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1. 发明申请

US20080298401A1 Device and Method for Creating a Spatial Dose Distribution in a Medium Volume 有权
标题翻译：在中等体积中创建空间剂量分布的装置和方法
公开(公告)号：US20080298401A1
公开(公告)日：2008-12-04
申请号：US11996292
申请日：2006-07-20
申请人： Jerome Faure , Yannick Glinec , Malka Victor , Thomas Fuchs , Hanitra Szymanowski , Uwe Oelfke
发明人： Jerome Faure , Yannick Glinec , Malka Victor , Thomas Fuchs , Hanitra Szymanowski , Uwe Oelfke
IPC分类号： H01S3/098
CPC分类号： H05H6/00 , A61N5/1084 , A61N2005/1088 , A61N2005/1089
摘要： A device and a method for creating a spatial dose distribution in a medium volume (22) are described. A laser system produces laser pulses (12) with a pulse length shorter than 200 fs (femtoseconds) and is capable to be focused to peak intensities greater than 10̂18 W/cm̂2 (watts per centimeter squared). An electron source (18) is capable of releasing a high-energy electron pulse (20), in particular the electrons having an energy greater than 100 MeV, upon irradiation with said laser pulses (12) propagating into the medium volume (22). The light paths (52, 56,58) of at least some of the laser pulses (12) are adjustable in such a way that high-energy electron pulses (20) are emitted from the irradiated at least one electron source on different trajectories (20,28,60,62) through the medium volume (22) thereby depositing their dose in the medium volume (22) according to a provided pattern.
摘要翻译：描述了用于在介质体积（22）中创建空间剂量分布的装置和方法。激光系统产生脉冲长度短于200fs（飞秒）的激光脉冲（12），并且能够聚焦到大于1018W / cm 2（瓦/厘米平方）的峰值强度。电子源（18）能够在照射传播到介质体积（22）中的所述激光脉冲（12）时释放高能电子脉冲（20），特别是能量大于100MeV的电子。至少一些激光脉冲（12）的光路（52,56,58）可以这样调节，使得高能电子脉冲（20）从辐射的至少一个电子源在不同的轨迹上发射（ 20,28,60,62），从而根据提供的图案将其剂量沉积在介质体积（22）中。

2. 发明授权

US08183541B2 Inverse treatment planning method 有权
标题翻译：逆治疗计划方法
公开(公告)号：US08183541B2
公开(公告)日：2012-05-22
申请号：US12223712
申请日：2007-02-02
申请人： Jan Wilkens , Uwe Oelfke
发明人： Jan Wilkens , Uwe Oelfke
IPC分类号： G21K5/04
CPC分类号： A61N5/1031 , A61N5/1042 , A61N2005/1087
摘要： The invention relates to a radiation treatment apparatus and an inverse treatment planning method for intensity modulated particle therapy for the treatment of a target within a biological system using at least two fields, each field comprising a plurality of Bragg peaks, the at least two fields being planned to place a defined number of beam spots j from different directions with certain weights wj within the target. The inverse treatment planning method optimizes the weights wj of the beam spots for the at least two fields simultaneously in order to produce a prescribed biological effect within the target by minimizing an objective function based on biological effects ε, the biological effects ε being treated in a linear-quadratic model, which describes the biological effects in the target by two parameters α and β, where ε=αD+βD2, D denoting a dose, and wherein the two parameters α and β for each voxel i of the target (αi and βi) are calculated as dose-averaged mean values of αi,j- and √{square root over (βi,j)}-components, which relate to all beam spots j contributing to a total dose Di in the voxel i.
摘要翻译：本发明涉及一种用于强度调制粒子治疗的放射治疗装置和逆治疗计划方法，用于使用至少两个场来处理生物系统内的靶，每个场包括多个布拉格峰，所述至少两个场是计划在目标内放置一定数量的来自不同方向的光束点j和某些重量wj。反向治疗计划方法同时优化至少两个场的束斑的权重wj，以便通过最小化基于生物效应和生物效应的目标函数来在目标内产生规定的生物效应。在线性二次模型中进行处理，其通过两个参数α和＆bgr来描述目标物的生物效应，其中＆egr =αD+＆bgr; D2，D表示剂量，并且其中两个参数α和＆bgr; 对于目标的每个体素i（αi和＆bgr; i）被计算为αi，j-和√{平方根超过（＆bgr; i，j）}分量的剂量平均平均值，其与所有束点 j对体素i中的总剂量Di有贡献。

