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1. 发明申请

US20160303132A1 PYRAZOLO [3,4-D] PYRIMIDINE DERIVATIVES USEFUL TO TREAT RESPIRATORY DISORDERS 审中-公开
标题翻译： PYRAZOLO [3,4-D]吡嗪衍生物有助于治疗呼吸道疾病
公开(公告)号：US20160303132A1
公开(公告)日：2016-10-20
申请号：US15194373
申请日：2016-06-27
申请人： Ian Bruce , Judy Fox Hayler , Graham Charles Bloomfield , Lee Edwards , Brian Cox , Catherine Howsham
发明人： Ian Bruce , Judy Fox Hayler , Graham Charles Bloomfield , Lee Edwards , Brian Cox , Catherine Howsham
IPC分类号： A61K31/519 , A61K31/5377
CPC分类号： A61K31/519 , A61K31/5377 , C07D487/04
摘要： The present invention concerns a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof, where R1-R3 and Y are defined in the description, and its use in the treatment of disorders in which pi3 kinase is implicated.
摘要翻译：或其药学上可接受的盐或溶剂化物，其中R1-R3和Y在说明书中定义，及其用于治疗其中涉及pi3激酶的病症。

2. 发明申请

US20160068546A1 TREATING DISEASES MEDIATED BY BLOCKADE OF THE EPITHELIAL SODIUM CHANNEL WITH PYRAZINE-2-CARBOXAMIDE DERIVATIVES 审中-公开
标题翻译：用吡嗪-2-羧酰胺衍生物治疗由上皮细胞通道引起的疾病
公开(公告)号：US20160068546A1
公开(公告)日：2016-03-10
申请号：US14847262
申请日：2015-09-08
申请人： Gurdip BHALAY , Emma BUDD , Graham Charles BLOOMFIELD , Stephen Paul COLLINGWOOD , Andrew DUNSTAN , Lee EDWARDS , Peter GEDECK , Catherine HOWSHAM , Peter HUNT , Thomas Anthony HUNT , Paul OAKLEY , Nichola SMITH
发明人： Gurdip BHALAY , Emma BUDD , Graham Charles BLOOMFIELD , Stephen Paul COLLINGWOOD , Andrew DUNSTAN , Lee EDWARDS , Peter GEDECK , Catherine HOWSHAM , Peter HUNT , Thomas Anthony HUNT , Paul OAKLEY , Nichola SMITH
IPC分类号： C07D519/00 , A61K31/497
CPC分类号： C07D519/00 , A61K31/497 , C07D403/12 , C07D471/04 , C07D471/10 , C07D471/20 , C07D473/34 , C07D487/04 , C07D487/10
摘要： A compound of Formula I in free or salt or solvate form, where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R11 have the meanings as indicated in the specification, is useful for treating diseases which respond to the blockade of the epithelial sodium channel. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
摘要翻译：式Ⅰ化合物，其中R1，R2，R3，R4，R5，R6，R7，R8，R9，R10和R11具有说明书中所述的含义，可用于治疗疾病，对上皮钠通道的阻断作出反应。还描述了含有化合物的药物组合物和用于制备化合物的方法。

3. 发明授权

US09056867B2 N-substituted heterocyclyl carboxamides 有权
标题翻译： N-取代的杂环基甲酰胺
公开(公告)号：US09056867B2
公开(公告)日：2015-06-16
申请号：US14345022
申请日：2012-09-14
申请人： Kamlesh Jagdis Bala , Emma Budd , Lee Edwards , Catherine Howsham , Darren Mark LeGrand , Roger John Taylor
发明人： Kamlesh Jagdis Bala , Emma Budd , Lee Edwards , Catherine Howsham , Darren Mark LeGrand , Roger John Taylor
IPC分类号： A61K31/4427 , C07D487/04 , A61K31/415 , A61K31/4439 , A61K31/497 , A61K45/06 , A61K31/4985 , A61K31/5377 , A61K31/444 , C07D231/40 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/14
CPC分类号： C07D487/04 , A61K31/415 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/4985 , A61K31/5377 , A61K45/06 , C07D231/40 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/14
摘要： A compound of Formula I and pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, Ra, A, B, D and E are all as defined herein. The compounds modulate the activity of CFTR and are useful in the treatment of inflammatory or obstructive airways diseases or mucosal hydration, including, for example cystic fibrosis. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
摘要翻译：式I化合物及其药学上可接受的盐和溶剂合物，其中R1，R2，R3，Ra，A，B，D和E全部如本文所定义。该化合物调节CFTR的活性，并且可用于治疗炎性或阻塞性气道疾病或粘膜水合，包括例如囊性纤维化。还描述了含有化合物的药物组合物和用于制备化合物的方法。

4. 外观设计

USD705091S1 HVAC control device 有权
公开(公告)号：USD705091S1
公开(公告)日：2014-05-20
申请号：US29345471
申请日：2009-10-16
申请人： Jan Andersson , Lee Edwards , Lyndon Shenton
设计人： Jan Andersson , Lee Edwards , Lyndon Shenton

