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1. 发明申请

WO2009142934A3 COATING COMPRISING AN AMORPHOUS PRIMER LAYER AND A SEMI-CRYSTALLINE RESERVOIR LAYER 审中-公开
标题翻译：包含不规则前置层和半结晶储层的涂层
公开(公告)号：WO2009142934A3
公开(公告)日：2010-09-10
申请号：PCT/US2009043379
申请日：2009-05-08
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , LIM FLORENCIA , TROLLSAS MIKAEL O , HOSSAINY SYED FAIYAZ AHMED , PACETTI STEPHEN D
发明人： LIM FLORENCIA , TROLLSAS MIKAEL O , HOSSAINY SYED FAIYAZ AHMED , PACETTI STEPHEN D
IPC分类号： A61L31/10 , A61L31/14
CPC分类号： A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/604 , A61L2300/606 , Y10T24/258 , C08L67/04
摘要： The present invention provides a coating comprising a reservoir layer comprising a semi-crystalline polymer and a primer layer comprising an amorphous polymer on an implantable device and methods of making and using the same.
摘要翻译：本发明提供一种包含储存层的涂层，其包含半结晶聚合物和在可植入装置上包含无定形聚合物的底漆层，以及制备和使用它的方法。

2. 发明申请

WO2009055426A2 RANDOM AMORPHOUS TERPOLYMER CONTAINING LACTIDE AND GLYCOLIDE 审中-公开
标题翻译：含有乳酸和甘露糖的无规非晶态无纺布
公开(公告)号：WO2009055426A2
公开(公告)日：2009-04-30
申请号：PCT/US2008080719
申请日：2008-10-22
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , PACETTI STEPHEN D , TROLLSAS MIKAEL O , LIM FLORENCIA
发明人： PACETTI STEPHEN D , TROLLSAS MIKAEL O , LIM FLORENCIA
IPC分类号： A61L31/10 , A61L31/16
CPC分类号： A61L31/148 , A61L31/10 , A61L31/16 , A61L2300/00 , C08L67/04
摘要： The present invention provides an amorphous terpolymer for a coating on an implantable device for controlling release of drug and methods of making and using the same.
摘要翻译：本发明提供用于控制药物释放的可植入装置上的涂层的无定形三元共聚物及其制备和使用方法。

3. 发明申请

WO2009149106A3 MICROPARTICLES FOR THE TREATMENT OF DISEASE 审中-公开
标题翻译：治疗疾病的微生物
公开(公告)号：WO2009149106A3
公开(公告)日：2010-12-09
申请号：PCT/US2009046006
申请日：2009-06-02
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , LIM FLORENCIA , TROLLSAS MIKAEL O , NGO MICHAEL H , GLAUSER THIERRY , WAN JINPING
发明人： LIM FLORENCIA , TROLLSAS MIKAEL O , NGO MICHAEL H , GLAUSER THIERRY , WAN JINPING
IPC分类号： A61K9/16
CPC分类号： A61K9/1647 , A61K9/0019 , A61K9/5031
摘要： Microparticle-bioactive agent based treatments for local treatment of diseased tissues/organs are disclosed.
摘要翻译：公开了用于局部治疗病变组织/器官的基于微粒 - 生物活性剂的治疗方法。

4. 发明申请

WO2010002584A3 POLY (ESTER-AMIDE) AND POLY (AMIDE) COATINGS FOR IMPLANTABLE MEDICAL DEVICES FOR CONTROLLED RELEASE OF A PROTEIN OR PEPTIDE AND A HYDROPHOBIC DRUG 审中-公开
标题翻译：用于控制释放蛋白质或肽和疏水性药物的可植入医疗装置的聚（酯 - 酰胺）和聚（酰胺）涂层
公开(公告)号：WO2010002584A3
公开(公告)日：2010-10-07
申请号：PCT/US2009047557
申请日：2009-06-16
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , LIM FLORENCIA , XU XINMIN , MASLANKA BOZENA Z , TROLLSAS MIKAEL O
发明人： LIM FLORENCIA , XU XINMIN , MASLANKA BOZENA Z , TROLLSAS MIKAEL O
IPC分类号： A61L31/10 , A61L31/16
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/252 , A61L2300/602 , A61L2300/606 , C08L77/00
摘要： This invention is generally related to coatings for implantable medical devices, such as drug delivery vascular stents. The coating includes a drug reservoir layer above the outer surface of the device body, the drug reservoir layer with a peptide or protein, a hydrophobic drug, and a polymer with a weight average molecular weight between about 10,000 to about 150,000 Daltons. A preferred polymer is a poly( ester amide) polymer.
摘要翻译：本发明通常涉及用于可植入医疗装置的涂层，例如药物输送血管支架。涂层包括在装置主体的外表面上方的药物储存层，具有肽或蛋白质的药物储存层，疏水性药物和重均分子量在约10,000至约150,000道尔顿之间的聚合物。优选的聚合物是聚（酯酰胺）聚合物。

