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1. 发明申请

WO2009094783A1 ION FRAGMENTATION IN MASS SPECTROMETRY 审中-公开
标题翻译：离子分散在质谱中
公开(公告)号：WO2009094783A1
公开(公告)日：2009-08-06
申请号：PCT/CA2009/000123
申请日：2009-01-30
申请人： MDS ANALYTICAL TECHNOLOGIES, A BUSINESS UNIT OF MDS INC., DOING BUSINESS THROUGH ITS SCIEX DIVISION , LIFE TECHNOLOGIES CORPORATION, A DELAWARE CORPORATION , MDS INC. , CHERNUSHEVICH, Igor , LOBODA, Alexandre V.
发明人： CHERNUSHEVICH, Igor , LOBODA, Alexandre V.
IPC分类号： H01J49/10 , H01J49/40
CPC分类号： H01J49/0045 , H01J49/062
摘要： In a tandem mass spectrometer using a collision cell for ion fragmentation, the upper limit of the collision energy required for collision induced dissociation (CID) can be extended without reaching or going beyond the upper electrical discharge limit of the system components. The present teachings describe a method of lifting the potential energy of ions to a predetermined level sufficient for CID fragmentation while satisfying a discharge free condition. The present teaching also describes a method of lifting the potential energy of the fragment ions after CID fragmentation so that the product ions have sufficient energy for mass analysis.
摘要翻译：在使用用于离子破碎的碰撞池的串联质谱仪中，碰撞诱导解离（CID）所需的碰撞能量的上限可以延长而不达到或超过系统部件的上限放电极限。本教导描述了一种在满足无放电条件的同时将离子的势能提升到足以进行CID碎裂的预定水平的方法。本教导还描述了在CID碎裂之后提升碎片离子的势能的方法，使得产物离子具有足够的能量进行质量分析。

2. 发明申请

WO2009023946A1 METHOD FOR ENHANCING MASS ASSIGNMENT ACCURACY 审中-公开
标题翻译：提高质量分配精度的方法
公开(公告)号：WO2009023946A1
公开(公告)日：2009-02-26
申请号：PCT/CA2007/001459
申请日：2007-08-21
申请人： MDS ANALYTICAL TECHNOLOGIES, A BUSINESS UNIT OF MDS INC., DOING BUSINESS THROUGH ITS SCIEX DIVISION , HAGER, James
发明人： HAGER, James
IPC分类号： H01J49/26 , H01J49/10
CPC分类号： H01J49/0031 , H01J49/0009 , H01J49/426
摘要： A method of operating an ion trap spectrometer system having an ion trap is provided. The method comprises a) providing a group of ions for analysis, wherein the group of ions includes a first analyte; b) providing a filtered first analyte having a first mass-to-charge ratio by filtering out ions other than the first analyte; c) storing the filtered first analyte in the ion trap; d) storing a first set of calibrant ions in the ion trap with the filtered first analyte, wherein the first set of calibrant ions has at least one calibrant ion and each calibrant ion in the first set of calibrant ions has a known mass-to-charge ratio; e) transmitting the filtered first analyte and the first set of calibrant ions from the ion trap for detection; f) detecting the filtered first analyte to generate a first analyte mass signal peak representing the filtered first analyte, and detecting each calibrant ion in the first set of calibrant ions to generate an associated calibrant mass signal peak for each calibrant ion in the first set of calibrant ions; and, g) calibrating a first mass signal derived from the first analyte mass signal peak by comparing the known mass-to-charge ratio and the associated calibrant mass signal peak for each calibrant ion in the first set of calibrant ions.
摘要翻译：提供了具有离子阱的离子阱光谱仪系统的操作方法。该方法包括：a）提供用于分析的一组离子，其中所述离子组包括第一分析物; b）通过滤除第一分析物以外的离子来提供具有第一质荷比的经过滤的第一分析物; c）将过滤的第一分析物储存在离子阱中; d）将第一组校准物离子存储在离子阱中与经过滤的第一分析物，其中第一组校准物离子具有至少一个校准离子，并且第一组校准离子中的每个校准离子具有已知的质量 - 电荷比; e）从所述离子阱传输所述经过滤的第一分析物和所述第一组校准物离子用于检测; f）检测经过滤的第一分析物以产生表示经过滤的第一分析物的第一分析物质量信号峰，并检测第一组校准物离子中的每个校准离子，以产生第一组中的每个校准离子的相关校准物质量信号峰校准离子; 以及g）通过比较所述第一组校准物离子中的每个校准离子的已知质荷比和相关校准物质量信号峰来校准从第一分析物质量信号峰导出的第一质量信号。

