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1. 发明授权

US06547827B2 Method for fixation of biological tissues having mitigated propensity for post-implantation calcification and thrombosis and bioprosthetic devices prepared thereby 有权
标题翻译：用于植入后钙化和血栓形成缓解倾向的生物组织的固定方法和由此制备的生物假体装置
公开(公告)号：US06547827B2
公开(公告)日：2003-04-15
申请号：US09828650
申请日：2001-04-06
申请人： Alain F. Carpentier , Sophie Carpentier , Crystal M. Cunanan , Lillian Quintero , Michael N. Helmus , Christine Loshbaugh , H. Chris Sarner
发明人： Alain F. Carpentier , Sophie Carpentier , Crystal M. Cunanan , Lillian Quintero , Michael N. Helmus , Christine Loshbaugh , H. Chris Sarner
IPC分类号： A61F202
CPC分类号： A61L27/3691 , A61L2/0088 , A61L27/3604 , A61L27/3641 , A61L27/3645 , A61L27/3683 , A61L27/3687 , A61L33/12 , A61L2400/02 , A61L2430/40 , Y10S623/901 , Y10S623/915 , Y10S623/917 , Y10S623/92
摘要： A method for fixation of biological tissues, and bioprosthetic devices prepared by such method. The method generally comprises the steps of A) fixing the tissue, B) treating the tissue with a mixture of i) a denaturant, ii) a surfactant and iii) a crosslinking agent, C) fabricating or forming the bioprosthesis (e.g., forming the tissue and attaching any non-biological components thereto) and D) subjecting the bioprosthesis to terminal sterilization.
摘要翻译：一种用于固定生物组织的方法，以及通过这种方法制备的生物假体装置。该方法通常包括以下步骤：A）固定组织，B）用i）变性剂，ii）表面活性剂和iii）交联剂的混合物处理组织，C）制备或形成生物假体（例如，形成组织并附着任何非生物成分）和D）使生物假体进行终末灭菌。

2. 发明授权

US08236241B2 Treating biological tissues to mitigate post-implantation calcification 有权
标题翻译：治疗生物组织以减轻植入后钙化
公开(公告)号：US08236241B2
公开(公告)日：2012-08-07
申请号：US11744614
申请日：2007-05-04
申请人： Alain F. Carpentier , Sophie Carpentier , Crystal M. Cunanan , Lillian J. Quintero , Michael N. Helmus , Christine Loshbaugh , H. Chris Sarner
发明人： Alain F. Carpentier , Sophie Carpentier , Crystal M. Cunanan , Lillian J. Quintero , Michael N. Helmus , Christine Loshbaugh , H. Chris Sarner
IPC分类号： A61L2/00 , A61F2/02
CPC分类号： A61L27/3691 , A61L2/0088 , A61L27/3604 , A61L27/3641 , A61L27/3645 , A61L27/3683 , A61L27/3687 , A61L33/12 , A61L2400/02 , A61L2430/40 , Y10S623/901 , Y10S623/915 , Y10S623/917 , Y10S623/92
摘要： A method of treating a biological tissue including crosslinking with glutaraldehyde; immersing the biological tissue in a first solution containing glutaraldehyde and heat in the first solution to a temperature of about 50° C. for a first period of time; immersing the biological tissue in a second solution containing a mixture of a crosslinking agent, a denaturing agent and a surfactant; and immersing the biological tissue in a sterilizing solution containing glutaraldehyde and heating the sterilizing solution to a temperature of 37.5±2.5° C. for a sterilizing period of time. The method may include a terminal sterilization step in a method for fixation of biological tissues, and bioprosthetic devices may be prepared by such fixation method. The fixation method may include the steps of A) fixing the tissue, B) treating the tissue with a mixture of i) a denaturant, ii) a surfactant and iii) a crosslinking agent, C) fabricating or forming the bioprosthesis (e.g., forming the tissue and attaching any non-biological components thereto) and D) subjecting the bioprosthesis to the terminal sterilization method.
摘要翻译：一种治疗生物组织的方法，包括用戊二醛交联; 将生物组织浸入含有戊二醛的第一溶液中并在第一溶液中加热至约50℃的温度持续第一时间; 将生物组织浸渍在含有交联剂，变性剂和表面活性剂的混合物的第二溶液中; 将生物体组织浸渍在含有戊二醛的杀菌溶液中并将灭菌液加热至37.5±2.5℃的温度进行杀菌的时间。该方法可以包括用于固定生物组织的方法中的终端灭菌步骤，并且生物假体装置可以通过这种固定方法制备。固定方法可以包括以下步骤：A）固定组织，B）用i）变性剂，ii）表面活性剂和iii）交联剂的混合物处理组织，C）制造或形成生物假体（例如，形成组织并附着任何非生物组分）和D）使生物假体进行终末灭菌方法。

