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1. 发明申请

US20090175812A1 Novel Skin Lightening Agents, Compositions and Methods 审中-公开
标题翻译：新型皮肤发光剂，组合物和方法
公开(公告)号：US20090175812A1
公开(公告)日：2009-07-09
申请号：US12406643
申请日：2009-03-18
申请人： Bijan Harichian , Michael James Barratt , Carol Annette Bosko , Victor De Florio , Jose Guillermo Rosa , Michael Tallman
发明人： Bijan Harichian , Michael James Barratt , Carol Annette Bosko , Victor De Florio , Jose Guillermo Rosa , Michael Tallman
IPC分类号： A61K8/49 , C07D339/06 , C07D339/08 , C07D339/00 , A61Q19/02
CPC分类号： A61Q19/02 , A61K8/4986 , C07D339/00 , C07D339/06 , C07D339/08
摘要： Compounds of formula I, process for making same, and cosmetic compositions and methods of skin lightening using compounds of formula I as skin lightening agents: Where each A1 and/or A2 independently is ═H or COR, CO2R, CONHR, the latter three having the following formula A: where R═C1-C18 saturated or unsaturated, linear or branched, hydrocarbon; and each Y1 and/or Y2 independently is H; C1-C18 saturated or unsaturated hydrocarbon; or OZ, where Z=H or COR1, CO2R1, CONHR1 of formula B: and where R1═C1-C18 saturated or unsaturated, linear or branched, hydrocarbon; X is Carbon, Nitrogen, Sulfur, or Oxygen; and N is in integer between 0 and 2.
摘要翻译：式I的化合物，其制备方法，以及使用式I化合物作为皮肤增亮剂的化妆品组合物和皮肤发白的方法：其中每个A1和/或A2独立地为-H或COR，CO 2 R，CONHR，后者三个具有下式A：其中R-C1-C18饱和或不饱和的直链或支链烃; 并且每个Y1和/或Y2独立地为H; C1-C18饱和或不饱和烃; 或OZ，其中Z = H或COR1，式B的CO 2 R 1，CONHR：其中R 1 -C 1 -C 18饱和或不饱和的直链或支链烃; X是碳，氮，硫或氧; 并且N在0和2之间的整数。

2. 发明授权

US07524485B2 Skin lightening agents, compositions and methods 有权
标题翻译：护肤剂，组合物和方法
公开(公告)号：US07524485B2
公开(公告)日：2009-04-28
申请号：US10718988
申请日：2003-11-21
申请人： Bijan Harichian , Michael James Barratt , Carol Annette Bosko , Victor De Florio , Jose Guillermo Rosa , Michael Tallman
发明人： Bijan Harichian , Michael James Barratt , Carol Annette Bosko , Victor De Florio , Jose Guillermo Rosa , Michael Tallman
IPC分类号： A61K8/18 , A61Q17/04 , A61K8/00 , A61Q5/00 , A61Q9/00 , A61K8/02
CPC分类号： A61Q19/02 , A61K8/4986 , C07D339/00 , C07D339/06 , C07D339/08
摘要： Compounds of formula I, process for making same, and cosmetic compositions and methods of skin lightening using compounds of formula I as skin lightening agents: Where each A1 and/or A2 independently is =H or COR, CO2R, CONHR, the latter three having the following formula A: where R=C1-C18 saturated or unsaturated, linear or branched, hydrocarbon; and each Y1 and/or Y2 independently is H; C1-C18 saturated or unsaturated hydrocarbon; or OZ, where Z=H or COR1, CO2R1, CONHR1 of formula B: and where R1=C1-C18 saturated or unsaturated, linear or branched, hydrocarbon; X is Carbon, Nitrogen, Sulfur, or Oxygen; and N is in integer between 0 and 2.
摘要翻译：式I的化合物，其制备方法，以及使用式I化合物作为皮肤增白剂的化妆品组合物和皮肤发白剂的方法：其中每个A1和/或A2独立地为= H或COR，CO 2 R，CONHR，后三者具有下式A：其中R = C1-C18饱和或不饱和的直链或支链烃; 并且每个Y1和/或Y2独立地为H; C1-C18饱和或不饱和烃; 或OZ，其中Z = H或COR1，CO 2 R 1，式B的CONHR1：其中R 1 = C 1 -C 18饱和或不饱和的直链或支链烃; X是碳，氮，硫或氧; 并且N在0和2之间的整数。

