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1. 发明专利

DE2644238A1 未知
公开(公告)号：DE2644238A1
公开(公告)日：1977-04-07
申请号：DE2644238
申请日：1976-09-30
申请人： CUNNINGHAM KENNETH D , RUBIN ROBERT H , SINNOTT RICHARD C , BERKELEY
发明人： SINNOTT RICHARD C
IPC分类号： C07C27/06 , B01J31/00 , C07B61/00 , C07C27/00 , C07C29/15 , C07C29/158 , C07C31/18 , C07C67/00 , H02K37/18 , H02K37/20 , H02K37/00
摘要： A unidirectional direct rotary stepper motor is adapted to step its rotor between successive stable rest positions in response to successive electrical pulses of opposite polarity. The motor includes a rotor having a central hub portion and a plurality of annularly aligned similar blades, an energizing coil, and a core which passes through the energizing coil and has a first pole face disposed in close relationship with the rotor hub portion, and a second spaced-apart pole face disposed in close relationship with the rotor blades. An annular array of similar permanent magnets of sequential opposite polarity is disposed on the surface of the core pole opposing the rotor blades in serial intervention in the coil flux path.

2. 发明申请

WO2009137129A2 RAPID DETECTION OF ANTI-CHROMATIN AUTOANTIBODIES IN HUMAN SERUM USING A PORTABLE ELECTROCHEMICAL BIOSENSOR 审中-公开
标题翻译：使用便携式电化学生物传感器快速检测人血清中的抗血清自身抗体
公开(公告)号：WO2009137129A2
公开(公告)日：2009-11-12
申请号：PCT/US2009033943
申请日：2009-02-12
申请人： STC UNM , RUBIN ROBERT , SITDIKOV RAVIL , ATANASSOV PLAMEN , LOPEZ GABRIEL , KONSTANTINOV KONSTANTIN
发明人： RUBIN ROBERT , SITDIKOV RAVIL , ATANASSOV PLAMEN , LOPEZ GABRIEL , KONSTANTINOV KONSTANTIN
CPC分类号： G01N33/564 , G01N33/5438 , G01N2800/104
摘要： A rapid electrochemical flow-through sensor and method for detecting the presence of autoantibodies in a fluid sample such as blood is shown and described. The sensor may take either a single- or multi-plexed form. The sensor comprises a fluid inlet, a reaction region comprising immobilized autoantigens and an electrode assembly, and a fluid outlet.
摘要翻译：显示和描述了用于检测流体样品如血液中自身抗体的存在的快速电化学流通传感器和方法。传感器可以采用单层或多层复合形式。传感器包括流体入口，包含固定的自身抗原的反应区域和电极组件以及流体出口。

3. 发明申请

WO1987004351A1 METHOD FOR THE DIAGNOSIS AND TREATMENT OF INFLAMMATION 审中-公开
标题翻译：用于诊断和治疗炎症的方法
公开(公告)号：WO1987004351A1
公开(公告)日：1987-07-30
申请号：PCT/US1987000079
申请日：1987-01-12
申请人： THE GENERAL HOSPITAL CORPORATION , RUBIN, Robert, H. , STRAUSS, William, H.
发明人： THE GENERAL HOSPITAL CORPORATION
IPC分类号： A61K49/00
CPC分类号： A61K51/1093 , A61K38/00 , A61K47/6817 , A61K47/6835 , A61K49/16 , A61K51/1018 , A61K2121/00 , A61K2123/00 , C07K16/00 , C07K16/12
摘要： A method of detecting an inflammation site in an individual by administering to the individual a diagnostically effective amount of detectably labeled immunoglobulin or fragment thereof, wherein the immunoglobulin substantially accumulates at the site when the site is inflamed.
摘要翻译：一种通过向个体施用诊断有效量的可检测标记的免疫球蛋白或其片段来检测个体中的炎症部位的方法，其中所述免疫球蛋白在所述部位发炎时基本上累积在所述部位。

4. 发明申请

WO2016007549A1 BIOMARKER SIGNATURES FOR LYME DISEASE AND METHODS OF USE THEREOF 审中-公开
标题翻译：生物标记物的LYME疾病及其使用方法
公开(公告)号：WO2016007549A1
公开(公告)日：2016-01-14
申请号：PCT/US2015/039436
申请日：2015-07-07
申请人： VERAMARX, INC. , RICHARDS, Whitney , TAUB, Floyd, E. , RUBIN, Robert, A.
发明人： RICHARDS, Whitney , TAUB, Floyd, E. , RUBIN, Robert, A.
IPC分类号： G01N33/68
CPC分类号： G01N33/56911 , G01N2333/20 , G01N2800/60 , Y02A50/57
摘要： The present invention relates to methods for the diagnosing, prognosing, monitoring, differentiating, treating, and managing of Lyme disease in a subject. The methods according to the invention are characterized by the detection of a biomarker signature comprised of a combination of two or more analytes indicative of disease.
摘要翻译：本发明涉及用于诊断，预测，监测，鉴别，治疗和管理受试者中莱姆病的方法。根据本发明的方法的特征在于检测由两种或更多种指示疾病的分析物的组合组成的生物标志物特征。

