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1. 发明专利

AU2005314236A1 Protein-protein interaction detection system using fluorescent protein microdomains 未知
公开(公告)号：AU2005314236A1
公开(公告)日：2006-06-15
申请号：AU2005314236
申请日：2005-12-03
申请人： THE REGENTS OF THE UNIV OF CALIFORNIA LOS ALAMOS NATIONAL LABORATORY
发明人： CABANTOUS STEPHANIE , WALDO GEOFFREY S
IPC分类号： C12Q1/66 , C12N15/63
摘要： The invention provides a protein labeling and interaction detection system based on engineered fragments of fluorescent and chromophoric proteins that require fused interacting polypeptides to drive the association of the fragments, and further are soluble and stable, and do not change the solubility of polypeptides to which they are fused. In one embodiment, a test protein X is fused to a sixteen amino acid fragment of GFP (&bgr;-strand 10, amino acids 198-214), engineered to not perturb fusion protein solubility. A second test protein Y is fused to a sixteen amino acid fragment of GFP (&bgr;-strand 11, amino acids 215-230), engineered to not perturb fusion protein solubility. When X and Y interact, they bring the GFP strands into proximity, and are detected by complementation with a third GFP fragment consisting of GFP amino acids 1-198 (strands 1-9). When GFP strands 10 and 11 are held together by interaction of protein X and Y, they spontaneous association with GFP strands 1-9, resulting in structural complementation, folding, and concomitant GFP fluorescence.

2. 发明申请

WO2006062882A2 PROTEIN-PROTEIN INTERACTION DETECTION SYSTEM USING FLUORESCENT PROTEIN MICRODOMAINS 审中-公开
标题翻译：荧光蛋白微球的蛋白质 - 蛋白质相互作用检测系统
公开(公告)号：WO2006062882A2
公开(公告)日：2006-06-15
申请号：PCT/US2005/043874
申请日：2005-12-03
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA LOS ALAMOS NATIONAL LABORATORY
发明人： WALDO, Geoffrey, S. , CABANTOUS, Stephanie
IPC分类号： C12Q1/00
CPC分类号： C40B30/04 , G01N33/5005 , G01N33/5008 , G01N33/542 , G01N33/582 , G01N33/6845
摘要： The invention provides a protein labeling and interaction detection system based on engineered fragments of fluorescent and chromophoric proteins that require fused interacting polypeptides to drive the association of the fragments, and further are soluble and stable, and do not change the solubility of polypeptides to which they are fused. In one embodiment, a test protein X is fused to a sixteen amino acid fragment of GFP (β-strand 10, amino acids 198-214), engineered to not perturb fusion protein solubility. A second test protein Y is fused to a sixteen amino acid fragment of GFP (β-strand 11, amino acids 215-230), engineered to not perturb fusion protein solubility. When X and Y interact, they bring the GFP strands into proximity, and are detected by complementation with a third GFP fragment consisting of GPF amino acids 1-198 (strands 1-9). When GFP strands 10 and 11 are held together by interaction of protein X and Y, they spontaneous association with GFP strands 1-9, resulting in structural complementation, folding, and concomitant GFP fluorescence.
摘要翻译：本发明提供基于荧光和发色蛋白质的工程化片段的蛋白质标记和相互作用检测系统，其需要融合的相互作用多肽来驱动片段的缔合，并且进一步是可溶的和稳定的，并且不改变它们所融合的多肽的溶解度。在一个实施方案中，测试蛋白X与GFP的十六个氨基酸片段（β-链10，氨基酸198-214）融合，工程化为不干扰融合蛋白溶解性。第二种测试蛋白Y与GFP的16个氨基酸片段（β-链11，氨基酸215-230）融合，工程化为不干扰融合蛋白的溶解性。当X和Y相互作用时，它们使GFP链接近，并通过与由GPF氨基酸1-198（链1-9）组成的第三个GFP片段互补来检测。当GFP链10和11通过蛋白质X和Y的相互作用结合在一起时，它们与GFP链1-9自发缔合，导致结构互补，折叠和伴随的GFP荧光。

