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1. 发明授权

US5855594A Self-calibration system for capture verification in pacing devices 失效
标题翻译：起搏装置捕获验证的自校准系统
公开(公告)号：US5855594A
公开(公告)日：1999-01-05
申请号：US907609
申请日：1997-08-08
申请人： Arthur L. Olive , Brian D. Pederson , Veerichetty A. Kadhiresan , Donald L. Villalta
发明人： Arthur L. Olive , Brian D. Pederson , Veerichetty A. Kadhiresan , Donald L. Villalta
IPC分类号： A61N1/37 , A61N1/362 , A61N1/36
CPC分类号： A61N1/3712
摘要： A cardiac pacing and sensing system includes a body implantable unit for generating tissue stimulation pulses and manipulating information based on sensed signals, and a catheter for transmitting pulses from the unit to a pacing electrode adjacent myocardial tissue. The unit incorporates circuitry for generating response values, one associated with each stimulation pulse, based on a predetermined characteristic or parameter of the signals evoked by the pulses. To evaluate the efficacy of the parameter in distinguishing capture versus non-capture, the stimulation pulses are generated according to a protocol of high energy pulses guaranteed to effect capture interspersed with low energy pulses guaranteed not to effect capture. Data, accumulated and sorted into separate "capture" and "non-capture" sets, provides respective capture and non-capture composite values. The ratio of the composite values is compared to a predetermined threshold, to generate an indication either accepting or rejecting the chosen parameter. A parameter, once accepted, can be employed in a self-test that either increments or decrements stimulation of signals to evaluate the capture threshold. Optionally, two or more designated parameters can be screened simultaneously and compared, with the most favorable ratio then being compared to the threshold.
摘要翻译：心脏起搏和感测系统包括用于产生组织刺激脉冲并基于感测到的信号来操纵信息的身体可植入单元，以及用于将脉冲从单元传输到心脏组织附近的起搏电极的导管。该单元包括用于产生响应值的电路，基于由脉冲诱发的信号的预定特性或参数产生与每个刺激脉冲相关的响应值。为了评估参数区分捕获与非捕获的功效，刺激脉冲是根据高能量脉冲的协议生成的，这些协议保证能够有效捕获散布在不能捕获的低能量脉冲上的捕获。数据，累积并分类为单独的“捕获”和“非捕获”集合，提供相应的捕获和非捕获复合值。将复合值的比率与预定阈值进行比较，以产生接受或拒绝所选参数的指示。一旦被接受，一个参数就可以用于自我测试中，该测试会增加或减少信号的刺激以评估捕获阈值。可选地，可以同时筛选两个或更多个指定参数，并以最有利的比例进行比较，然后与阈值进行比较。

2. 发明授权

US5931858A Implantable device for monitoring aerobic capacity of patients 失效
标题翻译：用于监测患者有氧能力的植入式装置
公开(公告)号：US5931858A
公开(公告)日：1999-08-03
申请号：US5501
申请日：1998-01-12
申请人： Veerichetty A. Kadhiresan , Arthur L. Olive , Bruce R. Jones
发明人： Veerichetty A. Kadhiresan , Arthur L. Olive , Bruce R. Jones
IPC分类号： A61B5/08 , A61B5/22 , A61N1/08 , A61N1/362 , A61N1/365 , A61N1/37 , A61N1/00
CPC分类号： A61N1/3704 , A61B5/0803 , A61N1/36514 , A61B5/0809 , A61B5/0816 , A61B5/22 , A61N1/3627
摘要： An implantable electronic circuit for monitoring a patient's aerobic capacity includes an accelerometer for detecting the onset and termination of a period of exercise and a means for measuring the patient's minute volume. By computing the time interval from the cessation of exercise to the point where the patient's minute volume reaches a predetermined value at or near an at-rest value thereof, a measure of aerobic capacity relating to a patient's physical fitness can be determined.
摘要翻译：用于监测患者有氧能力的可植入电子电路包括用于检测运动期间的开始和终止的加速度计和用于测量患者的微小体积的装置。通过计算从运动停止到患者的体积达到或接近静止值的预定值的时间间隔，可以确定与患者体力相关的有氧容量的量度。

