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1. 发明申请

WO2003024316A2 PORE-FORMING AGENTS FOR ORTHOPEDIC CEMENTS 审中-公开
标题翻译：用于矫形外用剂的成孔剂
公开(公告)号：WO2003024316A2
公开(公告)日：2003-03-27
申请号：PCT/US2002/029966
申请日：2002-09-20
申请人： STRYKER CORPORATION , DALAL, Paresh, S. , LANDERYOU, Tracy, J. , TOTH, Carol, Ann , KULKARNI, Shailesh, C.
发明人： DALAL, Paresh, S. , LANDERYOU, Tracy, J. , TOTH, Carol, Ann , KULKARNI, Shailesh, C.
IPC分类号： A61B
CPC分类号： A61L27/227 , A61L27/12 , A61L27/56
摘要： A bone precursor composition comprising a cement mixture and a pore-forming agent is provided for bone implant. Preferably, the pore-forming agent has a particle size of 20-500 μm. More preferably, the proportion of the pore-forming agent is 7-40% (w/w). The composition may further include a bioactive agent, preferably a bone morphogenic protein or nucleic acid encoding BMP encapsulated in the pore-forming agent. The moldability of the composition can be modulated by the addition of a binder. The invention provides a kit and implant device comprising the bone precursor composition. The invention also provides an implantable prosthetic device comprising a prosthetic implant having a surface region and a bone precursor material disposed on the surface region. The kit and devices may further comprise one or more additional components including a bioactive agent and a binder. Methods of inducing bone formation and delivering the bioactive agent are provided.
摘要翻译：提供包含水泥混合物和成孔剂的骨前体组合物用于骨植入物。优选成孔剂的粒径为20-500μm。更优选地，成孔剂的比例为7-40％（w / w）。该组合物可以进一步包括生物活性剂，优选骨形态发生蛋白或包封在成孔剂中的编码BMP的核酸。该组合物的模塑性可以通过添加粘合剂来调节。本发明提供了包含该骨前体组合物的试剂盒和植入装置。本发明还提供了一种植入式假体装置，其包括具有表面区域和设置在表面区域上的骨头前体材料的假体植入物。试剂盒和装置可以进一步包含一种或多种另外的组分，包括生物活性剂和粘合剂。提供诱导骨形成和递送生物活性剂的方法。

2. 发明申请

WO02070029A2 POROUS BETA-TRICALCIUM PHOSPHATE GRANULES AND METHODS FOR PRODUCING SAME 审中-公开
标题翻译：多孔磷酸三钙颗粒及其生产方法
公开(公告)号：WO02070029A2
公开(公告)日：2002-09-12
申请号：PCT/US0205827
申请日：2002-02-26
申请人： STRYKER CORP , DALAL PARESH S , DIMAANO GODOFREDO R , TOTH CAROL ANN , KULKARNI SHAILESH C
发明人： DALAL PARESH S , DIMAANO GODOFREDO R , TOTH CAROL ANN , KULKARNI SHAILESH C
IPC分类号： A61L27/00 , A61K47/04 , A61L24/00 , A61L27/12 , A61L27/56 , C01B25/32
CPC分类号： A61L27/50 , A61L27/12 , A61L27/56 , A61L2430/02 , Y10S530/811
摘要： A porous beta -tricalcium phosphate material for bone implantation is provided. The multiple pores in the porous TCP body are separate discrete voids and are not interconnected. The pore size diameter is in the range of 20-500 µm, preferably 50-125 µm. The porous beta -TCP material provides a carrier matrix for bioactive agents and can form a moldable putty composition upon the addition of a binder. Preferably, the bioactive agent is encapsulated in a biodegradable agent. The invention provides a kit and an implant device comprising the porous beta -TCP, and a bioactive agent and a binder. The invention also provides an implementable prosthetic device comprising a prosthetic implant having a surface region, a porous beta -TCP material disposed on the surface region optionally comprising at least a bioactive agent or a binder. Methods of producing the porous beta -TCP material and including bone formation are also provided.
摘要翻译：提供了用于骨植入的多孔β-磷酸三钙材料。多孔TCP体中的多个孔是分离的离散空隙并且不互连。孔径在20〜500μm的范围内，优选为50〜125μm。多孔β-TCP材料提供用于生物活性剂的载体基质，并且可以在添加粘合剂时形成可成型的油灰组合物。优选地，将生物活性剂包封在生物降解剂中。本发明提供了一种试剂盒和植入装置，其包含多孔β-TCP，以及生物活性剂和粘合剂。本发明还提供了一种可实施的假体装置，其包括具有表面区域的假体植入物，设置在表面区域上的多孔β-TCP材料，任选地至少包含生物活性剂或粘合剂。还提供了生产多孔β-TCP材料并包括骨形成的方法。

