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1. 发明授权

US5082840A Morpholine compounds and treatment 失效
标题翻译：吗啉化合物和处理
公开(公告)号：US5082840A
公开(公告)日：1992-01-21
申请号：US399902
申请日：1989-08-29
申请人： Jonathan R. Arch , Norman H. Rogers
发明人： Jonathan R. Arch , Norman H. Rogers
IPC分类号： A23K1/16 , A61K31/535 , A61K31/5375 , A61P3/04 , C07D265/30 , C07D265/32 , C07D413/04
CPC分类号： C07D265/30 , A61K31/535 , C07D413/04
摘要： A method for increasing the weight gain and/or improving the feed utilization efficiency and/or increasing the lean body mass and/or decreasing birth mortality rate and increasing post-natal survival rate of livestock comprises the administration to livestock of an effective, non-toxic amount of a compound of formula (I), or a veterinarily acceptable acid addition salt thereof: ##STR1## wherein R.sup.1 is phenyl (C.sub.1-6) alkyl or optionally substituted C.sub.1-6 alkyl, andW is optionally substituted phenyl, a heterocyclyl group, or phenoxymethyl optionally substituted on the phenyl group. Certain compounds of formula (I) are novel.

2. 发明授权

US4880834A Method for administering ethanolamine derivatives to livestock 失效
标题翻译：向家畜施用乙醇胺衍生物的方法
公开(公告)号：US4880834A
公开(公告)日：1989-11-14
申请号：US937030
申请日：1986-10-30
申请人： Jonathan R. Arch
发明人： Jonathan R. Arch
IPC分类号： A23K1/16 , A61K31/135
CPC分类号： A61K31/135 , A23K20/111 , A23K20/116
摘要： A method for treating livestock to decrease birth mortality rate and to increase post-natal survival rate by administering ethanolamine derivatives is disclosed.

3. 发明授权

US4873240A Method for administering ethanolamine derivatives to livestock 失效
标题翻译：向家畜施用乙醇胺衍生物的方法
公开(公告)号：US4873240A
公开(公告)日：1989-10-10
申请号：US216872
申请日：1988-07-08
申请人： Jonathan R. Arch
发明人： Jonathan R. Arch
IPC分类号： A23K1/16 , A61K31/135
CPC分类号： A61K31/135 , A23K20/111 , A23K20/116
摘要： A method for increasing the weight gain and/or improving the feed utilization efficiency of livestock is described which comprises the oral or non-oral administration to livestock of an effective, non-toxic amount of a compound of formula (XX): ##STR1## or a salt thereof, in which W is phenyl optionally substituted by halogen or trifluoromethyl, or a benzofuran-2-yl group, R.sup.1x is hydrogen or methyl, R.sup.2x is carboxyl or a group O--Z.sup.4 --CO.sub.2 H or an ester or amide thereof; a group O--E.sup.1 --NR.sup.3x R.sup.4x or a group O--E.sup.1 --OR.sup.5x, wherein R.sup.3x, R.sup.4x and R.sup.5x each represents hydrogen or C.sub.1-6 alkyl, Z.sup.4 is a C.sub.1-6 straight or branched alkylene chain, x is 1 or 2, y is 2 or 3, and E.sup.1 is C.sub.2-7 straight or branched alkylene chain with at least two carbon atoms separating the two heteroatoms in the group R.sup.2x. Also described is a veterinarily acceptable premix formulation administrable in a veterinarily effective amount in feed or water comprising a compound of the formula (XX) or, where appropriate, a veterinarily acceptable salt, ester or amide thereof; in association with a veterinarily acceptable carrier therefor. Additionally, a veterinarily acceptable premix formulation comprising from about 0.001% to about 95% by weight of a compound of formula (XX) administrable in feed or water or, where appropriate, a veterinarily acceptable salt, ester or amide thereof, together with a veterinarily acceptable carrier.
摘要翻译：描述了增加体重增加和/或提高牲畜饲料利用效率的方法，其包括向家畜口服或非口服施用有效的无毒量的式（XX）化合物：（XX）或其盐，其中W为任选被卤素或三氟甲基取代的苯基，或苯并呋喃-2-基，R1x为氢或甲基，R2x为羧基或O-Z4-CO2H基或酯或酰胺; O-E1-NR3xR4x或O-E1-OR5x基团，其中R3x，R4x和R5x各自表示氢或C1-6烷基，Z4为C1-6直链或支链亚烷基链，x为1或2，y 是2或3，E1是具有至少两个碳原子的直链或支链亚烷基链，其分离R2x中的两个杂原子。还描述了在饲料或水中以兽用有效量施用的可通用的预混合制剂，其包含式（XX）的化合物或其合适的可通用的盐，酯或酰胺; 与其兽医可接受的载体相关联。另外，包含约0.001％至约95％重量的式（XX）化合物在饲料或水中或其合适的情况下可兽用的盐，酯或酰胺以及兽用可接受的载体

4. 发明授权

US5087626A Method for increasing the weight gain and improving the feed utilization efficiency of livestock 失效
标题翻译：提高体重增益的方法，提高畜牧业饲料利用效率
公开(公告)号：US5087626A
公开(公告)日：1992-02-11
申请号：US404090
申请日：1989-09-07
申请人： Jonathan R. Arch
发明人： Jonathan R. Arch
IPC分类号： A23K1/16 , A61K31/135
CPC分类号： A61K31/135 , A23K20/111 , A23K20/116
摘要： A method for increasing the weight gain and/or improving the feed utilization of efficiency of livestock which comprises administering to livestock in need thereof an effective amount of a compound of formula (XXII): ##STR1## or a pharmaceutically acceptable salt thereof, wherein R.sup.1Z is hydrogen, halogen, or trifluoromethyl; R.sup.2Z is hydrogen or halogen; R.sup.3Z is hydrogen or methyl; R.sup.4Z is --O(CH.sub.2).sup.6 CO.sub.2 H or an ester or amide thereof, O(CH.sub.2).sup..epsilon. M.sup.4 or --CO.sub.2 H or an ester or amide thereof, wherein .delta. is an integer from 1 to 6, .epsilon. is an integer from 2 to 7, and M.sup.4 is hydroxy, alkoxy of 1 to 6 carbon atoms or ##STR2## wherein R.sup.6Z and R.sup.7Z are each hydrogen or alkyl of 1 to 6 carbons or ##STR3## is a 5- or 6-membered ring; R.sup.5Z is alkyl of 1 to 6 carbon atoms; alkyl of 1 to 6 carbon atoms substituted by carboxy or an ester or amide thereof; or phenyl unsubstituted or substituted by alkyl of 1 to 6 carbon atoms, halogen, lower alkoxy or trifluoromethyl R.sup.8Z is hydrogen or alkyl of 1 to 6 carbon atoms or R.sup.8Z together with R.sup.5Z is a carbocyclic ring.

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