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1. 发明授权

US08968280B2 Dose determination for inducing microcavitation in retinal pigment epithelium (RPE) 有权
标题翻译：用于诱导视网膜色素上皮（RPE）微量化的剂量测定
公开(公告)号：US08968280B2
公开(公告)日：2015-03-03
申请号：US13145605
申请日：2010-01-22
申请人： Charles P. Lin , Clemens Alt , Ho Lee
发明人： Charles P. Lin , Clemens Alt , Ho Lee
IPC分类号： A61B18/18 , A61F9/008
CPC分类号： A61F9/008 , A61F9/00821 , A61F2009/00863
摘要： Methods and systems for controlling selective targeting of retinal pigment epithelium (RPE) cells within a treatment region of the RPE. The methods include (a) depositing a selected amount of energy on a test region of the RPE; (b) determining an extent to which microcavitation has occurred in the test region; and (c) on the basis of the determination, either depositing the selected amount of energy on the treatment region, or depositing an increased amount of energy on the test region, and repeating steps (b) and (c).
摘要翻译：用于控制RPE治疗区域内视网膜色素上皮细胞（RPE）细胞选择性靶向的方法和系统。所述方法包括（a）在RPE的测试区域上沉积选定量的能量; （b）确定在测试区域发生微气蚀的程度; 和（c）基于该确定，将所选择的能量沉积在处理区域上，或者在测试区域上沉积增加的能量，并重复步骤（b）和（c）。

2. 发明申请

US20120029490A1 DOSE DETERMINATION FOR INDUCING MICROCAVITATION IN RETINAL PIGMENT EPITHELIUM (RPE) 有权
标题翻译：诱导上皮细胞（RPE）中微量滴定的剂量测定
公开(公告)号：US20120029490A1
公开(公告)日：2012-02-02
申请号：US13145605
申请日：2010-01-22
申请人： Charles P. Lin , Clemens Alt , Ho Lee
发明人： Charles P. Lin , Clemens Alt , Ho Lee
IPC分类号： A61F9/008
CPC分类号： A61F9/008 , A61F9/00821 , A61F2009/00863
摘要： Methods and systems for controlling selective targeting of retinal pigment epithelium (RPE) cells within a treatment region of the RPE. The methods include (a) depositing a selected amount of energy on a test region of the RPE; (b) determining an extent to which microcavitation has occurred in the test region; and (c) on the basis of the determination, either depositing the selected amount of energy on the treatment region, or depositing an increased amount of energy on the test region, and repeating steps (b) and (c).
摘要翻译：用于控制RPE治疗区域内视网膜色素上皮细胞（RPE）细胞选择性靶向的方法和系统。这些方法包括（a）在RPE的测试区域上沉积选定量的能量; （b）确定在测试区域发生微气蚀的程度; 和（c）基于该确定，将所选择的能量沉积在处理区域上，或者在测试区域上沉积增加的能量，并重复步骤（b）和（c）。

3. 发明申请

US20110060232A1 RETINAL FLOW CYTOMETRY 审中-公开
标题翻译：离体流式细胞术
公开(公告)号：US20110060232A1
公开(公告)日：2011-03-10
申请号：US12114413
申请日：2008-05-02
申请人： Charles P. Lin , Clemens Alt , Israel Veilleux , Daniel Cote
发明人： Charles P. Lin , Clemens Alt , Israel Veilleux , Daniel Cote
IPC分类号： A61B5/026 , A61K51/00
CPC分类号： A61B3/1241 , A61B3/1233
摘要： The present invention provides methods and devices for performing flow cytometry. In one embodiment, blood circulating through one or more retinal blood vessels of a subject is illuminated in-vivo so as to excite a plurality of fluorescent-labeled cells contained in the blood. The fluorescence radiation emitted by the excited cells is then detected and analyzed to count the cells from which fluorescence is detected.
摘要翻译：本发明提供了用于进行流式细胞术的方法和装置。在一个实施方案中，循环通过受试者的一个或多个视网膜血管的血液被体内照射，以激发包含在血液中的多个荧光标记的细胞。然后检测并分析由激发的细胞发射的荧光辐射以计数检测到荧光的细胞。

