专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07001922B2 Peptide deformylase activated prodrugs 失效
标题翻译：肽变性酶活化的前药
公开(公告)号：US07001922B2
公开(公告)日：2006-02-21
申请号：US10714255
申请日：2003-11-14
申请人： Carlo Ballatore , Maria V. Sergeeva , Venkata Ramana Doppalapudi
发明人： Carlo Ballatore , Maria V. Sergeeva , Venkata Ramana Doppalapudi
IPC分类号： A61K31/192 , A61K31/195 , C07F9/02 , C07F9/535
CPC分类号： C07F9/4084 , A61K47/65 , C07F9/4006
摘要： The invention provides compounds and methods for using them to inhibit the growth of microorganism that expresses Peptide Deformylase, the compounds having the general formula:
摘要翻译：本发明提供了使用它们抑制表达肽脱甲酰酶的微生物生长的化合物和方法，该化合物具有以下通式：化学式=“CHEM-US-00001”num =“000

2. 发明授权

US07163923B2 Peptide deformylase activated prodrugs 有权
标题翻译：肽变性酶活化的前药
公开(公告)号：US07163923B2
公开(公告)日：2007-01-16
申请号：US10142089
申请日：2002-05-09
申请人： Maria V. Sergeeva , Venkata Ramana Doppalapudi
发明人： Maria V. Sergeeva , Venkata Ramana Doppalapudi
IPC分类号： C07K5/06
CPC分类号： B82Y5/00 , A61K38/00 , A61K47/556 , A61K47/67 , C07K5/0606 , C07K5/06191 , Y02A50/473
摘要： This invention provides a method for inhibiting the growth of a microorganism that expresses Peptide Deformylase by contacting the microorganism with an effective amount of the compound described herein. This method inhibits the growth of gram-positive and gram-negative microorganism, e.g., S. aureus, S. epidermidis, K. pneumoniae, E. aerogenes, E. cloacae, M. catarrhalis, E. coli, E. faecalis, H. influenzae and P. aeruginosa. This method can be practiced in vitro, ex vivo and in vivo. Further provided is a method for alleviating the symptoms of an infection by a Peptide Deformylase expressing microorganism in a subject by administering or delivering to the subject an effective amount of the compound described above.
摘要翻译：本发明提供了通过使微生物与有效量的本文所述化合物接触来抑制表达肽脱甲硅烷基化酶的微生物生长的方法。该方法抑制革兰氏阳性和革兰氏阴性微生物的生长，例如金黄色葡萄球菌，表皮葡萄球菌，肺炎支原体，产气肠杆菌，阴沟肠杆菌，卡他莫拉菌，大肠杆菌，粪肠球菌，H 流感嗜血杆菌和铜绿假单胞菌。该方法可以在体外，离体和体内实施。还提供了一种通过向受试者施用或递送有效量的上述化合物来减轻受试者中表达肽变态酶的微生物的感染症状的方法。

3. 发明授权

US06171813B2 Enzyme catalysis in organic solutions containing water 失效
标题翻译：含有水的有机溶液中的酶催化
公开(公告)号：US06171813B2
公开(公告)日：2001-01-09
申请号：US08951506
申请日：1997-10-16
申请人： Jonathan S. Dordick , Vikram M. Paradkar , Maria V. Sergeeva
发明人： Jonathan S. Dordick , Vikram M. Paradkar , Maria V. Sergeeva
IPC分类号： C12P100
CPC分类号： C12N9/00 , C12P21/02
摘要： A method is presented for catalyzing the conversion of substrate into product in an organic reaction solvent with an enzyme-surfactant ion pair. The enzyme-surfactant ion pair comprises the enzyme catalyzing the reaction and a surfactant capable of forming an ion pair with the enzyme. Water present in the organic solvent at a concentration of about 0.03% to about 2.5% is sufficient to enhance the rate of catalysis and stabilize the enzyme without substantially increasing the rate of hydrolysis when compared to the anhydrous enzyme.
摘要翻译：提出了一种用酶催化表面活性剂离子对在有机反应溶剂中将底物转化成产物的方法。酶 - 表面活性剂离子对包括催化反应的酶和能够与酶形成离子对的表面活性剂。以约0.03％至约2.5％浓度存在于有机溶剂中的水足以提高催化速率并稳定酶，而与无水酶相比基本上不增加水解速率。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式