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1. 发明申请

US20060275825A1 Proteolipid membrane and lipid membrane biosensor 审中-公开
标题翻译：蛋白脂膜和脂质膜生物传感器
公开(公告)号：US20060275825A1
公开(公告)日：2006-12-07
申请号：US11403128
申请日：2006-04-12
申请人： Cheryl Baird , Guo Wang , Lance Laing , Gangadhar Jogikalmath , John Gerstenmaier
发明人： Cheryl Baird , Guo Wang , Lance Laing , Gangadhar Jogikalmath , John Gerstenmaier
IPC分类号： G01N33/53 , C12M1/34
CPC分类号： G01N33/5432 , G01N33/54373 , G01N33/551 , G01N33/92
摘要： The invention provides compositions and methods for detection of interaction of molecules.
摘要翻译：本发明提供了用于检测分子相互作用的组合物和方法。

2. 发明申请

US20090192049A1 Proteolipid Membrane and Lipid Membrane Biosensor 审中-公开
标题翻译：蛋白脂膜和脂质膜生物传感器
公开(公告)号：US20090192049A1
公开(公告)日：2009-07-30
申请号：US12414048
申请日：2009-03-30
申请人： Cheryl L. Baird , Guo Bin Wang , Lance Laing , Gangadhar Jogikalmath , John Gerstenmaier
发明人： Cheryl L. Baird , Guo Bin Wang , Lance Laing , Gangadhar Jogikalmath , John Gerstenmaier
IPC分类号： C40B30/04 , G01N21/55 , G01N21/59 , G01N21/41
CPC分类号： G01N33/5432 , G01N33/54373 , G01N33/551 , G01N33/92
摘要： The invention provides compositions and methods for detection of interaction of molecules.
摘要翻译：本发明提供了用于检测分子相互作用的组合物和方法。

3. 发明申请

US20080115567A1 Simultaneous aspirator and dispenser for multiwell plates and similar devices 失效
标题翻译：用于多孔板和类似装置的同时抽吸器和分配器
公开(公告)号：US20080115567A1
公开(公告)日：2008-05-22
申请号：US11601020
申请日：2006-11-17
申请人： Lance G. Laing , Timothy F. Smith , John Gerstenmaier , Gangadhar Jogikalmath
发明人： Lance G. Laing , Timothy F. Smith , John Gerstenmaier , Gangadhar Jogikalmath
IPC分类号： B01L11/00 , G01N33/00
CPC分类号： G01N35/1074 , G01N35/1011
摘要： A device for simultaneously dispensing a solution containing a sample to a test device and aspirating the sample from the device. In one embodiment the device is hand-held and includes a control mechanism, e.g., button for activating the dispensing and aspiration of the sample. The testing device may take the form of a multi-well plate with a plurality of wells arranged in rows and columns, with the bottom of the wells formed as a photonic crystal biosensor. The device can be configured with dispense and aspirate manifolds and associated dispense and aspirate ports which are positioned in all the wells along a row or column of wells so as to simultaneously aspirate and dispense solution to all the wells in a row or column of the multi-well plate.
摘要翻译：一种用于将含有样品的溶液同时分配到测试装置并从该装置抽吸样品的装置。在一个实施例中，该装置是手持式的并且包括控制机构，例如用于激活样品的分配和抽吸的按钮。测试装置可以采用具有排成行和列的多个孔的多孔板的形式，阱的底部形成为光子晶体生物传感器。该装置可以配置有分配和抽吸歧管以及相关联的分配和抽吸端口，这些端口位于沿着一列或多列井的所有井中，以便同时吸取并将溶液分配给该多层的一列或多列的所有孔 - 板。

4. 发明授权

US07429492B2 Multiwell plates with integrated biosensors and membranes 有权
标题翻译：具有集成生物传感器和膜的多孔板
公开(公告)号：US07429492B2
公开(公告)日：2008-09-30
申请号：US11566818
申请日：2006-12-05
申请人： Bo Lin , Gangadhar Jogikalmath , Timothy Smith , Kurt Albertson , Christine Genick , Lance Laing
发明人： Bo Lin , Gangadhar Jogikalmath , Timothy Smith , Kurt Albertson , Christine Genick , Lance Laing
IPC分类号： G01N33/543
CPC分类号： G01N21/41 , G01N21/253 , G01N21/75 , G01N2021/7779 , Y10S435/81 , Y10S436/805 , Y10S436/809 , Y10S436/815
摘要： The invention provides compositions and methods of detecting binding of molecules to a biosensor. Compositions of the invention comprise a multiwell plate with an integrated biosensor and a membrane.
摘要翻译：本发明提供检测分子与生物传感器结合的组合物和方法。本发明的组合物包括具有集成的生物传感器和膜的多孔板。