3. 发明授权

US07214344B2 Method for treatment of biological tissues to mitigate post-implantation calcification and thrombosis 有权
标题翻译：用于治疗生物组织以减轻植入后钙化和血栓形成的方法
公开(公告)号：US07214344B2
公开(公告)日：2007-05-08
申请号：US10345120
申请日：2003-01-14
申请人： Alain F. Carpentier , Sophie Carpentier , Crystal M. Cunanan , Lillian J. Quintero , Michael N. Helmus , Christine Loshbaugh , H. Chris Sarner
发明人： Alain F. Carpentier , Sophie Carpentier , Crystal M. Cunanan , Lillian J. Quintero , Michael N. Helmus , Christine Loshbaugh , H. Chris Sarner
IPC分类号： A61L2/00
CPC分类号： A61L27/3691 , A61L2/0088 , A61L27/3604 , A61L27/3641 , A61L27/3645 , A61L27/3683 , A61L27/3687 , A61L33/12 , A61L2400/02 , A61L2430/40 , Y10S623/901 , Y10S623/915 , Y10S623/917 , Y10S623/92
摘要： A method of treating a biological tissue including contacting the biological tissue with an aqueous sterilizing solution, and maintaining the aqueous sterilizing solution at a temperature of about 50° C. for a time period of about 1 to 2 days. The method of treating a biological tissue may be utilized as a terminal sterilization step in a method for fixation of biological tissues, and bioprosthetic devices may be prepared by such fixation method. The fixation method may include the steps of A) fixing the tissue, B) treating the tissue with a mixture of i) a denaturant, ii) a surfactant and iii) a crosslinking agent, C) fabricating or forming the bioprosthesis (e.g., forming the tissue and attaching any non-biological components thereto) and D) subjecting the bioprosthesis to the terminal sterilization method. The aqueous sterilizing solution may be glutaraldehyde of about 0.625 weight percent buffered to a pH of about 7.4.
摘要翻译：一种处理生物组织的方法，包括使生物组织与含水灭菌溶液接触，并将水性杀菌溶液保持在约50℃的温度下约1至2天的时间。生物组织的处理方法可以用作生物组织固定方法中的末端灭菌步骤，并且可以通过这种固定方法制备生物假体装置。固定方法可以包括以下步骤：A）固定组织，B）用i）变性剂，ii）表面活性剂和iii）交联剂的混合物处理组织，C）制造或形成生物假体（例如，形成组织并附着任何非生物组分）和D）使生物假体进行终末灭菌方法。含水灭菌溶液可以是约0.625重量％的戊二醛缓冲至约7.4的pH。