4. 发明授权

US08366704B2 Optical devices and methods for selective and conventional photocoagulation of the retinal pigment epithelium 有权
标题翻译：用于视网膜色素上皮的选择性和常规光凝的光学装置和方法
公开(公告)号：US08366704B2
公开(公告)日：2013-02-05
申请号：US13480955
申请日：2012-05-25
申请人： Charles P. Lin , Clemens Alt
发明人： Charles P. Lin , Clemens Alt
IPC分类号： A61B18/18
CPC分类号： A61F9/008 , A61B18/20 , A61B2017/00057 , A61B2018/00636 , A61F9/00821 , A61F2009/00863 , A61F2009/00897
摘要： The present invention provides devices and methods for applying radiation to the retina of a patient. In one embodiment, an apparatus includes a radiation source for generating a radiation beam suitable for absorption by retinal pigment epithelial cells. One or more optical components are included to direct the beam onto the retina. A scanner is optically coupled to the radiation source to control movement of the beam in two dimensions to allow a scan over the retina. A controller applies control signals to the scanner to adjust beam movement to illuminate a plurality of retinal locations in a temporal sequence according to a predefined pattern. The device can be operated in one mode to effect selective targeting of retinal pigment epithelial cells, or in another mode to effect thermal photocoagulation of the retina.
摘要翻译：本发明提供了用于向患者的视网膜施加辐射的装置和方法。在一个实施例中，一种装置包括用于产生适于由视网膜色素上皮细胞吸收的辐射束的辐射源。包括一个或多个光学部件以将光束引导到视网膜上。扫描仪光耦合到辐射源以控制光束在两个维度上的移动，以允许在视网膜上进行扫描。控制器将控制信号施加到扫描仪，以根据预定义的模式以时间顺序调整光束移动以照亮多个视网膜位置。该装置可以以一种模式操作以实现视网膜色素上皮细胞的选择性靶向，或在另一模式下进行视网膜的热凝固。

5. 发明申请

US20120136258A1 Retinal Flow Cytometry 审中-公开
标题翻译：视网膜流式细胞仪
公开(公告)号：US20120136258A1
公开(公告)日：2012-05-31
申请号：US13357939
申请日：2012-01-25
申请人： Charles P. Lin , Clemens Alt , Israel Veilleux , Daniel Cote
发明人： Charles P. Lin , Clemens Alt , Israel Veilleux , Daniel Cote
IPC分类号： A61B6/00
CPC分类号： A61B3/1241 , A61B3/1233
摘要： The present invention provides methods and devices for performing flow cytometry. In one embodiment, blood circulating through one or more retinal blood vessels of a subject is illuminated in-vivo so as to excite a plurality of fluorescent-labeled cells contained in the blood. The fluorescence radiation emitted by the excited cells is then detected and analyzed to count the cells from which fluorescence is detected.
摘要翻译：本发明提供了用于进行流式细胞术的方法和装置。在一个实施方案中，循环通过受试者的一个或多个视网膜血管的血液被体内照射，以激发包含在血液中的多个荧光标记的细胞。然后检测并分析由激发的细胞发射的荧光辐射以计数检测到荧光的细胞。