3. 发明授权

US4733667A Closed loop control of cardiac stimulator utilizing rate of change of impedance 失效
标题翻译：利用阻抗变化率对心脏刺激器进行闭环控制
公开(公告)号：US4733667A
公开(公告)日：1988-03-29
申请号：US895241
申请日：1986-08-11
申请人： Arthur L. Olive , Brian D. Pederson , Rodney W. Salo
发明人： Arthur L. Olive , Brian D. Pederson , Rodney W. Salo
IPC分类号： A61N1/365 , A61N1/36
CPC分类号： A61N1/36521
摘要： A cardiac pacer of the type having an implantable pulse generator and electrical leads deployed in the right ventricular chamber of the heart. The lead has a stimulating electrode as well as a plurality of sensing electrodes coupled to the pulse generator. Certain control circuitry associated with the implantable pacer provides for measurement of the impedance variations occasioned by the pumping action of the heart and a differentiating circuit operatively coupled to the impedance sensing circuit for developing a control signal corresponding to the rate of change of the impedance with respect to time. This control signal may be coupled to the timing circuit of the implantable pulse generator, allowing the pacing rate to be altered in accordance with the level of physiologic activity of the person in whom the pacer is implanted.
摘要翻译：该类型的心脏起搏器具有部署在心脏右心室的植入式脉冲发生器和电引线。引线具有刺激电极以及耦合到脉冲发生器的多个感测电极。与可植入起搏器相关联的某些控制电路提供用于测量由心脏的泵送作用引起的阻抗变化，以及可操作地耦合到阻抗感测电路的差分电路，用于开发对应于阻抗变化率的控制信号到时间该控制信号可以耦合到可植入脉冲发生器的定时电路，允许起搏速率根据其中植入人的人的生理活动水平而改变。

4. 发明授权

US4773401A Physiologic control of pacemaker rate using pre-ejection interval as the controlling parameter 失效
标题翻译：使用预喷射间隔作为控制参数对起搏器的生理控制
公开(公告)号：US4773401A
公开(公告)日：1988-09-27
申请号：US87869
申请日：1987-08-21
申请人： Brian P. Citak , Michael W. Dooley , Arthur L. Olive , Brian D. Pederson , Renold J. Russie , Rodney W. Salo , William L. Zimmer
发明人： Brian P. Citak , Michael W. Dooley , Arthur L. Olive , Brian D. Pederson , Renold J. Russie , Rodney W. Salo , William L. Zimmer
IPC分类号： A61N1/365 , A61N1/30
CPC分类号： A61N1/36521 , A61N1/36514
摘要： A multi-pole pacing/sensing lead is used to measure the instantaneous impedance in the right ventricle of a patient's heart. The resulting impedance waveform is signal processed to obtain a measure of the time interval beginning with the occurrence of a paced beat or a spontaneous QRS complex (systole marker) and ending with the point where the impedance versus time signal crosses the zero axis in the positive direction following the paced or spontaneous QRS complex initiating the interval or some other predetermined point along the positive-going waveform. The resulting time interval is inversely proportional to the contractility of the heart and is found to decrease with exercise and the introduction of catecholamines. Thus, it can be used as a control parameter for a demand-type cardiac pacemaker. A means for obviating changes in pacing rate due to long-term drift in the impedance sensing circuitry is also disclosed.
摘要翻译：多极起搏/感应引线用于测量患者心脏右心室的瞬时阻抗。对所得到的阻抗波形进行信号处理，以获得从出现节奏搏动或自发QRS复合（收缩标记）开始的时间间隔的测量结果，并以阻抗对时间信号穿过正轴的零轴的点结束沿着起搏或自发的QRS复合物沿着正向波形发起间隔或一些其它预定点。所产生的时间间隔与心脏的收缩力成反比，并且发现随着运动和引入儿茶酚胺而减少。因此，它可以用作需求型心脏起搏器的控制参数。还公开了一种用于消除由于阻抗感测电路中的长期漂移引起的起搏速率变化的方法。

