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    • 6. 发明授权
    • Novel rhodamine derivatives for photodynamic therapy of cancer and in
vitro purging of the leukemias
    • 用于光动力治疗癌症和体外清除白血病的新型罗丹明衍生物
    • US5556992A
    • 1996-09-17
    • US300179
    • 1994-09-02
    • Louis GabouryLuc VilleneuveRichard GiassonTiechao LiAjay K. Gupta
    • Louis GabouryLuc VilleneuveRichard GiassonTiechao LiAjay K. Gupta
    • A61K41/00C07D311/82
    • C07D311/82A61K41/0057
    • The present invention relates to novel photoactivable rhodamine derivatives for enhancing high quantum-yield production and singlet oxygen generation upon irradiation with light while maintaining desirable differential retention of rhodamine between normal and cancer cells, said derivatives are selected from the group consisting of 4,5-dibromorhodamine 123 (2-(4,5-dibromo-6-amino-3-imino-3H-xanthen-9-yl)-benzoic acid methyl ester hydrochloride); 4, 5-dibromorhodamine 123 (2-(4,5-dibromo-6-amino-3-imino-3H-xanthen-9-yl)-benzoic acid ethyl ester hydrochloride); 4, 5-dibromorhodamine 123 (2-(4,5-dibromo-6-amino-3-imino-3H-xanthen-9-yl)-benzoic acid octhyl ester hydrochloride); 4,5-dibromorhodamine 110 n-butyl ester (2-(4,5-dibromo-6-amino-3-imino-3H-xanthen-9-yl)-benzoic acid n-butyl ester hydrochloride); Rhodamine B n-butyl ester (2-(6-ethyl amino-3-ethyl imino-3H-xanthen-9-yl)-benzoic acid n-butyl ester hydrochloride); and photoactivable derivatives thereof; whereby photoactivation of the derivatives induces cell killing while unactivated derivatives are substantially non-toxic to cells. Also, the present invention relates to the use of the photoactivable derivatives of the present invention for the photodynamic therapy of a cancer patient by destroying human cancer cells, wherein appropriate intracellular levels of the derivatives are achieved and irradiation with light of a suitable wavelength is applied. The present invention also relates to a method for the photodynamic therapy of a patient suffering from leukemias, disseminated multiple myelomas or lymphomas.
    • 本发明涉及用于在照射光时增强高量子产率产生和单线态氧的新型可光致发光罗丹明衍生物,同时保持罗丹明在正常癌细胞与癌细胞之间的期望差异保留,所述衍生物选自4,5- 二溴罗丹明123(2-(4,5-二溴-6-氨基-3-亚氨基-3H-呫吨-9-基) - 苯甲酸甲酯盐酸盐); 4,5-二溴罗丹明123(2-(4,5-二溴-6-氨基-3-亚氨基-3H-呫吨-9-基) - 苯甲酸乙酯盐酸盐); 4,5-二溴罗丹明123(2-(4,5-二溴-6-氨基-3-亚氨基-3H-呫吨-9-基) - 苯甲酸辛酯盐酸盐); 4,5-二溴罗丹明110正丁基酯(2-(4,5-二溴-6-氨基-3-亚氨基-3H-呫吨-9-基) - 苯甲酸正丁酯盐酸盐); 罗丹明B正丁酯(2-(6-乙基氨基-3-乙基亚氨基-3H-呫吨-9-基) - 苯甲酸正丁酯盐酸盐); 及其可光活化衍生物; 由此衍生物的光活化诱导细胞杀伤,而未活化的衍生物对细胞基本上无毒性。 此外,本发明涉及本发明的可光反应衍生物在癌症患者的光动力治疗中的用途,其通过破坏人类癌细胞,其中实现了衍生物的适当的细胞内水平并且适用于适当波长的光的照射 。 本发明还涉及一种患有白血病,弥散性多发性骨髓瘤或淋巴瘤的患者的光动力疗法的方法。
    • 10. 发明授权
    • High availability data replication of smart large objects
    • 智能大对象的高可用性数据复制
    • US07200620B2
    • 2007-04-03
    • US10674149
    • 2003-09-29
    • Ajay K. Gupta
    • Ajay K. Gupta
    • G06F12/00G06F17/30
    • G06F17/30575Y10S707/99952
    • In a database, a high availability data replicator (28, 46, 48) synchronizes primary and secondary servers (10, 30). A smart large object application program interface (82) resides on the secondary server (30). A cache module (108) creates a memory cache (88) corresponding to a smart large object responsive to a smart large object read operation requested by a client (86). A smart large object read module (110) executes the read operation without acquiring a lock on the corresponding smart large object. An exception module (102) sends an exception to the client (86) responsive to a synchronizing event of the high availability data replicator (28, 46, 48) modifying said smart large object. On the primary server (10), log entries of the modifying operation are ordered so that a log entry updating a large object header of said smart large object is consistent immediately upon execution on the secondary server (30).
    • 在数据库中,高可用性数据复制器(28,46,48)同步主服务器(10,30)。 智能大对象应用程序接口(82)驻留在辅助服务器(30)上。 缓存模块(108)响应于由客户机(86)请求的智能大对象读取操作,创建对应于智能大型对象的存储器高速缓存(88)。 智能大对象读取模块(110)执行读取操作而不获取相应智能大对象上的锁定。 响应于修改所述智能大对象的高可用性数据复制器(28,46,48)的同步事件,异常模块(102)向客户机(86)发送异常。 在主服务器(10)上,修改操作的日志条目被排序,使得更新所述智能大对象的大对象头的日志条目在辅助服务器(30)上执行时立即一致。