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1. 发明申请

WO2012100205A3 PIEZOELECTRIC DISPENSER WITH A LONGITUDINAL TRANSDUCER AND REPLACEABLE CAPILLARY TUBE 审中-公开
标题翻译：具有纵向换能器和可更换毛细管的压电式分配器
公开(公告)号：WO2012100205A3
公开(公告)日：2012-12-27
申请号：PCT/US2012022091
申请日：2012-01-20
申请人： BIODOT INC , IVRI YEHUDA , TISONE THOMAS C , LEMMO ANTHONY V
发明人： IVRI YEHUDA , TISONE THOMAS C , LEMMO ANTHONY V
IPC分类号： B01L3/02
CPC分类号： B01L3/0268 , B01L2200/04 , B01L2200/0684 , B01L2400/0439
摘要： Systems, devices and methods are provided, for acquiring and dispensing predetermined volumes of liquids and, in particular, to a unique piezoelectric dispenser for acquiring and dispensing of small volumes of fluid in an automatic or manual production of DNA arrays and assays, wherein droplets are dispensed in a single drop format with volumes that may range from about a few picoliters to several nanoliters. The dispenser can advantageously utilize a disposable capillary tube assembly while desirably retaining the piezoelectric actuator for subsequent further uses, thereby mitigating the possibility of cross contamination of fluids and providing an economical and cost effective approach with reuse of the piezoelectric actuator for further operation such as with a variety of liquids to be dispensed and transferred. A unique longitudinal transducer can transmit radial tube displacement into controlled axial motion of the tube.
摘要翻译：提供了用于获取和分配预定体积的液体的系统，装置和方法，并且特别地，涉及一种独特的压电分配器，用于在DNA阵列和分析的自动或手动生产中采集和分配小体积流体，其中液滴是以单滴形式分配，体积范围可以从几皮升到几纳升。分配器可以有利地利用一次性毛细管组件，同时理想地保持压电致动器以用于随后的进一步使用，从而减轻流体交叉污染的可能性并且提供经济且节约成本的方法，其中压电致动器用于进一步操作，诸如各种要分配和转移的液体。独特的纵向传感器可以将径向管位移传递到管的受控轴向运动。

2. 发明申请

WO2005102431A2 AEROSOL DELIVERY APPARATUS, METHODS AND COMPOSITIONS FOR PRESSURE-ASSISTED BREATHING SYSTEMS 审中-公开
标题翻译：气溶胶输送装置，压力辅助呼吸系统的方法和组合物
公开(公告)号：WO2005102431A2
公开(公告)日：2005-11-03
申请号：PCT/US2005013488
申请日：2005-04-20
申请人： AEROGEN INC , FINK JAMES , IVRI YEHUDA
发明人： FINK JAMES , IVRI YEHUDA
IPC分类号： A61M11/00 , A61M15/00 , A61M16/00 , A61M16/08 , A61M16/14
CPC分类号： A61M11/005 , A61M15/0085 , A61M16/0666 , A61M16/08 , A61M16/0833 , A61M16/1055 , A61M16/107 , A61M16/14 , A61M2016/0021 , A61M2016/0033 , A61M2205/7518 , A61M2240/00
摘要： Improved pressure-assisted breathing systems are provided for the delivery of aerosolized medicaments. In addition, methods and compositions are provided for the treatment of respiratory diseases.
摘要翻译：提供改进的压力辅助呼吸系统用于递送雾化药物。另外，提供了治疗呼吸系统疾病的方法和组合物。

3. 发明公开

EP2964543A4 PRESSURE MULTIPLYING AEROSOL PUMP 审中-公开
标题翻译：压力倍增器气溶胶泵
公开(公告)号：EP2964543A4
公开(公告)日：2016-11-23
申请号：EP14760751
申请日：2014-03-05
申请人： IVRI YEHUDA
发明人： IVRI YEHUDA
IPC分类号： B05B11/00 , B05B1/34 , B05B11/06
CPC分类号： B05B11/3001 , A45D34/00 , A45D2200/056 , A45D2200/057 , A61L9/14 , A61L2209/134 , B05B1/341 , B05B11/061 , B05B11/3005 , B05B11/3052 , B05B11/3066

