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1. 发明专利

GB2367739A Drinking vessel with non-adhesion to coasters 未知
公开(公告)号：GB2367739A
公开(公告)日：2002-04-17
申请号：GB0024882
申请日：2000-10-11
申请人： GOOLD KEVIN OWEN
发明人： GOOLD KEVIN OWEN
IPC分类号： A47G19/22
摘要： A drinking vessel with a number of protuberances 2 provided on the exterior underside, which prevents the adhesion of a drinks mat or coaster onto which the vessel has been set down. In the preferred embodiment, three protuberances are provided, set at 120{ angular intervals in proximity to the circumference of a circular base.

2. 发明申请

WO2006104406A1 TRICYCLIC 1,2,4-TRIAZINE OXIDES AND COMPOSITIONS THEREFROM FOR THERAPEUTIC USE IN CANCER TREATMENTS 审中-公开
标题翻译：三联1,2,4-三唑氧化物及其治疗用于治疗癌症的组合物
公开(公告)号：WO2006104406A1
公开(公告)日：2006-10-05
申请号：PCT/NZ2006/000064
申请日：2006-03-31
申请人： AUCKLAND UNISERVICES LIMITED , HAY, Michael, Patrick , BLASER, Adrian , DENNY, William, Alexander , HICKS, Kevin, Owen , LEE, Ho, Huat , PCHALEK, Karin , PRUIJN, Frederik, Bastiaan , SIIM, Bronwyn, Gae , WILSON, William, Robert , YANG, Shangjin
发明人： HAY, Michael, Patrick , BLASER, Adrian , DENNY, William, Alexander , HICKS, Kevin, Owen , LEE, Ho, Huat , PCHALEK, Karin , PRUIJN, Frederik, Bastiaan , SIIM, Bronwyn, Gae , WILSON, William, Robert , YANG, Shangjin
IPC分类号： C07D253/10 , A61K31/53 , A61P35/00 , C07D471/04 , C07D487/04 , C07D491/048 , C07D491/052 , C07D491/056
CPC分类号： C07D253/10 , C07D471/04 , C07D487/04 , C07D491/048 , C07D491/052 , C07D491/056
摘要： The invention relates to novel tricyclic 1,2,4-triazine-1-oxides and novel tricyclic 1,2,4-triazine-1,4-dioxides of formula: (I); and to related analogues, to their preparation, and to their use as hypoxia-selective drugs and radiosensitizers for cancer therapy, both alone or in combination with radiation and/or other anticancer drugs.
摘要翻译：本发明涉及式（I）的新型三环1,2,4-三嗪-1-氧化物和新型三环1,2,4-三嗪-1,4-二氧化物：以及相关类似物，其制备方法，以及它们作为用于癌症治疗的缺氧选择性药物和放射增敏剂的用途，单独或与辐射和/或其它抗癌药物组合。

3. 发明申请

WO2004026846A8 DNA-TARGETED BENZOTRIAZINE 1,4-DIOXIDES AND THEIR USE IN CANCER THERAPY 审中-公开
标题翻译： DNA靶向苯扎他嗪1,4-二氧化物及其在癌症治疗中的应用
公开(公告)号：WO2004026846A8
公开(公告)日：2007-03-08
申请号：PCT/NZ0300210
申请日：2003-09-17
申请人： AUCKLAND UNISERVICES LTD , UNIV LELAND STANFORD JUNIOR , BROWN J MARTIN , DENNY WILLIAM ALEXANDER , HAY MICHAEL PATRICK , HICKS KEVIN OWEN , GAMAGE SWARNALATHA AKURATIYA , PRUIJIN FREDERIK BASTIAAN , WILSON WILLIAM ROBERT
发明人： BROWN J MARTIN , DENNY WILLIAM ALEXANDER , HAY MICHAEL PATRICK , HICKS KEVIN OWEN , GAMAGE SWARNALATHA AKURATIYA , PRUIJIN FREDERIK BASTIAAN , WILSON WILLIAM ROBERT
IPC分类号： C07D253/10 , A61P35/00 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14
CPC分类号： C07D253/10 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14
摘要： The present invention relates to DNA-targeted 1,2,4-benzotriazine- 1,4-dioxides and related analogues, to their preparation, and to their use as hypoxia-selective drugs and radiosensitizers for cancer therapy, both alone or in combination with radiation and/or other anticancer drugs.
摘要翻译：本发明涉及DNA靶向的1,2,4-苯并三嗪-1,4-二氧化物及其相关类似物及其制备方法，并且涉及它们作为用于癌症治疗的缺氧选择性药物和放射增敏剂，它们单独或与辐射和/或其他抗癌药物。

