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1. 发明授权

US07622484B2 Mixtures or organic compounds for the treatment of airway diseases 有权
标题翻译：用于治疗气道疾病的混合物或有机化合物
公开(公告)号：US07622484B2
公开(公告)日：2009-11-24
申请号：US11248462
申请日：2005-10-12
申请人： Bernard Cuenoud , Robin A Fairhurst , Nicholas Lowther
发明人： Bernard Cuenoud , Robin A Fairhurst , Nicholas Lowther
IPC分类号： C07D215/02 , A61K31/47
CPC分类号： A61K31/4704 , A61K31/00 , A61K31/57 , A61K31/573 , A61K31/575 , A61K31/47 , A61K2300/00
摘要： A medicament comprising, separately or together, (A) a compound of formula (I) in free or pharmaceutically acceptable salt or solvate form and (B) a corticosteroid, for simultaneous, sequential or separate administration in the treatment of an inflammatory or obstructive airways disease, the molar ratio of (A) to (B) being from 100:1 to 1:300.
摘要翻译：一种药物，其包含（A）游离或药学上可接受的盐或溶剂合物形式的式（I）化合物和（B）皮质类固醇，分别或一起用于治疗炎性或阻塞性气道的同时，连续或分开施用疾病，（A）与（B）的摩尔比为100:1-1:300。

2. 发明授权

US07820694B2 Beta-2-adrenoreceptor agonists 有权
标题翻译： β-2-肾上腺素受体激动剂
公开(公告)号：US07820694B2
公开(公告)日：2010-10-26
申请号：US12577855
申请日：2009-10-13
申请人： Bernard Cuenoud , Ian Bruce , Robin A Fairhurst , David Beattie
发明人： Bernard Cuenoud , Ian Bruce , Robin A Fairhurst , David Beattie
IPC分类号： A61K31/395 , C07D215/26 , C07D215/22
CPC分类号： A61K31/4709 , A61K45/06 , C07C215/80 , C07C233/43 , C07C311/08 , C07C2602/08 , C07D215/227 , C07D215/26 , C07D405/12
摘要： Compounds of formula in free or salt or solvate form, where Ar is a group of formula Y is carbon or nitrogen and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n, p, q and r are as defined in the specification, their preparation and their use as pharmaceuticals, particularly for the treatment of obstructive or inflammatory airways diseases.
摘要翻译：其中Ar为式Y的化合物为碳或氮，R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，X，n，p， q和r如说明书中所定义，它们的制备及其作为药物的用途，特别是用于治疗阻塞性或炎症性气道疾病。

3. 发明授权

US08283362B2 Beta-2-adrenoreceptor agonists 有权
标题翻译： β-2-肾上腺素受体激动剂
公开(公告)号：US08283362B2
公开(公告)日：2012-10-09
申请号：US13295426
申请日：2011-11-14
申请人： Bernard Cuenoud , Ian Bruce , Robin A Fairhurst , David Beattie
发明人： Bernard Cuenoud , Ian Bruce , Robin A Fairhurst , David Beattie
IPC分类号： A61P11/00 , A61K31/395
CPC分类号： A61K31/4709 , A61K45/06 , C07C215/80 , C07C233/43 , C07C311/08 , C07C2602/08 , C07D215/227 , C07D215/26 , C07D405/12
摘要： Compounds of formula in free or salt or solvate form, where Ar is a group of formula Y is carbon or nitrogen and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n, p, q and r are as defined in the specification, their preparation and their use as pharmaceuticals, particularly for the treatment of obstructive or inflammatory airways diseases.
摘要翻译：其中Ar为式Y的化合物为碳或氮，R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，X，n，p， q和r如说明书中所定义，它们的制备及其作为药物的用途，特别是用于治疗阻塞性或炎症性气道疾病。