4. 发明申请

WO2006127181A2 VIBRATION SYSTEMS AND METHODS 审中-公开
标题翻译：振动系统与方法
公开(公告)号：WO2006127181A2
公开(公告)日：2006-11-30
申请号：PCT/US2006014654
申请日：2006-04-17
申请人： AEROGEN INC , IVRI YEHUDA
发明人： IVRI YEHUDA
IPC分类号： E02B3/06
CPC分类号： H01L41/09 , A61M15/00 , A61M15/009 , B05B1/00 , B05B17/00 , B05B17/04 , B05B17/06 , B05B17/0638 , B05B17/0646 , B05B17/0676 , H01L41/053 , Y10T29/42
摘要： In one or more embodiments, a vibration system comprises a vibratable plate, a support member surrounding the vibratable plate, and a vibration-inducing member surrounding the support member, wherein the vibration-inducing member is configured to radially expand and contract against the support member so as to produce axial vibration of the vibratable plate. In one embodiment, the vibratable plate has an outer circumference; a tubular member is concentrically disposed about the outer circumference of the plate, and an annular vibration-inducing member is concentrically disposed about the outer circumference of the tubular member. The vibration-inducing member is preferably a piezoelectric ring that is radially expandable and contractable against the wall of the tubular member to cause the plate to vibrate in the axial direction. In another embodiment, an aerosol generating system comprises an piezoelectric ring that is radially expandable and contractable upon actuation thereof; a tubular member disposed within the center hole of the piezoelectric ring, and a circular vibratable aperture plate disposed across the internal lumen of the tubular member. The piezoelectric ring is radially expandable and contractable against the tubular member to cause the aperture plate to vibrate in the axial direction, and a reservoir of liquid is coupled to the tubular member so as to supply the liquid to the vibratable aperture plate and produce an aerosol upon vibration thereof.
摘要翻译：在一个或多个实施例中，振动系统包括可振动板，围绕可振动板的支撑构件和围绕支撑构件的振动诱导构件，其中，所述振动诱导构件被构造成径向地膨胀和收缩支撑构件以产生可振动板的轴向振动。在一个实施例中，可振动板具有外圆周; 管状构件围绕板的外周同心地设置，并且环形振动引导构件围绕管状构件的外周同心地设置。振动诱导构件优选为压缩环，该压电环径向膨胀和收缩，抵靠管状构件的壁，以使板在轴向方向上振动。在另一个实施例中，气溶胶发生系统包括压电环，其在致动时可径向膨胀和收缩; 设置在压电环的中心孔内的管状构件和横跨管状构件的内腔设置的圆形可振动孔板。压电环可径向膨胀和收缩抵靠管状构件，以使孔板在轴向方向上振动，并且液体储存器联接到管状构件上，以便将液体供应到可振动孔板并产生气溶胶振动时。

5. 发明申请

WO2011019954A2 INTRACOCHLEAR DRUG DELIVERY TO THE CENTRAL NERVOUS SYSTEM 审中-公开
标题翻译：输液给中央神经系统
公开(公告)号：WO2011019954A2
公开(公告)日：2011-02-17
申请号：PCT/US2010045372
申请日：2010-08-12
申请人： IVRI YEHUDA
发明人： IVRI YEHUDA
IPC分类号： A61M31/00 , A61K9/127 , A61M37/00 , A61N1/05
CPC分类号： A61M31/002 , A61F11/00 , A61F11/002 , A61K9/0009 , A61K9/0024 , A61K9/0046 , A61K9/0092 , A61K9/1075 , A61K9/127 , A61K9/513 , A61K9/5153 , A61K31/00 , A61K31/4168 , A61K31/4468 , A61K31/485 , A61M2210/0662
摘要： The present invention is directed to method and system for delivery of brain-targeted drugs to the cerebrospinal fluid via the perilymphatic fluid of the inner ear. The system utilizes the passage of cochlear aqueduct as a drug delivery route from the inner ear to the subarachnoid space of the brain. The delivery system includes an otological conduit which enables transfer of drugs from the auditory ear canal to the inner ear and a wearable dispenser for supplying drugs to the otological conduit. The drug composition comprises a suspension of solid lipid nanoparticles (SLN) which facilitate delivery through the cochlear aqueduct. Employing aspects of present invention, a method and system for treating chronic pain is described.
摘要翻译：本发明涉及通过内耳的外淋巴液将脑靶向药物递送至脑脊液的方法和系统。该系统利用耳蜗导水管的通过作为从内耳到脑的蛛网膜下腔的药物递送途径。输送系统包括能够将药物从听觉耳道传递到内耳的耳道，以及用于向耳道管道供应药物的可穿戴式分配器。药物组合物包含固体脂质纳米颗粒（SLN）的悬浮液，其有利于通过耳蜗输水管的输送。本发明涉及方面，描述了治疗慢性疼痛的方法和系统。