4. 发明申请

WO2004026846A1 DNA-TARGETED BENZOTRIAZINE 1,4-DIOXIDES AND THEIR USE IN CANCER THERAPY 审中-公开
标题翻译： DNA靶向苯扎他嗪1,4-二氧化物及其在癌症治疗中的应用
公开(公告)号：WO2004026846A1
公开(公告)日：2004-04-01
申请号：PCT/NZ2003/000210
申请日：2003-09-17
申请人： AUCKLAND UNISERVICES LIMITED , THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , BROWN, J Martin , DENNY, William, Alexander , HAY, Michael, Patrick , HICKS, Kevin, Owen , GAMAGE, Swarnalatha, Akuratiya , PRUIJIN, Frederik, Bastiaan , WILSON, William, Robert
发明人： BROWN, J Martin , DENNY, William, Alexander , HAY, Michael, Patrick , HICKS, Kevin, Owen , GAMAGE, Swarnalatha, Akuratiya , PRUIJIN, Frederik, Bastiaan , WILSON, William, Robert
IPC分类号： C07D253/10 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14
CPC分类号： C07D253/10 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14
摘要： The present invention relates to DNA-targeted 1,2,4-benzotriazine- 1,4-dioxides and related analogues, to their preparation, and to their use as hypoxia-selective drugs and radiosensitizers for cancer therapy, both alone or in combination with radiation and/or other anticancer drugs.
摘要翻译：本发明涉及DNA靶向的1,2,4-苯并三嗪-1,4-二氧化物及其相关类似物及其制备方法，并且涉及它们作为用于癌症治疗的缺氧选择性药物和放射增敏剂，它们单独或与辐射和/或其他抗癌药物。

5. 发明申请

WO2005082867A1 NOVEL 1,2,4-BENZOTRIAZINE-1,4-DIOXIDES 审中-公开
标题翻译：新的1,2,4-苯并噻唑-1,4-二氧化物
公开(公告)号：WO2005082867A1
公开(公告)日：2005-09-09
申请号：PCT/NZ2005/000034
申请日：2005-03-01
申请人： AUCKLAND UNISERVICES LIMITED , DENNY, William, Alexander , HAY, Michael, Patrick , HICKS, Kevin, Owen , PRUIJN, Frederik, Bastiaan , WILSON, William, Robert , PCHALEK, Karin
发明人： DENNY, William, Alexander , HAY, Michael, Patrick , HICKS, Kevin, Owen , PRUIJN, Frederik, Bastiaan , WILSON, William, Robert , PCHALEK, Karin
IPC分类号： C07D253/10
CPC分类号： C07D253/10 , C07D253/08 , C07D401/12
摘要： The present invention provides a simplified set of characteristics that can be used to select 1,2,4 benzotriazine 1,4 dioxide compounds (TPZ analogues) with therapeutic activity against hypoxic cells in human tumour xenografts, and to further provide a novel class of 1,2,4-benzotriazine-1,4-dioxides (TPZ analogues) with predicted in vivo activity against tumours, to their preparation, and to their use as hypoxia-selective cytotoxic drugs and radiosensitizers for cancer therapy, both alone or in combination with radiation and/or other anticancer drugs.
摘要翻译：本发明提供了可用于选择具有针对人肿瘤异种移植物中缺氧细胞的治疗活性的1,2,4苯并三嗪二氧化物化合物（TPZ类似物）的简化的特征集，并进一步提供新的1类，具有预测的肿瘤体内活性的2,4-苯并三嗪-1,4-二氧化物（TPZ类似物），其制备及其作为用于癌症治疗的缺氧选择性细胞毒性药物和放射增敏剂的用途，单独或与辐射和/或其他抗癌药物。

