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1. 发明申请

US20070104653A1 Use of inhaled gaseous nitric oxide as a mucolytic agent or expectorant 有权
标题翻译：使用吸入性气体一氧化氮作为粘膜溶解剂或祛痰剂
公开(公告)号：US20070104653A1
公开(公告)日：2007-05-10
申请号：US11595108
申请日：2006-11-10
申请人： Christopher Miller , Douglas Hole , Bruce Murray , Bryan Perry
发明人： Christopher Miller , Douglas Hole , Bruce Murray , Bryan Perry
IPC分类号： A61K9/12 , A61K33/00
CPC分类号： A61K33/00 , A61K9/007
摘要： Methods and devices for treating excess mucus accumulation in mammals by administering gaseous inhaled nitric oxide or nitric oxide releasing compounds as a mucolytic agent or expectorant are provided. Delivery of gaseous nitric oxide can be made nasally or orally and is preferably substantially coincident with inhalation of the mammal or based on a synchronous parameter of the mammal's respiratory cycle. Varying therapeutic profiles may be used for the delivery of gaseous nitric oxide depending on the severity of the excess mucus accumulation. Parameters for the therapeutic profiles may include flow rate of nitric oxide containing gas, duration of administration of nitric oxide containing gas, number of breaths for which nitric oxide containing gas is to be administered, and concentrations of therapeutic NO delivered to the airways.
摘要翻译：提供了通过施用气体吸入一氧化氮或一氧化氮释放化合物作为粘液溶解剂或祛痰剂来治疗哺乳动物中过量粘液积累的方法和装置。气态一氧化氮的输送可以鼻或口服制成，优选地基本上与哺乳动物的吸入或基于哺乳动物呼吸循环的同步参数一致。根据过量粘液积聚的严重程度，不同的治疗方案可用于输送气态一氧化氮。用于治疗特征的参数可以包括含有一氧化氮的气体的流速，含有一氧化氮的气体的施用持续时间，要施用一氧化氮的气体的呼吸次数和输送到气道的治疗性NO的浓度。

2. 发明申请

US20070154570A1 Use of nitric oxide in the treatment and disinfection of biofilms 审中-公开
标题翻译：使用一氧化氮进行生物膜的处理和消毒
公开(公告)号：US20070154570A1
公开(公告)日：2007-07-05
申请号：US11592950
申请日：2006-11-01
申请人： Christopher Miller , Douglas Hole
发明人： Christopher Miller , Douglas Hole
IPC分类号： A01N59/00 , A61K33/00
CPC分类号： A61K33/00 , A01N59/00 , A01N25/10 , A01N25/34
摘要： The administration of gaseous nitric oxide as a biocidal moiety is proffered as a de novo treatment in the control and eradication of biofilms. The present invention relates to the use or methods of application of exogenous nitric oxide gas (gNO) as a stand alone biocidal agent or in cohort with any or all adjunct vehicles in the control of biofilms generated by microbial organisms, i.e., bacteria, protozoa, amoeba, fungi etc. Further, the present invention introduces the concept of utilization and methods of application of gaseous nitric oxide in control and eradication of biofilm forming microorganisms. Other embodiments include the use of a nitric oxide releasing material to eradicate and-control the growth of biofilms. Another embodiment includes the use of a gaseous nitric oxide releasing material packaged in an air-tight container with a medical device to prevent the growth of biofilm on the medical device.
摘要翻译：作为杀生物部分的气态一氧化氮的施用作为在控制和根除生物膜中的从头处理提供。本发明涉及外源一氧化氮气体（gNO）作为独立杀生物剂或与任何或所有辅助载体一起应用于控制微生物生物体生物膜（即细菌，原生动物，变形虫，真菌等。此外，本发明介绍了气体一氧化氮在控制和根除生物膜形成微生物中的应用概念和应用方法。其他实施方案包括使用一氧化氮释放物质来消除和控制生物膜的生长。另一个实施方案包括使用封装在具有医疗装置的气密容器中的气态一氧化氮释放材料以防止生物膜在医疗装置上生长。

