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1. 发明申请

WO2007009062A2 TREATMENT OF LEG ULCERS USING PLACENTA DERIVED COLLAGEN BIOFABRIC 审中-公开
标题翻译：使用PLACENTA衍生的COLLAGEN BIOFABRIC治疗LEG ULCERS
公开(公告)号：WO2007009062A2
公开(公告)日：2007-01-18
申请号：PCT/US2006027364
申请日：2006-07-12
申请人： ANTHROGENESIS CORP , HARIRI ROBERT J , SMIELL JANICE M
发明人： HARIRI ROBERT J , SMIELL JANICE M
CPC分类号： A61L15/40 , A61F13/069 , A61F15/001 , A61F2013/0054 , A61F2013/00548 , A61F2013/0091 , A61F2013/00927 , A61K31/728 , A61K38/1841 , A61K38/1858 , A61K38/2292 , A61K38/363 , A61K38/39 , A61K38/4833 , A61L15/32 , A61L15/325 , A61L15/44 , A61L26/0033 , A61L26/0057 , A61L27/3604 , A61L27/60 , A61L31/005 , A61L2300/252 , A61L2300/414 , A61L2430/34 , A61L2430/40 , Y10T428/249921 , A61K2300/00
摘要： The present invention provides a method of treating a leg ulcer comprising contacting the leg ulcer with a collagen biofabric. The leg ulcer may be a venous, arterial, diabetic or decubitus (pressure) ulcer. The invention further provides kits comprising one or more pieces of collagen biofabric for the treatment of a leg ulcer.
摘要翻译：本发明提供一种治疗腿部溃疡的方法，包括使腿部溃疡与胶原蛋白生物纤维接触。腿部溃疡可能是静脉，动脉，糖尿病或褥疮（压力）溃疡。本发明还提供了包含一种或多种用于治疗腿部溃疡的胶原生物制品的试剂盒。

2. 发明公开

EP2882847A4 NATURAL KILLER CELLS AND USES THEREOF 审中-公开
标题翻译：自然杀伤细胞和它们的用途
公开(公告)号：EP2882847A4
公开(公告)日：2016-03-23
申请号：EP13829894
申请日：2013-08-13
申请人： ANTHROGENESIS CORP , LAW ERIC , KANG LIN , JANKOVIC VLADIMIR , ZHANG XIAOKUI , ABBOT STEWART , HARIRI ROBERT J
发明人： LAW ERIC , KANG LIN , JANKOVIC VLADIMIR , ZHANG XIAOKUI , ABBOT STEWART , HARIRI ROBERT J
IPC分类号： C12N5/07 , C12N5/078 , C12N5/0783
CPC分类号： C12N5/0646 , A01N1/02 , A61K35/17 , C12N2500/38 , C12N2500/44 , C12N2500/46 , C12N2501/125 , C12N2501/145 , C12N2501/22 , C12N2501/2306 , C12N2501/2307 , C12N2501/2315 , C12N2501/26 , C12N2506/11
摘要： Provided herein are methods of producing natural killer (NK) cells and NK progenitor cell populations using a two-step expansion and differentiation method. Also provided herein are methods of producing populations of NK cells and NK progenitor cell populations using a three-step expansion and differentiation method. Also provided herein are methods of suppressing tumor cell proliferation using the NK cells, the NK cell populations, and the NK progenitor cell populations produced by the methods described herein, as well as methods of treating individuals having cancer or a viral infection, comprising administering the NK cells, the NK cell populations, and the NK progenitor cell populations produced by the methods described herein to an individual having the cancer or viral infection.

3. 发明申请

WO2008051568A2 METHODS AND COMPOSITIONS FOR TREATMENT OF BONE DEFECTS WITH PLACENTAL CELL POPULATIONS 审中-公开
标题翻译：用胎盘细胞群处理骨缺损的方法和组合物
公开(公告)号：WO2008051568A2
公开(公告)日：2008-05-02
申请号：PCT/US2007022545
申请日：2007-10-23
申请人： ANTHROGENESIS CORP , EDINGER JAMES W , HARIRI ROBERT J , WANG JIA-LUN , YE QIAN , LABAZZO KRISTEN S , PEREIRA MARIAN , ABRAMSON SASCHA DAWN
发明人： EDINGER JAMES W , HARIRI ROBERT J , WANG JIA-LUN , YE QIAN , LABAZZO KRISTEN S , PEREIRA MARIAN , ABRAMSON SASCHA DAWN
IPC分类号： A61F2/28 , A61K35/50 , A61L27/38 , A61P19/00 , C12N5/073 , C12N5/074 , C12N5/077
CPC分类号： A61K35/50 , A61K9/0019 , A61K35/12 , A61K47/36 , A61K47/42 , A61L27/3834 , A61L27/3847 , C12N5/0605 , C12N5/0654 , C12N5/0668 , C12N2500/38 , C12N2500/42 , C12N2501/39 , C12N2506/025 , C12N2506/03 , C12N2533/18 , C12N2533/54
摘要： Provided herein are methods of using adherent placental stem cells and placental stem cell populations, and methods of culturing, proliferating and expanding the same. Also provided herein are methods of differentiating the placental stem cells. Further provided herein are methods of using the placental stem cells to formulate implantable or injectable compositions suitable for administration to a subject. Still further provided herein are provides methods for treating bone defects with stem cells and compositions comprising stem cells.
摘要翻译：本文提供了使用贴壁胎盘干细胞和胎盘干细胞群的方法，以及培养，增殖和扩增它们的方法。本文还提供了分化胎盘干细胞的方法。本文进一步提供了使用胎盘干细胞配制适合施用于受试者的可植入或可注射组合物的方法。本文进一步提供了用干细胞和包含干细胞的组合物治疗骨缺损的方法。

