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1. 发明专利

JP2014087661A Filter for use with imaging endoscope 审中-公开
标题翻译：过滤器与成像内窥镜一起使用
公开(公告)号：JP2014087661A
公开(公告)日：2014-05-15
申请号：JP2013246636
申请日：2013-11-28
申请人： Novadaq Technologies Inc , ノバダックテクノロジーズインコーポレイテッド
发明人： JOHN P FENGLER , FRANCIS REGAMEY
IPC分类号： A61B1/00
CPC分类号： A61B1/043 , A61B1/00006 , A61B1/00009 , A61B1/00045 , A61B1/00101 , A61B1/00186 , A61B1/05 , A61B1/0638 , A61B1/0646 , A61B1/0661 , G02B23/2423 , H04N5/2254 , H04N5/2256 , H04N2005/2255
摘要： PROBLEM TO BE SOLVED: To provide a fluorescent endoscope inspecting video system, in which the size, cost, weight and complexity of a camera are reduced.SOLUTION: A fluorescent endoscope inspection video system 50 comprises a multimode light source 52 for generating a beam to form a color image and a fluorescent image. The beam from the light source 52 is fed to a lighting guide 54 of an endoscope 60, and then illuminates a tissue sample 58 to be imaged. This system further comprises a multi-mode camera 100. This multi-mode camera 100 is arranged at an insertion terminal of the endoscope 60. A filter is disposed at the leading end portion of the multi-mode camera 100 so as to form fluorescent and white light images of the tissue 58.
摘要翻译：要解决的问题：提供一种照相机的尺寸，成本，重量和复杂性降低的荧光内窥镜检查视频系统。解决方案：荧光内窥镜检查视频系统50包括用于产生光束的多模光源52 形成彩色图像和荧光图像。来自光源52的光束被馈送到内窥镜60的照明引导件54，然后照射要成像的组织样本58。该系统还包括多模式照相机100.该多模式照相机100布置在内窥镜60的插入端子处。滤光器设置在多模式照相机100的前端部分，以形成荧光和组织58的白光图像。

2. 发明专利

JP2013176637A Device and system for visualizing fluid flow through vessel 审中-公开
标题翻译：通过船舶可视化流体流动的装置和系统
公开(公告)号：JP2013176637A
公开(公告)日：2013-09-09
申请号：JP2013123178
申请日：2013-06-11
申请人： Novadaq Technologies Inc , ノヴァダクテクノロジーズインコーポレイテッド
发明人： FLOWER ROBERT , KLING RONN
IPC分类号： A61B3/14 , A61B3/12
CPC分类号： A61B3/0058 , A61B3/1241
摘要： PROBLEM TO BE SOLVED: To visualize a fluid flow through vessels having a contrast component flowing therethrough.SOLUTION: A method for visualizing a fluid flow through vessels having a contrast component flowing therethrough includes the steps of: selecting from a sequence of angiographic images a subsequence of angiographic images; reading a plurality of dynamic parameters, the dynamic parameters controlling display of the angiographic images; serially displaying the subsequence repetitively in accordance with the dynamic parameters; and providing an interface allowing a user to dynamically update the dynamic parameters while displaying the subsequence.
摘要翻译：要解决的问题：使通过具有对流部件流过的容器的流体流动可视化。解决方案：一种用于使通过具有流过其中的对比成分的血管的流体流动的可视化方法包括以下步骤：从血管造影图像序列中选择子序列的血管造影图像; 读取多个动态参数，动态参数控制血管造影图像的显示; 根据动态参数重复显示子序列; 并提供允许用户在显示子序列的同时动态地更新动态参数的接口。