3. 发明授权

US06875425B2 Skin lightening agents, compositions and methods 失效
标题翻译：护肤剂，组合物和方法
公开(公告)号：US06875425B2
公开(公告)日：2005-04-05
申请号：US10317484
申请日：2002-12-12
申请人： Bijan Harichian , Michael James Barratt , Carol Annette Bosko , Michael Tallman
发明人： Bijan Harichian , Michael James Barratt , Carol Annette Bosko , Michael Tallman
IPC分类号： A61K8/49 , A61Q19/02 , A61K7/42 , A61K7/00 , A61K7/44
CPC分类号： A61K8/4986 , A61K8/49 , A61Q19/02
摘要： Cosmetic compositions and methods of skin lightening using compounds of formula I as skin lightening agents: Wherein X represents Carbon, Nitrogen, Sulfur or Oxygen; each A1 and/or A2 independently is =H or COR, CO2R, CONHR having the following formula A: where R=C1-C18 saturated or unsaturated, linear or branched, hydrocarbon; and each Y1 and/or Y2 independently is C1-C18 saturated or unsaturated hydrocarbon or OZ, where Z=H or COR1, CO2R1, CONHR1 of formula B: and where R1=C1-C18 saturated or unsaturated, linear or branched, hydrocarbon.
摘要翻译：使用式I化合物作为皮肤增亮剂的化妆品组合物和皮肤发白方法：其中X表示碳，氮，硫或氧;每个A1和/或A2独立地为= H或COR，CO 2 R，CONHR，具有下式A：其中R = C1-C18饱和或不饱和的直链或支链烃; Y 1和/或Y 2独立地是C 1 -C 18饱和或不饱和烃或OZ，其中Z = H或COR 1，CO 2 R 1，CONHR 1，其中R 1 = C1- C18饱和或不饱和的直链或支链烃。

4. 发明授权

US06852310B2 Skin lightening agents, compositions and methods 有权
标题翻译：护肤剂，组合物和方法
公开(公告)号：US06852310B2
公开(公告)日：2005-02-08
申请号：US10227642
申请日：2002-08-23
申请人： Bijan Harichian , Michael James Barratt , Carol Annette Bosko
发明人： Bijan Harichian , Michael James Barratt , Carol Annette Bosko
IPC分类号： A61K8/42 , A61Q19/02 , A61K7/42 , A61K7/00 , A61K7/44
CPC分类号： A61Q19/02 , A61K8/42
摘要： Cosmetic methods of skin lightening using coumarin derivatives of formula I as skin lightening agents alone or in combination with other skin benefit agents and together with a cosmetic vehicle: Where each or both R1 and/or R2 represents hydrogen; linear or branched C1-C18 alkyl, alkenyl, cycloalkyl, cycloalkenyl, hydroxyalkyl, hydroxyalkenyl, acyl, cycloacyl, or alkoxy groups; Each or both R3 and/or R4, which may be connected by a single or double carbon-carbon bond (shown as a dotted line), represents hydrogen; linear or branched C1-C18 alkyl, alkenyl, alkoxy, cycloalkyl, or cycloalkenyl group; and Each or both R5 and/or R6 represents a hydrogen atom, OH, C1-C4 acyl group, C1-C4 alkyl group, O—CO—R7, O—COO—R8 group, mesyl group or tosyl group, where each or both R7 and/or R8 represents hydrogen; linear or branched C1-C18 alkyl, alkenyl, hydroxyalkyl, hydroxyalkenyl, acyl, cycloacyl, or alkoxy groups.
摘要翻译：使用式I的香豆素衍生物作为皮肤增白剂单独使用或与其它皮肤有益剂组合以及与化妆品载体一起使用的美白方法：其中R1和/或R2各自表示氢; 直链或支链C 1 -C 18烷基，烯基，环烷基，环烯基，羟基烷基，羟基烯基，酰基，环酰基或烷氧基;可以通过单或双碳 - 碳键连接的各个或两个R 3和/或R 4 作为虚线）表示氢; 直链或支链C 1 -C 18烷基，烯基，烷氧基，环烷基或环烯基; R 5和/或R 6中的每一个或两个表示氢原子，OH，C 1 -C 4酰基，C 1 -C 4烷基，O-CO-R 7，O-COO-R 8基，甲磺酰基或甲苯磺酰基， R7和/或R8表示氢; 直链或支链C 1 -C 18烷基，烯基，羟烷基，羟烯基，酰基，环酰基或烷氧基。

