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1. 发明专利

AU779358B2 Filter apparatus for ostium of left atrial appendage 未知
公开(公告)号：AU779358B2
公开(公告)日：2005-01-20
申请号：AU1232701
申请日：2000-10-26
申请人： ATRITECH INC , TASSEL ROBERT A VAN , HAUSER ROBERT G , SCHWARTZ ROBERT , HOLMES DAVID , SUTTON GREGG S , BORILLO THOMAS E , WELCH JEFFREY
发明人： TASSEL ROBERT A VAN , HAUSER ROBERT G , SCHWARTZ ROBERT , HOLMES DAVID , SUTTON GREGG S , BORILLO THOMAS E , WELCH JEFFREY
IPC分类号： A61M31/00 , A61B17/00 , A61B17/12 , A61F2/01 , A61L29/00 , A61L31/00
摘要： Apparatus for permanent placement across an ostium of a left atrial appendage in a patient, which includes a filtering membrane configured to extend across the ostium of the left atrial appendage. The filtering membrane has a permeable structure which allows blood to flow through but substantially inhibits thrombus from passing therethrough. The apparatus also includes a support structure attached to the filtering membrane which retains the filtering membrane in position across the ostium of the left atrial appendage by permanently engaging a portion of the interior wall of the left atrial appendage. The support structure may be radially expandable from a first configuration to a second configuration which engages the ostium or the interior wall of the left atrial appendage. The filtering membrane may define an opening therethrough that is configured to expand from a first size which inhibits the passage of thrombus therethrough to a second size which allows an interventional device, e.g., an expansion balloon, to pass therethrough, and wherein the opening is resiliently biased towards the first size.

2. 发明专利

AU1232701A Filter apparatus for ostium of left atrial appendage 未知
公开(公告)号：AU1232701A
公开(公告)日：2001-05-08
申请号：AU1232701
申请日：2000-10-26
申请人： ATRITECH INC , SCHWARTZ ROBERT , HOLMES DAVID , SUTTON GREGG S , BORILLO THOMAS E , WELCH JEFFREY , TASSEL ROBERT A VAN , HAUSER ROBERT G
发明人： TASSEL ROBERT A VAN , HAUSER ROBERT G , SCHWARTZ ROBERT , HOLMES DAVID , SUTTON GREGG S , BORILLO THOMAS E , WELCH JEFFREY
IPC分类号： A61M31/00 , A61B17/00 , A61B17/12 , A61F2/01 , A61L29/00 , A61L31/00
摘要： Apparatus for permanent placement across an ostium of a left atrial appendage in a patient, which includes a filtering membrane configured to extend across the ostium of the left atrial appendage. The filtering membrane has a permeable structure which allows blood to flow through but substantially inhibits thrombus from passing therethrough. The apparatus also includes a support structure attached to the filtering membrane which retains the filtering membrane in position across the ostium of the left atrial appendage by permanently engaging a portion of the interior wall of the left atrial appendage. The support structure may be radially expandable from a first configuration to a second configuration which engages the ostium or the interior wall of the left atrial appendage. The filtering membrane may define an opening therethrough that is configured to expand from a first size which inhibits the passage of thrombus therethrough to a second size which allows an interventional device, e.g., an expansion balloon, to pass therethrough, and wherein the opening is resiliently biased towards the first size.