3. 发明申请

WO2015048760A1 INTERFACE POINT METHOD MODELING OF THE STEAM-ASSISTED GRAVITY DRAINAGE PRODUCTION OF OIL 审中-公开
标题翻译：蒸汽辅助排水生产油的界面点方法建模
公开(公告)号：WO2015048760A1
公开(公告)日：2015-04-02
申请号：PCT/US2014/058352
申请日：2014-09-30
申请人： BP CORPORATION NORTH AMERICA INC. , LOS ALAMOS NATIONAL LABORATORY
发明人： VANDERHEYDEN, William, Brian , ZHANG, Duan, Z.
IPC分类号： E21B44/00 , G06F19/00 , G06G7/48
CPC分类号： E21B43/2406 , E21B41/00
摘要： A computer system and method of simulating the behavior of an oil and gas reservoir including movement of the steam-bitumen interface during oil production using the Steam Assisted Gravity Drainage (SAGD) technique. A system of equations including state equations involving momentum and heat transport for each phase, mass conservation equations, and heat balance equations, in combination with a continuity constraint, is defined and discretized for the modeled volume. A material point model technique for numerically solving the system of discretized equations is applied, where interface marker particles that move through the Eulerian grid represent the location of points along the steam-bitumen interface.
摘要翻译：一种计算机系统和模拟油气储层行为的方法，包括使用蒸汽辅助重力排水（SAGD）技术在油生产过程中蒸汽 - 沥青界面的运动。对于建模体积定义了一个包含每个阶段的动量和热传递的状态方程组，方程组，质量守恒方程和热平衡方程以及连续性约束的方程组。应用用于数值求解离散方程系统的材料点模型技术，其中移动通过欧拉网格的界面标记颗粒表示沿着蒸汽 - 沥青界面的点的位置。

4. 发明申请

WO2010059732A1 ANTIVIRAL VACCINES WITH IMPROVED CELLULAR IMMUNOGENICITY 审中-公开
标题翻译：具有改善的细胞免疫原性的抗真菌药
公开(公告)号：WO2010059732A1
公开(公告)日：2010-05-27
申请号：PCT/US2009/064999
申请日：2009-11-18
申请人： BETH ISRAEL DEACONESS MEDICAL CENTER , LOS ALAMOS NATIONAL LABORATORY , BAROUCH, Dan, H. , KORBER, Bette, T. , FISCHER, William, M.
发明人： BAROUCH, Dan, H. , KORBER, Bette, T. , FISCHER, William, M.
IPC分类号： C07K17/00
CPC分类号： A61K39/21 , A61K39/12 , A61K39/235 , A61K39/275 , A61K2039/53 , C07K14/005 , C12N7/00 , C12N2710/10043 , C12N2710/10343 , C12N2710/24043 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171 , C12N2740/16222 , C12N2740/16234 , C12N2740/16271 , C12N2740/16322 , C12N2740/16334 , Y02A50/467
摘要： The invention provides compositions, methods, and kits for the treatment or prevention of viral infections. The polyvalent ( e.g. , 2-valent) vaccines described herein incorporate computationally-optimized viral polypeptides that can increase the diversity or breadth and depth of cellular immune response in vaccinated subjects.
摘要翻译：本发明提供用于治疗或预防病毒感染的组合物，方法和试剂盒。本文所述的多价（例如2价）疫苗引入计算优化的病毒多肽，其可以增加接种受试者的细胞免疫应答的多样性或广度和深度。

