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1. 发明申请

WO2009032749A3 SALICYLANILIDE MODIFIED PEPTIDES FOR USE AS ORAL THERAPEUTICS 审中-公开
标题翻译：用作口服治疗剂的SALICYLANILIDE改性肽
公开(公告)号：WO2009032749A3
公开(公告)日：2009-06-04
申请号：PCT/US2008074624
申请日：2008-08-28
申请人： UNIV CALIFORNINA , FOGELMAN ALAN M , NAVAB MOHAMAD
发明人： FOGELMAN ALAN M , NAVAB MOHAMAD
IPC分类号： A61K31/60 , A61K51/00
CPC分类号： C07K14/775 , A61K38/00 , A61K47/54 , C07K7/08
摘要： This invention pertains to the surprising discovery that salicylanilides, e.g., niclosamide and/or niclosamide analogues can be reacted with a therapeutically active peptide to produce a modified peptide complex that shows increased resistance to proteolysis and that shows higher bioactivity when orally administered than the unmodified peptide.
摘要翻译：本发明涉及令人惊奇的发现，即水杨酰苯胺（例如，氯硝柳胺和/或氯硝柳酰胺类似物）可以与治疗活性肽反应以产生改变的肽复合物，其显示增加的蛋白水解抗性，并且当口服施用时显示出比未修饰的肽更高的生物活性。

2. 发明申请

WO2008140493A3 ANTI-EGFR FAMILY ANTIBODIES, BISPECIFIC ANTI-EGFR FAMILY ANTIBODIES AND METHODS OF USE THEREOF 审中-公开
标题翻译：抗EGFR家族抗体，双特异性抗EGFR家族抗体及其使用方法
公开(公告)号：WO2008140493A3
公开(公告)日：2009-05-14
申请号：PCT/US2007024287
申请日：2007-11-20
申请人： UNIV CALIFORNINA , FOX CHASE CANCER CT , ADAMS GREGORY P , HORAK EVA M , WEINER LOUIS M , MARKS JAMES D
发明人： ADAMS GREGORY P , HORAK EVA M , WEINER LOUIS M , MARKS JAMES D
IPC分类号： C07K16/28 , A61K39/395 , C07K16/18
CPC分类号： C07K16/2863 , A61K47/6849 , A61K47/6879 , A61K49/0017 , A61K49/0058 , A61K49/16 , A61K51/1027 , A61K2039/505 , C07K16/32 , C07K2317/31 , C07K2317/622 , C07K2317/73 , C07K2317/75 , C07K2317/76 , G01N33/74 , G01N2333/485
摘要： Anti-EGFR family member antibodies and bispecific antibodies comprising one or more anti-EGFR family member antibodies are disclosed. These antibodies can be used to advantage to specifically target forms of cancer associated with the overexpression of members of the EGFR protein family.
摘要翻译：公开了包含一种或多种抗EGFR家族成员抗体的抗EGFR家族成员抗体和双特异性抗体。这些抗体可用于有利于特异性靶向与EGFR蛋白家族成员过表达相关的癌症形式。

3. 发明申请

WO2009012397A3 SURFACE PLASMON-ENHANCED PHOTOVOLTAIC DEVICE 审中-公开
标题翻译：表面等离子体增强光电器件
公开(公告)号：WO2009012397A3
公开(公告)日：2009-03-05
申请号：PCT/US2008070347
申请日：2008-07-17
申请人： UNIV CALIFORNINA , KOSTECKI ROBERT , MAO SAMUEL S
发明人： KOSTECKI ROBERT , MAO SAMUEL S
IPC分类号： H01L31/042
CPC分类号： H01L31/1085 , B82Y10/00 , H01L31/035281 , H01L31/03529 , H01L31/07 , Y02E10/50
摘要： Photovoltaic devices are driven by intense photoemission of "hot" electrons from a suitable nanostructured metal. The metal should be an electron source with surface plasmon resonance within the visible and near-visible spectrum range (near IR to near UV (about 300 to 1000 nm)). Suitable metals include silver, gold, copper and alloys of silver, gold and copper with each other. Silver is particularly preferred for its advantageous opto-electronic properties in the near UV and visible spectrum range, relatively low cost, and simplicity of processing.
摘要翻译：光伏器件由来自合适的纳米结构金属的“热”电子的强烈光电发射驱动。金属应该是在可见光和近可见光谱范围内的表面等离子体共振的电子源（近红外到近紫外（约300至1000nm））。合适的金属包括银，金，铜和银，金和铜的合金彼此。由于其在近紫外和可见光谱范围内的有利的光电特性，成本相对较低，处理简单，银是特别优选的。

