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1. 发明授权

US4969995A Removal of metal ions from aqueous solution 失效
标题翻译：从水溶液中去除金属离子
公开(公告)号：US4969995A
公开(公告)日：1990-11-13
申请号：US451860
申请日：1989-12-18
申请人： Paul J. Jackson , Emmanuel Delhaize , Nigel J. Robinson , Clifford J. Unkefer , Clement Furlong
发明人： Paul J. Jackson , Emmanuel Delhaize , Nigel J. Robinson , Clifford J. Unkefer , Clement Furlong
IPC分类号： B01J20/32 , B01J45/00 , C01G11/00 , C02F1/28 , C02F9/00
CPC分类号： B01J20/28019 , B01J20/28004 , B01J20/3212 , B01J20/3251 , B01J20/3274 , B01J20/3425 , B01J20/3475 , B01J45/00 , C01G11/003 , C02F1/285 , C02F1/288 , C02F1/62 , C02F9/00 , C22B3/24 , B01J2220/58 , C02F2101/20 , C02F2303/16 , Y02P10/234
摘要： A method of removing heavy metals from aqueous solution, a composition of matter used in effecting said removal, and apparatus used in effecting said removal. One or more of the polypeptides, poly (.gamma.-glutamylcysteinyl)glycines, is immobilized on an inert material in particulate form. Upon contact with an aqueous solution containing heavy metals, the polypeptides sequester the metals, removing them from the solution. There is selectivity of poly (.gamma.-glutamylcysteinyl)glycines having a particular number of monomer repeat unit for particular metals. The polypeptides are easily regenerated by contact with a small amount of an organic acid, so that they can be used again to remove heayv metals from solution. This also results in the removal of the metals from the column in a concentrated form.
摘要翻译：从水溶液中除去重金属的方法，用于进行除去的物质的组合物，以及用于进行所述除去的装置。聚（γ-谷氨酰半胱氨酰）甘氨酸中的一种或多种多肽以固体形式固定在惰性物质上。当与含有重金属的水溶液接触时，多肽螯合金属，将其从溶液中除去。对于特定金属，具有特定数目的单体重复单元的聚（γ-谷氨酰半胱氨酰）甘氨酸具有选择性。通过与少量有机酸的接触容易地再生多肽，从而可以再次使用它们以从溶液中除去乙炔金属。这也导致以浓缩形式从柱中除去金属。

2. 发明授权

US08821860B2 Targeted antimicrobials and related compositions, methods and systems 有权
标题翻译：靶向抗菌药物及相关成分，方法和系统
公开(公告)号：US08821860B2
公开(公告)日：2014-09-02
申请号：US12852358
申请日：2010-08-06
申请人： Paul J. Jackson , Brian E. Souza , Feliza A. Bourguet , Matthew A. Coleman
发明人： Paul J. Jackson , Brian E. Souza , Feliza A. Bourguet , Matthew A. Coleman
IPC分类号： C12N9/88 , A61K38/51
CPC分类号： A61K38/50 , A61K45/06 , C12P1/04 , C12Q1/18 , C12Y305/01028 , G01N2333/32 , G01N2333/914
摘要： Targeted antimicrobials are described and related, compositions, methods and systems.
摘要翻译：有针对性的抗微生物剂被描述和相关，组合物，方法和系统。

3. 发明授权

US06329156B1 Method for screening inhibitors of the toxicity of Bacillus anthracis 失效
标题翻译：筛选炭疽芽孢杆菌毒性抑制剂的方法
公开(公告)号：US06329156B1
公开(公告)日：2001-12-11
申请号：US09273839
申请日：1999-03-22
申请人： Nick M. Cirino , Paul J. Jackson , Bruce E. Lehnert
发明人： Nick M. Cirino , Paul J. Jackson , Bruce E. Lehnert
IPC分类号： G01N33567
CPC分类号： C12Q1/18
摘要： The protective antigen (PA) of Bacillus anthracis is integral to the mechanism of anthrax poisoning. The cloning, expression and purification of a 32 kDa B. anthracis PA fragment (PA32) is described. This fragment has also been expressed as a fusion construct to stabilized green fluorescent protein (EGFP-PA32). Both proteins were capable of binding to specific cell surface receptors as determined by fluorescent microscopy and a flow cytometric assay. To confirm binding specificity in the flow cytometric assay, non-fluorescent PA83 or PA32 was used to competitively inhibit fluorescent EGFP-PA32 binding to cell receptors. This assay can be employed as a rapid screen for compounds which disrupts binding of PA to cells. Additionally, the high intracellular expression levels and ease of purification make this recombinant protein an attractive vaccine candidate or therapeutic treatment for anthrax poisoning.
摘要翻译：炭疽芽孢杆菌的保护性抗原（PA）是炭疽中毒机制的组成部分。描述了32kDa炭疽杆菌PA片段（PA32）的克隆，表达和纯化。该片段也被表达为稳定的绿色荧光蛋白（EGFP-PA32）的融合构建体。两种蛋白质都能够通过荧光显微镜和流式细胞术测定法测定特异性细胞表面受体。为了在流式细胞术检测中确认结合特异性，使用非荧光的PA83或PA32来竞争性地抑制荧光EGFP-PA32与细胞受体的结合。该测定法可用作快速筛选能破坏PA与细胞结合的化合物。此外，高细胞内表达水平和易于纯化使得该重组蛋白质成为有吸引力的候选药物或治疗炭疽中毒的治疗方法。

