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1. 发明授权

US07599737B2 Medical device for neural stimulation and controlled drug delivery 有权
标题翻译：用于神经刺激和受控药物递送的医疗装置
公开(公告)号：US07599737B2
公开(公告)日：2009-10-06
申请号：US10679763
申请日：2003-10-06
申请人： Barry M. Yomtov , Stephen J. Herman , John T. Santini, Jr.
发明人： Barry M. Yomtov , Stephen J. Herman , John T. Santini, Jr.
IPC分类号： A61N1/00
CPC分类号： A61N1/30 , A61K9/0097 , A61N1/08 , A61N1/36071 , G06F19/00
摘要： Medical devices and methods are provided for electrical stimulation of neural tissue and controlled drug delivery to a patient. The device includes an implantable drug delivery module which comprises a plurality of reservoirs, a release system comprising at least one drug contained in each of the reservoirs, and control means for selectively releasing a pharmaceutically effective amount of drug from each reservoir; a neural electrical stimulator which comprises a signal generator connected to at least one stimulation electrode for operable engagement with a neural tissue of the patient; and at least one microcontroller for controlling operational interaction of the drug delivery module and the neural electrical stimulator. The microcontroller may control the signal generator and the control means of the drug delivery module. The device may further include a sensor operable to deliver a signal to the microcontroller, for example to indicate when to deliver electrical stimulation, drug, or both.
摘要翻译：提供医疗装置和方法用于电刺激神经组织和控制药物递送给患者。该装置包括可植入药物递送模块，其包括多个储存器，包含每个储存器中的至少一种药物的释放系统和用于从每个储存器中选择性释放药学有效量的药物的控制装置; 神经电刺激器，其包括连接到至少一个刺激电极的信号发生器，用于与患者的神经组织可操作地接合; 以及用于控制药物递送模块和神经电刺激器的操作相互作用的至少一个微控制器。微控制器可以控制药物递送模块的信号发生器和控制装置。该装置还可以包括可操作以将信号传送到微控制器的传感器，例如以指示何时传递电刺激，药物或两者。

2. 发明授权

US08095197B2 Medical device for sensing glucose 有权
标题翻译：用于感测葡萄糖的医疗设备
公开(公告)号：US08095197B2
公开(公告)日：2012-01-10
申请号：US10980551
申请日：2004-11-03
申请人： John T. Santini, Jr. , Stephen J. Herman
发明人： John T. Santini, Jr. , Stephen J. Herman
IPC分类号： A61B5/05 , A61B5/00
CPC分类号： A61B5/14865 , A61B5/0031 , A61B5/1486 , A61B5/4839 , B33Y80/00
摘要： Medical devices, utilizing multiple reservoirs to protect and selectively expose sensors or other reservoir contents, are provided having (i) a reservoir contents destruction mechanism to interrupt the release or exposure of reservoir contents, for example, to deactivate an unneeded sensor and prevent it from negatively impacting other sensors, (ii) a protective covering material layer over the sensor underneath the reservoir cap, which protects the sensor membrane and sensor during reservoir cap disintegration and then is removed, (iii) a device design for containing sensors in shallow, wide reservoir structures to enhance sensor exposure by minimizing molecular diffusion distances, (iv) an implantable sensor unit and a separate drug delivery unit, or (v) combinations thereof.
摘要翻译：提供了利用多个储存器来保护和选择性地暴露传感器或其他贮存器内容物的医疗装置，其具有（i）用于中断储存器内容物的释放或暴露的储存器内容物破坏机制，例如，去激活不需要的传感器并防止负面影响其他传感器，（ii）储存器盖下方的传感器上方的保护性覆盖材料层，其在储存器盖分解期间保护传感器膜和传感器然后被去除，（iii）用于在浅的，宽的储存器结构，以通过最小化分子扩散距离来增强传感器暴露，（iv）植入式传感器单元和单独的药物递送单元，或（v）其组合。