4. 发明申请

WO2008100498A3 TREATMENT OF INFLAMMATORY DISEASES USING PLACENTAL STEM CELLS 审中-公开
标题翻译：使用普通干细胞治疗炎症性疾病
公开(公告)号：WO2008100498A3
公开(公告)日：2008-10-30
申请号：PCT/US2008001831
申请日：2008-02-12
申请人： ANTHROGENESIS CORP , EDINGER JAMES W , HARIRI ROBERT J , WANG JIA-LUN , YE QIAN , FALECK HERBERT
发明人： EDINGER JAMES W , HARIRI ROBERT J , WANG JIA-LUN , YE QIAN , FALECK HERBERT
IPC分类号： A61K35/44 , A61K35/50 , A61K35/64 , A61K38/21 , A61P37/06 , C12N5/073
CPC分类号： A61K35/50 , A61K35/644 , A61K38/21 , A61K45/06 , A61K2035/122 , C12N5/0605 , C12N2500/25 , C12N2500/36 , C12N2501/11 , C12N2501/135 , C12N2501/39 , A61K2300/00
摘要： Provided herein are methods of treatment of individuals having an immune-related disease, disorder or condition, for example, inflammatory bowel disease, graft-versus-host disease, multiple sclerosis, rheumatoid arthritis, psoriasis, lupus erythematosus, diabetes, mycosis fungoides (Alibert-Bazin syndrome), or scleroderma using placental stem cells or umbilical cord stem cells.
摘要翻译：本文提供了治疗具有免疫相关疾病，病症或病症的个体的方法，例如炎性肠病，移植物抗宿主病，多发性硬化，类风湿性关节炎，银屑病，红斑狼疮，糖尿病，蕈样真菌病（Alibert -Bazin综合征）或使用胎盘干细胞或脐带干细胞的硬皮病。

5. 发明申请

WO2008051568A9 METHODS AND COMPOSITIONS FOR TREATMENT OF BONE DEFECTS WITH PLACENTAL CELL POPULATIONS 审中-公开
公开(公告)号：WO2008051568A9
公开(公告)日：2008-09-12
申请号：PCT/US2007022545
申请日：2007-10-23
申请人： ANTHROGENESIS CORP , EDINGER JAMES W , HARIRI ROBERT J , WANG JIA-LUN , YE QIAN , LABAZZO KRISTEN S , PEREIRA MARIAN , ABRAMSON SASCHA DAWN
发明人： EDINGER JAMES W , HARIRI ROBERT J , WANG JIA-LUN , YE QIAN , LABAZZO KRISTEN S , PEREIRA MARIAN , ABRAMSON SASCHA DAWN
IPC分类号： A61F2/28 , A61K35/50 , A61L27/38 , A61P19/00 , C12N5/073 , C12N5/074 , C12N5/077
CPC分类号： A61K35/50 , A61K9/0019 , A61K35/12 , A61K47/36 , A61K47/42 , A61L27/3834 , A61L27/3847 , C12N5/0605 , C12N5/0654 , C12N5/0668 , C12N2500/38 , C12N2500/42 , C12N2501/39 , C12N2506/025 , C12N2506/03 , C12N2533/18 , C12N2533/54
摘要： Provided herein are methods of using adherent placental stem cells and placental stem cell populations, and methods of culturing, proliferating and expanding the same. Also provided herein are methods of differentiating the placental stem cells. Further provided herein are methods of using the placental stem cells to formulate implantable or injectable compositions suitable for administration to a subject. Still further provided herein are provides methods for treating bone defects with stem cells and compositions comprising stem cells.