3. 发明申请

US20070014688A1 Use of nitric oxide gas in an extracorporeal circuitry to treat blood plasma 有权
标题翻译：在体外电路中使用一氧化氮气体来治疗血浆
公开(公告)号：US20070014688A1
公开(公告)日：2007-01-18
申请号：US11445965
申请日：2006-06-01
申请人： Douglas Hole , Christopher Miller
发明人： Douglas Hole , Christopher Miller
IPC分类号： A61M1/00
CPC分类号： A61K33/00 , A61M1/1698 , A61M1/3472 , A61M1/3496 , A61M1/3687 , A61M2202/0275 , A61K2300/00
摘要： A method of reducing pathogens in blood by exposure to a nitric oxide containing gas in an extracorporeal circuitry is provided. The method includes: obtaining blood from a mammal or a blood source, separating the blood into plasma and blood cells, exposing the plasma to nitric oxide containing gas, combining the exposed plasma with the blood cells, reducing nitric oxide content in the recombined blood, and returning the blood to the mammal or blood source.
摘要翻译：提供了通过在体外电路中暴露于含有一氧化氮的气体来减少血液中的病原体的方法。该方法包括：从哺乳动物或血液源获得血液，将血液分离成血浆和血细胞，将血浆暴露于含有一氧化氮的气体中，将暴露的血浆与血细胞结合，减少重组血液中的一氧化氮含量，并将血液返回哺乳动物或血源。

4. 发明申请

US20080097282A1 Methods and devices for the delivery of therapeutic gases including nitric oxide 有权
标题翻译：用于输送包括一氧化氮在内的治疗气体的方法和装置
公开(公告)号：US20080097282A1
公开(公告)日：2008-04-24
申请号：US11713344
申请日：2007-03-02
申请人： Douglas Hole , Curtis Figley , Robert Lee , Michael Hudec , Robert Rolfson
发明人： Douglas Hole , Curtis Figley , Robert Lee , Michael Hudec , Robert Rolfson
IPC分类号： A61M37/00
CPC分类号： A61K33/00 , A61F13/0216 , A61F13/0226 , A61F13/8405 , A61F2013/00646 , A61F2013/0091 , A61J3/08 , A61K9/7007 , A61L2/0094 , A61L15/44 , A61L2300/114 , A61L2300/60 , A61M16/1055 , A61M16/106 , A61M16/12 , A61M16/208 , A61M2202/0275
摘要： Gas packages for the delivery of therapeutic gases, and in particular gaseous nitric oxide (gNO) are provided herein. The gas packages comprise one or more of a gas reservoir, interface layer, sealing layer, and holding container. The interface layer regulates discharge of the therapeutic gas from the gas reservoir to the external environment. The sealing layer and/or holding container prevent evolution of the gas until the sealing layer is compromised or the holding container is opened. The gas packages and methods for using them are useful for the treatment, alleviation, and prevention of various disease and non-disease, medical and non-medical, conditions in humans and animals.
摘要翻译：用于递送治疗气体的气体包装，特别是气态一氧化氮（gNO）。气体包装包括气体储存器，界面层，密封层和保持容器中的一个或多个。界面层调节治疗气体从气体储存器到外部环境的排放。密封层和/或保持容器防止气体的逸出，直到密封层受损或保持容器打开。气体包装和使用它们的方法可用于治疗，缓解和预防人类和动物中的各种疾病和非疾病，医学和非医学的条件。

5. 发明授权

US07531133B2 Use of nitric oxide gas in an extracorporeal circuitry to treat blood plasma 有权
标题翻译：在体外电路中使用一氧化氮气体来治疗血浆
公开(公告)号：US07531133B2
公开(公告)日：2009-05-12
申请号：US11445965
申请日：2006-06-01
申请人： Douglas Hole , Christopher C. Miller
发明人： Douglas Hole , Christopher C. Miller
IPC分类号： A61M1/00 , A61M37/00 , C02F1/44
CPC分类号： A61K33/00 , A61M1/1698 , A61M1/3472 , A61M1/3496 , A61M1/3687 , A61M2202/0275 , A61K2300/00
摘要： A method of reducing pathogens in blood by exposure to a nitric oxide containing gas in an extracorporeal circuitry is provided. The method includes: obtaining blood from a mammal or a blood source, separating the blood into plasma and blood cells, exposing the plasma to nitric oxide containing gas, combining the exposed plasma with the blood cells, reducing nitric oxide content in the recombined blood, and returning the blood to the mammal or blood source.
摘要翻译：提供了通过在体外电路中暴露于含有一氧化氮的气体来减少血液中的病原体的方法。该方法包括：从哺乳动物或血液源获得血液，将血液分离成血浆和血细胞，将血浆暴露于含有一氧化氮的气体中，将暴露的血浆与血细胞结合，减少重组血液中的一氧化氮含量，并将血液返回哺乳动物或血源。

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