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1. 发明公开

EP2430057A1 TEMPERATURE-RESPONSIVE CO-POLYMERS AND USES THEREOF 有权
标题翻译：温度敏感的聚合物有限公司及其用途
公开(公告)号：EP2430057A1
公开(公告)日：2012-03-21
申请号：EP10720665.8
申请日：2010-05-14
申请人： The University Of Manchester , Yang, Lei
发明人： LU, Jian , YANG, Lei
IPC分类号： C08F220/56 , C08F220/26 , C09D133/26 , C09D143/04 , C12N1/02 , C12N11/08 , C12N5/00
CPC分类号： C09D133/26 , C08F220/26 , C08F220/56 , C08F230/08 , C09D143/04 , C12N1/02 , C12N11/08 , C12N2533/30
摘要： This invention relates to temperature-responsive co-polymers, such as poly(N- isopropylacrylamide -co- hydroxypropyl methacrylate -co- 3-trimethoxysilypropyl methacrylate). The invention also relates to polymeric films formed from these co-polymers and particular applications of these polymeric films, particularly in the cell culture field. More specifically, the present invention relates to the use of these polymeric films in the cell culture field to provide a means of controlling cellular adhesion to, and detachment from, the surface of a cell culture support substrate.

2. 发明专利

IL293862A Single domain antibodies and chimeric antigen receptors targeting bcma and methods of use thereof 未知
公开(公告)号：IL293862A
公开(公告)日：2022-08-01
申请号：IL29386222
申请日：2022-06-13
申请人： NANJING LEGEND BIOTECH CO LTD , FAN XIAOHU , ZHUANG QIUCHUAN , ZHAO YUNCHENG , YANG LEI , FANG XU , XU CHANGMENG
发明人： FAN XIAOHU , ZHUANG QIUCHUAN , ZHAO YUNCHENG , YANG LEI , FANG XU , XU CHANGMENG
IPC分类号： A61K39/00 , A61P35/00 , A61P35/02 , C07K14/725 , C07K16/28
摘要： A chimeric antigen receptor (CAR) comprising a polypeptide comprising an extracellular antigen binding domain comprising a first BCMA binding moiety and a second BCMA binding moiety, wherein the first BCMA binding moiety is a first anti-BCMA single domain antibody, and the second BCMA binding moiety is a second anti-BCMA sdAb; and wherein each of the first and second sdAb is a VHH domain.

3. 发明专利

ES2439281T3 Copolímeros sensibles a la temperatura y usos de los mismos 未知
公开(公告)号：ES2439281T3
公开(公告)日：2014-01-22
申请号：ES10720665
申请日：2010-05-14
申请人： UNIV MANCHESTER , YANG LEI
发明人： LU JIAN , YANG LEI
IPC分类号： C08F220/56 , C08F220/26 , C09D133/26 , C09D143/04 , C12N1/02 , C12N5/00 , C12N11/08
摘要： Un copolímero sensible a la temperatura para formar un recubrimiento de película sobre la superficie de unsustrato de cultivo celular, comprendiendo el copolímero unidades monoméricas hidrófilas sensibles a latemperatura, unidades monoméricas hidrófobas y/o hidrófilas no sensibles a la temperatura y medios de reticulaciónpara unir covalentemente el copolímero a la superficie del sustrato.

4. 发明公开

EP3844659A1 INTERNAL CHANNEL NETWORK DETECTIONS FOR 3D PRINTING 审中-实审
公开(公告)号：EP3844659A1
公开(公告)日：2021-07-07
申请号：EP18933037.6
申请日：2018-09-12
申请人： Siemens Industry Software Inc. , He, Xueqin , Tang, Sheng-Der , Li, Zhi , Chong, Chee-Keong , Wang, Jingmei , Wu, Yunfei , Yang, Lei
发明人： HE, Xueqin , TANG, Sheng-Der , LI, Zhi , CHONG, Chee-Keong , WANG, Jingmei , WU, Yunfei , YANG, Lei
IPC分类号： G06F30/00

