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1. 发明申请

WO2017095394A1 INTEGRATED SAMPLE PROCESSING SYSTEM 审中-公开
标题翻译：集成的样品处理系统
公开(公告)号：WO2017095394A1
公开(公告)日：2017-06-08
申请号：PCT/US2015/063232
申请日：2015-12-01
申请人： AKONNI BIOSYSTEMS, INC.
发明人： COONEY, Christopher, G. , HOLMBERG, Rebecca , BELGRADER, Phillip , QU, Peter, Qiang
IPC分类号： C12Q1/68 , C40B60/12
CPC分类号： C12Q1/6806 , G01N1/286 , G01N35/0099
摘要： An integrated sample purification system includes a housing, a sample container rack, a filter holder, and a cylindrical magnet. The sample container rack and the filter device holder are disposed in the housing. The sample container rack is configured to hold one or more sample containers, the filter device holder is configured to hold one or more filter devices. The cylindrical magnet is adjacent to and external to the sample container rack, and is rotated about a central, longitudinal axis of the magnet by an electric motor disposed in the housing to lyse cells. Molecules of interest in the lysed cells are purified using filters that bind specifically to the molecules of interest. The system is readily amenable to automation and rapid purification and analysis of molecules of interest, such as nucleic acids and proteins.
摘要翻译：集成式样品净化系统包括外壳，样品容器架，过滤器支架和圆柱形磁体。样本容器架和过滤装置保持器设置在壳体中。样本容器架被配置为保持一个或多个样本容器，过滤装置保持器被配置为保持一个或多个过滤装置。圆柱形磁体邻近样品容器架并在样品容器架的外部，并且通过设置在壳体中的电动马达围绕磁体的中心纵向轴线旋转以溶解细胞。裂解细胞中感兴趣的分子使用特异性结合感兴趣分子的过滤器纯化。该系统很容易进行自动化和快速纯化和分析感兴趣的分子，如核酸和蛋白质。

2. 发明申请

WO2012078863A2 SAMPLE ANALYSIS SYSTEM 审中-公开
标题翻译：样本分析系统
公开(公告)号：WO2012078863A2
公开(公告)日：2012-06-14
申请号：PCT/US2011/063937
申请日：2011-12-08
申请人： AKONNI BIOSYSTEMS , COONEY, Christopher , BELGRADER, Phillip , BUENO, Arial , GARBER, Steve , THAKORE, Nitu, Harshendu , QU, Peter, Qiang
发明人： COONEY, Christopher , BELGRADER, Phillip , BUENO, Arial , GARBER, Steve , THAKORE, Nitu, Harshendu , QU, Peter, Qiang
IPC分类号： G01N33/53 , G01N33/48 , G01N35/08
CPC分类号： B01L3/5025 , B01L3/502715 , B01L3/50855 , B01L7/52 , B01L2200/04 , B01L2200/0678 , B01L2200/16 , B01L2300/044 , B01L2300/0636 , B01L2300/0672 , B01L2300/0819 , B01L2300/0829 , B01L2300/087 , B01L2400/0487 , B01L2400/065 , B01L2400/0683
摘要： An integrated sample analysis system is disclosed. The sample analysis system contains (1) a sample preparation/analysis module having sample purification device comprising a monolith that binds specifically to nucleic acids and a sample analysis device comprising a microarray enclosed in a reaction chamber having a hydrophilic interior surface; (2) a temperature control module comprising a thermocycler having a thermally conductive temperature-control bladder; and (3) an imaging device capable of capturing an image of the microarray in the reaction chamber.
摘要翻译：公开了一种整合的样本分析系统。样品分析系统包含（1）具有样品纯化装置的样品制备/分析模块，样品纯化装置包含与核酸特异性结合的整体柱和样品分析装置，所述样品分析装置包括封装在具有亲水性内表面的反应室中的微阵列; （2）温度控制模块，其包括具有导热温控囊的热循环仪; 和（3）能够捕获反应室中微阵列图像的成像装置。