6. 发明申请

WO2007079183A3 PLACENTAL STEM CELL POPULATIONS 审中-公开
标题翻译：单位干细胞群体
公开(公告)号：WO2007079183A3
公开(公告)日：2007-11-15
申请号：PCT/US2006049491
申请日：2006-12-28
申请人： ANTHROGENESIS CORP , ABRAMSON SASCHA DAWN , EDINGER JAMES W , FALECK HERBERT , HARIRI ROBERT J , LABAZZO KRISTEN S , PERIERA MARIAN , WANG JIA-LUN , YE QIAN
发明人： ABRAMSON SASCHA DAWN , EDINGER JAMES W , FALECK HERBERT , HARIRI ROBERT J , LABAZZO KRISTEN S , PERIERA MARIAN , WANG JIA-LUN , YE QIAN
IPC分类号： C12N5/073 , C12N5/0735 , C12N5/074
CPC分类号： A61K35/50 , A61K9/0019 , A61K35/644 , A61K38/21 , A61K45/06 , A61K2035/122 , C12N5/0605 , C12N5/0607 , C12N2500/25 , C12N2500/36 , C12N2500/42 , C12N2501/11 , C12N2501/135 , C12N2501/39 , C12N2533/52 , A61K2300/00
摘要： The present invention provides placental stem cells and placental stem cell populations, and methods of culturing, proliferating and expanding the same. The invention also provides methods of differentiating the placental stem cells. The invention further provides methods of using the placental stem cells in assays and for transplanting.
摘要翻译：本发明提供胎盘干细胞和胎盘干细胞群体，以及培养，增殖和扩增胎盘干细胞的方法。本发明还提供了分离胎盘干细胞的方法。本发明还提供了在测定和移植中使用胎盘干细胞的方法。

7. 发明申请

WO2007047468A3 IMMUNOMODULATION USING PLACENTAL STEM CELLS 审中-公开
标题翻译：利用胎儿干细胞进行免疫调节
公开(公告)号：WO2007047468A3
公开(公告)日：2007-09-13
申请号：PCT/US2006040148
申请日：2006-10-13
申请人： ANTHROGENESIS CORP , PALUDAN CASPER , EDINGER JAMES , HARBACHEUSKI RYHOR , MURRAY ROSEANN , HARIRI ROBERT J
发明人： PALUDAN CASPER , EDINGER JAMES , HARBACHEUSKI RYHOR , MURRAY ROSEANN , HARIRI ROBERT J
IPC分类号： A61K35/50 , A61P37/06 , C12N5/073
CPC分类号： A61K35/50 , C12N5/0605 , C12N5/0668 , C12N2502/11
摘要： The present invention provides methods of immunomodulation using placental stem cells and placental stem cell populations. The invention also provides methods of producing and selecting placental cells and cell populations on the basis of immunomodulation, and compositions comprising such cells and cell populations.
摘要翻译：本发明提供了使用胎盘干细胞和胎盘干细胞群进行免疫调节的方法。本发明还提供了基于免疫调节产生和选择胎盘细胞和细胞群的方法，以及包含这种细胞和细胞群的组合物。

8. 发明申请

WO2014028453A2 NATURAL KILLER CELLS AND USES THEREOF 审中-公开
标题翻译：自然杀伤细胞及其用途
公开(公告)号：WO2014028453A2
公开(公告)日：2014-02-20
申请号：PCT/US2013054677
申请日：2013-08-13
申请人： ANTHROGENESIS CORP , LAW ERIC , KANG LIN , JANKOVIC VLADIMIR , ZHANG XIAOKUI , ABBOT STEWART , HARIRI ROBERT J
发明人： LAW ERIC , KANG LIN , JANKOVIC VLADIMIR , ZHANG XIAOKUI , ABBOT STEWART , HARIRI ROBERT J
IPC分类号： A61K35/18
CPC分类号： C12N5/0646 , A01N1/02 , A61K35/17 , C12N2500/38 , C12N2500/44 , C12N2500/46 , C12N2501/125 , C12N2501/145 , C12N2501/22 , C12N2501/2306 , C12N2501/2307 , C12N2501/2315 , C12N2501/26 , C12N2506/11
摘要： Provided herein are methods of producing natural killer (NK) cells and NK progenitor cell populations using a two-step expansion and differentiation method. Also provided herein are methods of producing populations of NK cells and NK progenitor cell populations using a three-step expansion and differentiation method. Also provided herein are methods of suppressing tumor cell proliferation using the NK cells, the NK cell populations, and the NK progenitor cell populations produced by the methods described herein, as well as methods of treating individuals having cancer or a viral infection, comprising administering the NK cells, the NK cell populations, and the NK progenitor cell populations produced by the methods described herein to an individual having the cancer or viral infection.
摘要翻译：本文提供了使用两步扩增和分化方法产生天然杀伤（NK）细胞和NK祖细胞群体的方法。本文还提供了使用三步扩增和分化方法产生NK细胞和NK祖细胞群的群体的方法。本文还提供了使用本文所述方法产生的NK细胞，NK细胞群和NK祖细胞群抑制肿瘤细胞增殖的方法，以及治疗患有癌症或病毒感染的个体的方法，包括施用 NK细胞，NK细胞群体和通过本文所述方法产生的NK祖细胞群体具有癌症或病毒感染的个体。