3. 发明申请

WO2008116283A1 METHOD FOR OPERATING AN ION TRAP MASS SPECTROMETER SYSTEM 审中-公开
标题翻译：操作离子质谱仪系统的方法
公开(公告)号：WO2008116283A1
公开(公告)日：2008-10-02
申请号：PCT/CA2008/000317
申请日：2008-02-20
申请人： MDS ANALYTICAL TECHNOLOGIES, A BUSINESS UNIT OF MDS INC., DOING BUSINESS THROUGH ITS SCIEX DIVISION , APPLERA CORPORATION , HAGER, James, W.
发明人： HAGER, James, W.
IPC分类号： H01J49/04 , H01J49/26
CPC分类号： H01J49/0045 , H01J49/4225
摘要： A method of operating a mass spectrometer system having an ion trap is provided. The method comprises encoding a selected characteristic in at least one of the first group of precursor ions and the first plurality of fragments, wherein the encoding operation is applied to at least one of the first group of precursor ions and the first plurality of fragments without being applied to other ions such that the first plurality of fragment ions has the first selected characteristic and the other ions lack the first selected characteristic.
摘要翻译：提供了具有离子阱的操作质谱仪系统的方法。所述方法包括在所述第一组前体离子和所述第一多个片段中的至少一个中编码所选择的特征，其中所述编码操作被应用于所述第一组前体离子和所述第一多个片段中的至少一个，施加到其他离子，使得第一多个碎片离子具有第一选择的特性，而其它离子缺少第一选择的特性。

4. 发明申请

WO2008009121A1 DYNAMIC PIXEL SCANNING FOR USE WITH MALDI-MS 审中-公开
标题翻译：用于MALDI-MS的动态像素扫描
公开(公告)号：WO2008009121A1
公开(公告)日：2008-01-24
申请号：PCT/CA2007/001276
申请日：2007-07-19
申请人： MDS ANALYTICAL TECHNOLOGIES, A BUSINESS UNIT OF MDS INC., DOING BUSINESS THROUGH ITS SCIEX DIVISION , APPLERA CORPORATION , JAMES, Andrew , YANG, Min J. , SCOTT, George
发明人： JAMES, Andrew , YANG, Min J. , SCOTT, George
IPC分类号： G01N30/72 , H01J49/26
CPC分类号： H01J49/164 , H01J49/0004
摘要： A method for dynamic pixel mass spectrometric imaging, or dynamic pixel imaging is disclosed. The method includes striking a sample to be scanned with a laser beam so that the laser beam releases analytes from the sample. The laser beam and the sample are then displaced relative to one another so that the laser beam substantially continuously traces a predefined path on the sample to release analytes from the sample along the predefined path. A mass analysis of the released analytes is performed.
摘要翻译：公开了一种用于动态像素质谱成像或动态像素成像的方法。该方法包括用激光束冲击要扫描的样品，使得激光束从样品中释放分析物。然后激光束和样品相对于彼此移位，使得激光束基本上连续地跟踪样品上的预定路径，以沿着预定路径释放来自样品的分析物。对释放的分析物进行质量分析。