5. 发明授权

US08697687B2 Treating diseases mediated by blockade of the epithelial sodium channel with pyrazine-2-carboxamide derivatives 有权
标题翻译：用吡嗪-2-甲酰胺衍生物治疗由上皮钠通道阻断介导的疾病
公开(公告)号：US08697687B2
公开(公告)日：2014-04-15
申请号：US13613495
申请日：2012-09-13
申请人： Gurdip Bhalay , Emma Budd , Graham Charles Bloomfield , Stephen Paul Collingwood , Andrew Dunstan , Lee Edwards , Peter Gedeck , Catherine Howsham , Peter Hunt , Thomas Anthony Hunt , Paul Oakley , Nichola Smith
发明人： Gurdip Bhalay , Emma Budd , Graham Charles Bloomfield , Stephen Paul Collingwood , Andrew Dunstan , Lee Edwards , Peter Gedeck , Catherine Howsham , Peter Hunt , Thomas Anthony Hunt , Paul Oakley , Nichola Smith
IPC分类号： A01N43/62 , A61K31/55 , A61K31/4965 , A61K31/535 , C07D237/00 , C07D239/00 , C07D241/00 , C07D413/00 , C07D243/08
CPC分类号： C07D519/00 , A61K31/497 , C07D403/12 , C07D471/04 , C07D471/10 , C07D471/20 , C07D473/34 , C07D487/04 , C07D487/10
摘要： A compound of Formula I in free or salt or solvate form, where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R11 have the meanings as indicated in the specification, is useful for treating diseases which respond to the blockade of the epithelial sodium channel. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
摘要翻译：式Ⅰ化合物，其中R1，R2，R3，R4，R5，R6，R7，R8，R9，R10和R11具有说明书中所述的含义，可用于治疗疾病，对上皮钠通道的阻断作出反应。还描述了含有化合物的药物组合物和用于制备化合物的方法。

6. 发明授权

US08476269B2 Pyridine and pyrazine derivative for the treatment of CF 有权
标题翻译：吡啶和吡嗪衍生物用于治疗CF
公开(公告)号：US08476269B2
公开(公告)日：2013-07-02
申请号：US13544182
申请日：2012-07-09
申请人： Urs Baettig , Kamlesh Jagdis Bala , Emma Budd , Lee Edwards , Catherine Howsham , Glyn Alan Hughes , Darren Mark Legrand , Katrin Spiegel
发明人： Urs Baettig , Kamlesh Jagdis Bala , Emma Budd , Lee Edwards , Catherine Howsham , Glyn Alan Hughes , Darren Mark Legrand , Katrin Spiegel
IPC分类号： A61K31/5355 , A61K31/497 , A61K31/4965 , A61K31/4453 , A61K31/454 , A61K31/443 , A61K31/444 , A61K31/445 , C07D213/22 , C07D213/26 , C07D211/06 , C07D413/12 , C07D213/61 , C07D213/04 , C07D241/16
CPC分类号： A61K31/44 , A61K31/4412 , A61K31/4418 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4965 , A61K31/497 , A61K31/5377 , A61K45/06 , C07D213/38 , C07D213/81 , C07D241/26 , C07D241/28 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/12 , C07D413/04 , C07D413/12
摘要： The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.
摘要翻译：本发明提供吡啶和吡嗪衍生物，其恢复或增强突变和/或野生型CFTR的功能以治疗囊性纤维化，原发性纤毛运动障碍，慢性支气管炎，慢性阻塞性肺病，哮喘，呼吸道感染，肺癌，口腔干燥症和角膜结膜炎或便秘（IBS，IBD，阿片样物质诱发）。还包括包含这些衍生物的药物组合物。

7. 发明申请

US20130041687A1 RECREATING THE STATE OF A CLINICAL SYSTEM 有权
标题翻译：恢复临床系统状态
公开(公告)号：US20130041687A1
公开(公告)日：2013-02-14
申请号：US13207777
申请日：2011-08-11
申请人： Ryan Alan Brush , David Lee Edwards
发明人： Ryan Alan Brush , David Lee Edwards
IPC分类号： G06Q50/00
CPC分类号： G06Q10/063114 , G06F19/00 , G06Q50/22
摘要： A method, system and medium are provided for enabling re-creation of a state of a computing system as it existed at a selected time. A plurality of data elements are tracked including functions and reference information employed in calculating one or more of the data elements. Versions of functions and reference information are also tracked. Thereby, a time at which to recreate the state of the system is selectable and the data elements that were available at or before the selected time are identifiable. And the versions of functions and reference information that were available at the selected time are identifiable. The state of the system at the selected time can thus be reviewed or analyzed as desired.
摘要翻译：提供了一种方法，系统和介质，用于使得能够重新创建在所选择的时间存在的计算系统的状态。跟踪多个数据元素，包括在计算一个或多个数据元素时使用的功能和参考信息。功能和参考信息的版本也被跟踪。因此，可以选择重新创建系统状态的时间，并且可以在所选时间之前或之前可用的数据元素是可识别的。并且在所选时间可用的功能和参考信息的版本是可识别的。因此可以根据需要对选定时间的系统状态进行检查或分析。