4. 发明申请

US20070255423A1 TREATING BIOLOGICAL TISSUES TO MITIGATE POST-IMPLANTATION CALCIFICATION 有权
标题翻译：治疗生物组织以减轻后植入计算
公开(公告)号：US20070255423A1
公开(公告)日：2007-11-01
申请号：US11744614
申请日：2007-05-04
申请人： Alain Carpentier , Sophie Carpentier , Crystal Cunanan , Lillian Quintero , Michael Helmus , Christine Loshbaugh , H. Chris Sarner
发明人： Alain Carpentier , Sophie Carpentier , Crystal Cunanan , Lillian Quintero , Michael Helmus , Christine Loshbaugh , H. Chris Sarner
IPC分类号： A61F2/02
CPC分类号： A61L27/3691 , A61L2/0088 , A61L27/3604 , A61L27/3641 , A61L27/3645 , A61L27/3683 , A61L27/3687 , A61L33/12 , A61L2400/02 , A61L2430/40 , Y10S623/901 , Y10S623/915 , Y10S623/917 , Y10S623/92
摘要： A method for fixation of biological tissues, and bioprosthetic devices prepared by such method. The method generally comprises the steps of A) fixing the tissue, B) treating the tissue with a mixture of i) a denaturant, ii) a surfactant and iii) a crosslinking agent, C) fabricating or forming the bioprosthesis (e.g., forming the tissue and attaching any non-biological components thereto) and D) subjecting the bioprosthesis to terminal sterilization.
摘要翻译：一种用于固定生物组织的方法，以及通过这种方法制备的生物假体装置。该方法通常包括以下步骤：A）固定组织，B）用i）变性剂，ii）表面活性剂和iii）交联剂的混合物处理组织，C）制备或形成生物假体（例如，形成组织并附着任何非生物成分）和D）使生物假体进行终末灭菌。

5. 发明授权

US06210957B1 Apparatuses for treating biological tissue to mitigate calcification 有权
标题翻译：用于治疗生物组织以减轻钙化的装置
公开(公告)号：US06210957B1
公开(公告)日：2001-04-03
申请号：US09283596
申请日：1999-04-10
申请人： Sophie Carpentier , Alain F. Carpentier , Lillian J. Quintero , Victor S. Packham , Jong H. Wang , Stefan G. Schreck
发明人： Sophie Carpentier , Alain F. Carpentier , Lillian J. Quintero , Victor S. Packham , Jong H. Wang , Stefan G. Schreck
IPC分类号： A01N100
CPC分类号： A61L27/3691 , A61L27/3625 , A61L27/3683 , A61L27/3687 , A61L2400/02 , Y10S623/915
摘要： An apparatus for treating fixed biological tissue to inhibit calcification of the biological tissue following implantation thereof in a mammalian body. The apparatus includes a container for placing the biological tissue in contact with a treatment solution, structure to induce relative tissue/solution movement, and structure to heat the solution. The relative movement may be induced by shaking a container in which the tissue is immersed in the treatment solution, or by stirring the solution within the container. The movement may also be induced by flowing a treatment solution past the tissue to be treated. The tissue may be free to move in the treatment container, or may be restrained from gross movements. The flow may be part of a circulation system having a reservoir, with a heater being provided to heat the treatment solution in the reservoir. Alternatively, a treatment apparatus, including a fluid circulation system if desired, may be enclosed in an incubator. The tissue may be mounted in a planar configuration generally parallel to the direction of fluid flow. A flow column having a plurality of sections divided by perforated baffles may be used to treat multiple tissues at once.
摘要翻译：一种用于在植入哺乳动物体内处理固定生物组织以抑制生物组织钙化的装置。该装置包括用于使生物组织与处理溶液接触的容器，用于诱导相对组织/溶液运动的结构和结构以加热溶液。可以通过将组织浸入处理溶液中的容器摇动或通过搅拌容器内的溶液来诱发相对运动。还可以通过使处理溶液流过要处理的组织来诱导运动。组织可以在治疗容器中自由移动，或者可以抑制粗大运动。流动可以是具有储存器的循环系统的一部分，其中设置加热器以加热储存器中的处理溶液。或者，如果需要，包括流体循环系统的处理装置可以封闭在培养箱中。组织可以安装在大致平行于流体流动方向的平面构造中。可以使用具有被穿孔挡板分开的多个部分的流动柱来一次性处理多个组织。