6. 发明申请

US20110044910A1 IN VIVO FLOW CYTOMETRY BASED ON CELLULAR AUTOFLUORESCENCE 有权
标题翻译：基于细胞自动化的血液流式细胞仪检测
公开(公告)号：US20110044910A1
公开(公告)日：2011-02-24
申请号：US12867141
申请日：2009-03-27
申请人： Charles P. Lin , Alicia L. Carlson , Clemens Alt , David P. Biss , Costas M. Pitsillides , Chunqiang Li
发明人： Charles P. Lin , Alicia L. Carlson , Clemens Alt , David P. Biss , Costas M. Pitsillides , Chunqiang Li
IPC分类号： A61K49/00 , G01J1/58
CPC分类号： A61B5/0071 , A61B5/0059 , A61B5/0068 , G01N15/1434 , G01N33/537 , G01N33/56972 , G01N2015/008 , G01N2015/1497 , Y10T436/13
摘要： The present invention generally provides methods and systems for performing in vivo flow cytometry by using blood vessels as flow chambers through which flowing cells can be monitored in a live subject in vivo without the need for withdrawing a blood sample. In some embodiments, one or more blood vessels are illuminated with radiation so as to cause a multi-photon excitation of an exogenous fluorophore that was previously introduced into the subject to label one or more cell types of interest. In some other embodiments, rather than utilizing an exogenous fluorophore, endogenous (intrinsic) cellular fluorescence can be employed for in vivo flow cytometry. The emission of fluorescence radiation from such fluorophores in response to the excitation can be detected and analyzed to obtain information regarding a cell type of interest.
摘要翻译：本发明通常提供了通过使用血管作为流动室进行体内流式细胞术的方法和系统，通过该流室可以在活体内体内监测流动细胞，而不需要抽出血样。在一些实施方案中，用辐射照射一个或多个血管，以便引起先前引入对象的外源性荧光团的多光子激发以标记一种或多种感兴趣的细胞类型。在一些其它实施方案中，不是利用外源荧光团，内源（内在）细胞荧光可用于体内流式细胞术。可以检测和分析来自这种荧光团的响应于激发的荧光辐射的发射以获得关于感兴趣的细胞类型的信息。

7. 发明授权

US08574859B2 In vivo flow cytometry based on cellular autofluorescence 有权
标题翻译：基于细胞自体荧光的体内流式细胞术
公开(公告)号：US08574859B2
公开(公告)日：2013-11-05
申请号：US12867141
申请日：2009-03-27
申请人： Charles P. Lin , Alicia L. Carlson , Clemens Alt , David P. Biss , Costas M. Pitsillides , Chunqiang Li
发明人： Charles P. Lin , Alicia L. Carlson , Clemens Alt , David P. Biss , Costas M. Pitsillides , Chunqiang Li
IPC分类号： G01N33/00
CPC分类号： A61B5/0071 , A61B5/0059 , A61B5/0068 , G01N15/1434 , G01N33/537 , G01N33/56972 , G01N2015/008 , G01N2015/1497 , Y10T436/13
摘要： The present invention generally provides methods and systems for performing in vivo flow cytometry by using blood vessels as flow chambers through which flowing cells can be monitored in a live subject in vivo without the need for withdrawing a blood sample. In some embodiments, one or more blood vessels are illuminated with radiation so as to cause a multi-photon excitation of an exogenous fluorophore that was previously introduced into the subject to label one or more cell types of interest. In some other embodiments, rather than utilizing an exogenous fluorophore, endogenous (intrinsic) cellular fluorescence can be employed for in vivo flow cytometry. The emission of fluorescence radiation from such fluorophores in response to the excitation can be detected and analyzed to obtain information regarding a cell type of interest.
摘要翻译：本发明通常提供了通过使用血管作为流动室进行体内流式细胞术的方法和系统，通过该流室可以在活体内体内监测流动细胞，而不需要抽出血样。在一些实施方案中，用辐射照射一个或多个血管，以便引起先前引入对象的外源性荧光团的多光子激发以标记一种或多种感兴趣的细胞类型。在一些其它实施方案中，不是利用外源荧光团，内源（内在）细胞荧光可用于体内流式细胞术。可以检测和分析来自这种荧光团的响应于激发的荧光辐射的发射以获得关于感兴趣的细胞类型的信息。

