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1. 发明申请

WO2006057619A1 METHOD AND APPARATUS FOR FORMING MICROSTRUCTURES 审中-公开
标题翻译：用于形成微结构的方法和装置
公开(公告)号：WO2006057619A1
公开(公告)日：2006-06-01
申请号：PCT/SG2004/000374
申请日：2004-11-26
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , TAN, Yuan Ling, Christina , LIM, Chee Yen , XU, Yuan , KAIS, Hbaieb
发明人： LIM, Chee Yen , XU, Yuan , KAIS, Hbaieb
IPC分类号： B26F1/00 , B26F1/14 , B26F1/24
CPC分类号： A61M37/0015 , A61M2037/0053 , B21G1/08 , B21J13/02 , B21K23/00
摘要： A method of micro forming an array of microstructures comprising: advancing a punch having an array of protrusions (620) towards a sheet of material (640) disposed between the punch (620) and a die (630), each protrusion (625) shaped to deform the sheet of material (640) into a corresponding microstructure; providing a holder for holding the sheet of material (640) in place; and punching the sheet of material (640) with the protrusions on the punch (620) to form the array of microstructures on the sheet of material(640).
摘要翻译：一种微观形成微结构阵列的方法，其特征在于，包括：朝向设置在冲头（620）和模具（630）之间的材料片（640）前进具有突起阵列（620）的冲头，每个凸起（625）成形使所述材料片（640）变形成相应的微结构; 提供用于将材料片（640）保持在适当位置的保持器; 以及用所述冲头（620）上的突起冲压所述材料片（640）以在所述材料片（640）上形成所述微结构阵列。

2. 发明申请

WO2005044364A1 MICRONEEDLES AND MICRONEEDLE FABRICATION 审中-公开
标题翻译： MICRONEEDLES和MICRONEEDLE制造
公开(公告)号：WO2005044364A1
公开(公告)日：2005-05-19
申请号：PCT/SG2003/000260
申请日：2003-11-10
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , XU, Yuan , CHEN, Mei Ma , LI, Zhongli , LIM, Chee Yen , TAN, Pei Ying, Joyce
发明人： XU, Yuan , CHEN, Mei Ma , LI, Zhongli , LIM, Chee Yen , TAN, Pei Ying, Joyce
IPC分类号： A61M37/00
CPC分类号： B81C1/00111 , A61M37/0015 , A61M2037/003 , A61M2037/0046 , A61M2037/0053 , B29C33/3878 , B29C33/42 , B29C45/00 , B29C2045/0094 , B29L2031/7544 , B29L2031/756 , B81B2201/055 , B81C2201/034
摘要： A master mould is made by wire cutting a plate in two or more directions to provide a base with an array of master mould needles protruding therefrom. The size and shape of the master mould needles can readily be varied by varying the angles of upward and downward cuts in the two or more directions. The master mould is used to make a secondary mould by hot embossing a secondary mould plate onto the master mould. This forms through-holes inthe secondary mould. The secondary mould is plated with a layer of metal, which forms a microneedle array.
摘要翻译：主模具通过在两个或更多个方向上对板进行线切割来制造，以提供具有从其突出的主模具针阵列的基座。通过改变在两个或更多个方向上的向上和向下切割的角度，可以容易地改变主模具针的尺寸和形状。主模具用于通过将二次模板热压在主模上来制造二次模具。这在二次模具中形成通孔。二次模具镀有一层金属，形成微针阵列。

3. 发明申请

WO2005044342A1 LIQUID HOUSING CHAMBER AND LIQUID DELIVERING DEVICE CONTAINING SUCH CHAMBER 审中-公开
标题翻译：液体室和包含这种室的液体输送装置
公开(公告)号：WO2005044342A1
公开(公告)日：2005-05-19
申请号：PCT/SG2003/000257
申请日：2003-11-07
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , XU, Yuan , LIM, Chee Yen , TAN, Yuan Ling , TAN, Pei Ying
发明人： XU, Yuan , LIM, Chee Yen , TAN, Yuan Ling , TAN, Pei Ying
IPC分类号： A61M5/145
CPC分类号： A61M37/0015 , A61B17/205 , A61M5/14593 , A61M5/155 , A61M2005/14513 , A61M2037/0023 , A61M2037/003
摘要： A liquid housing chamber for use in a device for administering liquid to a subject, said liquid chamber comprising a cavity defined by a base and a surrounding sidewall, said sidewall including an upper rim; a deformable membrane attached to the upper rim and covering said cavity; and an outlet located in the base; wherein said base is inclined from about said outlet to said surrounding sidewall and is formed of a substantially rigid material.
摘要翻译：一种液体容纳室，用于向受试者施用液体的装置，所述液体室包括由基部和周围侧壁限定的空腔，所述侧壁包括上缘; 可变形膜，附接到上边缘并覆盖所述空腔; 和位于基座中的出口; 其中所述基座从大约所述出口倾斜到所述周围的侧壁，并且由基本刚性的材料形成。