3. 发明申请

WO2002070029A3 POROUS BETA-TRICALCIUM PHOSPHATE GRANULES AND METHODS FOR PRODUCING SAME 审中-公开
公开(公告)号：WO2002070029A3
公开(公告)日：2002-09-12
申请号：PCT/US2002/005827
申请日：2002-02-26
申请人： STRYKER CORPORATION , DALAL, Paresh, S. , DIMAANO, Godofredo, R. , TOTH, Carol, Ann , KULKARNI, Shailesh, C.
发明人： DALAL, Paresh, S. , DIMAANO, Godofredo, R. , TOTH, Carol, Ann , KULKARNI, Shailesh, C.
IPC分类号： A61L27/12
摘要： A porous β-tricalcium phosphate material for bone implantation is provided. The multiple pores in the porous TCP body are separate discrete voids and are not interconnected. The pore size diameter is in the range of 20-500 µm, preferably 50-125 µm. The porous β-TCP material provides a carrier matrix for bioactive agents and can form a moldable putty composition upon the addition of a binder. Preferably, the bioactive agent is encapsulated in a biodegradable agent. The invention provides a kit and an implant device comprising the porous β-TCP, and a bioactive agent and a binder. The invention also provides an implementable prosthetic device comprising a prosthetic implant having a surface region, a porous β-TCP material disposed on the surface region optionally comprising at least a bioactive agent or a binder. Methods of producing the porous β-TCP material and including bone formation are also provided.

4. 发明申请

WO03024316A3 PORE-FORMING AGENTS FOR ORTHOPEDIC CEMENTS 审中-公开
标题翻译：成型剂的成核剂
公开(公告)号：WO03024316A3
公开(公告)日：2003-12-31
申请号：PCT/US0229966
申请日：2002-09-20
申请人： STRYKER CORP , DALAL PARESH S , LANDERYOU TRACY J , TOTH CAROL ANN , KULKARNI SHAILESH C
发明人： DALAL PARESH S , LANDERYOU TRACY J , TOTH CAROL ANN , KULKARNI SHAILESH C
IPC分类号： A61L27/00 , A01N43/04 , A01N63/00 , A61B20060101 , A61F2/00 , A61F13/00 , A61L27/12 , A61L27/22 , A61L27/56 , C07K14/47 , C08J9/26 , C08J9/28
CPC分类号： A61L27/227 , A61L27/12 , A61L27/56
摘要： A bone precursor composition comprising a cement mixture and a pore-forming agent is provided for bone implant. Preferably, the pore-forming agent has a particle size of 20-500 mu m. More preferably, the proportion of the pore-forming agent is 7-40% (w/w). The composition may further include a bioactive agent, preferably a bone morphogenic protein or nucleic acid encoding BMP encapsulated in the pore-forming agent. The moldability of the composition can be modulated by the addition of a binder. The invention provides a kit and implant device comprising the bone precursor composition. The invention also provides an implantable prosthetic device comprising a prosthetic implant having a surface region and a bone precursor material disposed on the surface region. The kit and devices may further comprise one or more additional components including a bioactive agent and a binder. Methods of inducing bone formation and delivering the bioactive agent are provided.
摘要翻译：提供包含水泥混合物和成孔剂的骨前体组合物用于骨植入。优选地，成孔剂的粒径为20-500μm。更优选的是，成孔剂的比例为7-40％（w / w）。组合物还可以包括生物活性剂，优选骨形态发生蛋白或编码包封在成孔剂中的BMP的核酸。可以通过添加粘合剂来调节组合物的成型性。本发明提供了包含骨前体组合物的试剂盒和植入装置。本发明还提供了一种植入式假体装置，其包括具有布置在表面区域上的表面区域和骨骼前体材料的假体植入物。试剂盒和装置还可以包含一种或多种另外的组分，包括生物活性剂和粘合剂。提供诱导骨形成和递送生物活性剂的方法。

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