4. 发明授权

US5120441A Method for removal of metal atoms from aqueous solution using suspended plant cells 失效
标题翻译：使用悬挂植物细胞从水溶液中去除金属成分的方法
公开(公告)号：US5120441A
公开(公告)日：1992-06-09
申请号：US530765
申请日：1990-05-30
申请人： Paul J. Jackson , Agapito P. Torres, deceased , Emmanuel Delhaize
发明人： Paul J. Jackson , Agapito P. Torres, deceased , Emmanuel Delhaize
IPC分类号： C02F1/58 , C02F1/28 , C02F1/62 , C02F1/64 , C02F3/12 , C02F3/32 , C22B3/18
CPC分类号： C02F3/1231 , C02F1/286 , C02F3/327 , C22B3/18 , C02F2101/006 , Y02P10/234 , Y02W10/15 , Y02W10/18 , Y10S210/903 , Y10S210/909 , Y10S210/912
摘要： The use of plant suspension cultures to remove ionic metallic species and TNT-based explosives and their oxidation products from aqueous solution is described. Several plant strains were investigated including D. innoxia, Citrus citrus, and Black Mexican Sweet Corn. All showed significant ability to remove metal ions. Ions removed to sub-ppm levels include barium, iron, and plutonium. D. innoxia cells growing in media containing weapons effluent contaminated with Ba.sup.2+ also remove TNT, other explosives and oxidation products thereof from solution. The use of dead, dehydrated cells were also found to be of use in treating waste directly.
摘要翻译：描述了使用植物悬浮培养物从水溶液中除去离子金属物质和TNT基爆炸物及其氧化产物。研究了几种植物菌株，包括D. innoxia，柑橘柑橘和黑墨西哥甜玉米。全部显示出显着的去除金属离子的能力。去除亚ppm级别的离子包括钡，铁和钚。在含有受Ba2 +污染的武器污水的介质中生长的无害细胞也可以从溶液中除去TNT，其他爆炸物及其氧化产物。还发现使用死亡脱水细胞直接用于处理废物。

5. 发明授权

US5296146A Method for removal of explosives from aqueous solution using suspended plant cells 失效
标题翻译：使用悬浮植物细胞从水溶液中除去爆炸物的方法
公开(公告)号：US5296146A
公开(公告)日：1994-03-22
申请号：US895306
申请日：1992-06-08
申请人： Paul J. Jackson , Agapito P. Torres, deceased , Emmanuel Delhaize
发明人： Paul J. Jackson , Agapito P. Torres, deceased , Emmanuel Delhaize
IPC分类号： C02F1/58 , C02F1/28 , C02F1/62 , C02F1/64 , C02F3/12 , C02F3/32 , C22B3/18
CPC分类号： C02F3/1231 , C02F1/286 , C02F3/327 , C22B3/18 , C02F2101/006 , Y02P10/234 , Y02W10/15 , Y02W10/18 , Y10S210/903 , Y10S210/909 , Y10S210/912
摘要： The use of plant suspension cultures to remove ionic metallic species and TNT-based explosives and their oxidation products from aqueous solution is described. Several plant strains were investigated including D. innoxia, Citrus citrus, and Black Mexican Sweet Corn. All showed significant ability to remove metal ions. Ions removed to sub-ppm levels include barium, iron, and plutonium. D. innoxia cells growing in media containing weapons effluent contaminated with Ba.sup.2+ also remove TNT, other explosives and oxidation products thereof from solution. The use of dead, dehydrated cells was also found to be of use in treating waste directly.
摘要翻译：描述了使用植物悬浮培养物从水溶液中除去离子金属物质和TNT基爆炸物及其氧化产物。研究了几种植物菌株，包括D. innoxia，柑橘柑橘和黑墨西哥甜玉米。全部显示出显着的去除金属离子的能力。去除亚ppm级别的离子包括钡，铁和钚。在含有受Ba2 +污染的武器污水的介质中生长的无害细胞也可以从溶液中除去TNT，其他爆炸物及其氧化产物。还发现使用死亡脱水细胞直接用于处理废物。