3. 发明申请

WO0130266A9 FILTER APPARATUS FOR OSTIUM OF LEFT ATRIAL APPENDAGE 审中-公开
标题翻译：过滤装置用于左心室附件
公开(公告)号：WO0130266A9
公开(公告)日：2002-08-15
申请号：PCT/US0029489
申请日：2000-10-26
申请人： ATRITECH INC , VAN TASSEL ROBERT A , HAUSER ROBERT G , SCHWARTZ ROBERT , HOLMES DAVID , SUTTON GREGG S , BORILLO THOMAS E , WELCH JEFFREY
发明人： VAN TASSEL ROBERT A , HAUSER ROBERT G , SCHWARTZ ROBERT , HOLMES DAVID , SUTTON GREGG S , BORILLO THOMAS E , WELCH JEFFREY
IPC分类号： A61M31/00 , A61B17/00 , A61B17/12 , A61F2/01 , A61L29/00 , A61L31/00
CPC分类号： A61F2/01 , A61B17/00234 , A61B17/0057 , A61B17/12122 , A61B17/12136 , A61B17/12159 , A61B17/12172 , A61B2017/00243 , A61B2017/00597 , A61B2017/00619 , A61B2017/00632 , A61B2017/1205 , A61F2002/018 , A61F2230/0006 , A61F2230/005 , A61F2230/0067 , A61F2230/0069 , A61F2230/0076 , A61F2230/0078 , A61F2230/008 , A61F2230/0093
摘要： Apparatus for permanent placement across an ostium of a left atrial appendage in a patient, which includes a filtering membrane configured to extend across the ostium of the left atrial appendage. The filtering membrane has a permeable structure which allows blood to flow through but substantially inhibits thrombus from passing therethrough. The apparatus also includes a support structure attached to the filtering membrane which retains the filtering membrane in position across the ostium of the left atrial appendage by permanently engaging a portion of the interior wall of the left atrial appendage. The support structure may be radially expandable from a first configuration to a second configuration which engages the ostium or the interior wall of the left atrial appendage. The filtering membrane may define an opening therethrough that is configured to expand from a first size which inhibits the passage of thrombus therethrough to a second size which allows an interventional device, e.g., an expansion balloon, to pass therethrough, and wherein the opening is resiliently biased towards the first size.
摘要翻译：用于永久性放置在患者左心耳的口上的装置，其包括配置成延伸穿过左心耳的口的过滤膜。过滤膜具有允许血液流过但可以基本上抑制血栓通过的可渗透结构。该装置还包括附接到过滤膜的支撑结构，其通过永久地接合左心耳内壁的一部分而将过滤膜保持在左心耳的口处的适当位置。支撑结构可以从第一构型径向扩张到接合左心耳的口或内壁的第二构型。过滤膜可以限定穿过其中的开口，其被构造成从阻止血栓通过的第一尺寸膨胀到允许介入装置（例如膨胀气囊）穿过其中的第二尺寸，并且其中开口是弹性的偏向于第一大小。

4. 发明申请

WO2012103556A2 METHODS AND DEVICES FOR TREATING THE LEFT ATRIAL APPENDAGE 审中-公开
标题翻译：用于治疗左心室附件的方法和装置
公开(公告)号：WO2012103556A2
公开(公告)日：2012-08-02
申请号：PCT/US2012023187
申请日：2012-01-30
申请人： TRICARDIA LLC , SCHWARTZ ROBERT S , VAN TASSEL ROBERT A , SUTTON GREGG S , SIMSO ERIC J
发明人： SCHWARTZ ROBERT S , VAN TASSEL ROBERT A , SUTTON GREGG S , SIMSO ERIC J
IPC分类号： A61B17/08
CPC分类号： A61B17/12122 , A61B17/0218 , A61B17/12168 , A61B2017/00243 , A61B2017/00349 , A61B2017/00606 , A61B2017/0237 , A61B2017/12054 , A61B2017/12068 , A61B2017/12095 , A61B2017/22067
摘要： Methods and devices that treat the left atrial appendage by bringing the distal wall of the appendage to a position where the tissue of the wall blocks the ostium, thereby preventing blood from flowing into the appendage. The methods and devices are adapted to create a separation between the distal wall of the appendage and the adjacent pericardium such that the risk of rupturing the pericardium are minimized.
摘要翻译：通过使附肢的远侧壁到达壁的组织阻挡口的位置，从而防止血液流入附属物来治疗左心耳的方法和装置。所述方法和装置适于在附属物的远侧壁和相邻的心包之间产生分离，使得将心包膜破裂的风险最小化。