6. 发明授权

US07029434B2 Methods for treating implantable biological tissues to mitigate post—implantation calcification 失效
标题翻译：用于治疗植入式生物组织以减轻植入后钙化的方法
公开(公告)号：US07029434B2
公开(公告)日：2006-04-18
申请号：US10359479
申请日：2003-02-05
申请人： Sophie Carpentier , Alain F. Carpentier
发明人： Sophie Carpentier , Alain F. Carpentier
IPC分类号： A61F2/04
CPC分类号： A61L27/3687 , A61L27/3604 , A61L2400/02 , Y10S623/915
摘要： A method for treating fixed biological tissue inhibits calcification of the biological tissue following implantation thereof in a mammalian body. The method includes placing the biological tissue in contact with glutaraldehyde and then heating the glutaraldehyde. Alternatively, methods other than heating (e.g., chemical or mechanical means), for effecting polymerization of the glutaraldehyde may also be utilized. Alternatively, the tissue may be heat treated prior to fixing thereof. Alternatively, methods other than glutaraldehyde may also be used for fixing the tissue. The biological tissue may be so treated at any time prior to implantation thereof in a mammalian body.
摘要翻译：用于治疗固定生物组织的方法在植入哺乳动物体内后抑制生物组织的钙化。该方法包括将生物组织与戊二醛接触，然后加热戊二醛。或者，也可以使用加热以外的方法（例如化学或机械方法）来实现戊二醛的聚合。或者，组织可以在其固定之前进行热处理。或者，除了戊二醛之外的方法也可以用于固定组织。生物组织在植入哺乳动物体内之前可以随时进行处理。

7. 再颁专利

USRE40570E1 Apparatuses and methods for treating biological tissue to mitigate calcification 有权
标题翻译：用于治疗生物组织以减轻钙化的装置和方法
公开(公告)号：USRE40570E1
公开(公告)日：2008-11-11
申请号：US10406354
申请日：2003-04-03
申请人： Sophie Carpentier , Alain F. Carpentier , Lillian J. Quintero , Victor S. Packham , Jong H. Wang , Stefan G. Schreck
发明人： Sophie Carpentier , Alain F. Carpentier , Lillian J. Quintero , Victor S. Packham , Jong H. Wang , Stefan G. Schreck
IPC分类号： A61F2/04 , A01N1/00
CPC分类号： A61L27/3691 , A61L27/3687 , A61L2400/02
摘要： An apparatus for treating fixed biological tissue to inhibit calcification of the biological tissue following implantation thereof in a mammalian body. The apparatus includes a container for placing the biological tissue in contact with a treatment solution, structure to induce relative tissue/solution movement, and structure to heat the solution. The relative movement may be induced by shaking a container in which the tissue is immersed in the treatment solution, or by stirring the solution within the container. The movement may also be induced by flowing a treatment solution past the tissue to be treated. The tissue may be free to move in the treatment container, or may be restrained from gross movements. The flow may be part of a circulation system having a reservoir, with a heater being provided to heat the treatment solution in the reservoir. Alternatively, a treatment apparatus, including a fluid circulation system if desired, may be enclosed in an incubator. The tissue may be mounted in a planar configuration generally parallel to the direction of fluid flow. A flow column having a plurality of sections divided by perforated baffles may be used to treat multiple tissues at once.
摘要翻译：一种用于在植入哺乳动物体内处理固定生物组织以抑制生物组织钙化的装置。该装置包括用于使生物组织与处理溶液接触的容器，用于诱导相对组织/溶液运动的结构和结构以加热溶液。可以通过将组织浸入处理溶液中的容器摇动或通过搅拌容器内的溶液来诱发相对运动。还可以通过使处理溶液流过要处理的组织来诱导运动。组织可以在治疗容器中自由移动，或者可以抑制粗大运动。流动可以是具有储存器的循环系统的一部分，其中设置加热器以加热储存器中的处理溶液。或者，如果需要，包括流体循环系统的处理装置可以封闭在培养箱中。组织可以安装在大致平行于流体流动方向的平面构造中。可以使用具有被穿孔挡板分开的多个部分的流动柱来一次性处理多个组织。