3. 发明申请

WO2012142397A2 MICROARRAY BASED SAMPLE DETECTION SYSTEM 审中-公开
标题翻译：基于微阵列样本检测系统
公开(公告)号：WO2012142397A2
公开(公告)日：2012-10-18
申请号：PCT/US2012/033498
申请日：2012-04-13
申请人： AKONNI BIOSYSTEMS, INC. , COONEY, Christopher, G. , QU, Peter, Qiang , PEROV, Alexander , PARKER, Jennifer
发明人： COONEY, Christopher, G. , QU, Peter, Qiang , PEROV, Alexander , PARKER, Jennifer
IPC分类号： G01N33/53 , G01N33/538
CPC分类号： C12Q1/6837 , B01J19/0046 , B01J2219/00385 , B01J2219/00576 , B01J2219/00644 , B01J2219/00722 , B01J2219/00725 , B01L3/502715 , B01L2200/026 , B01L2200/0684 , B01L2200/10 , B01L2300/0636 , B01L2300/0681 , B01L2300/069 , B01L2300/0816 , B01L2300/087 , B01L2300/0887 , B01L2300/161 , B01L2400/0406 , C12Q1/68 , G01N1/34 , G01N33/54386
摘要： A microarray assembly for detection of a target molecule is disclosed. The microarray assemblies comprise an array chamber having a microarray located therein and features that facilitate liquid movement within the array chamber. Also disclosed are methods for making the microarray assembly using reliable films and methods for detecting microarray spots using an internal control fiuorophore in the array spot.
摘要翻译：公开了一种用于检测靶分子的微阵列组件。微阵列组件包括具有位于其中的微阵列的阵列室，其特征在于使阵列室内的液体移动。还公开了使用可靠的膜制备微阵列组件的方法和使用阵列斑点中的内部控制荧光团来检测微阵列斑点的方法。

4. 发明申请

WO2015195918A1 MOLECULAR ANALYSIS SYSTEM AND USE THEREOF 审中-公开
标题翻译：分子分析系统及其应用
公开(公告)号：WO2015195918A1
公开(公告)日：2015-12-23
申请号：PCT/US2015/036433
申请日：2015-06-18
申请人： AKONNI BIOSYSTEMS, INC.
发明人： COONEY, Christopher, G. , QU, Peter, Qiang , BUENO, Arial
IPC分类号： B01L7/00
CPC分类号： B01L7/52 , B01L2200/12 , B01L2200/147 , B01L2300/0636 , B01L2300/0819 , B01L2300/1822
摘要： A molecular testing device comprises a heating and cooling module having a thin-film thermoelectric heating and cooling device, and a removable test module having a combined amplification and hybridization reaction chamber. The reaction chamber comprises a thermo-conductive exterior surface and a microarray on an interior surface. The thin-film thermoelectric heating and cooling device has a heat transfer surface that is adapted to make contact with the thermo-conductive exterior surface of the reaction chamber. The molecular testing device may be used to perform a PCR in the reaction chamber.
摘要翻译：分子测试装置包括具有薄膜热电加热和冷却装置的加热和冷却模块，以及具有组合的扩增和杂交反应室的可移除测试模块。反应室包括热导外表面和内表面上的微阵列。薄膜热电加热和冷却装置具有适于与反应室的热导外表面接触的传热表面。分子检测装置可用于在反应室中进行PCR。

5. 发明公开

EP2649447A2 SAMPLE ANALYSIS SYSTEM 审中-公开
标题翻译：样本分析系统
公开(公告)号：EP2649447A2
公开(公告)日：2013-10-16
申请号：EP11847744.7
申请日：2011-12-08
申请人： Akonni Biosystems
发明人： COONEY, Christopher , BELGRADER, Phillip , BUENO, Arial , GARBER, Steve , THAKORE, Nitu, Harshendu , QU, Peter, Qiang
IPC分类号： G01N33/53 , G01N33/48 , G01N35/08
CPC分类号： B01L3/5025 , B01L3/502715 , B01L3/50855 , B01L7/52 , B01L2200/04 , B01L2200/0678 , B01L2200/16 , B01L2300/044 , B01L2300/0636 , B01L2300/0672 , B01L2300/0819 , B01L2300/0829 , B01L2300/087 , B01L2400/0487 , B01L2400/065 , B01L2400/0683
摘要： An integrated sample analysis system is disclosed. The sample analysis system contains (1) a sample preparation/analysis module having sample purification device comprising a monolith that binds specifically to nucleic acids and a sample analysis device comprising a microarray enclosed in a reaction chamber having a hydrophilic interior surface; (2) a temperature control module comprising a thermocycler having a thermally conductive temperature-control bladder; and (3) an imaging device capable of capturing an image of the microarray in the reaction chamber.
摘要翻译：公开了一种综合样本分析系统。样品分析系统包含（1）具有样品纯化装置的样品制备/分析模块，样品纯化装置包含与核酸特异性结合的整体柱和样品分析装置，所述样品分析装置包括封装在具有亲水性内表面的反应室中的微阵列; （2）温度控制模块，其包括具有导热温控囊的热循环仪; 和（3）能够捕获反应室中的微阵列图像的成像装置。

6. 发明公开

EP3425396A2 MICROARRAY BASED SAMPLE DETECTION SYSTEM 审中-公开
公开(公告)号：EP3425396A2
公开(公告)日：2019-01-09
申请号：EP18184553.8
申请日：2012-04-13
申请人： Akonni Biosystems, Inc.
发明人： COONEY, Christopher, G. , QU, Peter, Qiang , PEROV, Alexander , PARKER, Jennifer
IPC分类号： G01N33/53 , G01N33/538 , B01L3/00 , C12Q1/68 , G01N1/34 , B01J19/00 , G01N33/543
摘要： A microarray assembly for detection of a target molecule is disclosed. The microarray assemblies comprise an array chamber having a microarray located therein and features that facilitate liquid movement within the array chamber. Also disclosed are methods for making the microarray assembly using reliable films and methods for detecting microarray spots using an internal control flurophore in the array spot.