5. 发明申请

WO0016705A9 VASCULAR FILTER SYSTEM 审中-公开
标题翻译：血管过滤系统
公开(公告)号：WO0016705A9
公开(公告)日：2000-08-17
申请号：PCT/US9912399
申请日：1999-07-20
申请人： ANGIOGUARD INC , YADAV JAY S , SUTTON GREGG S , RAATIKKA AMY , BORILLO THOMAS
发明人： YADAV JAY S , SUTTON GREGG S , RAATIKKA AMY , BORILLO THOMAS
IPC分类号： A61B17/00 , A61B17/22 , A61F2/01
CPC分类号： A61F2/013 , A61B17/22 , A61F2002/011 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/008 , A61F2230/0093
摘要： A removable vascular filter system for blocking micro-emboli, and macro-emboli while allowing the continued perfusion of blood, comprises a filter membrane (20) positioned on a guide wire (10), wherein a free end of the membrane sits tightly against the guide wire when the filter membrane (20) is in a collapsed state. The filter has a means for deploying the filter membrane to assume a position substantially normal to the longitudinal axis of the guide wire. The filter membrane (20) is comprised of a fine mesh material which has a pore size capable of blocking emboli while allowing continued blood flow, and a preferred embodiment of which comprises regularly spaced, laser-formed holes.
摘要翻译：一种可移除的血管过滤器系统，用于在允许血液持续灌注的同时阻塞微栓子和大血栓，包括位于导丝（10）上的过滤膜（20），其中膜的自由端紧紧地当过滤膜（20）处于折叠状态时引导导线。过滤器具有用于展开过滤膜的装置，以采取基本垂直于导丝的纵向轴线的位置。过滤膜（20）由细孔网状材料组成，该细孔材料具有能够阻止栓子同时允许持续血流的孔径，并且其优选实施方式包括规则间隔的激光成形孔。

6. 发明专利

JP2011005292A Filter apparatus for ostium of left atrial appendage 有权
标题翻译：过滤装置用于左心室附件
公开(公告)号：JP2011005292A
公开(公告)日：2011-01-13
申请号：JP2010203790
申请日：2010-09-10
申请人： Atritech Inc , アトリテックインコーポレイテッド
发明人： VAN TASSEL ROBERT A , HAUSER ROBERT G , SCHWARTZ ROBERT , HOLMES DAVID , SUTTON GREGG S , BORILLO THOMAS E , WELCH JEFFREY
IPC分类号： A61B17/00 , A61M31/00 , A61B17/12 , A61F2/01 , A61L29/00 , A61L31/00
CPC分类号： A61F2/01 , A61B17/00234 , A61B17/0057 , A61B17/12122 , A61B17/12136 , A61B17/12159 , A61B17/12172 , A61B2017/00243 , A61B2017/00597 , A61B2017/00619 , A61B2017/00632 , A61B2017/1205 , A61F2002/018 , A61F2230/0006 , A61F2230/005 , A61F2230/0067 , A61F2230/0069 , A61F2230/0076 , A61F2230/0078 , A61F2230/008 , A61F2230/0093
摘要： PROBLEM TO BE SOLVED: To provide an apparatus which is permanently placed across an ostium of a left atrial appendage in a patient.SOLUTION: The apparatus includes a filtering membrane configured to extend across the ostium of the left atrial appendage. The filtering membrane has a permeable structure which allows blood to flow through but substantially inhibits thrombus from passing therethrough. The apparatus also includes a support structure attached to the filtering membrane which retains the filtering membrane in position across the ostium of the left atrial appendage by permanently engaging a portion of the interior wall of the left atrial appendage. The support structure may be radially expandable from a first configuration to a second configuration which engages the ostium or the interior wall of the left atrial appendage. The filtering membrane may define an opening therethrough that is configured to expand from a first size which inhibits the passage of thrombus therethrough to a second size which allows an interventional device to pass therethrough, and wherein the opening is resiliently biased towards the first size.
摘要翻译：要解决的问题：提供一种永久性放置在患者左心耳的口中的装置。解决方案：该装置包括被配置成延伸穿过左心耳的口的过滤膜。过滤膜具有允许血液流过但可以基本上抑制血栓通过的可渗透结构。该装置还包括附接到过滤膜的支撑结构，其通过永久地接合左心耳内壁的一部分而将过滤膜保持在左心耳的口处的适当位置。支撑结构可以从第一构型径向扩张到接合左心耳的口或内壁的第二构型。过滤膜可以限定穿过其中的开口，其被构造成从阻止血栓通过的第一尺寸膨胀到允许介入装置通过的第二尺寸，并且其中开口朝向第一尺寸弹性偏压。