8. 发明授权

US5931969A Methods and apparatuses for treating biological tissue to mitigate calcification 失效
标题翻译：用于治疗生物组织以减轻钙化的方法和装置
公开(公告)号：US5931969A
公开(公告)日：1999-08-03
申请号：US874180
申请日：1997-06-13
申请人： Sophie Carpentier , Alain F. Carpentier , Lillian J. Quintero , Victor S. Packham , Jong H. Wang , Stefan G. Schreck
发明人： Sophie Carpentier , Alain F. Carpentier , Lillian J. Quintero , Victor S. Packham , Jong H. Wang , Stefan G. Schreck
IPC分类号： A61L27/00 , A01N1/02 , A61D1/00 , A61L27/36 , A61L2/04 , A61L17/00
CPC分类号： A61L27/3691 , A61L27/3625 , A61L27/3683 , A61L27/3687 , A61L2400/02 , Y10S623/915
摘要： A method for treating fixed biological tissue inhibits calcification of the biological tissue following implantation thereof in a mammalian body. The method includes placing the biological tissue in contact with a treatment solution, inducing relative tissue/solution movement, and heating the solution. The relative movement may be induced by shaking a container in which the tissue is immersed in the treatment solution, or by stirring the solution within the container. The movement may also be induced by flowing a treatment solution past the tissue to be treated. The tissue may be free to move in the treatment container, or may be restrained from gross movements. The flow may be part of a circulation system having a reservoir, with a heater being provided to heat the treatment solution in the reservoir. Alternatively, a treatment apparatus, including a fluid circulation system if desired, may be enclosed in an incubator. The tissue may be mounted in a planar configuration generally parallel to the direction of fluid flow. A flow column having a plurality of sections divided by perforated baffles may be used to treat multiple tissues at once.
摘要翻译：用于治疗固定生物组织的方法在植入哺乳动物体内后抑制生物组织的钙化。该方法包括使生物组织与处理溶液接触，引起相对组织/溶液运动，并加热溶液。可以通过将组织浸入处理溶液中的容器摇动或通过搅拌容器内的溶液来诱发相对运动。还可以通过使处理溶液流过要处理的组织来诱导运动。组织可以在治疗容器中自由移动，或者可以抑制粗大运动。流动可以是具有储存器的循环系统的一部分，其中设置加热器以加热储存器中的处理溶液。或者，如果需要，包括流体循环系统的处理装置可以封闭在培养箱中。组织可以安装在大致平行于流体流动方向的平面构造中。可以使用具有被穿孔挡板分开的多个部分的流动柱来一次性处理多个组织。

9. 发明授权

US4647283A Implantable biological tissue and process for preparation thereof 失效
标题翻译：植入式生物组织及其制备方法
公开(公告)号：US4647283A
公开(公告)日：1987-03-03
申请号：US670786
申请日：1984-11-13
申请人： Alain Carpentier , Sophie Carpentier , Aws S. Nashef
发明人： Alain Carpentier , Sophie Carpentier , Aws S. Nashef
IPC分类号： A01N1/02 , A61F2/24 , A61L26/00 , A61L27/00 , A61L27/36 , A61L33/00 , A61F2/02 , A61F2/06
CPC分类号： A61L27/3687 , A61F2/2412 , A61L2400/02 , Y10S623/918 , Y10S623/92 , Y10S623/922
摘要： A process for the preparation of implantable biological tissue, and in particular bioprosthetic heart valves, which are prone to calcification after implantation. The process includes treatment of tissue with solutions prior to implantation which have been found effective in reducing calcification of the implanted tissue.
摘要翻译：一种用于制备可植入生物组织的方法，特别是生物假体心脏瓣膜，其在植入后易于钙化。该方法包括在植入之前用解决方案处理组织，其已被发现有效减少植入组织的钙化。

10. 发明授权

US4648881A Implantable biological tissue and process for preparation thereof 失效
标题翻译：植入式生物组织及其制备方法
公开(公告)号：US4648881A
公开(公告)日：1987-03-10
申请号：US445345
申请日：1982-11-29
申请人： Alain Carpentier , Sophie Carpentier , Aws S. Nashef
发明人： Alain Carpentier , Sophie Carpentier , Aws S. Nashef
IPC分类号： A01N1/02 , A61F2/24 , A61L26/00 , A61L27/00 , A61L27/36 , A61L33/00 , A61F2/02 , A61F2/06
CPC分类号： A61L27/3687 , A61F2/2412 , A61L2400/02 , Y10S623/918 , Y10S623/92 , Y10S623/922
摘要： A process for the preparation of implantable biological tissue, and in particular bioprosthetic heart valves, which are prone to calcification after implantation. The process includes treatment of tissue with solutions prior to implantation which have been found effective in reducing calcification of the implanted tissue.

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