4. 发明授权

US08067437B2 Beta-2-adrenoreceptor agonists 有权
标题翻译： β-2-肾上腺素受体激动剂
公开(公告)号：US08067437B2
公开(公告)日：2011-11-29
申请号：US12885922
申请日：2010-09-20
申请人： Bernard Cuenoud , Ian Bruce , Robin A Fairhurst , David Beattie
发明人： Bernard Cuenoud , Ian Bruce , Robin A Fairhurst , David Beattie
IPC分类号： A61P11/00
CPC分类号： A61K31/4709 , A61K45/06 , C07C215/80 , C07C233/43 , C07C311/08 , C07C2602/08 , C07D215/227 , C07D215/26 , C07D405/12
摘要： Compounds of formula in free or salt or solvate form, where Ar is a group of formula Y is carbon or nitrogen and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n, p, q and r are as defined in the specification, their preparation and their use as pharmaceuticals, particularly for the treatment of obstructive or inflammatory airways diseases.
摘要翻译：其中Ar为式Y的化合物为碳或氮，R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，X，n，p， q和r如说明书中所定义，它们的制备及其作为药物的用途，特别是用于治疗阻塞性或炎症性气道疾病。

5. 发明授权

US07622483B2 β2-adrenoceptor agonists 有权
标题翻译： β2-肾上腺素受体激动剂
公开(公告)号：US07622483B2
公开(公告)日：2009-11-24
申请号：US11074400
申请日：2005-03-07
申请人： Bernard Cuenoud , Ian Bruce , Robin A Fairhurst , David Beattie
发明人： Bernard Cuenoud , Ian Bruce , Robin A Fairhurst , David Beattie
IPC分类号： A61K31/395
CPC分类号： A61K31/4709 , A61K45/06 , C07C215/80 , C07C233/43 , C07C311/08 , C07C2602/08 , C07D215/227 , C07D215/26 , C07D405/12
摘要： Compounds of formula in free or salt or solvate form, where Ar is a group of formula Y is carbon or nitrogen and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n, p, q and r are as defined in the specification, their preparation and their use as pharmaceuticals, particularly for the treatment of obstructive or inflammatory airways diseases.
摘要翻译：其中Ar为式Y的化合物为碳或氮，R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，X，n，p， q和r如说明书中所定义，它们的制备及其作为药物的用途，特别是用于治疗阻塞性或炎症性气道疾病。

6. 发明授权

US08076489B2 5-hydroxy-benzothiazole derivatives having beta-2-adrenoreceptor agonist activity 有权
标题翻译：具有β-2-肾上腺素受体激动剂活性的5-羟基 - 苯并噻唑衍生物
公开(公告)号：US08076489B2
公开(公告)日：2011-12-13
申请号：US11718829
申请日：2005-11-28
申请人： Robin A Fairhurst
发明人： Robin A Fairhurst
IPC分类号： A61K31/428 , C07D277/68
CPC分类号： C07D277/68
摘要： Compounds of formula (I) in free or salt or solvate form, wherein T has the meaning as indicated in the specification, are useful for treating conditions that are prevented or alleviated by activation of the β2-adrenoreceptor. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.
摘要翻译：游离或盐或溶剂合物形式的式（I）化合物，其中T具有说明书中指出的含义，可用于治疗通过活化2-肾上腺素受体而预防或缓解的病症。还描述了含有化合物的药物组合物和制备该化合物的方法。