5. 发明授权

US07300646B2 Skin lightening agents, compositions and methods 有权
标题翻译：护肤剂，组合物和方法
公开(公告)号：US07300646B2
公开(公告)日：2007-11-27
申请号：US10789293
申请日：2004-02-27
申请人： Bijan Harichian , Jose Rosa , Michael James Barratt , Carol Annette Bosko , John Steven Bajor
发明人： Bijan Harichian , Jose Rosa , Michael James Barratt , Carol Annette Bosko , John Steven Bajor
IPC分类号： A61Q19/02 , A61Q19/04 , A61K8/02 , A61K31/235
CPC分类号： A61K8/365 , A61K8/37 , A61K2800/782 , A61Q19/02 , C07C59/52 , C07C69/732
摘要： Disclosed are coumarin derived compounds of formula I as skin lightening agents alone or in combination with other skin benefit agents and together with a cosmetic vehicle: Where each or both R1 and/or R2 represents hydrogen (H); linear or branched, saturated or unsaturated C1-C12 alkyl, alkenyl, acyl, or heteroalkyl (preferably, alkoxy) groups; and R3 represents linear or branched, cyclic or acyclic, saturated or unsaturated C1-C12 alkyl, alkenyl, cycloalkyl, cycloalkenyl, or heteroalkyl group; and R4 represents a hydrogen atom (H); straight or branched, cyclic or acyclic, saturated or unsaturated, containing or not containing a heteroatom C1-C22 alkyl, alkenyl, cycloalkyl, cycloalkenyl, heteroalkyl, aryl, or heteroaryl group. In a most preferred embodiment, each R1, R2 and R4 represent H, while R3 represents a methyl group, referred to herein as a 4-methyl 7-hydroxy-coumarin derivative, or coumarin derived resorcinol derivative, which may be prepared by catalytic (nickel or paladium catalyst) hydrogenation of 4-methyl 7-hydroxy-coumarin followed by hydrolysis. The inventive compounds, compositions and methods have effective skin lightening properties, may be less irritating to the skin, and are cost-effective and relatively simple to manufacture. Also disclosed are processes for making the inventive compounds of general formula I from 4-substituted-7-hydroxy coumarin derivatives.
摘要翻译：披露式I的香豆素衍生化合物作为单独的皮肤增白剂或与其它皮肤有益剂组合以及化妆品载体：其中R 1和/或R 2中的每一个或两个， / SUB表示氢（H）; 链烯基，酰基或杂烷基（优选烷氧基）基团;直链或支链的饱和或不饱和的C 1 -C 12 - R 3表示直链或支链，环状或非环状，饱和或不饱和的C 1 -C 12烷基，烯基，环烷基，环烯基或杂烷基和R 4代表氢原子（H）; 直链或支链，环状或非环状，饱和或不饱和的，含或不含杂原子的C 1 -C 22烷基，烯基，环烷基，环烯基，杂烷基，芳基或杂芳基。在最优选的实施方案中，每个R 1，R 2和R 4均代表H，而R 3代表甲基，本文称为4-甲基7-羟基香豆素衍生物或香豆素衍生的间苯二酚衍生物，其可以通过4-甲基7-羟基香豆素的催化（镍或咔唑催化剂）氢化，随后水解制备。本发明的化合物，组合物和方法具有有效的皮肤发光特性，可能对皮肤刺激性较小，并且成本有效且制造相对简单。还公开了由4-取代-7-羟基香豆素衍生物制备本发明的通式I化合物的方法。