6. 发明申请

WO2008076606A3 SUBMINIATURE THERMOELECTRIC FRAGRANCE DISPENSER 审中-公开
标题翻译：辅助热电阻垢分配器
公开(公告)号：WO2008076606A3
公开(公告)日：2008-12-04
申请号：PCT/US2007085938
申请日：2007-11-29
申请人： IVRI YEHUDA , FELLINGHAM GEORGE , CIUNI SAM
发明人： IVRI YEHUDA , FELLINGHAM GEORGE , CIUNI SAM
IPC分类号： F24F6/00
CPC分类号： A45D34/02
摘要： A dispenser for dispensing a liquid includes a chamber holding a supply of liquid, an annular conduit substantial)" filled from the chamber, and a thermoelectric transducer near one end of the annular conduit. Upon electrical current to the thermoelectric transducer, the transducer operates to cause boiling of a quantity of liquid in the annular conduit forcing liquid out the of the end of the annular conduit.
摘要翻译：用于分配液体的分配器包括保持液体供应的腔室，基本上为“从腔室填充的环形导管”的腔室，以及靠近环形导管的一端的热电换能器，当到热电换能器的电流时，导致环形导管中的液体沸腾，迫使液体从环形管道的端部流出。

7. 发明申请

WO9301404A1 ULTRASONIC FLUID EJECTOR 审中-公开
标题翻译：超声波流体喷射器
公开(公告)号：WO9301404A1
公开(公告)日：1993-01-21
申请号：PCT/US9205275
申请日：1992-06-18
申请人： IVRI YEHUDA
发明人： IVRI YEHUDA
IPC分类号： B41J2/04
CPC分类号： B41J2/04 , A61M2205/3306 , B41J2202/15
摘要： A fluid injection device that ejects a quantum of fluid in response to an electrical signal. The device operates without kinematic elements or a pump and it does not need external pressure. In a preferred embodiment a circular membrane is mounted at its perimeter to an oscillating base. The membrane is shaped so that its cross-section is reduced toward its center. The membrane oscillates at a frequency which is at or near its natural frequency. In the preferred embodiment a second modal frequency is utilized. Because of the configuration of the membrane and the frequency of oscillation thereof, the center of the membrane oscillates over an amplitude which is significantly higher than the oscillation amplitude of the perimeter. The membrane is highly damped so that its amplitude is extremely responsive to variations in the base amplitude. The center area of the membrane is provided with one or more tapered apertures. One opening of each tapered aperture is in fluid communication with a reservoir of fluid, and the other opening of each aperture is positioned toward the fluid target, such as an engine manifold, towards which droplets of fuel from the reservoir are to be propelled. When the membrane oscillation amplitude is above a predetermined threshold, the interaction between the tapered aperture and the fuel reservoir creates a cycle of fluid compression and cavitation inside the aperture that causes a drop of fuel to accelerate through the aperture and be ejected upon each excursion of the membrane. The fluid in the reservoir, however, remains at complete rest and it is not disturbed by the small oscillation amplitude of the membrane.
摘要翻译：一种流体注射装置，其响应于电信号喷射流体的量子。该设备在没有运动元件或泵的情况下运行，并且不需要外部压力。在优选实施例中，圆形膜在其周边安装到振荡基座。膜的形状使得其横截面朝向其中心减小。膜以其固有频率处于或接近其频率振荡。在优选实施例中，使用第二模态频率。由于膜的结构及其振荡频率，膜的中心振动幅度明显高于周边的振荡振幅。膜被高度阻尼，使得其幅度对基本幅度的变化非常敏感。膜的中心区域设置有一个或多个锥形孔。每个锥形孔的一个开口与流体的储存器流体连通，并且每个孔的另一个开口朝向流体靶（例如发动机歧管）定位，来自储存器的燃料液滴将朝向该流体靶推进。当膜振荡幅度高于预定阈值时，锥形孔和燃料储存器之间的相互作用产生了孔内的流体压缩和空化的循环，其使得燃料滴下降通过孔加速并且在每次偏移膜。然而，储存器中的流体保持完全静止，并且不受膜的小的振荡幅度的干扰。