8. 发明申请

US20120296320A1 OPTICAL DEVICES AND METHODS FOR SELECTIVE AND CONVENTIONAL PHOTOCOAGULATION OF THE RETINAL PIGMENT EPITHELIUM 有权
标题翻译：用于选择性和常规色素沉积的光学设备和方法
公开(公告)号：US20120296320A1
公开(公告)日：2012-11-22
申请号：US13480955
申请日：2012-05-25
申请人： Charles P. Lin , Clemens Alt
发明人： Charles P. Lin , Clemens Alt
IPC分类号： A61F9/008
CPC分类号： A61F9/008 , A61B18/20 , A61B2017/00057 , A61B2018/00636 , A61F9/00821 , A61F2009/00863 , A61F2009/00897
摘要： The present invention provides devices and methods for applying radiation to the retina of a patient. In one embodiment, an apparatus includes a radiation source for generating a radiation beam suitable for absorption by retinal pigment epithelial cells. One or more optical components are included to direct the beam onto the retina. A scanner is optically coupled to the radiation source to control movement of the beam in two dimensions to allow a scan over the retina. A controller applies control signals to the scanner to adjust beam movement to illuminate a plurality of retinal locations in a temporal sequence according to a predefined pattern. The device can be operated in one mode to effect selective targeting of retinal pigment epithelial cells, or in another mode to effect thermal photocoagulation of the retina.
摘要翻译：本发明提供了用于向患者的视网膜施加辐射的装置和方法。在一个实施例中，一种装置包括用于产生适于由视网膜色素上皮细胞吸收的辐射束的辐射源。包括一个或多个光学部件以将光束引导到视网膜上。扫描仪光耦合到辐射源以控制光束在两个维度上的移动，以允许在视网膜上进行扫描。控制器将控制信号施加到扫描仪，以根据预定义的模式以时间顺序调整光束移动以照亮多个视网膜位置。该装置可以以一种模式操作以实现视网膜色素上皮细胞的选择性靶向，或在另一模式下进行视网膜的热凝固。

9. 发明授权

US08187257B2 Optical devices and methods for selective and conventional photocoagulation of the retinal pigment epithelium 有权
标题翻译：用于视网膜色素上皮的选择性和常规光凝的光学装置和方法
公开(公告)号：US08187257B2
公开(公告)日：2012-05-29
申请号：US11263677
申请日：2005-10-31
申请人： Charles P. Lin , Clemens Alt
发明人： Charles P. Lin , Clemens Alt
IPC分类号： A61B18/20
CPC分类号： A61F9/008 , A61B18/20 , A61B2017/00057 , A61B2018/00636 , A61F9/00821 , A61F2009/00863 , A61F2009/00897
摘要： The present invention provides devices and methods for applying radiation to the retina of a patient. In one embodiment, an apparatus includes a radiation source for generating a radiation beam suitable for absorption by retinal pigment epithelial cells. One or more optical components are included to direct the beam onto the retina. A scanner is optically coupled to the radiation source to control movement of the beam in two dimensions to allow a scan over the retina. A controller applies control signals to the scanner to adjust beam movement to illuminate a plurality of retinal locations in a temporal sequence according to a predefined pattern. The device can be operated in one mode to effect selective targeting of retinal pigment epithelial cells, or in another mode to effect thermal photocoagulation of the retina.
摘要翻译：本发明提供了用于向患者的视网膜施加辐射的装置和方法。在一个实施例中，一种装置包括用于产生适于由视网膜色素上皮细胞吸收的辐射束的辐射源。包括一个或多个光学部件以将光束引导到视网膜上。扫描仪光耦合到辐射源以控制光束在两个维度上的移动，以允许在视网膜上进行扫描。控制器将控制信号施加到扫描仪，以根据预定义的模式以时间顺序调整光束移动以照亮多个视网膜位置。该装置可以以一种模式操作以实现视网膜色素上皮细胞的选择性靶向，或在另一模式下进行视网膜的热凝固。

10. 发明申请

US20060161145A1 Optical devices and methods for selective and conventional photocoagulation of the retinal pigment epithelium 有权
公开(公告)号：US20060161145A1
公开(公告)日：2006-07-20
申请号：US11263677
申请日：2005-10-31
申请人： Charles Lin , Clemens Alt
发明人： Charles Lin , Clemens Alt
IPC分类号： A61B18/18
CPC分类号： A61F9/008 , A61B18/20 , A61B2017/00057 , A61B2018/00636 , A61F9/00821 , A61F2009/00863 , A61F2009/00897
摘要： The present invention provides devices and methods for applying radiation to the retina of a patient. In one embodiment, an apparatus includes a radiation source for generating a radiation beam suitable for absorption by retinal pigment epithelial cells. One or more optical components are included to direct the beam onto the retina. A scanner is optically coupled to the radiation source to control movement of the beam in two dimensions to allow a scan over the retina. A controller applies control signals to the scanner to adjust beam movement to illuminate a plurality of retinal locations in a temporal sequence according to a predefined pattern. The device can be operated in one mode to effect selective targeting of retinal pigment epithelial cells, or in another mode to effect thermal photocoagulation of the retina.

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