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1. 发明公开

EP3583127A1 ANTI-PROGRAMMED DEATH-LIGAND 1 (PD-L1) ANTIBODIES AND THERAPEUTIC USES THEREOF 审中-实审
公开(公告)号：EP3583127A1
公开(公告)日：2019-12-25
申请号：EP17896573.7
申请日：2017-02-16
申请人： Zhang, Ying , Xiangtan Tenghua Bioscience
发明人： ZHANG, Ying
IPC分类号： C07K16/28 , C12N5/10 , A61K39/395 , A61P35/00

2. 发明公开

EP1351699A1 METHODS FOR IMPROVED DIAGNOSIS AND TREATMENT OF MYCOBACTERIAL INFECTIONS 审中-公开
标题翻译：方法的改进的诊断和结核菌感染的治疗
公开(公告)号：EP1351699A1
公开(公告)日：2003-10-15
申请号：EP01987249.8
申请日：2001-12-07
申请人： Zhang, Ying, Dr.
发明人： Zhang, Ying, Dr.
IPC分类号： A61K38/00 , A61K39/00 , A61K39/02 , A61K39/04 , A61K39/38 , A61K49/00 , C07K1/00 , C07K14/00 , C12N1/00 , C12N1/12 , C12N1/20 , C12P1/00
CPC分类号： C12N1/20 , A61K31/20 , A61K31/202 , A61K31/683 , A61K31/685 , A61K35/74 , A61K39/04 , C07K14/35 , C12Q1/045 , G01N2333/35 , Y10S435/863
摘要： Media for growth enhancement and resuscitation of mycobacteria (such as Mycobacterium tuberculosis, Mycobacterium paratuberculosis, and Mycobacterium leprae) are provided. The media comprise isolated cell extract, early-stationary-phase or stationary phase supernatant, or a substantially purified component thereof such as a protein, a peptide fragment of the protein, or a phospholipid. The protein is Rv1147c and the phospholipid or a component of a phospholipid. Diagnostic methods and kits utilizing the media are also provided, as well as treatment methods utilizing spent culture supernatant and cell extracts, or components thereof.

3. 发明专利

ZA202105095B METHOD FOR INVESTIGATING MOLECULAR MECHANISM UNDERLYING HEPATOMA CELL INVASION AND METASTASIS 未知
公开(公告)号：ZA202105095B
公开(公告)日：2021-08-25
申请号：ZA202105095
申请日：2021-07-20
申请人： ZHANG YING , QIN FENG , WANG XIAOLU , SU CHANGQING
发明人： ZHANG YING , QIN FENG , WANG XIAOLU , SU CHANGQING

4. 发明专利

HK1039720A2 A NEW-TYPE WASTE HEAT UTILIZING HOT WATER UNIT 未知
公开(公告)号：HK1039720A2
公开(公告)日：2002-04-19
申请号：HK01108098
申请日：2001-11-16
申请人： ZHAO RU WEN , ZHANG YING HUA
发明人： ZHAO RU WEN , ZHANG YING HUA
IPC分类号： F24F5/00 , F25B6/04 , F25B30/02 , F25B40/04 , F24F

5. 发明公开

EP3589652A1 RECOMBINANT ANTIBODIES TO PROGRAMMED DEATH 1 (PD-1) AND USES THEREFOR 审中-实审
公开(公告)号：EP3589652A1
公开(公告)日：2020-01-08
申请号：EP17900235.7
申请日：2017-03-04
申请人： Xiangtan Tenghua Bioscience , Zhang, Ying
发明人： ZHANG, Ying
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00

6. 发明公开

EP3321371A1 NOVEL METHODS FOR RAPID DRUG SUSCEPTIBILITY TESTING AND DRUG SCREENS FOR GROWING AND NON-GROWING CELLS OF PROKARYOTIC AND EUKARYOTIC ORIGIN 审中-公开
标题翻译：用于快速药物敏感性试验和药物屏障的新方法用于生长和非生长的原核和真核生成细胞
公开(公告)号：EP3321371A1
公开(公告)日：2018-05-16
申请号：EP17159022.7
申请日：2017-03-02
申请人： Zhang, Ying , Feng, Jie , Yee, Rebecca , Zhang, Shuo , Zhang, Wenhong , Wang, Xiaodong
发明人： ZHANG, Ying , FENG, Jie , YEE, Rebecca , ZHANG, Wenhong , ZHANG, Shuo
IPC分类号： C12Q1/18 , G01N33/50
CPC分类号： G01N33/5014 , C12Q1/18 , Y02A50/57
摘要： The presently disclosed subject matter provides methods, compositions, and kits for extremely rapid assessment of drug susceptibility of growing as well as non-growing cells of prokaryotic and also eukaryotic origins, without the need for organism growth, which is in contrast to the current growth-dependent methods.This growth-independent new methodology achieves extremely rapid drug susceptibility testing results previously not possible. Methods for rapidly identifying compounds with inhibitory activity against both growing and non-growing cells in real-time continuous manner with previously unachievable efficiency in drug screens using the novel methodology are also provided. Cell cultures are incubated with a drug or test agent and with a staining mixture containing a first fluorescent dye indicative the emission of which is indicative of live cells (e.g. SYBR Green I) and a second fluorescent dye indicative emitting a different color, the emission of which is indicative of dead cells (e.g. Propidium iodide). The ratio of the intensities of the emitted fluorescence of the dyes is indicative of the percentage live and dead cells in the culture.
摘要翻译：本发明公开的主题提供了方法，组合物和试剂盒，用于非常快速评估原核生物和真核生物起源的生长以及非生长细胞的药物敏感性，而不需要生物体生长，这与目前的生长相反这种独立于生长的新方法实现了以前不可能的极快的药物敏感性测试结果。还提供了用实时连续方式迅速鉴定具有抑制生长和非生长细胞的活性的化合物的方法，以及使用新方法在药物筛选中以前无法实现的效率。将细胞培养物与药物或测试试剂以及含有第一荧光染料和第二荧光染料的染色混合物孵育，所述第一荧光染料指示其发射指示活细胞（例如SYBR Green I），第二荧光染料指示发射不同颜色，这是死细胞的指示（例如碘化丙锭）。染料荧光发射强度的比例表明培养物中活细胞和死细胞的百分比。