8. 发明专利

CA2066838A1 High Frequency Printing Mechanism 未知
公开(公告)号：CA2066838A1
公开(公告)日：1992-10-25
申请号：CA2066838
申请日：1992-04-22
申请人： IVRI YEHUDA
发明人： IVRI YEHUDA
IPC分类号： B41J2/015 , B41J2/04 , B41J2/045 , B41J2/055 , B41J2/175
摘要： High frequency printing mechanism with an ink-jet ejection device which is capable of ejection of ink (including hot melt ink) at jet frequencies greater than 50,000 Hz. A cantilevered beam (12) is mounted at its base (14) to a piezoelectric element (18) which oscillates the base. The beam is shaped so that its moment of inertia is reduced toward its free end (16). The element (18) is activated by an oscillating electrical signal the frequency of which is equal to or close to a natural frequency of oscillation of the beam (12). At this frequency of oscillation of the beam, the tip (15) of the beam ocillates over an amplitude which is significantly greater than the oscillation amplitude of the base. The tip (15) of the beam is provided with an aperture which is preferably tapered in cross-section. One opening of the tapered aperture is in fluid communication with a reservoir (19) of ink and the other opening of the aperture is positioned at an appropriate distance from a printing paper towards which individual droplets of ink from the reservoir are to be propelled. When the tip amplitude is above a predetermined threshold, the solid-fluid interaction between the aperture and the ink causes a drop of ink to be accelerated through the aperture and be ejected upon each excursion of the tip of the beam toward the printing media.

9. 发明专利

DK2665557T3 Piezoelektrisk dispenser med en langsgående transducer og udskifteligt kapillærrør 未知
公开(公告)号：DK2665557T3
公开(公告)日：2020-04-06
申请号：DK12735970
申请日：2012-01-20
申请人： BIODOT INC
发明人： IVRI YEHUDA , TISONE THOMAS C , LEMMO ANTHONY V
IPC分类号： B01L3/02

10. 发明公开

EP3171985A4 PIEZOELECTRIC DISPENSER WITH A LONGITUDINAL TRANSDUCER AND REPLACEABLE CAPILLARY TUBE 有权
公开(公告)号：EP3171985A4
公开(公告)日：2018-03-14
申请号：EP15825366
申请日：2015-07-24
申请人： BIODOT INC
发明人： IVRI YEHUDA , TISONE THOMAS C , KUO ERIC P , GUNSALUS SHANE
IPC分类号： B05B17/06
CPC分类号： B05B17/0669 , B01J19/0046 , B01J2219/00367 , B01J2219/00378 , B01J2219/00722 , B01L3/0268 , B01L2300/0838 , B01L2300/123 , B01L2300/165 , B01L2400/0481 , B05B17/0684
摘要： A dispenser and methods for transferring liquids are disclosed. The dispenser may include a capillary tube with tip having an aperture, a piezoelectric actuator coupled to the capillary tube at a location. Actuation of the piezoelectric actuator causes a pressure wave to propagate along the capillary tube toward the tip such that radial motion at the location is transmitted as distally extending axial motion of the tip, thereby causing a droplet of a predetermined volume to be ejected from the aperture. In some embodiments, the capillary tube has a modulus of elasticity in a range which dampens acoustical noise from the actuation and provides single drop stability over a range of drop sizes.

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