5. 发明申请

US20120209130A1 APPARATUS AND METHOD FOR OUTPUTTING HEART SOUNDS 有权
标题翻译：用于输出心脏声音的装置和方法
公开(公告)号：US20120209130A1
公开(公告)日：2012-08-16
申请号：US13456795
申请日：2012-04-26
申请人： Avram Scheiner , Qingsheng Zhu , Arthur L. Olive , Don Villalta
发明人： Avram Scheiner , Qingsheng Zhu , Arthur L. Olive , Don Villalta
IPC分类号： A61B5/0402 , A61B7/00
CPC分类号： A61B7/04 , A61B5/0002 , A61B5/0031 , A61B5/04012 , A61B5/04014 , A61B5/0402 , A61B5/042 , A61B5/044 , A61B5/0452 , A61B5/1118 , A61B5/742 , A61B7/023 , G06F19/00
摘要： An apparatus for outputting heart sounds includes an implantable system and an external system. The implantable system includes a sensor for generating sensed signals representing detected heart sounds, an interface circuit and a control circuit for receiving the sensed signals, generating data representing the heart sounds therefrom, and transmitting the data to the external system via the interface circuit. The external system includes an interface circuit for communicating with the implantable system, and a control circuit for receiving the data representing the heart sounds and for generating control signals that cause an output device to generate outputs representing the sounds. The implantable system may also include a sensor(s) for detecting cardiac electrical signals. In this case, outputs representing the cardiac electrical signals are also output.
摘要翻译：用于输出心音的装置包括可植入系统和外部系统。可植入系统包括用于产生表示检测到的心音的感测信号的传感器，接口电路和用于接收感测信号的控制电路，产生表示心音的数据，以及经由接口电路将数据发送到外部系统。外部系统包括用于与可植入系统进行通信的接口电路，以及用于接收表示心脏声音的数据的控制电路，以及用于产生使输出设备产生表示声音的输出的控制信号。可植入系统还可以包括用于检测心脏电信号的传感器。在这种情况下，还输出表示心电信号的输出。

6. 发明授权

US08478391B2 Apparatus and method for outputting heart sounds 有权
公开(公告)号：US08478391B2
公开(公告)日：2013-07-02
申请号：US13456795
申请日：2012-04-26
申请人： Avram Scheiner , Qingsheng Zhu , Arthur L. Olive , Don Villalta
发明人： Avram Scheiner , Qingsheng Zhu , Arthur L. Olive , Don Villalta
IPC分类号： A61B5/025
CPC分类号： A61B7/04 , A61B5/0002 , A61B5/0031 , A61B5/04012 , A61B5/04014 , A61B5/0402 , A61B5/042 , A61B5/044 , A61B5/0452 , A61B5/1118 , A61B5/742 , A61B7/023 , G06F19/00
摘要： An apparatus for outputting heart sounds includes an implantable system and an external system. The implantable system includes a sensor for generating sensed signals representing detected heart sounds, an interface circuit and a control circuit for receiving the sensed signals, generating data representing the heart sounds therefrom, and transmitting the data to the external system via the interface circuit. The external system includes an interface circuit for communicating with the implantable system, and a control circuit for receiving the data representing the heart sounds and for generating control signals that cause an output device to generate outputs representing the sounds. The implantable system may also include a sensor(s) for detecting cardiac electrical signals. In this case, outputs representing the cardiac electrical signals are also output.