3. 发明授权

US07497846B2 Hermetically sealed microchip reservoir devices 有权
标题翻译：密封微芯片油藏装置
公开(公告)号：US07497846B2
公开(公告)日：2009-03-03
申请号：US11005391
申请日：2004-12-06
申请人： Scott A. Uhland , Benjamin F. Polito , Stephen J. Herman , John T. Santini, Jr. , John M. Maloney
发明人： Scott A. Uhland , Benjamin F. Polito , Stephen J. Herman , John T. Santini, Jr. , John M. Maloney
IPC分类号： A61M5/00 , A61K9/22
CPC分类号： A61K9/0097
摘要： Devices are provided for the controlled exposure or release of contents stored in hermetically sealed reservoirs. The devices comprise a primary substrate having a front side and a back side, and including one or more hermetic sealing materials; a plurality of reservoirs in the primary substrate positioned between the front side and the back side; reservoir contents, which comprise chemical molecules (such as drugs) or a secondary device (such as a glucose sensor), located inside the reservoirs; a hermetic sealing substrate having a surface composed of one or more hermetic sealing materials; and a hermetic seal formed between and joining the primary substrate and the hermetic sealing substrate, wherein the hermetic seal independently seals the reservoirs.
摘要翻译：提供了用于控制曝光或释放存储在密封储存器中的内容物的装置。这些装置包括具有前侧和后侧的主基板，并且包括一个或多个密封材料; 位于前侧和后侧之间的主要基底中的多个储存器; 包括化学分子（如药物）或位于储存器内部的次级装置（如葡萄糖传感器）的储存器内容物; 具有由一种或多种密封材料构成的表面的气密密封基材; 以及形成在主基板和气密密封基板之间并与其接合的气密密封件，其中气密密封独立地密封储存器。

4. 发明授权

US06976982B2 Flexible microchip devices for ophthalmic and other applications 失效
标题翻译：用于眼科和其他应用的柔性微芯片器件
公开(公告)号：US06976982B2
公开(公告)日：2005-12-20
申请号：US10042996
申请日：2002-01-09
申请人： John T. Santini, Jr. , Michael J. Cima , Robert S. Langer , Dennis Ausiello , Norman F. Sheppard, Jr. , Stephen J. Herman
发明人： John T. Santini, Jr. , Michael J. Cima , Robert S. Langer , Dennis Ausiello , Norman F. Sheppard, Jr. , Stephen J. Herman
IPC分类号： A61F9/007 , A61K9/00 , A61M37/00 , A61K9/22 , A61B5/05 , A61M31/00
CPC分类号： A61K9/0051 , A61F9/0017 , A61K9/0009 , A61K9/0048 , A61K9/0097 , H01L24/96 , H01L2924/01004 , H01L2924/01005 , H01L2924/01006 , H01L2924/01011 , H01L2924/01013 , H01L2924/01015 , H01L2924/0102 , H01L2924/01027 , H01L2924/01033 , H01L2924/01074 , H01L2924/01075 , H01L2924/01079 , H01L2924/014 , H01L2924/12041 , H01L2924/12042 , H01L2924/12043 , H01L2924/14 , H01L2924/1461 , H01L2924/19041 , H01L2924/19043 , H01L2924/00
摘要： Microchip device arrays that can conform to a curved surface are provided for the controlled release or exposure of reservoir contents. The arrays comprise two or more microchip device elements, each of which includes a plurality of reservoirs that contain molecules for controlled release or components for selective exposure, and a means for flexibly connecting the device elements. The reservoirs can contain one or more drugs and/or one or more secondary devices, such as a sensor or a component thereof. Preferably, the microchip devices contain and controllably release therapeutic, prophylactic, and diagnostic molecules to and into the eye of a patient in need thereof.
摘要翻译：提供可以符合曲面的Microchip器件阵列用于控制释放或暴露储层内容物。阵列包括两个或更多个微芯片器件元件，每个微芯片器件元件包括多个储存器，其包含用于控制释放的分子或用于选择性曝光的部件，以及用于灵活地连接器件元件的装置。储存器可以包含一种或多种药物和/或一个或多个次要装置，例如传感器或其组件。优选地，微芯片装置包含并可控地释放出有需要的患者眼睛中的治疗，预防和诊断分子。