5. 发明申请

WO2004065616A3 USE OF THREE-DIMENSIONAL MICROFABRICATED TISSUE ENGINEERED SYSTEMS FOR PHARMACOLOGIC APPLICATIONS 审中-公开
标题翻译：三维微细组织工程系统在药理学应用中的应用
公开(公告)号：WO2004065616A3
公开(公告)日：2004-11-18
申请号：PCT/US2004001098
申请日：2004-01-16
申请人： GEN HOSPITAL CORP , VACANTI JOSEPH P M D , RUBIN ROBERT , CHEUNG WING
发明人： VACANTI JOSEPH P M D , RUBIN ROBERT , CHEUNG WING
IPC分类号： A01N1/00 , C12N5/00 , C12Q20060101 , C12Q1/00 , C12Q1/26 , C12Q1/34 , C12Q1/42 , C12Q1/44 , C12Q1/48 , G01N33/50 , G01N33/53
CPC分类号： C12Q1/48 , B33Y80/00 , C12Q1/00 , C12Q1/18 , C12Q1/26 , C12Q1/34 , C12Q1/42 , C12Q1/44 , G01N33/5038 , G01N33/5088
摘要： The present invention generally relates to a combination of the fields of tissue engineering, drug discovery and drug development. It more specifically provides new methods and materials for testing the efficacy and safety of experimental drugs, defining the metabolic pathways of experimental drugs and characterizing the properties (e.g., side effects, new uses) of existing drugs. Preferably, evaluation is carried out in three-dimensional tissue-engineered systems, wherein drug toxicity, metabolism, interaction and/or efficacy can be determined.
摘要翻译：本发明总体上涉及组织工程，药物开发和药物开发领域的组合。它更具体地提供了用于测试实验药物的功效和安全性的新方法和材料，定义了实验药物的代谢途径并且表征了现有药物的性质（例如副作用，新用途）。优选地，评估在三维组织工程系统中进行，其中可以确定药物毒性，代谢，相互作用和/或功效。

6. 发明申请

WO2004065616A2 USE OF THREE-DIMENSIONAL MICROFABRICATED TISSUE ENGINEERED SYSTEMS FOR PHARMACOLOGIC APPLICATIONS 审中-公开
标题翻译：三维微晶组织工程系统在药理学应用中的应用
公开(公告)号：WO2004065616A2
公开(公告)日：2004-08-05
申请号：PCT/US2004/001098
申请日：2004-01-16
申请人： THE GENERAL HOSPITAL CORPORATION , VACANTI, Joseph, P., M.D. , RUBIN, Robert, , CHEUNG, Wing
发明人： VACANTI, Joseph, P., M.D. , RUBIN, Robert, , CHEUNG, Wing
IPC分类号： C12Q
CPC分类号： C12Q1/48 , B33Y80/00 , C12Q1/00 , C12Q1/18 , C12Q1/26 , C12Q1/34 , C12Q1/42 , C12Q1/44 , G01N33/5038 , G01N33/5088
摘要： The present invention generally relates to a combination of the fields of tissue engineering, drug discovery and drug development. It more specifically provides new methods and materials for testing the efficacy and safety of experimental drugs, defining the metabolic pathways of experimental drugs and characterizing the properties (e.g., side effects, new uses) of existing drugs. Preferably, evaluation is carried out in three-dimensional tissue-engineered systems, wherein drug toxicity, metabolism, interaction and/or efficacy can be determined.
摘要翻译：本发明一般涉及组织工程，药物发现和药物开发领域的组合。它更具体地提供了用于测试实验药物的功效和安全性，定义实验药物的代谢途径和表征现有药物的性质（例如副作用，新用途）的新方法和材料。优选地，在三维组织工程系统中进行评价，其中可以确定药物毒性，代谢，相互作用和/或功效。

