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1. 发明申请

WO2011091213A3 REVERSE AMIDE COMPOUNDS AS PROTEIN DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF 审中-公开
标题翻译：反式酰胺化合物作为蛋白质脱乙酰酶抑制剂及其使用方法
公开(公告)号：WO2011091213A3
公开(公告)日：2011-12-01
申请号：PCT/US2011021982
申请日：2011-01-21
申请人： ACETYLON PHARMACEUTICALS , VAN DUZER JOHN H , MAZITSCHEK RALPH , OGIER WALTER , BRADNER JAMES ELLIOTT , HUANG GUOXIANG , XIE DEJIAN , YU NAN
发明人： VAN DUZER JOHN H , MAZITSCHEK RALPH , OGIER WALTER , BRADNER JAMES ELLIOTT , HUANG GUOXIANG , XIE DEJIAN , YU NAN
IPC分类号： C07D239/42 , A61K31/505 , A61P25/00 , A61P35/00 , C07C233/78
CPC分类号： A61K31/505 , A61K31/164 , A61K31/337 , A61K45/06 , C07C237/36 , C07C259/06 , C07D209/46 , C07D209/48 , C07D213/30 , C07D213/74 , C07D213/81 , C07D235/30 , C07D239/42 , C07D241/20 , C07D263/58 , C07D277/24 , C07D277/82 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D413/04 , C07D417/06
摘要： The present invention relates to novel "reverse amide" compounds comprising a zinc chelator group, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.
摘要翻译：本发明涉及包含锌螯合剂基团的新型“反向酰胺”化合物，以及这些化合物在抑制HDAC6和治疗与HDAC6相关的各种疾病，病症或病症中的用途。

2. 发明专利

CY1118156T1 ΕΝΩΣΕΙΣ ΑΝΤΙΣΤΡΟΦΗΣ ΑΜΙΔΗΣ ΩΣ ΑΝΑΣΤΟΛΕΙΣ ΔΕΑΚΕΤΥΛΑΣΗΣ ΠΡΩΤΕΪΝΩΝ ΚΑΙ ΜΕΘΟΔΟΙ ΧΡΗΣΗΣ ΑΥΤΩΝ 未知
公开(公告)号：CY1118156T1
公开(公告)日：2017-06-28
申请号：CY161101080
申请日：2016-10-26
申请人： ACETYLON PHARMACEUTICALS INC
发明人： VAN DUZER JOHN H , MAZITSCHEK RALPH , OGIER WALTER , BRADNER JAMES ELLIOTT , HUANG GUOXIANG , XIE DEJIAN , YU NAN
IPC分类号： C07D239/42 , A61K31/505 , A61P25/00 , A61P35/00 , C07C233/78
摘要： Ηπαρούσαεφεύρεσηαναφέρεταισεκαινοτόμεςενώσεις «αντίστροφηςαμίδης» πουπεριέχουνμιαψευδαργυρικήομάδαχηλίωσης, καιστηνχρήσητέτοιωνενώσεωνγιατηναναστολήτου HDAC6 καιστηνθεραπευτικήαντιμετώπισηδιαφόρωνασθενειών, διαταραχώνή καταστάσεωνπουσχετίζονταιμετο HDAC6.

3. 发明专利

PL2526093T3 Odwrócone związki amidowe jako inhibitory deacetylazy białkowej oraz sposoby ich stosowania 未知
公开(公告)号：PL2526093T3
公开(公告)日：2017-02-28
申请号：PL11735212
申请日：2011-01-21
申请人： ACETYLON PHARMACEUTICALS INC
发明人： VAN DUZER JOHN H , MAZITSCHEK RALPH , OGIER WALTER , BRADNER JAMES ELLIOTT , HUANG GUOXIANG , XIE DEJIAN , YU NAN
IPC分类号： C07D239/42 , A61K31/505 , A61P25/00 , A61P35/00 , C07C233/78

4. 发明专利

NZ601655A Reverse amide compounds as protein deacetylase inhibitors and methods of use thereof 未知
公开(公告)号：NZ601655A
公开(公告)日：2014-10-31
申请号：NZ60165511
申请日：2011-01-21
申请人： ACETYLON PHARMACEUTICALS INC
发明人： VAN DUZER JOHN H , BRADNER JAMES ELLIOTT , MAZITSCHEK RALPH , OGIER WALTER , XIE DEJIAN , YU NAN , HUANG GUOXIANG
IPC分类号： C07D239/42 , A61K31/505 , A61P25/00 , A61P35/00 , C07C233/78
摘要： Disclosed herein are reverse amide compounds of formula (I), wherein the substituents are as defined within the specification, processes for their preparation, compositions comprising said compounds and uses thereof. Said compounds are useful as protein deacetylase inhibitors (HDAC), particularly HDAC6, as such is useful in the treatment of lung cancer, colon cancer, breast cancer, prostate cancer, liver cancer, pancreas cancer, brain cancer, kidney cancer, ovarian cancer, stomach cancer, skin cancer, bone cancer, gastric cancer, breast cancer, pancreatic cancer, glioma, gliobastoma, hepatocellular carcinoma, papillary renal carcinoma, head and neck squamous cell carcinoma, leukemias, lymphomas, myelomas, solid tumors, Wilson’s disease, spinocerebellar ataxia, prion disease, Parkinson’s disease, Huntington’s disease, amy trophic 15 lateral sclerosis, amyloidosis, Alzheimer’s disease, Alexander’s disease, alcoholic liver disease, cystic fibrosis, Pick’s Disease, spinal muscular dystrophy or Lewy body dementia. Particularly preferred compounds include: 2-(diphenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide; N-(7-(hydroxyamino)-7-oxoheptyl)-4-(phenyl(pyridin-2-yl)amino)benzamide; 4-((2-cyanophenyl)(methyl)amino)-N-(7-(hydroxyamino)-7-oxoheptyl)-N-methylbenzamide; 2-(2,6-dimethylphenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)-N-methylpyrimidine-5-carboxamide; 3-(2,6-dimethylphenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)benzamide; 4-((2,6-dimethylphenyl)(pyrimidin-2-yl)amino)-N-(7-(hydroxyamino)-7-oxoheptyl)-N-methylbenzamide; 4-(ethoxydiphenylmethyl)-N-(7-(hydroxyamino)-7-oxoheptyl)benzamide.