6. 发明申请

US20140263598A1 CARTON WITH PLASTIC RECLOSABLE HEADER 审中-公开
标题翻译：带塑料可拆卸头的纸箱
公开(公告)号：US20140263598A1
公开(公告)日：2014-09-18
申请号：US14293340
申请日：2014-06-02
申请人： Clifton HOWELL , David WALLACE , Kenny MCCRACKEN , Robert HOGAN , Kevin OWEN , Steven OLECHOWSKI , Eric PLOURDE , David ANZINI , Steven AUSNIT , Rusty KOENIGKRAMER
发明人： Clifton HOWELL , David WALLACE , Kenny MCCRACKEN , Robert HOGAN , Kevin OWEN , Steven OLECHOWSKI , Eric PLOURDE , David ANZINI , Steven AUSNIT , Rusty KOENIGKRAMER
IPC分类号： B65D5/66
CPC分类号： B65D5/3628 , B65D5/6697 , B65D31/08
摘要： The disclosure relates to a method and apparatus for manufacturing a package with a rigid or semi-rigid container and a polymeric or plastic header with a reclosure, such as a zipper. The rigid or semi-rigid container is typically provided in a stack of flat containers. The header is sealed, glued or otherwise secured to the containers. The container, typically inverted, is filled, and the bottom is formed by folding and sealing the bottom portion of the container.
摘要翻译：本公开涉及一种用于制造具有刚性或半刚性容器的包装的方法和装置，以及具有诸如拉链的重合闸的聚合物或塑料集管。刚性或半刚性容器通常设置在一堆扁平容器中。集管被密封，胶合或以其他方式固定到容器。通常倒置的容器被填充，底部通过折叠和密封容器的底部而形成。

7. 发明授权

US07816521B2 1,2,4-benzotriazine-1,4-dioxides 有权
标题翻译： 1,2,4-苯并三嗪-1,4-二氧化物
公开(公告)号：US07816521B2
公开(公告)日：2010-10-19
申请号：US10590796
申请日：2005-03-01
申请人： William Alexander Denny , Michael Patrick Hay , Kevin Owen Hicks , Frederik Pruijn , William Robert Wilson , Karin Pchalek
发明人： William Alexander Denny , Michael Patrick Hay , Kevin Owen Hicks , Frederik Pruijn , William Robert Wilson , Karin Pchalek
IPC分类号： C07D253/10 , C07D413/12 , A61K31/53 , A61P35/00
CPC分类号： C07D253/10 , C07D253/08 , C07D401/12
摘要： The compound 3-ethyl-6-[3-(4-morpholinyl)propoxy]-1,2,4-benzotriazine 1,4-dioxide and pharmacologically acceptable salts thereof. A method of treating cancer in a subject is also described in which 3-ethyl-6-[3-(4-morpholinyl)propoxy]-1,2,4-benzotriazine 1,4-dioxide or a pharmacologically acceptable salt thereof is administered to tumor cells in a hypoxic environment. Also described is a method of radiosensitising in a subject tumor cells of solid tumors in hypoxic conditions by administering to the subject a pharmaceutical composition containing 3-ethyl-6-[3-(4-morpholinyl)propoxy]-1,2,4-benzotriazine 1,4-dioxide or a pharmacologically acceptable salt thereof in an amount sufficient to produce radiosensitivity in the tumor cells, and subjecting the tumor cells to radiation. A pharmaceutical composition is additionally provided containing a therapeutically effective amount of 3-ethyl-6-[3-(4-morpholinyl)propoxy]-1,2,4-benzotriazine 1,4-dioxide or a pharmacologically acceptable salt thereof and a pharmaceutically acceptable excipient, adjuvant, carrier, buffer or stabiliser.
摘要翻译：化合物3-乙基-6- [3-（4-吗啉基）丙氧基] -1,2,4-苯并三嗪1,4-二氧化物及其药理学上可接受的盐。还描述了在受试者中治疗癌症的方法，其中给予3-乙基-6- [3-（4-吗啉基）丙氧基] -1,2,4-苯并三嗪1,4-二氧化物或其药理学上可接受的盐到缺氧环境中的肿瘤细胞。还描述了通过向受试者施用含有3-乙基-6- [3-（4-吗啉基）丙氧基] -1,2,4-恶二唑的药物组合物，在缺氧条件下的实体瘤的受试肿瘤细胞中放射增敏的方法，苯并三嗪1,4-二氧化物或其药理学上可接受的盐，其量足以在肿瘤细胞中产生放射敏感性，并对肿瘤细胞进行辐射。另外提供含有治疗有效量的3-乙基-6- [3-（4-吗啉基）丙氧基] -1,2,4-苯并三嗪1,4-二氧化物或其药学上可接受的盐和药学上可接受的盐的药物组合物可接受的赋形剂，佐剂，载体，缓冲液或稳定剂。