3. 发明专利

JP2014111614A Imaging methods and compositions comprising fluorescent dyes associated with viral components for nerve imaging 有权
标题翻译：包含与用于神经成像的病毒组件相关联的荧光染料的成像方法和组合物
公开(公告)号：JP2014111614A
公开(公告)日：2014-06-19
申请号：JP2014006203
申请日：2014-01-16
申请人： Novadaq Technologies Inc , ノバダックテクノロジーズインコーポレイテッド
发明人： ROBERT W FLOWER
IPC分类号： A61K49/00
CPC分类号： A61K49/0056 , A61K35/76 , A61K35/763 , A61K47/6901 , A61K49/0021 , A61K49/0034 , A61K49/0041 , A61K49/0043 , A61K49/0045 , A61K49/0097
摘要： PROBLEM TO BE SOLVED: To provide new compositions for nerve imaging, which are used to definitely distinguish between a nerve tissue and non-neural tissues, such as a prostate tissue, that exist around the nerve tissue, during surgery or the like.SOLUTION: A composition comprises: a fluorescent dye; and a neurotropic herpes varicellae unable to replicate in nerve cells, wherein the fluorescent dye is bound to the virus to form a complex that is capable of penetrating nerve cells. Preferably, the dye is indocyanine green, infracyanine green, green fluorescent dye, fluorescein isothiocyanate, rhodamine, phycoerythrin, phycocyanin, allophycocyanin, o-phthaldehyde, fluorescamine, Rose Bengal, trypan blue, fluoro-gold, 3-indocyanine-green-acyl-1, 3-thiazolidine-thione, or green fluorescent protein and other fluorescent proteins. More preferably, the dye is indocyanine green.
摘要翻译：要解决的问题：提供用于神经成像的新组合物，其用于在神经组织和存在于神经组织周围的手术之类的前列腺组织等神经组织和神经组织之间进行绝对区分。解决方案：组合物包含：荧光染料; 以及不能在神经细胞中复制的神经营养性疱疹性水痘，其中荧光染料与病毒结合形成能够穿透神经细胞的复合物。优选地，染料是靛青绿，花青素绿，绿色荧光染料，异硫氰酸荧光素，罗丹明，藻红蛋白，藻蓝蛋白，别藻蓝蛋白，邻苯二甲醛，荧光胺，玫瑰红，台盼蓝，氟金，3-吲哚青绿酰 - 1,3-噻唑烷 - 硫酮，或绿色荧光蛋白和其他荧光蛋白。更优选地，染料是吲哚菁绿。

4. 发明专利

JP2011005302A System and method for visualizing fluid flow through vessels 审中-公开
标题翻译：通过船舶可视化流体流动的系统和方法
公开(公告)号：JP2011005302A
公开(公告)日：2011-01-13
申请号：JP2010228943
申请日：2010-10-08
申请人： Novadaq Technologies Inc , ノヴァダクテクノロジーズインコーポレイテッド
发明人： FLOWER ROBERT , KLING RONN
IPC分类号： A61B3/14 , A61B3/12
CPC分类号： A61B3/0058 , A61B3/1241
摘要： PROBLEM TO BE SOLVED: To visualize fluid flow through vessels having a visualizing composition flowing therethrough.SOLUTION: This invention relates to a method for visualizing fluid flow through vessels having the visualizing composition flowing therethrough, the method comprising the steps of: selecting from a sequence of angiographic images a subsequence of angiographic images, reading a plurality of dynamic parameters, the dynamic parameters for controlling display of the angiographic images, serially displaying the subsequence repetitively in accordance with the dynamic parameters, and providing an interface for a user dynamically update of the dynamic parameters while displaying the subsequence.
摘要翻译：要解决的问题：使具有流过其中的可视化组合物的容器的流体流动可视化。解决方案：本发明涉及一种用于使通过其中流动的可视化组合物的血管流体流动的可视化方法，所述方法包括以下步骤：的血管造影图像的子序列，读取多个动态参数，用于控制血管造影图像的显示的动态参数，根据动态参数重复地显示子序列，以及为用户提供动态更新的界面显示子序列时的动态参数。