5. 发明专利

SMT201600382B COMPOSTI DI AMMIDE INVERSA COME INIBITORI DI PROTEINA DEACETILASI E METODI PER IL LORO IMPIEGO 未知
公开(公告)号：SMT201600382B
公开(公告)日：2017-01-10
申请号：SM201600382
申请日：2016-10-26
申请人： ACETYLON PHARMACEUTICALS INC
发明人： XIE DEJIAN , HUANG GUOXIANG , BRADNER JAMES ELLIOTT , DUZER JOHN H VAN , YU NAN , MAZITSCHEK RALPH , OGIER WALTER

6. 发明专利

BR112012018246A2 compostos de amida reversa como inibidores de proteína desacetilase e métodos de uso destes 未知
公开(公告)号：BR112012018246A2
公开(公告)日：2016-04-05
申请号：BR112012018246
申请日：2011-01-21
申请人： ACETYLON PHARMACEUTICALS INC
发明人： XIE DEJIAN , HUANG GUOXIANG , BRADNER JAMES ELLIOTT , DUZER JOHN H VAN , YU NAN , MAZITSCHEK RALPH , OGIER WALTER
IPC分类号： A61K31/505 , A61P25/00 , A61P35/00 , C07C233/78 , C07D239/42
摘要： compostos de amida reversa como inibidores de proteína desacetilase e métodos de emprego destes. a presente invenção refere-se a novos compostos de ''amida reversa'' compreendendo um grupo quelante de zinco, e o emprego de tais compostos na inibição de hdac6 e no tratamento de várias doenças. distúrbios ou condições relacionados com hdac6.

7. 发明专利

MX2012008553A COMPUESTOS DE AMIDA INVERSA COMO INHIBIDORES DE PROTEINA DESACETILASA Y METODOS DE USO DE LOS MISMOS. 未知
公开(公告)号：MX2012008553A
公开(公告)日：2012-11-30
申请号：MX2012008553
申请日：2011-01-21
申请人： ACETYLON PHARMACEUTICALS INC
发明人： DUZER JOHN H VAN , XIE DEJIAN , BRADNER JAMES ELLIOT , MAZITSCHEK RALPH , OGIER WALTER , HUANG GUOXIANG , YU NAN
IPC分类号： C07D239/42 , A61K31/505 , A61P25/00 , A61P35/00 , C07C233/78
摘要： La presente invención se refiere a los nuevos compuestos de "amida inversa" que comprenden un grupo quelante de zinc, y el uso de tales compuestos en la inhibición de HDAC6 y en el tratamiento de diversas enfermedades, trastornos o condiciones relacionadas a HDAC6.

8. 发明专利

AU2011207289A1 Reverse amide compounds as protein deacetylase inhibitors and methods of use thereof 未知
公开(公告)号：AU2011207289A1
公开(公告)日：2012-08-16
申请号：AU2011207289
申请日：2011-01-21
申请人： ACETYLON PHARMACEUTICALS INC
发明人： VAN DUZER JOHN H , MAZITSCHEK RALPH , OGIER WALTER , BRADNER JAMES ELLIOTT , HUANG GUOXIANG , XIE DEJIAN , YU NAN
IPC分类号： C07C233/78 , A61K31/505 , A61P25/00 , A61P35/00 , C07D239/42
摘要： The present invention relates to novel "reverse amide" compounds comprising a zinc chelator group, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.

9. 发明专利

RS55227B1 JEDINJENJA REVERZNOG AMIDA KAO INHIBITORI PROTEIN DEACETILAZE I POSTUPCI ZA NJIHOVU UPOTREBU 未知
公开(公告)号：RS55227B1
公开(公告)日：2017-02-28
申请号：RSP20160849
申请日：2011-01-21
申请人： ACETYLON PHARMACEUTICALS INC
发明人： VAN DUZER JOHN H , MAZITSCHEK RALPH , OGIER WALTER , BRADNER JAMES ELLIOTT , HUANG GUOXIANG , XIE DEJIAN , YU NAN
IPC分类号： C07D239/42 , A61K31/505 , A61P25/00 , A61P35/00 , C07C233/78

10. 发明专利

HRP20161367T1 SPOJEVI REVERZNOG AMIDA KAO INHIBITORI PROTEIN DEACETILAZE I POSTUPCI ZA NJIHOVU UPORABU 未知
公开(公告)号：HRP20161367T1
公开(公告)日：2016-12-02
申请号：HRP20161367
申请日：2016-10-19
申请人： ACETYLON PHARMACEUTICALS INC
发明人： VAN DUZER JOHN H , MAZITSCHEK RALPH , OGIER WALTER , BRADNER JAMES ELLIOTT , HUANG GUOXIANG , XIE DEJIAN , YU NAN
IPC分类号： C07D239/42 , A61K31/505 , A61P25/00 , A61P35/00 , C07C233/78

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