5. 发明申请

WO2005026376A2 IMPROVED METHODS FOR SEQUENCING GC-RICH AND CCT REPEAT DNA TEMPLATES 审中-公开
标题翻译：测序GC富集和CCT重复DNA模板的改进方法
公开(公告)号：WO2005026376A2
公开(公告)日：2005-03-24
申请号：PCT/US2004/027606
申请日：2004-08-26
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA LOS ALAMOS NATIONAL LABORATORY
发明人： ROBINSON, Donna, L.
IPC分类号： C12Q
CPC分类号： C12P19/34 , C12Q1/6869 , C12Q2535/113 , C12Q2527/101 , C12Q2525/151
摘要： The present invention is directed to a PCR-based method of cycle sequencing DNA and other polynucleotide sequences having high CG content and regions of high GC content, and includes for example DNA strands with a high Cytosine and/or Guanosine content and repeated motifs such as CCT repeats.
摘要翻译：本发明涉及具有高CG含量和高GC含量区域的循环测序DNA和其他多核苷酸序列的基于PCR的方法，并且包括例如具有高胞嘧啶和/ 或鸟嘌呤核苷含量和重复的基序，如CCT重复。

6. 发明申请

WO1997028567A1 STRUCTURE FOR HTS COMPOSITE CONDUCTORS AND THE MANUFACTURE OF SAME 审中-公开
标题翻译： HTS复合导体结构及其制造
公开(公告)号：WO1997028567A1
公开(公告)日：1997-08-07
申请号：PCT/US1997001920
申请日：1997-02-05
申请人： AMERICAN SUPERCONDUCTOR CORPORATION , LOS ALAMOS NATIONAL LABORATORY
发明人： AMERICAN SUPERCONDUCTOR CORPORATION , LOS ALAMOS NATIONAL LABORATORY , RILEY, Gilbert, N., Jr. , COTTON, James, D.
IPC分类号： H01L39/14
CPC分类号： H01L39/143 , Y10S428/93 , Y10S505/704 , Y10T29/49014 , Y10T428/12611 , Y10T428/2944 , Y10T428/2949
摘要： A superconducting oxide composite structure is provided which includes a superconducting oxide member (10), a metal layer (30) surrounding the superconducting oxide member, and an insulating layer (20) of a complex oxide formed in situ adjacent to the superconducting oxide member (10) and the metal layer (30). A method of forming such a superconducting oxide composite structure includes encapsulating a superconducting oxide member or precursor within a metal matrix layer from the group of: (i) a reactive metal sheath adjacent to the superconducting oxide member or precursor, the reactive metal sheath surrounded by a second metal layer or (ii) an alloy containing a reactive metal; to form an intermediate product, and, heating the intermediate product at temperatures and for time sufficient to form an insulating layer of a complex oxide in situ, the insulating layer (20) being adjacent to the superconducting oxide member (10), or precursor, and the metal matrix layer (20).
摘要翻译：提供了一种超导氧化物复合结构，其包括超导氧化物构件（10），围绕超导氧化物构件的金属层（30）以及与超导氧化物构件相邻形成的复合氧化物的绝缘层（20） 10）和金属层（30）。形成这种超导氧化物复合结构的方法包括将超导氧化物构件或前体从以下组中包含在金属基质层内：（i）与超导氧化物构件或前体相邻的反应性金属鞘，由第二金属层或（ii）含有活性金属的合金; 形成中间产物，并且在温度和时间足以在原地形成复合氧化物的绝缘层的情况下加热中间产物，绝缘层（20）与超导氧化物构件（10）或前体相邻，和金属基质层（20）。

7. 发明授权

US10988663B2 Method for sealing a void in a well using a smart gel sealant 有权
公开(公告)号：US10988663B2
公开(公告)日：2021-04-27
申请号：US16091943
申请日：2017-04-04
申请人： Chevron U.S.A. Inc. , Los Alamos National Laboratory, LC / IP
发明人： Harvey E. Goodman , Robert Clifford Roback , Robert D. Gilbertson , Hakim Boukhalfa , Scott W. Imbus
IPC分类号： E21B47/10 , C09K8/508 , C09K8/512 , E21B33/13 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/14 , A61P31/18
摘要： Embodiments of the disclosure include swellable smart gel sealants. In certain embodiments, the smart gel sealants reversibly swell when exposed to a certain trigger, such as temperature or pH. In specific embodiments, the smart gel is disposed within voids in a well and triggered to swell in order to seal the voids. One application of the smart gel sealant is to seal the casing of a well against the leakage of gas, such as CO2.