5. 发明专利

IL208334A Methods for producing human cardiovascular progenitor cells of cardiomyocytes, endothelial cells and vascular smooth muscle cells 未知
公开(公告)号：IL208334A
公开(公告)日：2015-09-24
申请号：IL20833410
申请日：2010-09-21
申请人： ICAHN SCHOOL MED MOUNT SINAI , KELLER GORDON , YANG LEI , KATTMAN STEVEN
发明人： KELLER GORDON , YANG LEI , KATTMAN STEVEN
IPC分类号： A61K35/12 , C12N5/077
摘要： The present invention provides populations of human cardiovascular progenitor cells, methods of making such cells, and methods of using the cells for production of populations of cardiovascular colonies and populations of cardiomyocytes. Methods of cardiomyocytes replacement therapy are also provided.

6. 发明专利

TWI383961B 用於處理含鹽污水之人工溼地失效
简体标题：用于处理含盐污水之人工湿地
公开(公告)号：TWI383961B
公开(公告)日：2013-02-01
申请号：TW097140914
申请日：2008-10-24
申请人：楊磊 , YANG, LEI , 于嘉順 , YU, CHIA SHUN
发明人：楊磊 , YANG, LEI , 于嘉順 , YU, CHIA SHUN
IPC分类号： C02F9/14 , C02F103/08

7. 发明申请

WO2018178902A1 NITRIC OXIDE-RELEASING POLYAMINOGLYCOSIDES AS BIODEGRADABLE ANTIBACTERIAL SCAFFOLDS AND METHODS PERTAINING THERETO 审中-公开
公开(公告)号：WO2018178902A1
公开(公告)日：2018-10-04
申请号：PCT/IB2018/052144
申请日：2018-03-28
申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , YANG, Lei
发明人： YANG, Lei , SCHOENFISCH, Mark H.
IPC分类号： A61K31/7036 , C12N15/76
摘要： Provided herein are hyperbranched polyaminoglycosides, where in some embodiments, the hyperbranched polyaminoglycosides are covalently modified to store and release nitric oxide. Some embodiments pertain to methods of making and use of hyperbranched polyaminoglycosides. In some embodiments, the covalently modified hyperbranched polyaminoglycosides may be tailored to release nitric oxide in a controlled manner and are useful for eradication of both gram positive and gram negative bacteria as well as other microbes.

8. 发明申请

WO2017111824A1 TWO-DIMENSIONAL ENCOUNTER LOCATION DETECTION 审中-公开
标题翻译：二维入侵者位置检测
公开(公告)号：WO2017111824A1
公开(公告)日：2017-06-29
申请号：PCT/US2015/000382
申请日：2015-12-26
申请人： INTEL CORPORATION , CHEN, Yi, Lin , PARK, Mi, Sun , YANG, Shao-Wen , YANG, Lei
发明人： CHEN, Yi, Lin , PARK, Mi, Sun , YANG, Shao-Wen , YANG, Lei
IPC分类号： G01S1/02 , G01S5/02
CPC分类号： G01S5/02 , G01S11/06
摘要： Sensors provisioned on a first device detect a movement of the first device corresponding to the first device changing position within an environment. Location information for the first device is updated based on the position change. A plurality of signals are detected, at the first device, from a second device in the environment, determine, and a distance between the first and second devices is determined based on each of the signals. From the signals, another change in position of the first device within the environment is determined and the location information updated for the first device. The movement is detected at the first device at an instance between two of the plurality of signals, and location information for the first device based on the first position change is updated prior to detection of the later of the two signals in the plurality of signals.
摘要翻译：在第一设备上提供的传感器检测第一设备在环境内对应于第一设备改变位置的移动。第一个设备的位置信息根据位置变化进行更新。在第一设备处从环境中的第二设备检测多个信号，并且基于每个信号确定第一和第二设备之间的距离。根据这些信号，确定环境内第一设备的位置的另一个变化，并且为第一设备更新位置信息。在多个信号中的两个信号之间的实例中在第一设备处检测该移动，并且在检测到多个信号中的两个信号中的较晚的信号之前更新基于第一位置改变的第一设备的位置信息。