8. 发明申请

US20120277232A1 Pyridine and Pyrazine Derivative for the Treatment of CF 有权
标题翻译：吡啶和吡嗪衍生物用于治疗CF
公开(公告)号：US20120277232A1
公开(公告)日：2012-11-01
申请号：US13544182
申请日：2012-07-09
申请人： Urs BAETTIG , Kamlesh Jagdis BALA , Emma BUDD , Lee EDWARDS , Catherine Howsham , Glyn HUGHES , Darren Mark LEGRAND , Katrin SPIEGEL
发明人： Urs BAETTIG , Kamlesh Jagdis BALA , Emma BUDD , Lee EDWARDS , Catherine Howsham , Glyn HUGHES , Darren Mark LEGRAND , Katrin SPIEGEL
IPC分类号： A61K31/44 , C07D405/12 , A61K31/443 , A61P11/00 , A61K31/4545 , A61K31/497 , C07D413/12 , A61K31/5377 , C07D213/81 , C07D401/12
CPC分类号： A61K31/44 , A61K31/4412 , A61K31/4418 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4965 , A61K31/497 , A61K31/5377 , A61K45/06 , C07D213/38 , C07D213/81 , C07D241/26 , C07D241/28 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/12 , C07D413/04 , C07D413/12
摘要： The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.
摘要翻译：本发明提供吡啶和吡嗪衍生物，其恢复或增强突变和/或野生型CFTR的功能以治疗囊性纤维化，原发性纤毛运动障碍，慢性支气管炎，慢性阻塞性肺病，哮喘，呼吸道感染，肺癌，口腔干燥症和角膜结膜炎或便秘（IBS，IBD，阿片样物质诱发）。还包括包含这些衍生物的药物组合物。

9. 发明申请

US20120214800A1 Organic Compounds 有权
标题翻译：有机化合物
公开(公告)号：US20120214800A1
公开(公告)日：2012-08-23
申请号：US13460504
申请日：2012-04-30
申请人： Ian Bruce , Emma Budd , Lee Edwards , Catherine Howsham
发明人： Ian Bruce , Emma Budd , Lee Edwards , Catherine Howsham
IPC分类号： A61K31/551 , A61K31/497 , C07D413/14 , A61K31/5377 , C07D401/06 , C07D413/12 , C07D241/20 , A61K31/4965 , C07D265/36 , A61K31/536 , A61P11/00 , A61P37/08 , A61P19/02 , A61P17/06 , A61P1/04 , A61P1/00 , A61P35/00 , A61P9/10 , A61P37/06 , A61P3/10 , A61P3/04 , C07D401/14
CPC分类号： C07D401/06 , C07D241/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/14
摘要： The present invention concerns a compound of formula (I) or a salt, suitably a pharmaceutically acceptable salt, or solvate thereof, wherein the groups R1, R2, Ar′, A and Y are defined in the description, to compositions and use of the compounds in the treatment of inflammatory and allergic conditions.
摘要翻译：本发明涉及式（I）化合物或其盐，其合适的药学上可接受的盐或溶剂合物，其中R 1，R 2，Ar'，A和Y基团在说明书中定义为组合物和用途化合物治疗炎症和过敏症状。

10. 发明授权

US08247436B2 Pyridine and pyrazine derivative for the treatment of CF 有权
标题翻译：吡啶和吡嗪衍生物用于治疗CF
公开(公告)号：US08247436B2
公开(公告)日：2012-08-21
申请号：US13047319
申请日：2011-03-14
申请人： Urs Baettig , Kamlesh Jagdis Bala , Emma Budd , Lee Edwards , Catherine Howsham , Glyn Hughes , Darren Mark Legrand , Katrin Spiegel
发明人： Urs Baettig , Kamlesh Jagdis Bala , Emma Budd , Lee Edwards , Catherine Howsham , Glyn Hughes , Darren Mark Legrand , Katrin Spiegel
IPC分类号： A61K31/445 , A61K31/4418 , A61K31/444 , C07D213/22 , C07D213/24
CPC分类号： A61K31/44 , A61K31/4412 , A61K31/4418 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4965 , A61K31/497 , A61K31/5377 , A61K45/06 , C07D213/38 , C07D213/81 , C07D241/26 , C07D241/28 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/12 , C07D413/04 , C07D413/12
摘要： The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.
摘要翻译：本发明提供吡啶和吡嗪衍生物，其恢复或增强突变和/或野生型CFTR的功能以治疗囊性纤维化，原发性纤毛运动障碍，慢性支气管炎，慢性阻塞性肺病，哮喘，呼吸道感染，肺癌，口腔干燥症和角膜结膜炎或便秘（IBS，IBD，阿片样物质诱发）。还包括包含这些衍生物的药物组合物。

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