7. 发明专利

CA2441119A1 ATRIAL FILTER IMPLANTS 未知
公开(公告)号：CA2441119A1
公开(公告)日：2002-09-19
申请号：CA2441119
申请日：2002-03-08
申请人： ATRITECH INC
发明人： PETERSON DEAN , WELCH JEFFREY , SUTTON GREGG S
IPC分类号： A61B17/00 , A61B17/12 , A61F2/01 , A61F2/02
摘要： Implant devices for filtering blood flowing through atrial appendage ostiums have elastic cover and anchoring substructures. The substructures may includ e reversibly folding tines or compressible wire braid structures. The devices are folded to fit in catheter tubes for delivery to the atrial appendages. T he devices elastically expand to their natural sizes when they are expelled fro m the catheter tubes. Filter elements in the covers block emboli from escaping through the ostiums. The devices with tine substructures may have H-shaped cross sections. These devices seal the appendages by pinching an annular region of ostium tissue between the cover and the anchoring substructures. T he shallow deployment depth of these H-shaped devices allows use of an universa l device size for atrial appendages of varying lengths. The devices may includ e remotely activated fixtures for refolding the tines for device recovery or position adjustment.

8. 发明专利

CA2388600A1 FILTER APPARATUS FOR OSTIUM OF LEFT ATRIAL APPENDAGE 未知
公开(公告)号：CA2388600A1
公开(公告)日：2001-05-03
申请号：CA2388600
申请日：2000-10-26
申请人： ATRITECH INC
发明人： WELCH JEFFREY , BORILLO THOMAS E , SUTTON GREGG S , SCHWARTZ ROBERT , HAUSER ROBERT G , VAN TASSEL ROBERT A , HOLMES DAVID
IPC分类号： A61M31/00 , A61B17/00 , A61B17/12 , A61F2/01 , A61L29/00 , A61L31/00
摘要： Apparatus for permanent placement across an ostium of a left atrial appendag e in a patient, which includes a filtering membrane configured to extend acros s the ostium of the left atrial appendage. The filtering membrane has a permeable structure which allows blood to flow through but substantially inhibits thrombus from passing therethrough. The apparatus also includes a support structure attached to the filtering membrane which retains the filtering membrane in position across the ostium of the left atrial appendag e by permanently engaging a portion of the interior wall of the left atrial appendage. The support structure may be radially expandable from a first configuration to a second configuration which engages the ostium or the interior wall of the left atrial appendage. The filtering membrane may defin e an opening therethrough that is configured to expand from a first size which inhibits the passage of thrombus therethrough to a second size which allows an interventional device, e.g., an expansion balloon, to pass therethrough, and wherein the opening is resiliently biased towards the first size.