5. 发明申请

WO2009043149A1 ANALYSIS OF CONJUGATED METABOLITES OF ALCOHOL CONSUMPTION 审中-公开
标题翻译：酒精消费的结合代谢物的分析
公开(公告)号：WO2009043149A1
公开(公告)日：2009-04-09
申请号：PCT/CA2008/001728
申请日：2008-09-29
申请人： MDS ANALYTICAL TECHNOLOGIES, A BUSINESS UNIT OF MDS INC., DOING BUSINESS THROUGH ITS SCIEX DIVISION , APPLIED BIOSYSTEMS INC. , SAKUMA, Takeo
发明人： SAKUMA, Takeo
IPC分类号： G01N33/98 , G01N33/483 , G01N33/50 , G01N33/70
CPC分类号： G01N33/98 , G01N30/466 , G01N30/7233 , Y10T436/11 , Y10T436/144444 , Y10T436/18 , Y10T436/204165 , Y10T436/24
摘要： A method, system, kit and uses for quantifying and normalizing at least one product of ethanol metabolism are provided. A method is provided for quantifying and normalizing at least one product of ethanol metabolism in a sample comprising creatinine. The method comprises adding a predetermined amount of at least one internal standard to the sample; adding deuterated creatinine to the sample; detecting and measuring at least one product of ethanol metabolism, the predetermined amount of at least one internal standard in the sample, the deuterated creatinine, and the creatinine. The method also comprises quantifying the amount of at least one product of ethanol metabolism in the sample using the measurement of the at least one internal standard; quantifying the amount of creatinine in the sample using the measurement of the deuterated creatinine; and normalizing the quantity of the at least one product of metabolism using the measurement of the creatinine.
摘要翻译：提供了用于定量和标准化至少一种乙醇代谢产物的方法，系统，试剂盒和用途。提供了一种用于定量和标准化包含肌酸酐的样品中至少一种乙醇代谢产物的方法。该方法包括向样品中加入预定量的至少一种内标; 向样品中加入氘代肌酐; 检测和测量至少一种乙醇代谢产物，样品中至少一种内标物的预定量，氘代肌酐和肌酸酐。该方法还包括使用至少一种内标的测量来量化样品中至少一种乙醇代谢产物的量; 使用氘代肌酐的测量量化样品中肌酸酐的量; 以及使用所述肌酸酐的测量使所述至少一种代谢产物的量归一化。

6. 发明申请

WO2008037073A1 MULTIPLE SAMPLE SOURCES FOR USE WITH MASS SPECTROMETERS, AND APPARATUS, DEVICES, AND METHODS THEREFOR 审中-公开
标题翻译：用于质谱仪的多个样品来源及其设备及其方法
公开(公告)号：WO2008037073A1
公开(公告)日：2008-04-03
申请号：PCT/CA2007/001716
申请日：2007-09-25
申请人： MDS ANALYTICAL TECHNOLOGIES, A BUSINESS UNIT OF MDS INC., DOING BUSINESS THROUGH ITS SCIEX DIVISION , APPLERA CORPORATION , SCHNEIDER, Bradley B. , COVEY, Thomas R.
发明人： SCHNEIDER, Bradley B. , COVEY, Thomas R.
IPC分类号： H01J49/04 , H01J49/26
CPC分类号： H01J49/107 , H01J49/0009 , H01J49/0095 , H01J49/067 , H01J49/165
摘要： A method for introducing samples through a boundary member partially defining a chamber at an entrance point coaxial to a sampling inlet of a mass spectrometer is described. Field-free conditions can be established in at least one region of the chamber. The sample can be introduced adjacent to the sampling inlet, and introducing at least a second sample can be introduced through at least one other entrance point in the chamber not adjacent to the sampling inlet. An apparatus having a sampling inlet and a boundary member partially defining a chamber is also described. Field-free conditions can be established in at least one region of the chamber, and there can be a first aperture in the boundary member through which a source emits sample. Related devices, uses and mass spectrometers are also described.
摘要翻译：描述了通过在与质谱仪的取样入口同轴的入口处部分地限定腔室的边界构件引入样品的方法。可以在室的至少一个区域建立无场的条件。可以将样品引入到采样入口附近，并且引入至少第二样品可以通过不与采样入口相邻的室中的至少一个其它入口引入。还描述了具有采样入口和部分地限定腔室的边界构件的装置。可以在室的至少一个区域中建立无场条件，并且在边界构件中可以有一个第一孔，源通过该孔发射样品。还描述了相关的装置，用途和质谱仪。