5. 发明申请

WO2009005909A3 BIODEGRADABLE TRIBLOCK COPOLYMERS FOR IMPLANTABLE DEVICES 审中-公开
标题翻译：用于可植入器件的可生物降解的三嵌段共聚物
公开(公告)号：WO2009005909A3
公开(公告)日：2009-10-22
申请号：PCT/US2008064585
申请日：2008-05-22
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , PACETTI STEPHEN D , TROLLSAS MIKAEL O
发明人： PACETTI STEPHEN D , TROLLSAS MIKAEL O
IPC分类号： A61L29/16 , A61L31/16
CPC分类号： A61L31/10 , A61K31/436 , A61L29/041 , A61L29/16 , A61L31/048 , A61L31/06 , A61L31/16 , A61L2300/606 , A61L2420/00 , C08G81/00
摘要： The present invention is directed to polymeric materials made of biodegradable, bioabsorbable triblock copolymers and implantable devices (e.g., drug-delivery stents) containing such polymeric materials. The polymeric materials may also contain at least one therapeutic substance. The polymeric materials are formulated so as to improve the mechanical and adhesion properties, degradation, biocompatibility and drug permeability of such materials and, thus, implantable devices formed of such materials.
摘要翻译：本发明涉及由可生物降解的，生物可吸收的三嵌段共聚物和含有这种聚合材料的可植入装置（例如药物递送支架）制成的聚合材料。聚合物材料还可含有至少一种治疗物质。配制聚合物材料以改善这些材料的机械和粘合性能，降解，生物相容性和药物渗透性，从而改善由这些材料形成的可植入装置。

6. 发明申请

WO2009126590A2 A COATING COMPRISING POLY (ETHYLENE GLYCOL)-POLY (LACTIDE-GLYCOLIDE-CAPROLACTONE) INTERPENETRATING NETWORK 审中-公开
标题翻译：包含聚（乙二醇） - 酚酸（LACTIDE-GLYCOLIDE-CAPROLACTONE）互连网络的涂料
公开(公告)号：WO2009126590A2
公开(公告)日：2009-10-15
申请号：PCT/US2009039691
申请日：2009-04-06
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , TROLLSAS MIKAEL O , LIM FLORENCIA , HOSSAINY SYED F A
发明人： TROLLSAS MIKAEL O , LIM FLORENCIA , HOSSAINY SYED F A
IPC分类号： A61L31/10
CPC分类号： A61L31/10 , Y10S623/926 , C08L71/02 , C08L67/04
摘要： Methods for fabricating coatings for implantable medical devices are disclosed. The method comprises forming a coating on an implantable device comprising an interpenetrating network or semi-interpenetrating network. The interpenetrating network or semi-interpenetrating network comprises poly(ethylene glycol) and an aliphatic polyester copolymer. It is also provided an implantable device and a method of using the implantable device.
摘要翻译：公开了用于制造可植入医疗装置的涂层的方法。该方法包括在包括互穿网络或半互穿网络的可植入装置上形成涂层。互穿网络或半互穿网络包括聚（乙二醇）和脂族聚酯共聚物。还提供了可植入装置和使用可植入装置的方法。

7. 发明申请

WO2010021883A3 BIOSOLUBLE COATING WITH LINEAR OVER TIME MASS LOSS 审中-公开
标题翻译：具有线性超时间质量损失的BIOSOLUBLE涂层
公开(公告)号：WO2010021883A3
公开(公告)日：2010-10-07
申请号：PCT/US2009053476
申请日：2009-08-11
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , LIM FLORENCIA , NGO MICHAEL H , TROLLSAS MIKAEL O
发明人： LIM FLORENCIA , NGO MICHAEL H , TROLLSAS MIKAEL O
IPC分类号： A61L31/10 , A61L31/14
CPC分类号： A61L31/148 , A61L31/10 , A61L31/16 , A61L2300/604 , A61L2300/606 , C08L71/02
摘要： Implantable devices such as stents having a biosoluble coating with linear over time mass loss are provided. Also disclosed are methods of making and using the implantable device.
摘要翻译：提供可植入装置，例如具有线性随时间质量损失的生物可溶涂层的支架。还公开了制造和使用可植入装置的方法。