9. 发明申请

WO2014152339A1 TIME AND ENVIRONMENT AWARE GRAPHICAL DISPLAYS FOR DRIVER INFORMATION AND DRIVER ASSISTANCE SYSTEMS 审中-公开
标题翻译：时间和环境指导用于驾驶员信息和驾驶员辅助系统的图形显示
公开(公告)号：WO2014152339A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/027229
申请日：2014-03-14
申请人： ROBERT BOSCH GMBH , REN, Liu , YANG, Lei
发明人： REN, Liu , YANG, Lei
IPC分类号： G06T15/00
CPC分类号： G01C21/3638
摘要： A graphics display system for driver information and driver assistance applications generates controllable and dynamic graphical effects in conjunction with 3D visualization of maps. The system generates a display of a map in a 3D virtual environment that responds to the environment changes in a dynamic and visually intuitive manner for a vehicle operator. The system processes environment information, including lighting condition, weather condition, and other data acquired from different sensors in the vehicle such as cameras and lighting sensors, or through networked information services. The graphics display can be integrated with different driver information and driver assistance system embodiments including mobile platforms, in- vehicle information systems, web platforms, and PC systems.
摘要翻译：用于驾驶员信息和驾驶员辅助应用的图形显示系统与地图的3D可视化一起产生可控和动态的图形效果。系统在3D虚拟环境中生成对于车辆操作者以动态和视觉直观的方式响应于环境变化的地图的显示。该系统处理环境信息，包括照明条件，天气条件以及从诸如照相机和照明传感器之类的车辆中的不同传感器获得的其它数据，或通过联网信息服务。图形显示可以与不同的驱动程序信息和驾驶员辅助系统实施例集成，包括移动平台，车载信息系统，网络平台和PC系统。

10. 发明申请

WO2013059014A1 RATE-DISTORTION-COMPLEXITY OPTIMIZATION OF VIDEO ENCODING 审中-公开
标题翻译：视频编码的失真复杂度优化
公开(公告)号：WO2013059014A1
公开(公告)日：2013-04-25
申请号：PCT/US2012/059192
申请日：2012-10-08
申请人： GOOGLE INC. , YANG, Lei , MUKHERJEE, Debargha
发明人： YANG, Lei , MUKHERJEE, Debargha
IPC分类号： H04N21/2662 , H04N21/234
CPC分类号： H04N19/154 , H04N19/10 , H04N19/115 , H04N19/127 , H04N19/147 , H04N19/15 , H04N19/152 , H04N19/192 , H04N19/194 , H04N19/40 , H04N21/2662 , H04N21/2743
摘要： A system and method provide a video coding system for optimizing encoding bitrate, distortion and complexity for a video hosting service. The system comprises an encoding module configured to encode multiple videos with a bitrate control strategy, a pair of complexity allocation control parameters and one or more target output video formats specifications, which include target resolution, target bitrate and target quality information. The encoding module obtains encoding bitrate, distortion and complexity performance samples from the encoding. From the encoding bitrate, distortion and complexity performance samples, the encoding module is configured to select optimal encoding bitrate, distortion and complexity performance samples. The encoding computation profile mapping module is configured to obtain multiple computation levels from the optimal encoding bitrate, distortion and complexity performance samples. For each computational level, a pair of optimized complexity allocation control parameters and number of encoding passes are selected.
摘要翻译：系统和方法提供用于优化视频托管服务的编码比特率，失真和复杂度的视频编码系统。该系统包括编码模块，其被配置为利用比特率控制策略，一对复杂度分配控制参数和一个或多个目标输出视频格式规范来编码多个视频，其包括目标分辨率，目标比特率和目标质量信息。编码模块从编码中获得编码比特率，失真和复杂度性能样本。从编码比特率，失真和复杂度性能样本中，编码模块被配置为选择最佳编码比特率，失真和复杂度性能样本。编码计算简档映射模块被配置为从最佳编码比特率，失真和复杂度性能样本获得多个计算级别。对于每个计算级别，选择一对优化的复杂度分配控制参数和编码遍数。

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