7. 发明授权

US08167811B2 Apparatus and method for outputting heart sounds 有权
标题翻译：用于输出心音的装置和方法
公开(公告)号：US08167811B2
公开(公告)日：2012-05-01
申请号：US13004543
申请日：2011-01-11
申请人： Avram Scheiner , Qingsheng Zhu , Arthur L. Olive , Don Villalta
发明人： Avram Scheiner , Qingsheng Zhu , Arthur L. Olive , Don Villalta
IPC分类号： A61B5/02
CPC分类号： A61B7/04 , A61B5/0002 , A61B5/0031 , A61B5/04012 , A61B5/04014 , A61B5/0402 , A61B5/042 , A61B5/044 , A61B5/0452 , A61B5/1118 , A61B5/742 , A61B7/023 , G06F19/00
摘要： An apparatus for outputting heart sounds includes an implantable system and an external system. The implantable system includes a sensor for generating sensed signals representing detected heart sounds, an interface circuit and a control circuit for receiving the sensed signals, generating data representing the heart sounds therefrom, and transmitting the data to the external system via the interface circuit. The external system includes an interface circuit for communicating with the implantable system, and a control circuit for receiving the data representing the heart sounds and for generating control signals that cause an output device to generate outputs representing the sounds. The implantable system may also include a sensor(s) for detecting cardiac electrical signals. In this case, outputs representing the cardiac electrical signals are also output.
摘要翻译：用于输出心音的装置包括可植入系统和外部系统。可植入系统包括用于产生表示检测到的心音的感测信号的传感器，接口电路和用于接收感测信号的控制电路，产生表示心音的数据，以及经由接口电路将数据发送到外部系统。外部系统包括用于与可植入系统进行通信的接口电路，以及用于接收表示心脏声音的数据的控制电路，以及用于产生使输出设备产生表示声音的输出的控制信号。可植入系统还可以包括用于检测心脏电信号的传感器。在这种情况下，还输出表示心电信号的输出。

8. 发明申请

US20110105933A1 APPARATUS AND METHOD FOR OUTPUTTING HEART SOUNDS 有权
标题翻译：用于输出心脏声音的装置和方法
公开(公告)号：US20110105933A1
公开(公告)日：2011-05-05
申请号：US13004543
申请日：2011-01-11
申请人： Avram Scheiner , Qingsheng Zhu , Arthur L. Olive , Don Villalta
发明人： Avram Scheiner , Qingsheng Zhu , Arthur L. Olive , Don Villalta
IPC分类号： A61B5/02
CPC分类号： A61B7/04 , A61B5/0002 , A61B5/0031 , A61B5/04012 , A61B5/04014 , A61B5/0402 , A61B5/042 , A61B5/044 , A61B5/0452 , A61B5/1118 , A61B5/742 , A61B7/023 , G06F19/00
摘要： An apparatus for outputting heart sounds includes an implantable system and an external system. The implantable system includes a sensor for generating sensed signals representing detected heart sounds, an interface circuit and a control circuit for receiving the sensed signals, generating data representing the heart sounds therefrom, and transmitting the data to the external system via the interface circuit. The external system includes an interface circuit for communicating with the implantable system, and a control circuit for receiving the data representing the heart sounds and for generating control signals that cause an output device to generate outputs representing the sounds. The implantable system may also include a sensor(s) for detecting cardiac electrical signals. In this case, outputs representing the cardiac electrical signals are also output.
摘要翻译：用于输出心音的装置包括可植入系统和外部系统。可植入系统包括用于产生表示检测到的心音的感测信号的传感器，接口电路和用于接收感测信号的控制电路，产生表示心音的数据，以及经由接口电路将数据发送到外部系统。外部系统包括用于与可植入系统进行通信的接口电路，以及用于接收表示心脏声音的数据的控制电路，以及用于产生使输出设备产生表示声音的输出的控制信号。可植入系统还可以包括用于检测心脏电信号的传感器。在这种情况下，还输出表示心电信号的输出。