9. 发明申请

WO02071977A3 ATRIAL FILTER IMPLANTS 审中-公开
标题翻译： ATRIAL过滤器
公开(公告)号：WO02071977A3
公开(公告)日：2003-06-26
申请号：PCT/US0207009
申请日：2002-03-08
申请人： ATRITECH INC
发明人： SUTTON GREGG S , PETERSON DEAN , WELCH JEFFREY
IPC分类号： A61B17/00 , A61B17/12 , A61F2/01 , A61F2/02
CPC分类号： A61B17/12045 , A61B17/12022 , A61B17/12122 , A61B17/12172 , A61B2017/00575 , A61B2017/00592 , A61B2017/00597 , A61B2017/00615 , A61B2017/00632 , A61B2017/1205 , A61B2017/12059 , A61B2017/12072 , A61F2/01 , A61F2002/018 , A61F2230/0006 , A61F2230/0076 , A61F2230/008 , A61F2230/0093
摘要： Implant devices for filtering blood flowing through atrial appendage ostiums have elastic cover and anchoring substructures. The substructures may include reversibly folding tines or compressible wire braid structures. The devices are folded to fit in catheter tubes for delivery to the atrial appendages. The devices elastically expand to their natural sizes when they are expelled from the catheter tubes. Filter elements in the covers block emboli from escaping through the ostiums. The devices with tine substructures may have H-shaped cross sections. These devices seal the appendages by pinching an annular region of ostium tissue between the cover and the anchoring substructures. The shallow deployment depth of these H-shaped devices allows use of an universal device size for atrial appendages of varying lengths. The devices may include remotely activated fixtures for refolding the tines for device recovery or position adjustment.
摘要翻译：用于过滤通过心耳附件的血液的植入装置具有弹性覆盖物和锚固子结构。子结构可以包括可逆地折叠齿或可压缩的线编织结构。这些装置被折叠以适合导管，用于递送到心房附件。当装置从导管管排出时，这些装置弹性膨胀至其自然尺寸。过滤元件在盖子阻塞栓塞从逃离通过口。具有叉形结构的装置可具有H形横截面。这些装置通过在盖和锚定子结构之间夹住口腔组织的环形区域来密封附件。这些H型装置的浅部署深度允许使用通用装置尺寸用于不同长度的心房附件。这些装置可以包括用于重新折叠齿的用于装置恢复或位置调整的远程激活的固定装置。

10. 发明申请

WO0215793A3 EXPANDABLE IMPLANT DEVICES FOR FILTERING BLOOD FLOW FROM ATRIAL APPENDAGES 审中-公开
标题翻译：用于从ATRIAL附件过滤血液的可扩展植入装置
公开(公告)号：WO0215793A3
公开(公告)日：2002-08-29
申请号：PCT/US0125920
申请日：2001-08-17
申请人： ATRITECH INC
发明人： BORILLO THOMAS E , PETERSON DEAN , SUTTON GREGG S , WELCH JEFFREY
IPC分类号： A61B17/00 , A61B17/12 , A61F2/01
CPC分类号： A61F2/013 , A61B17/12022 , A61B17/12122 , A61B17/12136 , A61B17/12159 , A61B17/12172 , A61B2017/00575 , A61F2/01 , A61F2002/015 , A61F2002/016 , A61F2002/018 , A61F2230/0006 , A61F2230/0069 , A61F2230/008
摘要： Implant devices for filtering blood flowing through the ostium of an atrial appendage have component structures one or more of which are expandable. Devices with component structures in their unexpanded state have a compact size suitable for intra-cutaneous delivery to an atrial appendage situs. The expandable component structures are expanded in situ to deploy the devices. A device may have sufficiently short axial length so that most or almost all of the device length may fit within the ostium region. An expandable component structure in the device may include a blood-permeable filter element. The device may be deployed so that this component structure covers the ostium so as to direct the blood flow to pass through the filter element. The filter elements used in the devices may have hole size distributions selected to filter out harmful-size emboli. The filter elements may be embedded in elastic material so that hole-size distributions remain substantially unaffected by expansion of the device structures. Anchors attached to a component structure engage tissue surrounding the device and maintain the devices in position. The anchors may include inflatable anchors which engage interior walls of the atrial appendage.
摘要翻译：用于过滤血流通过心房的口的植入装置具有其中一个或多个可膨胀的部件结构。具有未膨胀状态的组件结构的装置具有适合于皮内递送至心房附属部位的紧凑尺寸。可扩展组件结构在现场扩展以部署设备。装置可以具有足够短的轴向长度，使得装置长度的大部分或几乎全部可以适合于口腔区域。该装置中的可扩张组件结构可包括透血过滤元件。该装置可以部署成使得该部件结构覆盖口，以引导血液流过过滤元件。在装置中使用的过滤器元件可以具有选择用于过滤有害尺寸栓塞的孔尺寸分布。过滤元件可以嵌入弹性材料中，使得孔尺寸分布基本上不受设备结构的膨胀的影响。附接到部件结构的锚点接合设备周围的组织并将设备维持在适当位置。锚定器可以包括接合心房内壁附近的充气锚。

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