6. 发明授权

US08425885B2 Substituted 3-(phenoxymethyl) benzyl amines and personal care compositions 有权
标题翻译：取代的3-（苯氧基甲基）苄基胺和个人护理组合物
公开(公告)号：US08425885B2
公开(公告)日：2013-04-23
申请号：US12614731
申请日：2009-11-09
申请人： Jose Guillermo Rosa , Bijan Harichian , John Steven Bajor , Carol Annette Bosko , Diana Jean Drennan , John Chun-Sing Nip
发明人： Jose Guillermo Rosa , Bijan Harichian , John Steven Bajor , Carol Annette Bosko , Diana Jean Drennan , John Chun-Sing Nip
IPC分类号： A61Q19/02 , A61Q17/04 , A61K8/41
CPC分类号： C07C217/48
摘要： Certain novel substituted 3-(phenoxymethyl) benzyl amines and personal care compositions comprising such, which are particularly beneficial for skin lightening and achieving evenness of color, especially for face and underarm skin.
摘要翻译：某些新颖的取代的3-（苯氧基甲基）苄基胺和包含这些的个人护理组合物，其特别有利于减轻皮肤并实现颜色均匀，特别是对于面部和腋下皮肤。

7. 发明授权

US08476251B2 Skin care compositions comprising substituted diamines 有权
标题翻译：包含取代二胺的护肤组合物
公开(公告)号：US08476251B2
公开(公告)日：2013-07-02
申请号：US12845840
申请日：2010-07-29
申请人： Jose Guillermo Rosa , Bijan Harichian , Diana Jean Drennan , John Steven Bajor , Carol Annette Bosko
发明人： Jose Guillermo Rosa , Bijan Harichian , Diana Jean Drennan , John Steven Bajor , Carol Annette Bosko
IPC分类号： A61K8/41 , A61K8/19 , A61Q15/00
CPC分类号： A61K8/41 , A61K8/4913 , A61K8/69 , A61Q1/02 , A61Q5/02 , A61Q15/00 , A61Q19/02 , A61Q19/10
摘要： Skin care compositions comprising certain substituted diamines, which are particularly beneficial for skin lightening and achieving evenness of color, especially for face and underarm skin.
摘要翻译：包含某些取代的二胺的护肤组合物，其特别有利于皮肤发亮，并且实现颜色均匀，特别是对于面部和腋下皮肤。