7. 发明申请

WO2009114932A8 SYSTEMS AND METHODS FOR ANALYZING SUBSTANCES USING A MASS SPECTROMETER 审中-公开
公开(公告)号：WO2009114932A8
公开(公告)日：2009-09-24
申请号：PCT/CA2009/000310
申请日：2009-03-12
申请人： MDS ANALYTICAL TECHNOLOGIES, a business unit of MDS Inc., doing business through its Sciex division , LIFE TECHNOLOGIES CORPORATION , LOCK, Chris, M. , BLOOMFIELD, Nic
发明人： LOCK, Chris, M. , BLOOMFIELD, Nic
IPC分类号： H01J49/26 , G01N30/72 , H01J49/10
摘要： Systems and methods for analyzing compounds in a sample. In one embodiment, the present technology is directed towards a method of analyzing a sample, comprising: emitting ions from the sample; selectively filtering the emitted ions for at least one designated trigger ion; fragmenting the designated trigger ions; scanning for a designated trigger ion fragment; and upon detecting the designated trigger ion fragment, scanning for at least one confirmatory ion fragment.

8. 发明申请

WO2009094762A1 METHODS FOR FRAGMENTING IONS IN A LINEAR ION TRAP 审中-公开
标题翻译：用于在线性离子阱中去除离子的方法
公开(公告)号：WO2009094762A1
公开(公告)日：2009-08-06
申请号：PCT/CA2009/000090
申请日：2009-01-26
申请人： MDS ANALYTICAL TECHNOLOGIES, a business unit of MDS INC., doing business through its SCIEX DIVISION , LIFE TECHNOLOGIES CORPORATION , GUNA, Mircea , COLLINGS, Bruce
发明人： GUNA, Mircea , COLLINGS, Bruce
IPC分类号： H01J49/10 , H01J49/26
CPC分类号： H01J49/005 , H01J49/063 , H01J49/4225
摘要： Methods for fragmenting ions retained in an ion trap are described. In various embodiments, a non-steady-state pressure of a neutral collision gas of less than about 5 x 10 -4 Torr and an excitation amplitude of less than about 500 mV (peak to ground) is used to fragment ions with greater than about 80% fragmentation efficiency. In various embodiments, duration of ion excitation is greater than about 25 ms.
摘要翻译：描述了保留在离子阱中的分离离子的方法。在各种实施例中，使用小于约5×10 -4乇的中性碰撞气体的非稳定状态压力和小于约500mV（峰对地）的激发振幅用于将大于约 80％的碎片效率。在各种实施例中，离子激发的持续时间大于约25ms。

