) disposé à l'extérieur de la micro-pompe caractérisé par le fait que ladite membrane (2) est rendue solidaire de l'actuateur (5) par l'intermédiaire d'au moins un élément se présentant sous la forme d'une bande (6), rigide selon son axe principal et flexible selon la direction perpendiculaire à son axe principal.
摘要翻译：一种堆叠形式的微型泵，其中包括柔性隔膜（2），泵送室（4）和关闭板（3），所述泵送室（4）与外部连通，例如通过柔性隔膜（2）; 所述隔膜（2）还被固定到布置在微型泵外部的致动器（5）上，其特征在于，所述隔膜（2）通过至少一种元件形式（6）固定到致动器（5）），其沿其主轴线是刚性的，并且在垂直于其主轴线的方向上是柔性的。

8. 发明申请

WO2010020891A1 PASSIVE FLUID FLOW REGULATOR 审中-公开
标题翻译：被动流体流量调节器
公开(公告)号：WO2010020891A1
公开(公告)日：2010-02-25
申请号：PCT/IB2009/052775
申请日：2009-06-26
申请人： DEBIOTECH S.A. , CHAPPEL, Eric
发明人： CHAPPEL, Eric
IPC分类号： A61M5/168 , F15C3/04 , A61M5/145 , A61M27/00
CPC分类号： A61M5/16881 , A61M5/145 , A61M27/006 , A61M37/00 , A61M2205/0244 , F16K99/0001 , F16K99/0013 , F16K99/0015 , F16K99/0026 , F16K99/0057 , F16K2099/0088 , Y10T137/86718 , Y10T137/87306
摘要： A fluid flow regulator (1) of the passive type is disclosed which has a fluid inlet adapted to be connected to a fluid reservoir and a fluid outlet (13)adapted to be connected to a patient's body. The regulator comprises a rigid substrate (2) and a resilient membrane (3) tightly linked together so as to define a cavity (6) there between which is disconnected to the fluid outlet while the membrane has a first surface (12) opposite the cavity which is connected to the fluid inlet. The membrane has a plurality of through holes (15) contiguous with the cavity,to define a pathway for a fluid from the fluid inlet to the fluid outlet, and is flexible so as to be able to come into contact with the substrate as a fluid applies a sufficient pressure on the first surface. The through holes are arranged such that,when the fluid pressure increases, they close one after the other to increase the regulator fluidic resistance so that a fluid flow rate would be substantially constant as a function of the pressure applied on the first surface within a predefined pressure range.
摘要翻译：公开了一种无源型流体流量调节器（1），其具有适于连接到流体储存器的流体入口和适于连接到患者身体的流体出口（13）。调节器包括刚性基板（2）和紧密连接在一起的弹性膜（3），以便限定一个空腔（6），在该空腔之间与流体出口断开，而膜具有与空腔相对的第一表面（12）其连接到流体入口。膜具有多个与空腔邻接的通孔（15），以限定用于流体从流体入口到流体出口的路径，并且是柔性的，以便能够作为流体与基底接触在第一表面施加足够的压力。通孔布置成使得当流体压力增加时，它们一个接一个地关闭以增加调节器的流体阻力，使得流体流速基本上恒定，这是在预定义的范围内施加在第一表面上的压力的函数压力范围。

9. 发明申请

WO2012176170A1 METHOD AND SYSTEM FOR DETECTING MALFUNCTION OF A MEMS MICROPUMP 审中-公开
标题翻译：用于检测MEMS微型计算机的故障的方法和系统
公开(公告)号：WO2012176170A1
公开(公告)日：2012-12-27
申请号：PCT/IB2012/053176
申请日：2012-06-22
申请人： DEBIOTECH S.A. , CHAPPEL, Eric , PROENNECKE, Stephan , NEFTEL, Frédéric
发明人： CHAPPEL, Eric , PROENNECKE, Stephan , NEFTEL, Frédéric
IPC分类号： A61M5/142 , A61M5/168 , F04B43/04 , G01F1/34
CPC分类号： A61M5/14244 , A61M5/14593 , A61M5/16859 , A61M5/16881 , A61M5/5086 , F04D15/0005
摘要： Method for detecting failure including possible under or over delivery of a micropump having at least an inlet valve, a pumping chamber with an inner pressure sensor and an outlet valve, said method comprising the determination of the pump tightness via the measurement of the pressure by said inner pressure sensor in said pumping chamber at least at certain intervals when the pump is inactive and the comparison with a value of reference.
摘要翻译：用于检测故障的方法，包括可能在至少具有入口阀的微型泵，或具有内部压力传感器的泵送室和出口阀之间或之后输送的方法，所述方法包括通过所述压力的测量来确定泵的紧度至少在泵不活动的情况下至少以一定的间隔和与参考值的比较，所述泵送室中的内部压力传感器。

10. 发明申请

WO2010046728A1 MEMS FLUID PUMP WITH INTEGRATED PRESSURE SENSOR FOR DYSFUNCTION DETECTION 审中-公开
标题翻译：具有集成压力传感器的MEMS流体泵进行功能检测
公开(公告)号：WO2010046728A1
公开(公告)日：2010-04-29
申请号：PCT/IB2008/054353
申请日：2008-10-22
申请人： DEBIOTECH S.A. , CHAPPEL, Eric , SCHNEEBERGER, Niklaus , NEFTEL, Frédéric
发明人： CHAPPEL, Eric , SCHNEEBERGER, Niklaus , NEFTEL, Frédéric
IPC分类号： A61M5/168 , F04B19/00
CPC分类号： F04B51/00 , A61M5/14224 , A61M5/168 , A61M5/16854 , A61M5/365 , A61M2005/16863 , A61M2005/16868 , A61M2205/0244 , A61M2205/0294 , A61M2205/3355 , A61M2205/70 , F04B43/043
摘要： The invention relates to a pumping device including a pump (1) comprising - a pumping chamber (11) having a variable volume, - an inlet (2) communicating with the pumping chamber (11) and comprising a valve, - an outlet (5) communicating with the pumping chamber and comprising a valve, - an actuator adapted to change the volume of the pumping chamber, - a fluidic pathway comprising said inlet (2), said pumping chamber (11), said outlet (5) and a downstream line (7) situated downstream of the outlet valve, - a pressure sensor (4) for measuring the pressure between the valves of said pathway, - processing means for processing the received pressure data from the pressure sensor (4). The invention also covers a method for detecting a dysfunction in a pumping device as defined above.
摘要翻译：本发明涉及一种泵送装置，其包括泵（1），泵（1）包括：具有可变容积的泵送室（11），与泵送室（11）连通并包括阀的入口（2）， - 出口）与泵送室连通并且包括阀， - 适于改变泵送室的体积的致动器， - 包括所述入口（2），所述泵送室（11），所述出口（5）和下游位于出口阀下游的管线（7）， - 用于测量所述通道的阀之间的压力的压力传感器（4）， - 用于处理来自压力传感器（4）的接收的压力数据的处理装置。本发明还涉及如上所述的用于检测泵送装置中的功能障碍的方法。

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