8. 发明授权

US06916851B2 Skin care cosmetic methods of sebum control using carboxyalkylates of branched alcohols and/or alkoxylates thereof 有权
标题翻译：使用支化醇和/或其烷氧基化物的羧烷基化物进行皮脂控制的皮肤护理美容方法
公开(公告)号：US06916851B2
公开(公告)日：2005-07-12
申请号：US10196770
申请日：2002-07-17
申请人： Bijan Harichian , Carol Annette Bosko , John Steven Bajor , Laurence Boen , Surajit Mukherjee
发明人： Bijan Harichian , Carol Annette Bosko , John Steven Bajor , Laurence Boen , Surajit Mukherjee
IPC分类号： A61K8/39 , A61Q15/00 , A61Q17/00 , A61Q19/00 , A61Q19/08 , C07C53/126 , C07C59/125 , A61K31/26
CPC分类号： A61Q19/08 , A61K8/39 , A61Q15/00 , A61Q17/005 , A61Q19/00 , A61Q19/008 , C07C53/126 , C07C59/125 , Y10S514/844
摘要： Cosmetic skin care methods of using and process of making carboxyalkylates of branched alcohols and/or alkoxylates thereof and process of making same. The compounds and compositions provide control of sebum secretion from sebocytes, improved oil control and improved skin feel, prevent shine and stickiness, while also providing anti-microbial activity against bacteria associated with acne, as well as providing anti-aging benefits which results in reduced appearance of wrinkles and aged skin, improved skin color, treatment of photoaged skin, improvement in skin's radiance and clarity and finish, and an overall healthy and youthful appearance of the skin.
摘要翻译：使用和制备支链醇和/或烷氧基化物的羧烷基化物的化妆品护肤方法及其制备方法。化合物和组合物提供对皮脂分泌从皮脂细胞的控制，改善的油控制和改善的皮肤感觉，防止光泽和粘性，同时还提供针对与痤疮相关的细菌的抗微生物活性，以及提供抗老化的益处，这导致减少皱纹和老化皮肤的外观，皮肤颜色的改善，皮肤光泽的治疗，皮肤的光亮度，清晰度和光洁度的改善以及皮肤的整体健康和年轻的外观。

9. 发明授权

US08309064B2 Skin care compositions comprising phenoxyalkyl amines 有权
标题翻译：包含苯氧基烷基胺的护肤组合物
公开(公告)号：US08309064B2
公开(公告)日：2012-11-13
申请号：US12614687
申请日：2009-11-09
申请人： Jose Guillermo Rosa , Bijan Harichian , John Steven Bajor , Carol Annette Bosko , Diana Jean Drennan , John Chun-Sing Nip
发明人： Jose Guillermo Rosa , Bijan Harichian , John Steven Bajor , Carol Annette Bosko , Diana Jean Drennan , John Chun-Sing Nip
IPC分类号： A61K8/00
CPC分类号： A61K8/41 , A61K8/49 , A61K8/4946 , A61Q1/02 , A61Q5/02 , A61Q15/00 , A61Q19/02 , A61Q19/10
摘要： Skin care compositions comprising certain phenoxyalkylamines, which are particularly beneficial for skin lightening and achieving evenness of color, especially for face and underarm skin.
摘要翻译：包含某些苯氧基烷基胺的皮肤护理组合物，其特别有利于皮肤发亮并且实现颜色均匀，特别是对于脸部和腋下皮肤。

10. 发明授权

US08293218B2 Skin care compositions comprising substituted monoamines 有权
标题翻译：包含取代的单胺的护肤组合物
公开(公告)号：US08293218B2
公开(公告)日：2012-10-23
申请号：US12845814
申请日：2010-07-29
申请人： Jose Guillermo Rosa , Bijan Harichian , Diana Jean Drennan , John Steven Bajor , Carol Annette Bosko
发明人： Jose Guillermo Rosa , Bijan Harichian , Diana Jean Drennan , John Steven Bajor , Carol Annette Bosko
IPC分类号： A61Q19/02 , A61K8/00 , A61K8/41 , A61K31/137
CPC分类号： A61K8/41 , A61K31/137 , A61K45/06 , A61Q1/02 , A61Q5/02 , A61Q15/00 , A61Q19/02 , A61Q19/10 , C11D9/30 , A61K2300/00
摘要： Skin care compositions comprising certain substituted monoamines, which are particularly beneficial for skin lightening and achieving evenness of color, especially for face and underarm skin.
摘要翻译：包含某些取代的单胺的护肤组合物，其特别有利于皮肤发亮，并且实现颜色均匀，特别是对于面部和腋下皮肤。

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