3. 发明申请

US20120136677A1 RADIATION TREATMENT PLANNING SYSTEM AND COMPUTER PROGRAM PRODUCT 审中-公开
标题翻译：辐射处理计划系统和计算机程序产品
公开(公告)号：US20120136677A1
公开(公告)日：2012-05-31
申请号：US13376884
申请日：2010-06-08
申请人： Peter Ziegenhein , Uwe Oelfke
发明人： Peter Ziegenhein , Uwe Oelfke
IPC分类号： G06Q50/22
CPC分类号： A61N5/1031 , A61N5/1042 , G06Q50/22
摘要： The present invention relates to a radiation treatment planning system and a corresponding computer program product. The system comprises means for graphically displaying an image representing a target area 10 to be treated with a set o therapeutic radiation beams and an adjacent structure comprising healthy tissue 14 and/or organs at risk 12, and for displaying corresponding dose values according to a preliminary treatment plan. The system further comprises means for allowing a user to interactively input a local dose variation, local dose variation means for revising the preliminary treatment plan such as to account for the local dose variation inputted by the user and dose recovery means comprising means for revising the treatment plan again such as to at least partially compensate for a change of dose in a predetermined recovery area caused by said dose variation.
摘要翻译：本发明涉及辐射治疗计划系统和相应的计算机程序产品。该系统包括用于图形地显示表示要用治疗辐射束进行治疗的目标区域10的图像的装置，以及包括健康组织14和/或风险12的器官的相邻结构，并且用于根据初步显示相应的剂量值治疗计划。该系统还包括用于允许用户交互地输入局部剂量变化的装置，用于修改初步治疗计划的局部剂量变化装置，例如考虑用户输入的局部剂量变化，以及剂量恢复装置，包括用于修复治疗再次计划，以便至少部分地补偿由所述剂量变化引起的预定恢复区域中的剂量变化。

4. 发明授权

US08039819B2 Device and method for creating a spatial dose distribution in a medium volume 有权
标题翻译：用于在中等体积中产生空间剂量分布的装置和方法
公开(公告)号：US08039819B2
公开(公告)日：2011-10-18
申请号：US11996292
申请日：2006-07-20
申请人： Jérôme Faure , Yannick Glinec , Victor Malka , Thomas Fuchs , Hanitra Szymanowski , Uwe Oelfke
发明人： Jérôme Faure , Yannick Glinec , Victor Malka , Thomas Fuchs , Hanitra Szymanowski , Uwe Oelfke
IPC分类号： H01S3/098
CPC分类号： H05H6/00 , A61N5/1084 , A61N2005/1088 , A61N2005/1089
摘要： A device and a method for creating a spatial dose distribution in a medium volume (22) are described. A laser system produces laser pulses (12) with a pulse length shorter than 200 fs (femtoseconds) and is capable to be focused to peak intensities greater than 10^18 W/cm^2 (watts per centimeter squared). An electron source (18) is capable of releasing a high-energy electron pulse (20), in particular the electrons having an energy greater than 100 MeV, upon irradiation with said laser pulses (12) propagating into the medium volume (22). The light paths (52, 56,58) of at least some of the laser pulses (12) are adjustable in such a way that high-energy electron pulses (20) are emitted from the irradiated at least one electron source on different trajectories (20,28,60,62) through the medium volume (22) thereby depositing their dose in the medium volume (22) according to a provided pattern.
摘要翻译：描述了用于在介质体积（22）中创建空间剂量分布的装置和方法。激光系统产生脉冲长度短于200fs（飞秒）的激光脉冲（12），并且能够被聚焦以达到大于10 ^ 18W / cm ^ 2（瓦/平方厘米）的峰值强度。电子源（18）能够在照射传播到介质体积（22）中的所述激光脉冲（12）时释放高能电子脉冲（20），特别是能量大于100MeV的电子。至少一些激光脉冲（12）的光路（52,56,58）可以这样调节，使得高能电子脉冲（20）从辐射的至少一个电子源在不同的轨迹上发射（ 20,28,60,62），从而根据提供的图案将其剂量沉积在介质体积（22）中。

5. 发明申请

US20090060130A1 Inverse Treatment Planning Method 有权
标题翻译：反向治疗计划方法
公开(公告)号：US20090060130A1
公开(公告)日：2009-03-05
申请号：US12223712
申请日：2007-02-02
申请人： Jan Wilkens , Uwe Oelfke
发明人： Jan Wilkens , Uwe Oelfke
IPC分类号： A61N5/10 , G06K9/00
CPC分类号： A61N5/1031 , A61N5/1042 , A61N2005/1087
摘要： The invention relates to a radiation treatment apparatus and an inverse treatment planning method for intensity modulated particle therapy for the treatment of a target within a biological system using at least two fields, each field comprising a plurality of Bragg peaks, the at least two fields being planned to place a defined number of beam spots j from different directions with certain weights wj within the target. The inverse treatment planning method optimizes the weights wj of the beam spots for the at least two fields simultaneously in order to produce a prescribed biological effect within the target by minimizing an objective function based on biological effects ε, the biological effects ε being treated in a linear-quadratic model, which describes the biological effects in the target by two parameters α and β, where ε=αD+βD2, D denoting a dose, and wherein the two parameters α and β for each voxel i of the target (αi and βi) are calculated as dose-averaged mean values of αi,j- and √{square root over (βi,j)}-components, which relate to all beam spots j contributing to a total dose Di in the voxel i.
摘要翻译：本发明涉及一种用于强度调制粒子治疗的放射治疗装置和逆治疗计划方法，用于使用至少两个场来处理生物系统内的靶，每个场包括多个布拉格峰，所述至少两个场是计划在目标内放置一定数量的来自不同方向的光束点j和某些重量wj。逆治疗计划方法同时优化至少两个场的束斑的权重wj，以便通过使基于生物效应的最小化目标函数来产生规定的生物效应，所述目标函数是在一个线性二次模型，其通过两个参数α和β描述目标中的生物效应，其中epsilon =αD+βD2，D表示剂量，并且其中目标的每个体素i的两个参数α和β（alphai和 betai）计算为alphai，j-和√{平方根超过（betai，j）}分量的剂量平均平均值，其涉及对体素i中的总剂量Di有贡献的所有束斑点j。

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