5. 发明授权

US08308707B2 Method and system for drug delivery to the eye 失效
标题翻译：药物输送到眼睛的方法和系统
公开(公告)号：US08308707B2
公开(公告)日：2012-11-13
申请号：US13012426
申请日：2011-01-24
申请人： John T. Santini, Jr. , Michael J. Cima , Robert S. Langer , Dennis Ausiello , Norman F. Sheppard, Jr. , Stephen J. Herman
发明人： John T. Santini, Jr. , Michael J. Cima , Robert S. Langer , Dennis Ausiello , Norman F. Sheppard, Jr. , Stephen J. Herman
IPC分类号： A61M31/00
CPC分类号： A61K9/0051 , A61F9/0017 , A61K9/0009 , A61K9/0048 , A61K9/0097 , H01L24/96 , H01L2924/01004 , H01L2924/01005 , H01L2924/01006 , H01L2924/01011 , H01L2924/01013 , H01L2924/01015 , H01L2924/0102 , H01L2924/01027 , H01L2924/01033 , H01L2924/01074 , H01L2924/01075 , H01L2924/01079 , H01L2924/014 , H01L2924/12041 , H01L2924/12042 , H01L2924/12043 , H01L2924/14 , H01L2924/1461 , H01L2924/19041 , H01L2924/19043 , H01L2924/00
摘要： Methods and systems are provided for delivering drug to the eye. The method and system may include implanting into the eye a device which comprises two or more discrete reservoirs, each reservoir containing a drug; and directing focused light to the implanted device to open a first one of the reservoirs and thereby permit the drug to diffuse from the first reservoir to the patient's eye.
摘要翻译：提供了将药物输送到眼睛的方法和系统。该方法和系统可以包括将包括两个或更多个离散储器的装置植入眼中，每个储存器包含药物; 以及将聚焦光引导到所述植入装置以打开所述储存器中的第一个，从而允许所述药物从所述第一储存器扩散到所述患者的眼睛。

6. 发明授权

US07582080B2 Implantable, tissue conforming drug delivery device 失效
标题翻译：可植入，组织贴合药物输送装置
公开(公告)号：US07582080B2
公开(公告)日：2009-09-01
申请号：US11291973
申请日：2005-12-01
申请人： John T. Santini, Jr. , Michael J. Cima , Norman F. Sheppard, Jr. , Stephen J. Herman
发明人： John T. Santini, Jr. , Michael J. Cima , Norman F. Sheppard, Jr. , Stephen J. Herman
IPC分类号： A61K9/22
CPC分类号： A61K9/0051 , A61F9/0017 , A61K9/0009 , A61K9/0048 , A61K9/0097 , H01L24/96 , H01L2924/01004 , H01L2924/01005 , H01L2924/01006 , H01L2924/01011 , H01L2924/01013 , H01L2924/01015 , H01L2924/0102 , H01L2924/01027 , H01L2924/01033 , H01L2924/01074 , H01L2924/01075 , H01L2924/01079 , H01L2924/014 , H01L2924/12041 , H01L2924/12042 , H01L2924/12043 , H01L2924/14 , H01L2924/1461 , H01L2924/19041 , H01L2924/19043 , H01L2924/00
摘要： A drug delivery device for implantation into a patient is provided that includes at least one device element that includes a substrate having a plurality of discrete reservoirs disposed therein, the reservoirs containing drug molecules and a degradable matrix material which controls in vivo release of the drug molecules from the reservoirs, wherein the drug delivery device is adapted to conform to a curved bone tissue surface. In one embodiment, the substrate is flexible and conforms to a bone tissue surface. In another embodiment, the device has two or more device elements attached to or integral with a flexible supporting layer.
摘要翻译：提供了用于植入患者体内的药物递送装置，其包括至少一个装置元件，其包括具有设置在其中的多个分立储存器的基底，所述储存器包含药物分子和可降解基质材料，其控制药物分子的体内释放其中所述药物递送装置适于符合弯曲的骨组织表面。在一个实施例中，基底是柔性的并且符合骨组织表面。在另一个实施例中，该装置具有两个或更多个装置元件，其连接到柔性支撑层或与柔性支撑层成一体。