8. 发明申请

US20190292435A1 Smart Gel Sealants for Well Systems 审中-公开
公开(公告)号：US20190292435A1
公开(公告)日：2019-09-26
申请号：US16091943
申请日：2017-04-04
申请人： CHEVRON U.S.A. INC. , LOS ALAMOS NATIONAL LABORATORY, LC / IP
发明人： Harvey E. GOODMAN , Robert Clifford ROBACK , Robert D. GILBERTSON , Hakim BOUKHALFA , Scott W. IMBUS
IPC分类号： C09K8/508 , C09K8/512 , C09K8/516 , E21B33/13 , E21B47/10
摘要： Embodiments of the disclosure include swellable smart gel sealants. In certain embodiments, the smart gel sealants reversibly swell when exposed to a certain trigger, such as temperature or pH. In specific embodiments, the smart gel is disposed within voids in a well and triggered to swell in order to seal the voids. One application of the smart gel sealant is to seal the casing of a well against the leakage of gas, such as CO2.

9. 发明申请

US20150094999A1 INTERFACE POINT METHOD MODELING OF THE STEAM-ASSISTED GRAVITY DRAINAGE PRODUCTION OF OIL 审中-公开
标题翻译：蒸汽辅助排水生产油的界面点方法建模
公开(公告)号：US20150094999A1
公开(公告)日：2015-04-02
申请号：US14502418
申请日：2014-09-30
申请人： BP Corporation North America Inc. , Los Alamos National Laboratory
发明人： William Brian VanderHeyden , Duan Z. Zhang
IPC分类号： E21B43/00 , E21B43/24 , E21B43/20 , G06F17/50
CPC分类号： E21B43/2406 , E21B41/00
摘要： A computer system and method of simulating the behavior of an oil and gas reservoir including movement of the steam-bitumen interface during oil production using the Steam Assisted Gravity Drainage (SAGD) technique. A system of equations including state equations involving momentum and heat transport for each phase, mass conservation equations, and heat balance equations, in combination with a continuity constraint, is defined and discretized for the modeled volume. A material point model technique for numerically solving the system of discretized equations is applied, where interface marker particles that move through the Eulerian grid represent the location of points along the steam-bitumen interface.
摘要翻译：一种计算机系统和模拟油气储层行为的方法，包括使用蒸汽辅助重力排水（SAGD）技术在油生产过程中蒸汽 - 沥青界面的运动。对于建模体积定义了一个包含每个阶段的动量和热传递的状态方程组，方程组，质量守恒方程和热平衡方程以及连续性约束的方程组。应用用于数值求解离散方程系统的材料点模型技术，其中移动通过欧拉网格的界面标记颗粒表示沿着蒸汽 - 沥青界面的点的位置。

10. 发明申请

WO2006073455A3 PREPARATION OF SINGLE-WALLED CARBON NANOTUBES 审中-公开
公开(公告)号：WO2006073455A3
公开(公告)日：2006-07-13
申请号：PCT/US2005/015045
申请日：2005-04-29
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA LOS ALAMOS NATIONAL LABORATORY
发明人： ZHU, Yutain, T. , O'CONNELL, Michael J. , LIU, Jie , ZHENG, Lianxi
IPC分类号： D01F9/12
摘要： Carbon nanotubes were prepared using a transition metal catalyst and alcohol carbon source. After putting a small amount of a solution of ethanol and ferric chloride on one end of a Si (100) substrate, the substrate was heated in a furnace, first under a flowing gas mixture of argon and hydrogen and thereafter under a flowing gas miture of argon, hydrogen, and ethanol. The product included semiconducting and metallic type carbon nanotubes. Scanning electron micrograph images demonstrated that the product included carbon nanotubes that were about as long as the substrate (about 4 cm), suggesting that even longer carbon nanotubes would result if an even longer substrate was used.

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