4. 发明申请

WO2008027011A1 MICRONEEDLES AND METHODS FOR FABRICATING MICRONEEDLES 审中-公开
标题翻译：麦克风和制备麦克风的方法
公开(公告)号：WO2008027011A1
公开(公告)日：2008-03-06
申请号：PCT/SG2006/000246
申请日：2006-08-28
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , LIM, Chee Yen
发明人： LIM, Chee Yen
IPC分类号： A61M37/00 , A61M5/32
CPC分类号： A61B5/151 , A61B5/14514 , A61B5/150022 , A61B5/150236 , A61B5/150244 , A61B5/150282 , A61B5/150984 , A61B17/205 , A61M37/0015 , A61M2037/003 , A61M2037/0053 , B29C33/3878
摘要： A plastic microneedle comprising: a body portion tapering from a larger end of the body portion towards a tip portion of the body portion; at least one side port; and a lumen extending from the larger end of the body portion and within the body portion of the microneedle, wherein the side port extends into the lumen such that the side port and the lumen are in fluid communication with each other.
摘要翻译：一种塑料微针，包括：主体部分，其从所述主体部分的较大端朝向所述主体部分的尖端部分渐缩; 至少一个侧端口; 以及从所述主体部分的较大端部延伸并且在所述微针的主体部分内延伸的内腔，其中所述侧部端口延伸到所述内腔中，使得所述侧端口和所述内腔彼此流体连通。

5. 发明申请

WO2010016807A1 CONTACTLESS CONDUCTIVITY DETECTOR 审中-公开
标题翻译：无连接电导率检测器
公开(公告)号：WO2010016807A1
公开(公告)日：2010-02-11
申请号：PCT/SG2009/000277
申请日：2009-08-07
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , MAHABADI, Kambiz Ansari , RODRIGUEZ FERNANDEZ, Isabel , LIM, Chee Yen
发明人： MAHABADI, Kambiz Ansari , RODRIGUEZ FERNANDEZ, Isabel , LIM, Chee Yen
IPC分类号： G01N27/07 , B81B7/02 , G01N27/22 , B81B1/00 , G01N27/02
CPC分类号： G01N27/4473 , G01N27/44791
摘要： The contactless conductivity detector in one embodiment includes a microfluidic chip having a channel (102) thereon and four detection electrodes: first and second emitting electrodes (10Oa, 101a), and first and second receiving electrodes (100b, 101b). The channel (102) is defined by channel walls. The first emitting electrode (100a) and the first receiving electrode (100b) are adjacent a first channel wall, and the second emitting electrode (101a) and the second receiving electrode (101b) are adjacent a second channel wall, the second channel wall being opposite the first channel wall.
摘要翻译：一个实施例中的非接触电导检测器包括其上具有通道（102）的微流体芯片和四个检测电极：第一和第二发射电极（100a，101a）以及第一和第二接收电极（100b，101b）。通道（102）由通道壁限定。第一发光电极（100a）和第一接收电极（100b）与第一通道壁相邻，第二发光电极（101a）和第二接收电极（101b）相邻于第二通道壁，第二通道壁为在第一个通道墙对面。

6. 发明申请

WO2009029044A1 A SYSTEM AND METHOD FOR DETECTING SKIN PENETRATION 审中-公开
标题翻译：一种用于检测皮肤渗透的系统和方法
公开(公告)号：WO2009029044A1
公开(公告)日：2009-03-05
申请号：PCT/SG2007/000279
申请日：2007-08-24
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , LIM, Chee Yen , LAI, Szu Cheng
发明人： LIM, Chee Yen , LAI, Szu Cheng
IPC分类号： A61B5/15 , A61B5/053 , A61M5/00
CPC分类号： A61M5/46 , A61B5/0531 , A61B5/150022 , A61B5/150954 , A61B5/150984 , A61B5/415 , A61B5/418 , A61B5/685 , A61M37/0015
摘要： A system and method for detecting skin penetration. The system comprises an invasive component for penetrating the skin; a dummy electrode for making contact with the surface of the skin; at least one penetrating electrode disposed in the invasive component; and a Wheatstone bridge circuit; wherein a resistance across the dummy electrode and the penetrating electrode constitutes one of the resistive legs of the Wheatstone bridge circuit and skin penetration of the invasive component is detected based on a differential output voltage from the Wheatstone bridge circuit.
摘要翻译：用于检测皮肤渗透的系统和方法。该系统包括用于穿透皮肤的侵入性组件; 用于与皮肤表面接触的虚拟电极; 设置在所述侵入性成分中的至少一个穿透电极; 和惠斯登电桥电路; 其中穿过所述虚拟电极和所述穿透电极的电阻构成所述惠斯通电桥电路的电阻支路之一，并且基于所述惠斯通电桥电路的差分输出电压来检测所述侵入性部件的皮肤穿透。