5. 发明申请

US20080020480A1 Multiwell Plates with Integrated Biosensors and Membranes 有权
标题翻译：具有集成生物传感器和膜的多孔板
公开(公告)号：US20080020480A1
公开(公告)日：2008-01-24
申请号：US11566818
申请日：2006-12-05
申请人： Bo Lin , Gangadhar Jogikalmath , Timothy Smith , Kurt Albertson , Christine Genick , Lance Laing
发明人： Bo Lin , Gangadhar Jogikalmath , Timothy Smith , Kurt Albertson , Christine Genick , Lance Laing
IPC分类号： G01N21/00 , G01N21/01
CPC分类号： G01N21/41 , G01N21/253 , G01N21/75 , G01N2021/7779 , Y10S435/81 , Y10S436/805 , Y10S436/809 , Y10S436/815
摘要： The invention provides compositions and methods of detecting binding of molecules to a biosensor. Compositions of the invention comprise a multiwell plate with an integrated biosensor and a membrane.
摘要翻译：本发明提供检测分子与生物传感器结合的组合物和方法。本发明的组合物包括具有集成的生物传感器和膜的多孔板。

6. 发明授权

US07628085B2 Simultaneous aspirator and dispenser for multiwell plates and similar devices 失效
标题翻译：用于多孔板和类似装置的同时抽吸器和分配器
公开(公告)号：US07628085B2
公开(公告)日：2009-12-08
申请号：US11601020
申请日：2006-11-17
申请人： Lance G. Laing , Timothy F. Smith , John Gerstenmaier, III , Gangadhar Jogikalmath
发明人： Lance G. Laing , Timothy F. Smith , John Gerstenmaier, III , Gangadhar Jogikalmath
IPC分类号： G01N1/00
CPC分类号： G01N35/1074 , G01N35/1011
摘要： A device for simultaneously dispensing a solution containing a sample to a test device and aspirating the sample from the device. In one embodiment the device is hand-held and includes a control mechanism, e.g., button for activating the dispensing and aspiration of the sample. The testing device may take the form of a multi-well plate with a plurality of wells arranged in rows and columns, with the bottom of the wells formed as a photonic crystal biosensor. The device can be configured with dispense and aspirate manifolds and associated dispense and aspirate ports which are positioned in all the wells along a row or column of wells so as to simultaneously aspirate and dispense solution to all the wells in a row or column of the multi-well plate.
摘要翻译：一种用于将含有样品的溶液同时分配到测试装置并从该装置抽吸样品的装置。在一个实施例中，该装置是手持式的并且包括控制机构，例如用于激活样品的分配和抽吸的按钮。测试装置可以采用具有排成行和列的多个孔的多孔板的形式，阱的底部形成为光子晶体生物传感器。该装置可以配置有分配和抽吸歧管以及相关联的分配和抽吸端口，这些端口位于沿着一列或多列井的所有井中，以便同时吸取并将溶液分配给该多层的一列或多列的所有孔 - 板。

7. 发明授权

US07832291B2 Simultaneous aspirator and dispenser for multiwell plates and similar devices 失效
标题翻译：用于多孔板和类似装置的同时抽吸器和分配器
公开(公告)号：US07832291B2
公开(公告)日：2010-11-16
申请号：US12460288
申请日：2009-07-15
申请人： Lance G. Laing , Timothy F. Smith , John Gerstenmeier, III , Gangadhar Jogikalmath
发明人： Lance G. Laing , Timothy F. Smith , John Gerstenmeier, III , Gangadhar Jogikalmath
IPC分类号： G01N1/00
CPC分类号： G01N35/1074 , G01N35/1011
摘要： A method of making a measurement of binding affinity of a sample comprises the steps of: introducing the sample into a well having a bottom formed as a photonic crystal biosensor, wherein a portion of the sample becomes bound to the biosensor; making a measurement of the change in the shift in peak wavelength value as a function of time (kon) from the well as the sample is introduced into the well; simultaneously dispensing the sample to the well and aspirating the sample from the well and measuring the change in the shift in peak wavelength value as a function of time (koff) during the simultaneous dispensing and aspirating, and calculating an equilibrium association constant or an equilibrium dissociation constant for the sample from the values of kon and koff.
摘要翻译：测量样品的结合亲和力的方法包括以下步骤：将样品导入具有形成为光子晶体生物传感器的底部的孔中，其中样品的一部分与生物传感器结合; 在将样品引入到井中时，测量作为时间（kon）的函数的峰值波长值的偏移的变化; 同时将样品分配到孔中并从孔中吸出样品，并测量在同时分配和抽吸期间作为时间（k off）的函数的峰值波长值的偏移的变化，并计算平衡缔合常数或平衡解离从kon和koff的值得到样本的常数。