8. 发明申请

WO2008103264A2 POLYMER PARTICLES 审中-公开
标题翻译：聚合物颗粒
公开(公告)号：WO2008103264A2
公开(公告)日：2008-08-28
申请号：PCT/US2008001931
申请日：2008-02-13
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , TROLLSAS MIKAEL O , GLAUSER THIERRY , NGO MICHAEL , WAN JINPING
发明人： TROLLSAS MIKAEL O , GLAUSER THIERRY , NGO MICHAEL , WAN JINPING
IPC分类号： A61K47/30
CPC分类号： A61K9/0019 , A61K9/5031 , A61K47/34
摘要： A composition including a solution suitable for introduction into a blood vessel comprising particles comprising a treatment agent and a polymeric product of at least one activated diamine and at least one activated dicarboxylic acid. A method including introducing a delivery device into a blood vessel; and introducing a solution into the blood vessel, the solution comprising particles comprising a treatment agent and a polymeric product of at least one activated diamine and at least one activated dicarboxylic acid, wherein the activated diamine comprises a product of a diol and an amino acid. A method including combining a treatment agent and a polymeric product of at least one activated diamine and at least one activated dicarboxylic acid; and forming particles of the combination suitable for delivery through a blood vessel.
摘要翻译：包含适于引入血管的溶液的组合物，所述溶液包含含有处理剂和至少一种活化二胺和至少一种活化二羧酸的聚合物产物的颗粒。一种方法，包括将输送装置引入血管中; 并将溶液引入血管中，所述溶液包含含有处理剂和至少一种活化二胺和至少一种活化二羧酸的聚合产物的颗粒，其中所述活化二胺包含二醇和氨基酸的产物。一种方法，包括将处理剂和至少一种活化二胺和至少一种活化二羧酸的聚合产物结合; 并形成适合通过血管递送的组合的颗粒。

9. 发明申请

WO2008076771A3 COATINGS OF ACRYLAMIDE-BASED COPOLYMERS 审中-公开
标题翻译：基于丙烯酰胺的共聚物的涂层
公开(公告)号：WO2008076771A3
公开(公告)日：2008-08-07
申请号：PCT/US2007087300
申请日：2007-12-12
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , HOSSAINY SYED FAIYAZ AHMED , GLAUSER THIERRY , TROLLSAS MIKAEL O
发明人： HOSSAINY SYED FAIYAZ AHMED , GLAUSER THIERRY , TROLLSAS MIKAEL O
IPC分类号： A61L31/10 , A61L31/16
CPC分类号： A61K47/32 , A61F2/82 , A61K45/06 , A61K47/65 , A61K47/6957 , A61L31/10 , A61L31/16 , A61L2300/00 , C08L33/26
摘要： An implantable device including conjugate formed of an acrylamide-based copolymer and a bioactive agent is provided.
摘要翻译：提供了包括由丙烯酰胺基共聚物和生物活性剂形成的缀合物的可植入装置。

10. 发明申请

WO2009058694A3 AN IMPLANTABLE DEVICE HAVING A SLOW DISSOLVING POLYMER 审中-公开
标题翻译：具有缓慢溶解聚合物的可植入装置
公开(公告)号：WO2009058694A3
公开(公告)日：2010-04-08
申请号：PCT/US2008081209
申请日：2008-10-24
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , TROLLSAS MIKAEL O , NGO MICHAEL HUY , SHERMAN DAVID J , HOSSAINY SYED F A
发明人： TROLLSAS MIKAEL O , NGO MICHAEL HUY , SHERMAN DAVID J , HOSSAINY SYED F A
IPC分类号： A61L31/10 , A61L31/16
CPC分类号： A61L31/10 , A61K9/5031 , A61K9/5089 , A61K31/33 , A61K31/436 , A61K31/497 , A61K31/56 , A61K38/13 , A61K38/446 , A61K45/06 , A61K47/34 , A61L27/34 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2420/02 , C08L71/02 , C08L67/04
摘要： The present invention provides an implantable device having a coating including a slow dissolving polymer or material and the methods of making and using the same.
摘要翻译：本发明提供具有包含缓慢溶解性聚合物或材料的涂层的可植入装置及其制造和使用方法。

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