7. 发明公开

EP3148630A1 A FLEXIBLE DISSOLVABLE PATCH 有权转让
标题翻译：灵活的LÖSLICHESPFLASTER
公开(公告)号：EP3148630A1
公开(公告)日：2017-04-05
申请号：EP14893532.3
申请日：2014-05-28
申请人： Lim, Chee Yen
发明人： LIM, Chee Yen , CHIA, Yong Wei , LEE, Wei Siong
IPC分类号： A61M37/00 , A61K9/00
CPC分类号： A61K9/0021 , A61M37/0015 , A61M2037/0046 , A61M2037/0053
摘要： The present invention involves a flexible dissolvable patch, comprising (i) a plurality of microneedles (40) that is made with dissolvable and hard materials, and (ii) a flexible substrate (50) made with non-dissolving and soft materials on which the microneedles are disposed. In particular, the flexible substrate (50) may be made from a tacky silicone gel to provide a natural adhesion to the substrate (50) to further provides self-sealing function so that the drug or dissolving substance which are delivered into the skin are sealed to prevent them from coming off the skin or getting contamination from the environment.
摘要翻译：本发明涉及柔性可溶性贴片，其包括（i）由可溶解和硬质材料制成的多个微针（40），和（ii）由不溶解和软质材料制成的柔性基底（50），其上配置微针。特别地，柔性基底（50）可以由粘性硅凝胶制成，以提供对基底（50）的天然粘合，以进一步提供自密封功能，使得输送到皮肤中的药物或溶解物质被密封防止皮肤脱落或受到环境污染。

8. 发明公开

EP1740256A1 MICRONEEDLES AND MICRONEEDLE FABRICATION 审中-公开
标题翻译：微针和微针生产
公开(公告)号：EP1740256A1
公开(公告)日：2007-01-10
申请号：EP03770215.6
申请日：2003-11-10
申请人： Agency for Science, Technology and Research
发明人： XU, Yuan , CHEN, Mei Ma , LI, Zhongli , LIM, Chee Yen , TAN, Pei Ying, Joyce
IPC分类号： A61M37/00 , B29C33/42
CPC分类号： B81C1/00111 , A61M37/0015 , A61M2037/003 , A61M2037/0046 , A61M2037/0053 , B29C33/3878 , B29C33/42 , B29C45/00 , B29C2045/0094 , B29L2031/7544 , B29L2031/756 , B81B2201/055 , B81C2201/034
摘要： A master mould is made by wire cutting a plate in two or more directions to provide a base with an array of master mould needles protruding therefrom. The size and shape of the master mould needles can readily be varied by varying the angles of upward and downward cuts in the two or more directions. The master mould is used to make a secondary mould by hot embossing a secondary mould plate onto the master mould. This forms through-holes inthe secondary mould. The secondary mould is plated with a layer of metal, which forms a microneedle array.

9. 发明公开

EP2073888A1 MICRONEEDLES AND METHODS FOR FABRICATING MICRONEEDLES 审中-公开
标题翻译：微针和生产微型针叶方法
公开(公告)号：EP2073888A1
公开(公告)日：2009-07-01
申请号：EP06784258.3
申请日：2006-08-28
申请人： Agency for Science Technology and Research
发明人： LIM, Chee Yen
IPC分类号： A61M37/00 , A61M5/32
CPC分类号： A61B5/151 , A61B5/14514 , A61B5/150022 , A61B5/150236 , A61B5/150244 , A61B5/150282 , A61B5/150984 , A61B17/205 , A61M37/0015 , A61M2037/003 , A61M2037/0053 , B29C33/3878
摘要： A plastic microneedle comprising: a body portion tapering from a larger end of the body portion towards a tip portion of the body portion; at least one side port; and a lumen extending from the larger end of the body portion and within the body portion of the microneedle, wherein the side port extends into the lumen such that the side port and the lumen are in fluid communication with each other.

10. 发明申请

WO2018208222A1 PYRAMIDAL MICRONEEDLES WITH ENHANCED DRUG LOADING CAPACITY AND METHOD FOR MANUFACTURING 审中-公开
公开(公告)号：WO2018208222A1
公开(公告)日：2018-11-15
申请号：PCT/SG2017/050243
申请日：2017-05-10
申请人： LIM, Chee Yen
发明人： LIM, Chee Yen
IPC分类号： A61M37/00
摘要： The present invention provides a solution to increase the drug loading capacity and drug delivery precision of dissolving microneedles. These solutions include: (a) increasing the base of the microneedle cavities without substantially changing the microneedle's height and geometry, (b) use of drug suspension and sedimentation of drug by centrifugation, and (c) a specific centrifugation order for filling drug and matrix material. In the first preferred embodiment, a microneedle master mould comprising a plurality of pyramidal microneedles (5100), wherein each of the pyramidal microneedles further comprising a chamfered base (5200) which extends to and adjoins with its neighbouring chamfered bases is provided. In the second preferred embodiment, a method of making dissolving microneedles is provided, comprising (a) providing a microneedle template comprising a plurality of pyramidal microneedle cavities, wherein each of the pyramidal microneedle cavities further comprising a chamfered base which extends to and adjoins with its neighbouring chamfered bases; (b) loading a drug suspension in the substrate cavity on the microneedle template; (c) centrifuging the microneedle template which is loaded with a drug suspension, (d) loading a matrix material solution in the substrate cavity on the microneedle template; (d) centrifuging the microneedle template loaded with the drug suspension and the matrix material solution; and (e) drying the centrifuged microneedle template in a controlled environment.

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