8. 发明申请

US20120152476A1 HIGH STRENGTH PAPER 有权
标题翻译：高强度纸
公开(公告)号：US20120152476A1
公开(公告)日：2012-06-21
申请号：US13331861
申请日：2011-12-20
申请人： Gangadhar Jogikalmath , Patrick D. Kincaid , Lynn Reis , David S. Soane
发明人： Gangadhar Jogikalmath , Patrick D. Kincaid , Lynn Reis , David S. Soane
IPC分类号： D21H17/33 , D21H23/00 , D21H17/63 , D21H11/00 , D21H17/29
CPC分类号： D21H17/455 , D21H17/29 , D21H17/375 , D21H17/41 , D21H17/42 , D21H17/44 , D21H17/56 , D21H21/18
摘要： Disclosed herein are systems and methods for attaching particulate additives to a population of cellulose fibers dispersed in an aqueous solution. The cellulose fibers are treated with an activator that forms complexes with them. The particulate additive is attached to a tether that is capable of interacting with the activator, thereby forming a tether-bearing particulate additive. The tether-bearing particulate additive can be added to the activated suspension of cellulose fibers. The resulting interaction between the tether and the activator forms durable complexes that attach the particulate additive to the cellulose fibers. Using these systems and methods, useful additives like starches can be attached to cellulose fibers, imparting advantageous properties such as increased strength to paper products formed thereby. These systems and methods are particularly useful for papermaking involving virgin pulp fibers, recycled fibers, or any combination thereof.
摘要翻译：本文公开了用于将微粒添加剂附着到分散在水溶液中的纤维素纤维群体的系统和方法。纤维素纤维用与它们形成复合物的活化剂处理。颗粒状添加剂连接到能够与活化剂相互作用的系链上，从而形成带束缚的微粒添加剂。可将带状的颗粒添加剂加入到纤维素纤维的活化悬浮液中。所产生的系链和活化剂之间的相互作用形成将颗粒添加剂附着到纤维素纤维上的耐久复合物。使用这些系统和方法，可以将有用的添加剂如淀粉粘附到纤维素纤维上，赋予有利的性质，例如由此形成的纸产品的强度增加。这些系统和方法对于涉及原浆纸浆纤维，再循环纤维或其任何组合的造纸特别有用。

9. 发明授权

US07863052B2 Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor 有权
公开(公告)号：US07863052B2
公开(公告)日：2011-01-04
申请号：US11490556
申请日：2006-07-20
申请人： Stephen C. Schulz , Brian T. Cunningham , Lance G. Laing , Peter Y. Li , Brant Binder , Gangadhar Jogikalmath , Alex Borsody
发明人： Stephen C. Schulz , Brian T. Cunningham , Lance G. Laing , Peter Y. Li , Brant Binder , Gangadhar Jogikalmath , Alex Borsody
IPC分类号： G01N33/551
CPC分类号： G01N21/648 , G01N21/552 , G01N21/6428 , G01N21/7743 , Y10S435/808 , Y10S436/805 , Y10T436/143333
摘要： A grating-based sensor is disclosed that has a grating structure constructed and designed for both evanescent resonance (ER) fluorescence detection and label-free detection applications. Some embodiments are disclosed which are optimized for ER detection in an air mode, in which the sample is dry. Other embodiments are optimized for ER detection in liquid mode, in which the sample is suspended in liquid medium such as water. One and two-dimensional gratings are also disclosed, including gratings characterized by unit cells with central posts, central holes, and two-level, two-dimensional gratings. A readout system for such sensors is also disclosed. One embodiment includes a first light source optimized for collecting label-free detection data, a second light source optimized for collecting ER fluorescence amplification data, and at least one detector. In one embodiment, the detector is an imaging system and includes a CCD camera for collecting both ER and label-free data. In other embodiments, the at least one detector takes the form of a spectrometer for collection of label-free data and a photomultiplier for collecting ER data. In other embodiments, a single light source such as a tunable laser or broad band light source is used.

10. 发明申请

US20100263818A1 Retention Systems and Methods for Papermaking 失效
标题翻译：造纸保留系统和方法
公开(公告)号：US20100263818A1
公开(公告)日：2010-10-21
申请号：US12761620
申请日：2010-04-16
申请人： Lynn Reis , Gangadhar Jogikalmath , David S. Soane
发明人： Lynn Reis , Gangadhar Jogikalmath , David S. Soane
IPC分类号： D21H17/35 , D21H21/30 , D21H17/33 , D21H17/54
CPC分类号： D21H17/35 , D21H17/33 , D21H21/10 , D21H21/30 , D21H21/32
摘要： Compositions and methods of producing an optically-enhanced paper-based material are disclosed. The composition can include an optical brightening agent and an additive having an aromatic portion, where the aromatic portion is associated with an optical brightening agent. The paper-based material can exhibit a higher capacity for the optical brightening agent relative to a paper-based material that lacks the additive. Techniques for increasing optical brightening agent retention in a paper-based material are also disclosed. The techniques include using an additive having an aromatic portion, where the aromatic portion associates with an optical brightening agent so that the retention of the optical brightening agent is improved.
摘要翻译：公开了制备光学增强的纸基材料的组合物和方法。组合物可以包括荧光增白剂和具有芳族部分的添加剂，其中芳族部分与荧光增白剂相关联。相对于缺乏添加剂的纸基材料，纸基材料可以显示出对于增亮剂的较高容量。还公开了用于增加纸基材料中光学增亮剂保留的技术。这些技术包括使用具有芳族部分的添加剂，其中芳族部分与荧光增白剂缔合，从而提高了荧光增白剂的保留性。

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