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1. 发明授权

US08466164B2 4-substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof 有权
标题翻译：吡唑并[3,4-d]嘧啶和吡咯并[2,3-d]嘧啶的4-取代衍生物及其用途
公开(公告)号：US08466164B2
公开(公告)日：2013-06-18
申请号：US12678021
申请日：2008-09-12
申请人： Silvia Schenone , Francesco Bondavalli , Olga Bruno , Maurizio Botta , Fabrizio Manetti , Marco Radi , Alessandra Santucci , Giovanni Maga , Mauro Bologna , Adriano Angelucci , Annalisa Santucci , Adriano Spreafico , Fabio Carraro , Jurgen Borlak
发明人： Silvia Schenone , Francesco Bondavalli , Olga Bruno , Maurizio Botta , Fabrizio Manetti , Marco Radi , Alessandra Santucci , Giovanni Maga , Mauro Bologna , Adriano Angelucci , Annalisa Santucci , Adriano Spreafico , Fabio Carraro , Jurgen Borlak
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00
CPC分类号： C07D487/04
摘要： The present invention relates to a compound 4-substituted derivative of pyrazolo[3,4-d]pyrimidine or of pyrrolo[2,3-d]pyrimidine having the formula (I) and uses thereof, in particular for the treatment of bone related diseases and tumors.
摘要翻译：本发明涉及吡唑并[3,4-d]嘧啶或具有式（I）的吡咯并[2,3-d]嘧啶的化合物4-取代的衍生物及其用途，特别是用于治疗骨相关疾病和肿瘤。

2. 发明申请

US20050011777A1 Shaped container carrier 审中-公开
标题翻译：成型集装箱运输车
公开(公告)号：US20050011777A1
公开(公告)日：2005-01-20
申请号：US10892311
申请日：2004-07-16
申请人： Olga Bruno
发明人： Olga Bruno
IPC分类号： B65D71/00 , B65D75/00 , B65D65/00
CPC分类号： B65D71/00
摘要： The invention concerns a shaped container carrier, having one or more shaped housings for containers and a substantially plane support, wherein the support and said one or more housings are capable to be coupled in an at least partially removable manner through mechanical means so that the container carrier is apt to assume at least one first loading configuration, wherein the inside of at least one housing of said one or more housings is accessible, and at least one second use configuration, wherein the inside of said one or more housings is closed and not accessible from the outside.
摘要翻译：本发明涉及一种成形的容器载体，其具有用于容器的一个或多个成形壳体和基本上平面的支撑件，其中支撑件和所述一个或多个壳体能够以至少部分可移除的方式通过机械装置联接，使得容器载体易于呈现至少一个第一装载构造，其中所述一个或多个壳体的至少一个壳体的内部是可接近的，以及至少一个第二使用构造，其中所述一个或多个壳体的内部是封闭的，而不是可从外面进入。

3. 发明申请

US20070010510A1 4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof 有权
标题翻译： 4-取代的吡唑并[3,4-d]嘧啶和吡咯并[2,3-d]嘧啶的衍生物及其用途
公开(公告)号：US20070010510A1
公开(公告)日：2007-01-11
申请号：US10558553
申请日：2004-05-26
申请人： Francesco Bondavalli , Maurizio Botta , Olga Bruno , Fabrizio Manetti , Silvia Schenone , Fabio Carraro
发明人： Francesco Bondavalli , Maurizio Botta , Olga Bruno , Fabrizio Manetti , Silvia Schenone , Fabio Carraro
IPC分类号： A61K31/55 , A61K31/5377 , A61K31/519 , C07D487/02
CPC分类号： C07D487/04
摘要： 4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine are described. Compounds are active as antitumoural agents.
摘要翻译：描述了吡唑并[3,4-d]嘧啶和吡咯并[2,3-d]嘧啶的4-取代的衍生物。化合物作为抗肿瘤剂是有活性的。

4. 发明申请

US20100249152A1 NEW 4-SUBSTITUTED DERIVATIVES OF PYRAZOLO[3,4-D PYRIMIDINE AND PYRROLO[2,3-D]PYRIMIDINE AND USES THEREOF 有权
标题翻译：吡唑并[3,4-D]嘧啶和吡咯并[2,3-D]吡啶的新4-取代衍生物及其用途
公开(公告)号：US20100249152A1
公开(公告)日：2010-09-30
申请号：US12678021
申请日：2008-09-12
申请人： Silvia Schenone , Francesco Bondavalli , Olga Bruno , Maurizio Botta , Fabrizio Manetti , Marco Radi , Alessandra Santucci , Giovanni Maga , Mauro Bologna , Adriano Angelucci , Annalisa Santucci , Adriano Spreafico , Fabio Carraro , Jurgen Borlak
发明人： Silvia Schenone , Francesco Bondavalli , Olga Bruno , Maurizio Botta , Fabrizio Manetti , Marco Radi , Alessandra Santucci , Giovanni Maga , Mauro Bologna , Adriano Angelucci , Annalisa Santucci , Adriano Spreafico , Fabio Carraro , Jurgen Borlak
IPC分类号： A61K31/519 , C07D487/04 , A61P35/04
CPC分类号： C07D487/04
摘要： The present invention relates to a compound 4-substituted derivative of pyrazolo[3,4-d]pyrimidine or of pyrrolo[2,3-d]pyrimidine having the formula (I) and uses thereof, in particular for the treatment of bone related diseases and tumours.
摘要翻译：本发明涉及吡唑并[3,4-d]嘧啶或具有式（I）的吡咯并[2,3-d]嘧啶的化合物4-取代的衍生物及其用途，特别是用于治疗骨相关疾病和肿瘤。

5. 发明授权

US07589086B2 Substituted pyrazolo[3,4-D]pyrimidines as anti-tumor agents 有权
标题翻译：取代的吡唑并[3,4-D]嘧啶作为抗肿瘤剂
公开(公告)号：US07589086B2
公开(公告)日：2009-09-15
申请号：US10558553
申请日：2004-05-26
申请人： Francesco Bondavalli , Maurizio Botta , Olga Bruno , Fabrizio Manetti , Silvia Schenone , Fabio Carraro
发明人： Francesco Bondavalli , Maurizio Botta , Olga Bruno , Fabrizio Manetti , Silvia Schenone , Fabio Carraro
IPC分类号： C07D487/04 , A61K31/519 , C07D403/04 , A61K31/551 , A61K31/5355 , C07D413/04 , A61P35/04
CPC分类号： C07D487/04
摘要： The present invention provides a compound of pyrazolo[3,4-d]pyrimidine having the formula wherein: X=N; R=H, alkylthio, or aminoalkylthio; R1=NHcyclopropyl, NHC3H7, NHC4H9, N(CH2CH3)2, NHCH2CH2OC2H5, 1-pyrrolidinyl, 1-piperidinyl, 4-morpholinyl, NHcyclohexyl, 1-hexahydroazepinyl, NHCH2C6H5, or NHCH2CH2C6H5; wherein R3=H, halogen, or alkyl and R5=Cl, Br or OH.
摘要翻译：本发明提供具有下式的吡唑并[3,4-d]嘧啶的化合物：其中：X = N; R = H，烷硫基或氨基烷硫基; R1 = NH环丙基，NHC3H7，NHC4H9，N（CH2CH3）2，NHCH2CH2OC2H5,1-吡咯烷基，1-哌啶基，4-吗啉基，NH环己基，1-六氢氮杂基，NHCH2C6H5或NHCH2CH2C6H5; 其中R3 = H，卤素或烷基，R5 = Cl，Br或OH。

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