7. 发明授权

US07361661B2 8-quinolinxanthine and 8-isoquinolinxanthine derivatives as PDE 5 inhibitors 失效
标题翻译： 8-喹啉黄嘌呤和8-异喹啉黄嘌呤衍生物作为PDE 5抑制剂
公开(公告)号：US07361661B2
公开(公告)日：2008-04-22
申请号：US11329889
申请日：2006-01-11
申请人： Gurdip Bhalay , Stephen P Collingwood , Robin A Fairhurst , Sylvie F Gomez , Reto Naef , David A Sandham
发明人： Gurdip Bhalay , Stephen P Collingwood , Robin A Fairhurst , Sylvie F Gomez , Reto Naef , David A Sandham
IPC分类号： A61K31/522 , C07D473/04
CPC分类号： C07D239/545 , A61K31/522 , C07D473/04 , C07D473/06
摘要： A compound of formula (I) R1 is hydrogen or alkyl optionally substituted by hydroxy, alkoxy, or alkylthio, R2 is hydrogen, alkyl, hydroxyalkyl, alkylcarbonyloxyalkyl, alkoxyalkyl, alkylthioalkyl, alkenyl, cycloalkylalkyl, heterocyclylalkyl, aralkyl in which the aryl ring thereof is optionally fused to a 5-membered heterocyclic group or is optionally substituted by one or more substituents selected from alkoxy, amino, alkylamino, dialkylamino, acylamino, halogen, hydroxy, aminosulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, alkylsufonylamino or dialkylaminosulfonylamino, R3 is hydrogen or alkyl optionally substituted by hydroxy, alkoxy, or alkylthio, R4 is hydrogen or alkyl, R5 is a quinolinyl, isoquinolinyl or oxodihydroisoquinolinyl group optionally fused to a 5-membered heterocyclic group and optionally substituted by one or more substituents selected from halogen, cyano, hydroxy, alkyl, hydroxyalkyl, alkoxyalkyl, alkylthioalkyl, alkoxy, alkylthio, alkenyl, alkoxycarbonyl, alkynyl, carboxyl, acyl, a group of formula —N(R6)R7, aryl optionally substituted by one or more substituents selected from halogen or alkoxy, or heteroaryl having 5 or 6 ring atoms attached through a ring carbon atom to the indicated carbon atom, and R6 and R7 are each independently hydrogen or alkyl optionally substituted by hydroxy or alkoxy or one of R6 and R7 is hydrogen and the other is acyl, or R6 and R7 together with the nitrogen atom to which they are attached denote a 5- or 66-mambered heterocyclyl group.
摘要翻译：式（I）R 1的化合物是氢或任选被羟基，烷氧基或烷硫基取代的烷基，R 2是氢，烷基，羟基烷基，烷基羰氧基烷基，烷氧基烷基，烷基硫代烷基，烯基，环烷基烷基，杂环基烷基，芳烷基，其中其芳基环任选地与5元杂环基稠合，或任选被一个或多个选自烷氧基，氨基，烷基氨基，二烷基氨基，酰氨基，卤素，羟基，氨基磺酰基，烷基氨基磺酰基，二烷基氨基磺酰基，烷基磺酰基氨基或二烷基氨基磺酰基氨基，R 3是氢或任选被羟基，烷氧基或烷硫基取代的烷基，R 4是氢或烷基，R 0 任选地与5元杂环基稠合并且任选地被一个或多个选自卤素，氰基，羟基，烷基，羟基烷基，烷氧基烷基，烷基硫基的取代基取代的喹啉基，异喹啉基或氧代二氢异喹啉基烷基，烷硫基，烯基，烷氧基羰基，炔基，羧基，酰基，式-N（R 6）R 7的基团，任选地被一个或多个选自卤素或烷氧基的取代基或具有5或6个环原子通过环碳原子连接到指定碳原子的杂芳基，R 6和R 7各自独立地任选被羟基或烷氧基取代的氢或烷基或R 6和R 7中的一个是氢，另一个是酰基或R 6和 R 7与它们所连接的氮原子一起表示5-或66-杂芳基。

8. 发明授权

US08114877B2 Organic compounds 失效
标题翻译：有机化合物
公开(公告)号：US08114877B2
公开(公告)日：2012-02-14
申请号：US11722835
申请日：2006-01-12
申请人： Robin A Fairhurst , Roger J Taylor
发明人： Robin A Fairhurst , Roger J Taylor
IPC分类号： C07D473/16 , C07D473/40 , C07D473/34 , A61K31/52 , A61P11/06
CPC分类号： C07D473/00
摘要： Compounds of formula I in free or salt form, wherein R1, R2 and R3 have the meanings as indicated in the specification, are useful for treating conditions mediated by activation of the adenosine A2A receptor, especially inflammatory or obstructive airways diseases. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.
摘要翻译：游离或盐形式的式I化合物，其中R 1，R 2和R 3具有说明书中指出的含义，可用于治疗由腺苷A2A受体的活化，特别是炎性或阻塞性气道疾病介导的病症。还描述了含有化合物的药物组合物和制备该化合物的方法。

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