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1. 发明授权

US5991697A Method and apparatus for optical Doppler tomographic imaging of fluid flow velocity in highly scattering media 失效
标题翻译：用于高分散介质中流体流速的光学多普勒断层成像的方法和装置
公开(公告)号：US5991697A
公开(公告)日：1999-11-23
申请号：US775279
申请日：1996-12-31
申请人： John Stuart Nelson , Thomas Edward Milner , Zhongping Chen
发明人： John Stuart Nelson , Thomas Edward Milner , Zhongping Chen
IPC分类号： A61B5/026 , G01P5/26 , G01P3/36
CPC分类号： A61B5/412 , G01P5/26 , A61B5/0261
摘要： Optical Doppler tomography permits imaging of fluid flow velocity in highly scattering media. The tomography system combines Doppler velocimetry with high spatial resolution of partially coherent optical interferometry to measure fluid flow velocity at discrete spatial locations. Noninvasive in vivo imaging of blood flow dynamics and tissue structures with high spatial resolutions of the order of 2 to 10 microns is achieved in biological systems. The backscattered interference signals derived from the interferometer may be analyzed either through power spectrum determination to obtain the position and velocity of each particle in the fluid flow sample at each pixel, or the interference spectral density may be analyzed at each frequency in the spectrum to obtain the positions and velocities of the particles in a cross-section to which the interference spectral density corresponds. The realized resolutions of optical Doppler tomography allows noninvasive in vivo imaging of both blood microcirculation and tissue structure surrounding the vessel which has significance for biomedical research and clinical applications.
摘要翻译：光学多普勒层析成像允许在高散射介质中成像流体流速。断层摄影系统将多普勒测速与部分相干光学干涉测量的高空间分辨率相结合，以测量离散空间位置处的流体流速。在生物系统中实现了具有2至10微米量级的高空间分辨率的血流动力学和组织结构的非侵入性体内成像。可以通过功率谱确定来分析来自干涉仪的反向散射干涉信号，以获得每个像素处的流体样品中每个颗粒的位置和速度，或者可以在频谱中的每个频率处分析干扰谱密度，以获得在干扰频谱密度对应的横截面中颗粒的位置和速度。光学多普勒层析成像的实现分辨率允许血管微循环和围绕血管的组织结构的非侵入性体内成像，这对生物医学研究和临床应用具有重要意义。

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