9. 发明授权

US5423870A Rate responsive cardiac pacemaker 失效
标题翻译：速率响应心脏起搏器
公开(公告)号：US5423870A
公开(公告)日：1995-06-13
申请号：US155482
申请日：1993-11-22
申请人： Arthur L. Olive , Rodney W. Salo
发明人： Arthur L. Olive , Rodney W. Salo
IPC分类号： A61N1/365 , A61N1/36
CPC分类号： A61N1/36585
摘要： A cardiac pacemaker having an automatic pulse rate response gain factor responsive to at least one cardiac-related physiological characteristic of a patient. The pacemaker includes a rate controller that comprises a detector for detecting a plurality of individual measurements of at least one physiological characteristic over each of a plurality of pre-determined time periods, with each of the individual measurements being an average of values detected over each of a respective multiple number of incremental time periods occurring within each of the pre-determined time periods. The pacemaker saves the highest measurement from one incremental time period of each of several consecutive pre-determined time periods, and these highest measurements are averaged. Thereafter, the rate controller adjusts the rate response gain factor or slope of the pulse rate in relation to the physiological characteristic measurement and a pre-determined target pulse rate. In a preferred embodiment, two physiological characteristics are measured, with high values averaged of only one characteristic when that characteristic exceeds a threshold level of the other characteristic. One embodiment is pulse rate responsive to minute volume measurement in combination with accelerometer measurement, with accelerometer measurement requiring a threshold value over an increment of time prior to minute volume recordation for input toward rate response gain factor.
摘要翻译：一种心脏起搏器，其具有响应于患者的至少一个心脏相关生理特征的自动脉搏响应增益因子。起搏器包括速率控制器，其包括用于在多个预定时间段中的每一个上检测至少一个生理特性的多个单独测量值的检测器，其中每个单独测量值是在在每个预定时间周期内出现的相应的多个增量时间段。起搏器从几个连续预定时间段的每个增量时间段节省最高测量值，并对这些最高测量值进行平均。此后，速率控制器相对于生理特征测量和预定的目标脉率调节脉率的速率响应增益因子或斜率。在优选实施例中，测量两个生理特征，当该特征超过另一个特征的阈值水平时，仅测量一个特征的高值。一个实施例是响应于微小体积测量的脉冲速率与加速度计测量结合，加速度计测量需要在微小体积记录之前的时间上增加阈值，以便向速率响应增益因子输入。

10. 发明授权

US5318597A Rate adaptive cardiac rhythm management device control algorithm using trans-thoracic ventilation 失效
标题翻译：使用胸腔通气率自适应心律管理装置控制算法
公开(公告)号：US5318597A
公开(公告)日：1994-06-07
申请号：US31454
申请日：1993-03-15
申请人： John A. Hauck , Arthur L. Olive
发明人： John A. Hauck , Arthur L. Olive
IPC分类号： A61N1/365
CPC分类号： A61N1/36521
摘要： A rate adaptive cardiac rhythm management device in which the pacing rate is adjusted in accordance with changes in the patient's minute ventilation. An adaptive four-pole elliptic digital filter, preferably implemented in software, functions to attenuate any signal components due to cardiac activity and motion from the minute ventilation signal over the range of breathing frequencies encountered in going from a sedentary state to active exercise. The pacemaker incorporates a microprocessor-based controller that is programmed to compute from peak-to-peak excursions of the sensed parameter the instantaneous tidal volume. Likewise, it computes, using a zero-crossing technique, the breathing interval. Knowing the breathing interval and the instantaneous tidal volume, it is possible to compute minute ventilation over a predetermined time interval and it is that factor that is employed in developing the ultimate control signal used to vary the stimulating rate between a lower rate limit and an upper rate limit.
摘要翻译：一种速率自适应心律管理装置，其中根据患者分钟通气的变化调整起搏速率。优选以软件实现的自适应四极椭圆数字滤波器用于在从久坐状态到主动运动中遇到的呼吸频率范围内衰减由于心脏活动和来自分钟通气信号的运动的任何信号分量。起搏器结合了一个基于微处理器的控制器，该控制器被编程为从感测参数的峰 - 峰偏移计算瞬时潮气量。同样，它使用过零技术计算呼吸间隔。了解呼吸间隔和瞬时潮气量，可以在预定的时间间隔内计算每分通气量，并且是用于开发用于改变较低速率限制和上限之间的刺激速率的最终控制信号的因素速率限制。

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