6. 发明授权

US5089470A Compositions containing poly (.gamma.-glutamylcysteinyl)glycines 失效
标题翻译：含有聚（γ-谷氨酰半胱氨酰）甘氨酸的组合物
公开(公告)号：US5089470A
公开(公告)日：1992-02-18
申请号：US452013
申请日：1989-12-18
申请人： Paul J. Jackson , Emmanuel Delhaize , Nigel J. Robinson , Clifford J. Unkefer , Clement Furlong
发明人： Paul J. Jackson , Emmanuel Delhaize , Nigel J. Robinson , Clifford J. Unkefer , Clement Furlong
IPC分类号： B01J20/32 , B01J45/00 , C01G11/00 , C02F1/28 , C02F9/00
CPC分类号： B01J20/28019 , B01J20/28004 , B01J20/3212 , B01J20/3274 , B01J20/3425 , B01J20/3475 , B01J45/00 , C01G11/003 , C02F1/285 , C02F1/288 , C02F1/62 , C22B3/24 , B01J2220/58 , C02F2101/20 , C02F2303/16 , Y02P10/234
摘要： A method of removing heavy metals from aqueous solution, a composition of matter used in effecting said removal, and apparatus used in effecting said removal. One or more of the polypeptides, poly (.gamma.-glutamylcysteinyl)glycines, is immobilized on an inert material in particulate form. Upon contact with an aqueous solution containing heavy metals, the polypeptides sequester the metals, removing them from the solution. There is selectivity of poly (.gamma.-glutamylcysteinyl)glycines having a particular number of monomer repeat units for particular metals. The polypeptides are easily regenerated by contact with a small amount of an organic acid, so that they can be used again to remove heavy metals from solution. This also results in the removal of the metals from the column in a concentrated form.
摘要翻译：从水溶液中除去重金属的方法，用于进行除去的物质的组合物，以及用于进行所述除去的装置。聚（γ-谷氨酰半胱氨酰）甘氨酸中的一种或多种多肽以固体形式固定在惰性物质上。当与含有重金属的水溶液接触时，多肽螯合金属，将其从溶液中除去。对于特定金属，具有特定数目的单体重复单元的聚（γ-谷氨酰半胱氨酰）甘氨酸具有选择性。通过与少量有机酸的接触容易地再生多肽，从而可以再次使用它们以从溶液中除去重金属。这也导致以浓缩形式从柱中除去金属。

7. 发明授权

US4909944A Removal of metal ions from aqueous solution 失效
标题翻译：从水溶液中去除金属离子
公开(公告)号：US4909944A
公开(公告)日：1990-03-20
申请号：US237263
申请日：1988-08-26
申请人： Paul J. Jackson , Emmanuel Delhaize , Nigel J. Robinson , Clifford J. Unkefer , Clement Furlong
发明人： Paul J. Jackson , Emmanuel Delhaize , Nigel J. Robinson , Clifford J. Unkefer , Clement Furlong
IPC分类号： C02F1/62 , B01D15/00 , B01J20/32 , B01J45/00 , C01G11/00 , C02F1/28 , C02F9/00 , C07K17/02 , C07K17/10
CPC分类号： C02F9/00 , B01J20/28004 , B01J20/28019 , B01J20/3208 , B01J20/3212 , B01J20/3251 , B01J20/3274 , B01J20/3425 , B01J20/3475 , C01G11/003 , C02F1/285 , C02F1/288 , C22B3/24 , B01J2220/58 , C02F2101/20 , Y02P10/234 , Y10S210/912 , Y10S210/914
摘要： A method of removing heavy metals from aqueous solution, a composition of matter used in effecting said removal, and apparatus used in effecting said removal. One or more of the polypeptides, poly (.gamma.-glutamylcysteinyl)glycines, is immobilized on an inert material in particulate form. Upon contact with an aqueous solution containing heavy metals, the polypeptides sequester the metals, removing them from the solution. There is selectivity of poly (.gamma.-glutamylcysteinyl)glycines having a particular number of monomer repeat units for particular metals. The polypeptides are easily regenerated by contact with a small amount of an organic acid, so that they can be used again to remove heavy metals from solution. This also results in the removal of the metals from the column in a concentrated form.
摘要翻译：从水溶液中除去重金属的方法，用于进行除去的物质的组合物，以及用于进行所述除去的装置。聚（γ-谷氨酰半胱氨酰）甘氨酸中的一种或多种多肽以固体形式固定在惰性物质上。当与含有重金属的水溶液接触时，多肽螯合金属，将其从溶液中除去。对于特定金属，具有特定数目的单体重复单元的聚（γ-谷氨酰半胱氨酰）甘氨酸具有选择性。通过与少量有机酸的接触容易地再生多肽，从而可以再次使用它们以从溶液中除去重金属。这也导致以浓缩形式从柱中除去金属。

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