5. 发明专利

JP2013163027A Imaging system for combined full-color reflectance and near-infrared imaging 有权
标题翻译：用于组合全彩色反射和近红外成像的成像系统
公开(公告)号：JP2013163027A
公开(公告)日：2013-08-22
申请号：JP2013058356
申请日：2013-03-21
申请人： Novadaq Technologies Inc , ノヴァダクテクノロジーズインコーポレイテッド
发明人： FENGLER JOHN , WESTWICK PAUL , BAILEY ARTHUR E , COTTLE PAUL
IPC分类号： A61B1/06 , A61B1/00 , A61B1/04 , G02B23/24 , G02B23/26
CPC分类号： A61B5/0086 , A61B1/00009 , A61B1/00043 , A61B1/00045 , A61B1/0005 , A61B1/00163 , A61B1/00186 , A61B1/04 , A61B1/042 , A61B1/043 , A61B1/045 , A61B1/06 , A61B1/0638 , A61B1/0646 , A61B1/0669 , A61B5/0062 , A61B5/0071 , A61B5/0075 , A61B5/418 , A61B5/7425 , G06T2207/10048 , H04N5/33 , H04N5/332
摘要： PROBLEM TO BE SOLVED: To provide an imaging system for acquiring NIR and full-color images.SOLUTION: This imaging system for acquisition of NIR and full-color images includes a light source providing visible light and NIR light to an area under observation, such as living tissue, one or more image sensors configured to separately detect blue reflectance light, green reflectance light, and combined red reflectance light/detected NIR light returned from the area under observation. A controller in signal communication with the light source and the camera is configured to control the light source to continuously illuminate the area under observation with temporally continuous blue/green illumination light and with red illumination light and NIR excitation light. At least one of the red illumination light and NIR excitation light is switched on and off periodically in synchronism with the acquisition of red and NIR light images in the camera.
摘要翻译：要解决的问题：提供一种用于获取NIR和全色图像的成像系统。解决方案：用于获取NIR和全色图像的该成像系统包括向观察区域提供可见光和近红外光的光源，例如作为生物体组织，一个或多个图像传感器被配置为分别检测从观察区域返回的蓝色反射光，绿色反射光和组合的红色反射光/检测到的NIR光。与光源和照相机进行信号通信的控制器被配置为控制光源以连续照亮观察区域，并且具有时间上连续的蓝/绿照明光以及红色照明光和NIR激发光。与摄像机中的红色和NIR光图像的获取同步，周期性地打开和关闭红色照明光和NIR激发光中的至少一个。

6. 发明专利

JP2013150830A Compact fluorescence endoscopy image system 有权
标题翻译：紧密荧光内窥镜成像系统
公开(公告)号：JP2013150830A
公开(公告)日：2013-08-08
申请号：JP2013070424
申请日：2013-03-28
申请人： Novadaq Technologies Inc , ノバダックテクノロジーズインコーポレイテッド
发明人： CLINE RICHARD W , FENGLER JOHN J , BOEHM JOACHIM W
IPC分类号： A61B1/00 , G02B23/24 , A61B1/04 , A61B1/06 , A61B5/00 , H04N7/18 , H04N9/04
CPC分类号： A61B5/0071 , A61B1/00009 , A61B1/00057 , A61B1/00186 , A61B1/041 , A61B1/043 , A61B1/045 , A61B1/051 , A61B1/0638 , A61B1/0646 , A61B1/0669 , A61B1/2676 , A61B5/0084
摘要： PROBLEM TO BE SOLVED: To provide a fluorescence endoscopy video system.SOLUTION: A fluorescence endoscopy video system 50 includes a multimode light source 52 that produces light for a color imaging and fluorescence imaging modes. A system 50 includes a multimode camera 100 for color imaging and fluorescence imaging. Images obtained through the endoscope are optically divided and projected onto one or more image sensors by a fixed beam splitter in the camera 100. The fixed beam splitter eliminates the need for inserting a movable mirror into the light path between the endoscope and the image sensors. Image signals from the camera 100 are processed in a processor/controller 64 where a contrast enhancement function can be applied. The contrast enhancement function increases the color contrast between normal tissue and tissue suspicious for early cancer.
摘要翻译：要解决的问题：提供荧光内窥镜视频系统。解决方案：荧光内窥镜视频系统50包括产生用于彩色成像和荧光成像模式的光的多模光源52。系统50包括用于彩色成像和荧光成像的多模照相机100。通过内窥镜获得的图像通过相机100中的固定分束器在光学上被分割并投影到一个或多个图像传感器上。固定分束器不需要将可移动反射镜插入到内窥镜和图像传感器之间的光路中。来自相机100的图像信号在可应用对比度增强功能的处理器/控制器64中进行处理。对比度增强功能增加了早期癌症可疑的正常组织和组织之间的颜色对比。