7. 发明专利

AU2016408342A1 Filled polyurethane foam having tailored microstructures 未知
公开(公告)号：AU2016408342A1
公开(公告)日：2018-10-25
申请号：AU2016408342
申请日：2016-05-23
申请人： BORAL IP HOLDINGS AUSTRALIA PTY LTD , CROCCO GUY , HILL RUSSELL , LAKROUT HAMED , ZHANG YING
发明人： LAKROUT HAMED , ZHANG YING , CROCCO GUY , HILL RUSSELL
IPC分类号： C08L75/04 , C08G18/72 , C08J9/00 , C08J9/228 , C08K7/14 , C08K7/16 , C08K7/18
摘要： Filled polyurethane foams having tailored microstructures, as well as methods of making these polyurethane foams, are described herein. By tailoring the microstructure of the polyurethane foam, composite materials having desirable mechanical properties (e.g., elastic modulus, compressive strength, or combination thereof) can be obtained.

8. 发明公开

EP1351699A4 METHODS FOR IMPROVED DIAGNOSIS AND TREATMENT OF MYCOBACTERIAL INFECTIONS 审中-公开
标题翻译：方法的改进的诊断和结核菌感染的治疗
公开(公告)号：EP1351699A4
公开(公告)日：2006-07-05
申请号：EP01987249
申请日：2001-12-07
申请人： ZHANG YING DR
发明人： ZHANG YING DR
IPC分类号： A61K38/00 , A61K35/74 , A61K39/00 , A61K39/02 , A61K39/04 , A61K39/38 , A61K49/00 , A61P31/04 , C07K1/00 , C07K14/00 , C07K14/35 , C12N1/00 , C12N1/12 , C12N1/20 , C12Q1/04
CPC分类号： C12N1/20 , A61K31/20 , A61K31/202 , A61K31/683 , A61K31/685 , A61K35/74 , A61K39/04 , C07K14/35 , C12Q1/045 , G01N2333/35 , Y10S435/863
摘要： Media for growth enhancement and resuscitation of mycobacteria (such as Mycobacterium tuberculosis, Mycobacterium paratuberculosis, and Mycobacterium leprae) are provided. The media comprise isolated cell extract, early-stationary-phase or stationary phase supernatant, or a substantially purified component thereof such as a protein, a peptide fragment of the protein, or a phospholipid. The protein is Rv1147c and the phospholipid or a component of a phospholipid. Diagnostic methods and kits utilizing the media are also provided, as well as treatment methods utilizing spent culture supernatant and cell extracts, or components thereof.

9. 发明专利

IL293512A Use of an anti-factor xii antibody for the treatment or prevention of hereditary angioedema 未知
公开(公告)号：IL293512A
公开(公告)日：2022-08-01
申请号：IL29351222
申请日：2022-06-01
申请人： CSL INNOVATION PTY LTD , PRAGST INGO , PAWASKAR DIPTI , YURASZECK THERESA , ZHANG YING
发明人： PRAGST INGO , PAWASKAR DIPTI , YURASZECK THERESA , ZHANG YING
IPC分类号： A61K39/00 , C07K16/36
摘要： The present disclosure relates to methods of treating or preventing hereditary angioedema (HAE) in a subject in need thereof by subcutaneously administering to the subject an effective amount an anti-FXII antibody comprising (i) a VH comprising a CDRH1 comprising a sequence set forth in SEQ ID NO:1; a CDRH2 comprising a sequence set forth in SEQ ID NO:2; and a CDRH3 comprising a sequence set forth in SEQ ID NO:3; and (ii) a VL comprising a CDRL1 comprising a sequence set forth in SEQ ID NO:4; a CDRL2 comprising a sequence set forth in SEQ ID NO:5; and a CDRL3 comprising a sequence set forth in SEQ ID NO:6.

10. 发明专利

AU2016101636A4 VEGETABLE CHOPPER 未知
公开(公告)号：AU2016101636A4
公开(公告)日：2016-10-13
申请号：AU2016101636
申请日：2016-09-15
申请人： ZHANG YING
发明人： ZHANG YING
IPC分类号： B26D3/26 , A47J21/00 , A47J23/00 , A47J25/00 , B26D1/25
摘要： A vegetable chopper comprises: a base, having an upper end surface with a slideway and one end of the base corresponding to the slideway being vertically provided with a tool mounting plate, and the tool mounting plate being formed with a notch; a hand cranking rotary socket, disposed in the slideway in a slidable manner; a fixed blade, corresponding to the notch, fixed on the tool mounting plate; and further comprises: a rotary toolholder, corresponding to the notch, disposed on the tool mounting plate in a rotatable manner, having an outer side being provided with at least two sets of toothed blades in different pitches along the direction of the rotating axis of the rotary toolholder; and, a rotary mechanism, disposed on the base and connected with the rotary toolholder. The vegetable chopper disclosed in the present invention enables it to change its tools simply by rotary knobs, thus enriching its functions and making it easier and safer to access. 121- 12- 11 2 122-\ 41- j 1-7 Figure 1

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