7. 发明授权

US07497855B2 Method and device for the controlled delivery of parathyroid hormone 有权
标题翻译：用于甲状旁腺激素受控递送的方法和装置
公开(公告)号：US07497855B2
公开(公告)日：2009-03-03
申请号：US10654761
申请日：2003-09-04
申请人： Dennis Ausiello , John T. Santini, Jr. , Stephen J. Herman , James H. Prescott , Scott A. Uhland , John M. Maloney , Benjamin F. Polito
发明人： Dennis Ausiello , John T. Santini, Jr. , Stephen J. Herman , James H. Prescott , Scott A. Uhland , John M. Maloney , Benjamin F. Polito
IPC分类号： A61K9/22
CPC分类号： A61K9/0024 , A61K9/0009 , A61K9/0036 , A61K9/0097 , A61K38/29 , A61K2300/00
摘要： Method and devices are provided for extended and controlled delivery of parathyroid hormone to a patient. The method includes implanting a medical device into the patient, the medical device comprising a substrate, a plurality of reservoirs in the substrate, a release system contained in each of the reservoirs, wherein the release system comprises parathyroid hormone; and controllably releasing a pharmaceutically effective amount of the parathyroid hormone from the reservoirs. The parathyroid hormone can be released intermittently, such as once daily over an extended period (e.g., two months, ten months, or more.). The device can further include reservoirs containing a bone resorption inhibitor or other drug for release. The devices are useful in delivering PTH for the treatment and prevention of bone loss, such as associated with osteoporosis.
摘要翻译：提供了将甲状旁腺激素延伸和控制递送给患者的方法和装置。所述方法包括将医疗装置植入患者体内，所述医疗装置包括衬底，衬底中的多个储存器，每个储存器中包含的释放系统，其中所述释放系统包括甲状旁腺激素; 并且可控地从储存器释放药学有效量的甲状旁腺激素。间歇性地释放甲状旁腺激素，例如每天一次（例如两个月，十个月或更长时间）释放。该装置还可以包括含有骨吸收抑制剂或其它用于释放的药物的储存器。该装置可用于输送PTH以治疗和预防骨丢失，例如与骨质疏松症有关。

8. 发明授权

US07226442B2 Microchip reservoir devices using wireless transmission of power and data 有权
标题翻译： Microchip库设备使用无线传输电源和数据
公开(公告)号：US07226442B2
公开(公告)日：2007-06-05
申请号：US09975672
申请日：2001-10-10
申请人： Norman F. Sheppard, Jr. , John T. Santini, Jr. , Stephen J. Herman , Michael J. Cima , Robert S. Langer , Dennis Ausiello
发明人： Norman F. Sheppard, Jr. , John T. Santini, Jr. , Stephen J. Herman , Michael J. Cima , Robert S. Langer , Dennis Ausiello
IPC分类号： A61K9/22
CPC分类号： A61B1/041 , A61B5/0402 , A61B5/0476 , A61B5/14539 , A61K9/0009 , A61K9/0051 , A61K9/0097 , A61M5/14 , A61M5/14276 , A61M2205/0244 , A61M2205/3523 , A61M2210/0612 , A61M2210/1042 , G06F19/00
摘要： Devices, systems, and methods are provided for wirelessly powering and/or communicating with microchip devices used for the controlled exposure and release of reservoir contents, such as drugs, reagents, and sensors. In one embodiment, the system includes (1) a microchip device comprising a substrate having a plurality of reservoirs containing reservoir contents for release or exposure; and (2) a rechargeable or on-demand power source comprising a local component which can wirelessly receive power from a remote transmitter wherein the received power can be used, directly or following transduction, to activate said release or exposure of the reservoir contents. In another embodiment, the system comprises (1) a microchip device comprising a substrate a plurality of reservoirs containing reservoir contents for release or exposure; and (2) a telemetry system for the wireless transfer of data between the microchip device and a remote controller.
摘要翻译：提供了设备，系统和方法，用于与用于受控地暴露和释放储存器内容物（例如药物，试剂和传感器）的微芯片装置的无线供电和/或通信。在一个实施例中，系统包括（1）微芯片装置，其包括具有多个储存器的基板，所述储存器包含用于释放或曝光的储存器内容物; 和（2）可充电或点播电源，其包括本地组件，其可以从远程发射器无线地接收电力，其中可以直接或继续使用所接收的功率来激活所述储存器内容物的释放或暴露。在另一个实施例中，系统包括（1）微芯片装置，其包括基板，多个储存器包含用于释放或曝光的储存器内容物; 和（2）用于在微芯片设备和遥控器之间无线传输数据的遥测系统。