4. 发明专利

AU2007333001A1 Nanoplasmonic molecular ruler for nuclease activity and DNA footprinting 未知
公开(公告)号：AU2007333001A1
公开(公告)日：2008-06-19
申请号：AU2007333001
申请日：2007-09-14
申请人： UNIV CALIFORNINA
发明人： LIU GANG L , CHEN FANQING FRANK , LEE LUKE P
IPC分类号： C12Q1/68 , C12M3/00
摘要： This invention provides a nanoplasmonic molecular ruler, which can perform label-free and real-time monitoring of nucleic acid (e.g., DNA) length changes and perform nucleic acid footprinting. In various embodiments the ruler comprises a nucleic acid attached to a nanoparticle, such that changes in the nucleic acid length are detectable using surface plasmon resonance. The nanoplamonic ruler provides a fast and convenient platform for mapping nucleic acid-protein interactions, for nuclease activity monitoring, and for other footprinting related methods.

5. 发明申请

WO2009039192A2 INTERNALIZING HUMAN MONOCLONAL ANTIBODIES TARGETING PROSTATE CANCER CELLS IN SITU 审中-公开
标题翻译：内化靶向前列腺癌细胞的人单克隆抗体
公开(公告)号：WO2009039192A2
公开(公告)日：2009-03-26
申请号：PCT/US2008076704
申请日：2008-09-17
申请人： UNIV CALIFORNINA , LIU BIN , MARKS JAMES D
发明人： LIU BIN , MARKS JAMES D
IPC分类号： A61K51/10
CPC分类号： C07K16/3069 , A61K47/48638 , A61K51/1072 , A61K2039/505 , C07K16/005 , C07K16/18 , C07K16/2803 , C07K16/30 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/569 , C07K2317/622 , C07K2317/77 , G01N33/5044 , G01N33/57434 , G01N33/6845 , G01N33/6854
摘要： This invention provides a method that allows selection of antibodies against cells (e.g. tumor cells) in situ using laser capture microdissection. By restricting antibody selection to binders of internalizing epitopes, a panel of phage antibodies was generated that targets clinically represented prostate cancer antigens.
摘要翻译：本发明提供了使用激光捕获显微切割在原位选择抗细胞（例如肿瘤细胞）的抗体的方法。通过将抗体选择限制于内化表位的结合物，产生靶向临床上表示的前列腺癌抗原的一组噬菌体抗体。

6. 发明申请

WO2008021088A3 SALICYLANILIDES ENHANCE ORAL DELIVERY OF THERAPEUTIC PEPTIDES 审中-公开
标题翻译：水杨酰胺增强了治疗性肽的口服给药
公开(公告)号：WO2008021088A3
公开(公告)日：2008-12-24
申请号：PCT/US2007017551
申请日：2007-08-06
申请人： UNIV CALIFORNINA , FOGELMAN ALAN M , NAVAB MOHAMAD
发明人： FOGELMAN ALAN M , NAVAB MOHAMAD
IPC分类号： A61K38/00 , A61K31/165 , C07K7/00 , C07K14/00
CPC分类号： A61K31/165 , A61K38/03 , A61K38/04 , A61K38/16 , A61K38/17 , A61K2300/00
摘要： This invention pertains to the surprising discovery that salicylanilides, e.g., niclosamide and/or niclosamide analogues when orally administered in conjunction with a peptide pharmaceutical (e.g., a class A amphipathic helical peptide as described herein) significantly increases the bioavailability of that peptide. Methods of peptide delivery using such "delivery agents" and pharmaceutical formulations are provided.
摘要翻译：本发明涉及令人惊讶的发现，即当与肽药物（例如本文所述的A类两亲性螺旋肽）一起口服给药时，水杨酰苯胺，例如氯硝柳胺和/或氯硝柳胺类似物显着增加该肽的生物利用度。提供了使用这种“递送剂”和药物制剂递送肽的方法。