9. 发明申请

WO2008025144A1 SYSTEMS AND METHODS FOR CORRECTING FOR UNEQUAL ION DISTRIBUTION ACROSS A MULTI-CHANNEL TOF DETECTOR 审中-公开
标题翻译：通过多通道TOF检测器校正不均匀离子分布的系统和方法
公开(公告)号：WO2008025144A1
公开(公告)日：2008-03-06
申请号：PCT/CA2007/001511
申请日：2007-08-29
申请人： MDS ANALYTICAL TECHNOLOGIES, a business unit of MDS INC., doing business through its Sciex Division , APPLERA CORPORATION , BLOOMFIELD, Nic , IVOSEV, Gordana
发明人： BLOOMFIELD, Nic , IVOSEV, Gordana
IPC分类号： H01J49/26 , G01N27/00 , G01N27/62 , G01T1/16
CPC分类号： H01J49/0027
摘要： Systems and methods for calculating ion flux. In one embodiment, a mass spectrometer includes an ion source for emitting a beam of ions from a sample and at least one detector positioned downstream of said ion source. The at least one detector comprises a plurality of detector channels. The mass spectrometer also includes a controller operatively coupled to the plurality of detector channels. The controller is configured to: determine ion abundance data correlated to each detector channel; determine corrected ion abundance data correlated to each detector channel; determine confidence data corresponding to the ion abundance data for each of the detector channels; and determine a confidence weighted abundance estimate of the ion flux correlated to both the ion abundance data and to the confidence data.
摘要翻译：用于计算离子通量的系统和方法。在一个实施例中，质谱仪包括用于从样品发射离子束的离子源和位于所述离子源下游的至少一个检测器。所述至少一个检测器包括多个检测器通道。质谱仪还包括可操作地耦合到多个检测器通道的控制器。控制器被配置为：确定与每个检测器通道相关的离子丰度数据; 确定与每个检测器通道相关的校正离子丰度数据; 确定对应于每个检测器通道的离子丰度数据的置信度数据; 并确定与离子丰度数据和置信数据两者相关的离子通量的置信加权丰度估计。

10. 发明申请

WO2008009108A1 METHOD OF OPERATING A MASS SPECTROMETER TO PROVIDE RESONANT EXCITATION ION TRANSFER 审中-公开
标题翻译：操作质谱仪以提供共振激发离子传输的方法
公开(公告)号：WO2008009108A1
公开(公告)日：2008-01-24
申请号：PCT/CA2007/001256
申请日：2007-07-17
申请人： MDS ANALYTICAL TECHNOLOGIES, A BUSINESS UNIT OF MDS INC., DOING BUSINESS THROUGH ITS SCIEX DIVISION , APPLERA CORPORATION , THOMSON, Bruce , HAGER, Jim
发明人： THOMSON, Bruce , HAGER, Jim
IPC分类号： G01N30/72 , H01J49/10 , H01J49/40
CPC分类号： H01J49/4225 , H01J49/004 , H01J49/4265 , H01J49/4285
摘要： A method of operating a mass spectrometer having a rod set is provided. The rod set has a first end, a second end opposite to the first end, and a longitudinal axis extending between the first end and the second end. The method comprises a) admitting ions into the rod set; b) trapping at least some of the ions in the rod set by i) producing a first barrier field at a first end member adjacent to the first end of the rod set, ii) producing a second barrier field at a second end member adjacent to the second end of the rod set, and iii) providing an aggregate field comprising an RF field between the rods of the rod set; c) selecting a first selected mass to charge ratio of a first group of ions in the ions; d) determining a first excitement level of a selected characteristic of the aggregate field for the first group of ions; e) adjusting the selected characteristic of the aggregate field to the first excitement level to resonantly excite the first group of ions to mass selectively eject the first group of ions from the rod set past the barrier field; and, f) maintaining the selected characteristic of the aggregate field at the first excitement level during an excitement time interval wherein the excitation time interval is at least 1 millisecond.
摘要翻译：提供了具有棒组的操作质谱仪的方法。杆组具有第一端，与第一端相对的第二端和在第一端和第二端之间延伸的纵向轴线。该方法包括：a）将离子进入棒组; b）通过以下步骤捕获所述棒组中的至少一些离子：i）在与所述棒组的第一端相邻的第一端构件处产生第一屏障场，ii）在邻近所述杆组的第二端构件处产生第二屏障场所述杆组的第二端，以及iii）提供包括所述杆组的杆之间的RF场的聚集场; c）选择离子中的第一组离子的第一选择质量与电荷比; d）确定第一组离子的聚集场的选定特征的第一兴奋度; e）将聚集场的所选特征调整到第一兴奋水平以共振地激发第一组离子以质量选择性地从穿过屏障场的棒组中弹出第一组离子; 以及f）在所述激发时间间隔至少为1毫秒的兴奋时间间隔期间将所述聚集场的选定特性保持在所述第一兴奋度水平。

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