9. 发明授权

US07537590B2 Multi-reservoir device for transdermal drug delivery and sensing 有权
标题翻译：用于透皮药物传递和感测的多储器装置
公开(公告)号：US07537590B2
公开(公告)日：2009-05-26
申请号：US11194157
申请日：2005-08-01
申请人： John T. Santini, Jr. , Mark A. Staples , Stephen J. Herman
发明人： John T. Santini, Jr. , Mark A. Staples , Stephen J. Herman
IPC分类号： A61K9/22
CPC分类号： A61K9/703 , A61F2013/00642 , A61K9/0009 , A61K9/0021 , A61K9/0097 , A61K9/7084 , A61K9/7092 , A61M37/0015 , A61M2037/0023 , A61N1/30
摘要： Devices and methods are provided for transdermal administration of a pharmaceutical agent to a patient in need thereof. The device includes a substrate, a plurality of discrete reservoirs in the substrate, one or more pharmaceutical agents stored in the reservoirs, discrete reservoir caps that prevent the pharmaceutical agent from passing out from the reservoirs until desired, control means for actuating release of the one or more pharmaceutical agents from one or more of the reservoirs by disintegrating or permeabilizing the reservoir caps, means for securing the device to the skin of the patient, and means for transporting the pharmaceutical agent to the skin following release from the one or more of the reservoirs. In another embodiment, the device is adapted for diagnostic sensing instead of or in addition to drug delivery.
摘要翻译：提供了用于向有需要的患者透皮施用药剂的装置和方法。该装置包括衬底，衬底中的多个分立贮存器，储存在储存器中的一个或多个药剂，防止药剂从储存器中流出直到期望的离散贮存器盖，用于致动释放一个或更多的药剂从一个或多个储存器中分解或渗透储存器盖，用于将装置固定到患者皮肤的装置，以及用于在药物释放之后将药剂运送到皮肤的装置水库在另一个实施方案中，该装置适用于代替药物递送或除药物递送之外的诊断感测。

10. 发明授权

US06827250B2 Methods for hermetically sealing microchip reservoir devices 有权
标题翻译：密封微芯片储液装置的方法
公开(公告)号：US06827250B2
公开(公告)日：2004-12-07
申请号：US10184259
申请日：2002-06-28
申请人： Scott A. Uhland , Benjamin F. Polito , Stephen J. Herman , John T. Santini, Jr. , John M. Maloney
发明人： Scott A. Uhland , Benjamin F. Polito , Stephen J. Herman , John T. Santini, Jr. , John M. Maloney
IPC分类号： B23K106
CPC分类号： A61K9/0097
摘要： Methods are provided for hermetically sealing the reservoirs of microchip devices and for hermetically sealing the substrate assemblies in a hermetic packaging structure. In one embodiment, the method comprises (1) providing a primary substrate having a front side and a back side, the substrate comprising a plurality of reservoirs positioned between the front side and the back side, each reservoir being loaded with molecules or a secondary device for controlled release or exposure, the reservoirs having at least one opening in need of sealing, the primary substrate including one or more hermetic sealing materials; (2) providing a hermetic sealing substrate having a surface composed of one or more hermetic sealing materials; (3) positioning the hermetic sealing substrate over the reservoir openings and contacting said hermetic sealing materials of the primary substrate with said hermetic sealing materials of the hermetic sealing substrate; and (4) applying energy or a mechanical force to the contacted sealing materials effective to form a hermetic seal between the hermetic sealing substrate and the primary substrate to hermetically seal the reservoir openings.
摘要翻译：提供了用于气密地密封微芯片装置的储存器的方法，以及用于密封密封封装结构中的基板组件。在一个实施例中，该方法包括（1）提供具有前侧和后侧的主基底，所述基底包括位于前侧和后侧之间的多个储存器，每个储存器装载有分子或辅助装置为了控制释放或暴露，储存器具有至少一个需要密封的开口，主基底包括一个或多个气密密封材料; （2）提供具有由一种或多种密封材料构成的表面的气密密封基材; （3）将气密密封基板定位在储存器开口上，并使主基板的气密密封材料与气密密封基板的气密密封材料接触; 和（4）将能量或机械力施加到接触的密封材料上，以有效地在气密密封基底和初级基底之间形成气密密封，从而气密地密封储层开口。

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