7. 发明申请

WO2009008916A3 THERAPEUTIC MONOCLONAL ANTIBODIES THAT NEUTRALIZE BOTULINUM NEUROTOXINS 审中-公开
标题翻译：治疗嗜碱性神经毒素的治疗性单克隆抗体
公开(公告)号：WO2009008916A3
公开(公告)日：2010-01-07
申请号：PCT/US2008003767
申请日：2008-03-21
申请人： UNIV CALIFORNINA , MARKS JAMES D , GEREN ISIN N , GARCIA MARIA CONSUELO , LOU JIANLONG , RAZAI ALI
发明人： MARKS JAMES D , GEREN ISIN N , GARCIA MARIA CONSUELO , LOU JIANLONG , RAZAI ALI
IPC分类号： A61K39/40
CPC分类号： C07K16/40 , C07K16/1282 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： This invention provides antibodies that specifically bind to and typically neutralize botulinum neurotoxins (e.g., BoNT/A, BoNT/B, BoNT/E, etc.) and the epitopes bound by those antibodies. The antibodies and derivatives thereof and/or other antibodies that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism.
摘要翻译：本发明提供了特异性结合并典型地中和肉毒杆菌神经毒素（例如BoNT / A，BoNT / B，BoNT / E等）和由这些抗体结合的表位的抗体。特异性结合本文提供的中和表位的抗体及其衍生物和/或其他抗体可用于中和肉毒杆菌神经毒素，因此也可用于治疗肉毒中毒。

8. 发明申请

WO2009002386A3 SIZE-DEPENDENT BIOLOGICAL EFFECT OF NANOPARTICLES 审中-公开
标题翻译：纳米粒子的大小依赖性生物学效应
公开(公告)号：WO2009002386A3
公开(公告)日：2009-03-05
申请号：PCT/US2008006701
申请日：2008-05-23
申请人： UNIV CALIFORNINA , CHEN FANQING FRANK
发明人： CHEN FANQING FRANK
IPC分类号： A61K9/14
CPC分类号： C12Q1/6809 , B82Y5/00
摘要： Nanoparticles are used increasingly in consumer products and biomedical applications. Yet the cellular interaction mechanism at the molecular level is not well understood for nanomaterials of different size, shape and surface chemistry. Gold nanoparticles (Au-NPs), which have been explored extensively for various applications in recent years, are used as the model system to help understand the size-dependent biological effects of nanoparticles. Jurkat cells treated with Au-NPs ranging from 2 nm to 200 nm were studied. Whole genome expression measurements indicate size-dependent effects, including linear scaling and threshold effects. In addition, a non-linear pattern of gene responses that persisted over time were observed in 20-40 nm Au-NP treated cells. Gene function, promoter, and pathway analyses reveal differential signaling processes that are correlated with nanoparticle sizes. The size may play a role in cellular sorting of naturally occurring particulates, particle interaction with the receptors, intracellular transportation, signaling and stress responses.
摘要翻译：纳米颗粒越来越多地用于消费品和生物医学应用。然而，在分子水平上的细胞相互作用机制对于不同尺寸，形状和表面化学的纳米材料来说是不太了解的。近年来已经广泛应用于各种应用的金纳米颗粒（Au-NP）被用作模型系统，以帮助了解纳米颗粒的尺寸依赖性生物学效应。研究了用Au-NP处理的Jurkat细胞，范围为2nm至200nm。全基因组表达测量显示尺寸依赖性影响，包括线性缩放和阈值效应。此外，在20-40nm Au-NP处理的细胞中观察到随时间持续的基因应答的非线性模式。基因功能，启动子和通路分析揭示与纳米颗粒尺寸相关的差异信号传导过程。大小可能在天然存在的颗粒的细胞分选，与受体的颗粒相互作用，细胞内运输，信号传导和应激反应中起作用。