7. 发明公开

EP3384042A1 INTEGRATED SAMPLE PROCESSING SYSTEM 审中-公开
公开(公告)号：EP3384042A1
公开(公告)日：2018-10-10
申请号：EP15909910.0
申请日：2015-12-01
申请人： Akonni Biosystems, Inc.
发明人： COONEY, Christopher, G. , HOLMBERG, Rebecca , BELGRADER, Phillip , QU, Peter, Qiang
IPC分类号： C12Q1/68 , C40B60/12
CPC分类号： C12Q1/6806 , G01N1/286 , G01N35/0099
摘要： An integrated sample purification system includes a housing, a sample container rack, a filter holder, and a cylindrical magnet. The sample container rack and the filter device holder are disposed in the housing. The sample container rack is configured to hold one or more sample containers, the filter device holder is configured to hold one or more filter devices. The cylindrical magnet is adjacent to and external to the sample container rack, and is rotated about a central, longitudinal axis of the magnet by an electric motor disposed in the housing to lyse cells. Molecules of interest in the lysed cells are purified using filters that bind specifically to the molecules of interest. The system is readily amenable to automation and rapid purification and analysis of molecules of interest, such as nucleic acids and proteins.

8. 发明公开

EP3549675A1 MOLECULAR ANALYSIS SYSTEM AND USE THEREOF 审中-公开
公开(公告)号：EP3549675A1
公开(公告)日：2019-10-09
申请号：EP19176149.3
申请日：2015-06-18
申请人： Akonni Biosystems, Inc.
发明人： COONEY, Christopher, G. , QU, Peter, Qiang , BUENO, Arial
IPC分类号： B01L7/00
摘要： A molecular testing device comprises a heating and cooling module having a thin-film thermoelectric heating and cooling device, and a removable test module having a combined amplification and hybridization reaction chamber. The reaction chamber comprises a thermo-conductive exterior surface and a microarray on an interior surface. The thin-film thermoelectric heating and cooling device has a heat transfer surface that is adapted to make contact with the thermo-conductive exterior surface of the reaction chamber. The molecular testing device may be used to perform a PCR in the reaction chamber.

9. 发明公开

EP3425396A3 MICROARRAY BASED SAMPLE DETECTION SYSTEM 审中-公开
公开(公告)号：EP3425396A3
公开(公告)日：2019-05-01
申请号：EP18184553.8
申请日：2012-04-13
申请人： Akonni Biosystems, Inc.
发明人： COONEY, Christopher, G. , QU, Peter, Qiang , PEROV, Alexander , PARKER, Jennifer
IPC分类号： G01N33/53 , G01N33/538 , B01L3/00 , C12Q1/68 , G01N1/34 , B01J19/00 , G01N33/543
摘要： A microarray assembly for detection of a target molecule is disclosed. The microarray assemblies comprise an array chamber having a microarray located therein and features that facilitate liquid movement within the array chamber. Also disclosed are methods for making the microarray assembly using reliable films and methods for detecting microarray spots using an internal control flurophore in the array spot.

10. 发明授权

EP2697648B1 MICROARRAY BASED SAMPLE DETECTION SYSTEM 有权
公开(公告)号：EP2697648B1
公开(公告)日：2018-08-22
申请号：EP12771527.4
申请日：2012-04-13
申请人： Akonni Biosystems, Inc.
发明人： COONEY, Christopher, G. , QU, Peter, Qiang , PEROV, Alexander , PARKER, Jennifer
IPC分类号： B01J19/00 , C12Q1/6837 , G01N33/543 , G01N33/53 , G01N33/538 , B01L3/00 , C12Q1/68 , G01N1/34
CPC分类号： C12Q1/6837 , B01J19/0046 , B01J2219/00385 , B01J2219/00547 , B01J2219/00567 , B01J2219/00576 , B01J2219/00644 , B01J2219/00693 , B01J2219/00722 , B01J2219/00725 , B01L3/502715 , B01L2200/026 , B01L2200/0684 , B01L2200/10 , B01L2300/0636 , B01L2300/0681 , B01L2300/069 , B01L2300/0816 , B01L2300/087 , B01L2300/0887 , B01L2300/161 , B01L2400/0406 , C12Q1/68 , G01N1/34 , G01N33/54386
摘要： A microarray assembly for detection of a target molecule is disclosed. The nucroarray assemblies comprise an array chamber having a microarray located therein and features that facilitate liquid movement within the array chamber. Also disclosed are methods for making the microarray assembly using reliable films and methods for detecting microarray spots using an internal control fiuorophore in the array spot.

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