7. 发明申请

WO2017119881A1 BIOMARKER SIGNATURES FOR LYME DISEASE DIFFERENTIATION AND METHODS OF USE THEREOF 审中-公开
标题翻译：生物标记物用于莱姆病分化及其使用方法
公开(公告)号：WO2017119881A1
公开(公告)日：2017-07-13
申请号：PCT/US2016/012387
申请日：2016-01-06
申请人： VERAMARX, INC. , RICHARDS, Whitney , TAUB, Floyd, E. , RUBIN, Robert, A.
发明人： RICHARDS, Whitney , TAUB, Floyd, E. , RUBIN, Robert, A.
IPC分类号： G01N33/53 , C12Q1/00
CPC分类号： G01N33/56911 , G01N2333/20 , G01N2800/52 , G01N2800/60 , Y02A50/57
摘要： The present invention relates to methods for the differentiating, diagnosing, and treating Lyme disease in a subject. The methods according to the invention are characterized by the detection of a biomarker signature capable of differentiating Lyme disease from like- symptom diseases, the biomarker signature being comprised of a combination of two or more analytes.
摘要翻译：本发明涉及用于区分，诊断和治疗受试者莱姆病的方法。根据本发明的方法的特征在于检测能够区分莱姆病与类似症状疾病的生物标志物标签，所述生物标志物标签由两种或更多种分析物的组合组成。

8. 发明申请

WO2015116769A1 ELECTROCHEMICAL QUANTITATION OF AUTOANTIBODIES 审中-公开
标题翻译：自动化学的电化学量化
公开(公告)号：WO2015116769A1
公开(公告)日：2015-08-06
申请号：PCT/US2015/013434
申请日：2015-01-29
申请人： STC. UNM , RUBIN, Robert, L. , KONSTANTINOV, Konstantin, N. , WALL, David, A.
发明人： RUBIN, Robert, L. , KONSTANTINOV, Konstantin, N. , WALL, David, A.
IPC分类号： G01N27/327
CPC分类号： G01N27/3273 , G01N27/3276 , G01N33/5438
摘要： This disclosure describes, in one aspect, a device for electrochemical quantitation of autoantibodies. Generally, the device includes a housing that defines a plurality of channels and at least two reaction zones. A first reaction zone includes a porous membrane and a first electrode assembly in fluid communication with a first channel. The first reaction zone also includes a first plurality of autoantigens immobilized to the porous membrane. The first electrode assembly is in communication with an amperometric reader. A second reaction zone includes a porous membrane and a second electrode assembly in fluid communication with a second channel. The second reaction zone includes a second plurality of autoantigens immobilized to the porous membrane. The second electrode assembly is in communication with the amperometric reader. Finally, the device includes a source of negative pressure in fluid communication with the first reaction zone and the second reaction zone.
摘要翻译：本公开在一个方面描述了一种用于自身抗体的电化学定量的装置。通常，该装置包括限定多个通道的壳体和至少两个反应区域。第一反应区包括多孔膜和与第一通道流体连通的第一电极组件。第一反应区还包括固定在多孔膜上的第一组多个自身抗原。第一电极组件与电流读数器连通。第二反应区包括多孔膜和与第二通道流体连通的第二电极组件。第二反应区包括固定在多孔膜上的第二多个自身抗原。第二电极组件与电流读数器连通。最后，该装置包括与第一反应区和第二反应区流体连通的负压源。

9. 发明申请

WO2009137129A3 RAPID DETECTION OF ANTI-CHROMATIN AUTOANTIBODIES IN HUMAN SERUM USING A PORTABLE ELECTROCHEMICAL BIOSENSOR 审中-公开
公开(公告)号：WO2009137129A3
公开(公告)日：2009-11-12
申请号：PCT/US2009/033943
申请日：2009-02-12
申请人： STC.UNM , RUBIN, Robert , SITDIKOV, Ravil , ATANASSOV, Plamen , LOPEZ, Gabriel , KONSTANTINOV, Konstantin
发明人： RUBIN, Robert , SITDIKOV, Ravil , ATANASSOV, Plamen , LOPEZ, Gabriel , KONSTANTINOV, Konstantin
IPC分类号： G01N33/53 , G01N27/26 , G01N33/561
摘要： A rapid electrochemical flow-through sensor and method for detecting the presence of autoantibodies in a fluid sample such as blood is shown and described. The sensor may take either a single- or multi-plexed form. The sensor comprises a fluid inlet, a reaction region comprising immobilized autoantigens and an electrode assembly, and a fluid outlet.

10. 发明授权

US2996832A Toy construction kit 失效
标题翻译：玩具建筑套件
公开(公告)号：US2996832A
公开(公告)日：1961-08-22
申请号：US78797859
申请日：1959-01-20
申请人： RUBIN ROBERT L
发明人： RUBIN ROBERT L
IPC分类号： A63H33/04
CPC分类号： A63H33/04 , Y10S273/02 , Y10T24/46 , Y10T24/468

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