7. 发明专利

CA2981353C MULTI-CHANNEL WIDE FIELD IMAGING SYSTEM AND OPTICAL SYSTEM FOR USE THEREIN 未知
公开(公告)号：CA2981353C
公开(公告)日：2020-02-25
申请号：CA2981353
申请日：2016-03-29
申请人： NOVADAQ TECHNOLOGIES INC
发明人： MOORE FREDERICK ALLEN
IPC分类号： G01J3/36 , G02B13/22
摘要： An optical system for use with a multi-channel wide field imaging system, the optical system including an objective lens, a dichroic element to split light into a first wavelength range and a second wavelength range, the dichroic element positioned to receive near parallel chief rays from the objective lens, a first channel lens system to receive light of the first wavelength range from the dichroic element; and a second channel lens system to receive light of the second wavelength range from the dichroic element.

8. 发明专利

AU2019204511A1 SYSTEMS AND METHODS FOR ILLUMINATION AND IMAGING OF A TARGET 未知
公开(公告)号：AU2019204511A1
公开(公告)日：2019-07-18
申请号：AU2019204511
申请日：2019-06-26
申请人： NOVADAQ TECHNOLOGIES INC
发明人： MOORE FREDERICK ALLEN , LAMPRECHT ANTON WALTER , OTSIG LESLEY MYRON , WESTWICK PAUL ROALD , AL-DIN BIN ZULKAFLY NASIR , MURRAY GAVIN MICHAEL , TYNAN ADAM JOHN , CAMERON JAMES ELLIOTT , BROWNE GREGORY VINCENT , FONTAINE ISABELLE
IPC分类号： A61B90/30 , A61B5/00 , A61B46/00 , A61B46/10 , G03B15/02
摘要： An imaging device may include a first illumination port to output first light having a first illumination distribution at a target to illuminate the target, a second illumination port to output second light having a second illumination distribution at the target to illuminate the target, the second illumination distribution being substantially similar to the first illumination distribution at the target, the second illumination port being spaced apart from the first illumination port, the first and second illumination distributions being simultaneously provided to the target and overlapping at the target. The illumination from the first and second ports may be matched to a same aspect ratio and field of view coverage as the imaging field of view. Fig 7. WO 2017/079844 PCT/CA2016/051315 (0D Li~m

9. 发明专利

CA171282S DEVICE FOR ILLUMINATION AND IMAGING OF A TARGET 未知
公开(公告)号：CA171282S
公开(公告)日：2017-06-14
申请号：CA171282
申请日：2016-10-27
申请人： NOVADAQ TECHNOLOGIES INC
摘要： The design is the visual features of a device for illumination and imaging of a target shown in solid lines in the drawings, whether those features are features of one of shape, configuration, ornament or pattern or are a combination of any of these features. The broken lines in the figures represent portions of the article that form no part of the claimed design. Figure 1 is a perspective view of a device for illumination and imaging of a target; Figure 2 is a front view of the device for illumination and imaging of a target of Figure 1; Figure 3 is a rear view of the device for illumination and imaging of a target of Figure 1; Figure 4 is a left-side view of the device for illumination and imaging of a target of Figure 1; Figure 5 is a right side view of the device for illumination and imaging of a target of Figure 1; Figure 6 is a top view of the device for illumination and imaging of a target of Figure 1; and Figure 7 is a bottom view of the device for illumination and imaging of a target of Figure 1.

10. 发明专利

AU2015327665A1 Imaging a target fluorophore in a biological material in the presence of autofluorescence 未知
公开(公告)号：AU2015327665A1
公开(公告)日：2017-04-13
申请号：AU2015327665
申请日：2015-09-28
申请人： NOVADAQ TECHNOLOGIES INC
发明人： MORIYAMA EDUARDO HIROYUKI , SZE CHUN HO
IPC分类号： G01N21/64 , A61B6/00
摘要： Methods and systems are disclosed for extracting an image of a target fluorophore in a biological material, which involve inducing both autofluorescence of the biological material and fluorescence of the fluorophore, acquiring an image arising from both the autofluorescence of the biological material and the fluorophore, and an image arising only from the autofluorescence, subtracting the two images to produce an image representing only the fluorophore, wherein relative intensities of the excitation light used to induce the autofluorescence and the fluorescence are modulated prior to acquiring the images.

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