8. 发明申请

US20100122513A1 AUTOMATIC APPLICATION OF ZIPPER SEGMENT 审中-公开
标题翻译：拉链分段自动应用
公开(公告)号：US20100122513A1
公开(公告)日：2010-05-20
申请号：US12558662
申请日：2009-09-14
申请人： Kevin OWEN , Stephen S. RUDERMAN
发明人： Kevin OWEN , Stephen S. RUDERMAN
IPC分类号： B65B11/58
CPC分类号： B31B70/00 , B31B70/8132 , B31B2160/10
摘要： The disclosure relates to a method and apparatus for the application of zipper segments to opposite sides of a flat, form cut cardboard, paper or plastic card using double-sided adhesive tape. The card receives double-sided tape, and then zipper profiles are secured to the double-sided tape. Alternately, the zipper profiles and double-sided tape may be joined together and then applied to the card. The card is then folded and used for the packing of pieces of chewing gum or similar applications.
摘要翻译：本公开涉及一种用于使用双面胶带将拉链片段应用于平面的切割纸板，纸张或塑料卡片的相对侧的方法和装置。卡片接收双面胶带，然后将拉链型材固定在双面胶带上。或者，拉链轮廓和双面胶可以连接在一起，然后施加到卡上。然后将卡折叠并用于包装口香糖或类似应用。

9. 发明申请

US20090186886A1 Tricyclic 1,2,4-Triazine Oxides and Compositions for Therapeutic Use in Cancer Treatments 有权
标题翻译：用于治疗癌症治疗的三环1,2,4-三嗪氧化物和组合物
公开(公告)号：US20090186886A1
公开(公告)日：2009-07-23
申请号：US11887368
申请日：2006-03-31
申请人： Michael Patrick Hay , Adrian Blaser , William Alexander Denny , Kevin Owen Hicks , Ho Huat Lee , Karin Pchalek , Frederik Bastiaan Pruijn , Bronwyn Gae Siim , William Robert Wilson , Shangjin Yang
发明人： Michael Patrick Hay , Adrian Blaser , William Alexander Denny , Kevin Owen Hicks , Ho Huat Lee , Karin Pchalek , Frederik Bastiaan Pruijn , Bronwyn Gae Siim , William Robert Wilson , Shangjin Yang
IPC分类号： A61K31/5377 , C07D253/10 , A61K31/53 , C07D413/06 , C07D491/048 , A61P35/00
CPC分类号： C07D253/10 , C07D471/04 , C07D487/04 , C07D491/048 , C07D491/052 , C07D491/056
摘要： The invention relates to novel tricyclic 1,2,4-triazine-1-oxides and novel tricyclic 1,2,4-triazine-1,4-dioxides of formula I and to related analogues, to their preparation, and to their use as hypoxia-selective drugs and radiosensitizers for cancer therapy, both alone or in combination with radiation and/or other anticancer drugs.
摘要翻译：本发明涉及式I的新型三环1,2,4-三嗪-1-氧化物和新型三环1,2,4-三嗪-1,4-二氧化物及其相关类似物及其制备方法及其用途低氧选择性药物和用于癌症治疗的放射增敏剂，单独或与辐射和/或其它抗癌药物组合。

10. 发明申请

US20080271415A1 Dual drum configuration for transverse direction application of zippers 有权
标题翻译：用于横向应用拉链的双鼓配置
公开(公告)号：US20080271415A1
公开(公告)日：2008-11-06
申请号：US11799597
申请日：2007-05-02
申请人： Kevin Owen , David C. Wallace
发明人： Kevin Owen , David C. Wallace
IPC分类号： B29D5/00
CPC分类号： B65B61/188 , B31B70/8133 , Y10S493/927
摘要： A drum configuration uses first and second rotary drums to apply alternate zipper segments in a transverse direction to a sheet of moving web or film. This allows the web to maintain a constant speed without the intermittent pausing while the zipper segments are sealed to the web.
摘要翻译：滚筒构造使用第一和第二旋转滚筒将横向方向上的替代拉链部分施加到一张移动的幅材或薄膜上。这样就可以使纸幅保持恒定的速度，而不会间歇地停顿，同时拉链片段被密封到卷筒纸上。

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