9. 发明申请

WO2004047770A3 CYTOTHERAPEUTICS, CYTOTHERAPEUTIC UNITS AND METHODS FOR TREATMENTS USING THEM 审中-公开
标题翻译： CYTOTHERAPEUTICS，CYTOTHERAPEUTIC单位和使用它们进行治疗的方法
公开(公告)号：WO2004047770A3
公开(公告)日：2004-08-19
申请号：PCT/US0338143
申请日：2003-11-25
申请人： ANTHROGENESIS CORP , HARIRI ROBERT J
发明人： HARIRI ROBERT J
IPC分类号： A01N63/00 , A61K35/14 , A61K48/00 , C12N5/00 , C12N5/08 , C12N15/63 , C12N15/00
CPC分类号： A61K35/51 , A61K35/50 , A61K35/54
摘要： The present invention provides cytotherapeutic units comprising predetermined numbers of selected types of potent cells. Assurance of the nature and identities of such cells is achieved through assay and certification of said numbers and identities. Therapeutic modalities are provided. Libraries of cell preparations with assayed and preferably certified populations are preferred and the preparation of cell preparations tailored to specific patients or disease states are provided.
摘要翻译：本发明提供了包含预定数量的选定类型的有效细胞的细胞治疗单位。通过对所述数字和身份的分析和认证来保证这些细胞的性质和特性。提供治疗模式。具有分析的且优选为认证群体的细胞制剂文库是优选的，并且提供了针对特定患者或疾病状态定制的细胞制剂的制备。

10. 发明申请

WO03082201A2 COLLAGEN BIOFABRIC AND METHODS OF PREPARATION AND USE THEREFOR 审中-公开
标题翻译： COLLAGEN BIOFABRIC及其制备和使用方法
公开(公告)号：WO03082201A2
公开(公告)日：2003-10-09
申请号：PCT/US0309304
申请日：2003-03-26
申请人： ANTHROGENESIS CORP , HARIRI ROBERT J , KAPLUNOVSKY ALEKSANDR M , MURPHY PATRICIA A
发明人： HARIRI ROBERT J , KAPLUNOVSKY ALEKSANDR M , MURPHY PATRICIA A
IPC分类号： A61L27/36 , C12N5/00 , A61K
CPC分类号： C12N5/0068 , A61K35/50 , A61L27/3604 , A61L27/3683 , A61L27/3691 , A61L2430/40 , C12N2533/92 , Y10T442/2525
摘要： The present invention relates to collagenous membranes produced from amnion, herein referred to as a collagen biofabric. The collagen biofabric of the invention has the structural integrity of the native non-treated amniotic membrane, i.e., the native tertiary and quaternary structure. The present invention provides a method for preparing a collagen biofabric from a placental membrane, preferably a human placental membrane having a chorionic and amniotic membrane, by decellularizing the amniotic membrane. In a preferred embodiment, the amniotic membrane is completely decellularized. The collagen biofabric of the invention has numerous utilities in the medical and surgical field including for example, blood vessel repair, construction and replacement of a blood vessel, tendon and ligament replacement, wound-dressing, surgical grafts, ophthalmic uses, sutures, and others. The benefits of the biofabric are, in part, due to its physical properties such as biomechanical strength, flexibility, suturability, and low immunogenicity, particularly when derived from human placenta.
摘要翻译：本发明涉及由羊膜制成的胶原膜，本文称为胶原生物制品。本发明的胶原生物制品具有天然未处理的羊膜的结构完整性，即天然的三级和四级结构。本发明提供了通过使羊膜脱细胞从胎盘膜，优选具有绒毛膜和羊膜的人胎盘膜制备胶原蛋白生物制剂的方法。在优选的实施方案中，羊膜完全脱细胞。本发明的胶原蛋白生物制剂在医疗和外科领域中具有许多用途，包括例如血管修复，血管的构造和替换，腱和韧带置换术，伤口敷料，手术移植物，眼用途，缝合线等。生物制品的优点部分是由于其物理性质如生物力学强度，柔韧性，可渗透性和低免疫原性，特别是当衍生自人胎盘时。

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