9. 发明申请

WO2008060375A3 UPREGULATING BDNF LEVELS TO MITIGATE MENTAL RETARDATION 审中-公开
标题翻译：改善BDNF水平以减轻心理障碍
公开(公告)号：WO2008060375A3
公开(公告)日：2008-12-31
申请号：PCT/US2007021461
申请日：2007-10-05
申请人： UNIV CALIFORNINA , LAUTERBORN JULIE , LYNCH GARY , GALL CHRISTINE , REX CHRISTOPHER
发明人： LAUTERBORN JULIE , LYNCH GARY , GALL CHRISTINE , REX CHRISTOPHER
IPC分类号： A61K31/00 , A61K31/4525 , A61K31/453 , A61K31/454 , A61K31/498 , A61K31/536 , A61K31/5365 , A61K31/5415 , A61P25/28
CPC分类号： A61K31/00 , A61K31/4525 , A61K31/453 , A61K31/454 , A61K31/498 , A61K31/536 , A61K31/5365 , A61K31/5415
摘要： This invention provides methods of preserving, improving, or restoring cognitive function in mammal having one or more mutations in the FMRl gene (e.g. at risk for or having fragile x syndrome), where the methods involve the brain derived neurotrophic factor (BDNF) level or activity in the brain of said mammal. In certain embodiments the methods involve administering one or more AMPA potentiators (e.g., ampakines) to the mammal in an amount sufficient to increase BDNF levels in the brain of the mammal.
摘要翻译：本发明提供了在FMR1基因中具有一个或多个突变（例如具有或具有脆性x综合征的风险）的哺乳动物中保留，改善或恢复认知功能的方法，其中所述方法涉及脑源性神经营养因子（BDNF）水平或所述哺乳动物的脑中的活性。在某些实施方案中，所述方法包括以足以增加哺乳动物脑中BDNF水平的量向哺乳动物施用一种或多种AMPA增效剂（例如，ampakines）。

10. 发明申请

WO2008073175A3 NANOPLASMONIC MOLECULAR RULER FOR NUCLEASE ACTIVITY AND DNA FOOTPRINTING 审中-公开
标题翻译：用于核酸活性的NANOPLASMONIC分子规则和DNA加工
公开(公告)号：WO2008073175A3
公开(公告)日：2008-10-16
申请号：PCT/US2007020026
申请日：2007-09-14
申请人： UNIV CALIFORNINA , CHEN FANQING FRANK , LIU GANG L , LEE LUKE P
发明人： CHEN FANQING FRANK , LIU GANG L , LEE LUKE P
IPC分类号： C07H21/00 , C07H21/02 , C12Q1/68
CPC分类号： C12Q1/683 , C12Q1/6825 , C12Q1/6827 , C12Q1/6834 , C12Q1/6876 , G01N21/554 , C12Q2565/628 , C12Q2563/155 , C12Q2521/319
摘要： This invention provides a nanoplasmonic molecular ruler, which can perform label-free and real-time monitoring of nucleic acid (e.g., DNA) length changes and perform nucleic acid footprinting. In various embodiments the ruler comprises a nucleic acid attached to a nanoparticle, such that changes in the nucleic acid length are detectable using surface plasmon resonance. The nanoplamonic ruler provides a fast and convenient platform for mapping nucleic acid -protein interactions, for nuclease activity monitoring, and for other footprinting related methods.
摘要翻译：本发明提供了一种纳米质谱分子尺，其可进行核酸（例如DNA）长度变化的无标记和实时监测并进行核酸足迹。在各种实施方案中，尺子包括连接到纳米颗粒的核酸，使得可以使用表面等离子体共振来检测核酸长度的变化。纳米尺度标尺为核酸 - 蛋白质相互作用，核酸酶活性监测和其他足迹相关方法提供了一个快捷方便的平台。

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