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1. 发明授权

US07232801B2 IL-16 antagonists 有权
标题翻译： IL-16拮抗剂
公开(公告)号：US07232801B2
公开(公告)日：2007-06-19
申请号：US11167710
申请日：2005-06-27
申请人： David M. Center , William W. Cruikshank , Hardy Kornfeld
发明人： David M. Center , William W. Cruikshank , Hardy Kornfeld
IPC分类号： A61K38/08 , A61K38/04 , A61K38/00 , A61K45/00 , C07K7/06
CPC分类号： C07K7/06 , A61K38/00 , C07K5/1013 , C07K14/70514
摘要： In accordance with the present invention, novel IL-16 antagonists, preferably peptides derived from CD4, have been isolated and synthesized. These peptides possess IL-16 antagonistic properties including the ability to selectively bind to IL-16 and inhibit IL-16-mediated biological activity. The peptides comprise specific portions of the native human CD4 receptor and variations thereof and therefore are non-immunogenic when administered to humans. The present invention also provides compositions containing at least one IL-16 antagonist peptide which can inhibit, suppress or cause the cessation of at least one IL-16-mediated biological activity in mammals, including humans. The present invention provides a method and composition for treating inflammation associated with disease states such as asthma, rheumatoid arthritis, inflammatory bowel disease (IBD) and systemic lupus (SLE) in mammals such as, for example, humans.
摘要翻译：根据本发明，已经分离并合成了新的IL-16拮抗剂，优选衍生自CD4的肽。这些肽具有IL-16拮抗性质，包括选择性结合IL-16并抑制IL-16介导的生物活性的能力。肽包含天然人CD4受体的特定部分及其变体，因此在给予人时是非免疫原性的。本发明还提供含有至少一种IL-16拮抗剂肽的组合物，其可以抑制，抑制或引起包括人在内的哺乳动物中至少一种IL-16介导的生物活性的停止。本发明提供了用于治疗与诸如例如人类的哺乳动物中的疾病状态如哮喘，类风湿性关节炎，炎症性肠病（IBD）和系统性红斑狼疮（SLE）相关的炎症的方法和组合物。

2. 发明授权

US06723697B2 IL-16 antagonists 有权
标题翻译： IL-16拮抗剂
公开(公告)号：US06723697B2
公开(公告)日：2004-04-20
申请号：US09929922
申请日：2001-08-15
申请人： David M. Center , William W. Cruikshank , Hardy Kornfeld
发明人： David M. Center , William W. Cruikshank , Hardy Kornfeld
IPC分类号： A61K3800
CPC分类号： C07K7/06 , A61K38/00 , C07K5/1013 , C07K14/70514
摘要： In accordance with the present invention, novel IL-16 antagonists, preferably peptides derived from CD4, have been isolated and synthesized. These peptides possess IL-16 antagonistic properties including the ability to selectively bind to IL-16 and inhibit IL-16-mediated biological activity. The peptides comprise specific portions of the native human CD4 receptor and variations thereof and therefore are non-immunogenic when administered to humans. The present invention also provides compositions containing at least one IL-16 antagonist peptide which can inhibit, suppress or cause the cessation of at least one IL-16-mediated biological activity in mammals, including humans. The present invention provides a method and composition for treating inflammation associated with disease states such as asthma, rheumatoid arthritis, inflammatory bowel disease (IBD) and systemic lupus (SLE) in mammals such as, for example, humans.
摘要翻译：根据本发明，已经分离并合成了新的IL-16拮抗剂，优选衍生自CD4的肽。这些肽具有IL-16拮抗性质，包括选择性结合IL-16并抑制IL-16介导的生物活性的能力。肽包含天然人CD4受体的特定部分及其变体，因此在给予人时是非免疫原性的。本发明还提供含有至少一种IL-16拮抗剂肽的组合物，其可以抑制，抑制或引起包括人在内的哺乳动物中至少一种IL-16介导的生物活性的停止。本发明提供了用于治疗与诸如例如人类的哺乳动物中的疾病状态如哮喘，类风湿性关节炎，炎症性肠病（IBD）和系统性红斑狼疮（SLE）相关的炎症的方法和组合物。

3. 发明申请

US20070031375A1 IL-16 antagonist peptides and DNA encoding the peptides 有权
标题翻译： IL-16拮抗剂肽和编码肽的DNA
公开(公告)号：US20070031375A1
公开(公告)日：2007-02-08
申请号：US11544055
申请日：2006-10-06
申请人： David Center , William Cruikshank , Hardy Kornfeld
发明人： David Center , William Cruikshank , Hardy Kornfeld
IPC分类号： A61K38/20 , A61K38/10 , A61K38/08 , A61K38/06
CPC分类号： A61K38/13 , A61K31/00 , A61K38/00 , A61K39/395 , A61K45/06 , C07K14/5446 , A61K2300/00
摘要： The present invention has found that a series of peptides having sequences that substantially correspond to specific regions of the C-terminus of IL-16 can inhibit the activity of IL-16. The present invention has demonstrated that such IL-16-inhibiting peptides can be as short as 4 amino acid in length. Based on these discoveries, the present invention provides IL-16 antagonist peptides and the use thereof for the treatment of IL-16 mediated disorders such as certain inflammatory diseases.
摘要翻译：本发明已经发现，具有基本上对应于IL-16的C末端的特定区域的序列的一系列肽可以抑制IL-16的活性。本发明已经证明，这种IL-16抑制肽的长度可以短至4个氨基酸。基于这些发现，本发明提供IL-16拮抗剂肽及其用于治疗IL-16介导的病症例如某些炎性疾病的用途。

4. 发明授权

US07019118B2 IL-16 antagonists 有权
公开(公告)号：US07019118B2
公开(公告)日：2006-03-28
申请号：US09929924
申请日：2001-08-15
申请人： David M. Center , William W. Cruikshank , Hardy Kornfeld
发明人： David M. Center , William W. Cruikshank , Hardy Kornfeld
IPC分类号： C07K16/00 , C07K14/00 , A61K39/395
CPC分类号： C07K7/06 , A61K38/00 , C07K5/1013 , C07K14/70514
摘要： In accordance with the present invention, novel IL-16 antagonists, preferably peptides derived from CD4, have been isolated and synthesized. These peptides possess IL-16 antagonistic properties including the ability to selectively bind to IL-16 and inhibit IL-16-mediated biological activity. The peptides comprise specific portions of the native human CD4 receptor and variations thereof and therefore are non-immunogenic when administered to humans. The present invention also provides compositions containing at least one IL-16 antagonist peptide which can inhibit, suppress or cause the cessation of at least one IL-16-mediated biological activity in mammals, including humans. The present invention provides a method and composition for treating inflammation associated with disease states such as asthma, rheumatoid arthritis, inflammatory bowel disease (IBD) and systemic lupus (SLE) in mammals such as, for example, humans.

5. 发明授权

US06699466B1 IL-16 antagonist peptides and DNA encoding the peptides 有权
标题翻译： IL-16拮抗剂肽和编码肽的DNA
公开(公告)号：US06699466B1
公开(公告)日：2004-03-02
申请号：US09368630
申请日：1999-08-05
申请人： David M. Center , William W. Cruikshank , Hardy Kornfeld
发明人： David M. Center , William W. Cruikshank , Hardy Kornfeld
IPC分类号： A61K3807
CPC分类号： A61K38/13 , A61K31/00 , A61K38/00 , A61K39/395 , A61K45/06 , C07K14/5446 , A61K2300/00
摘要： The present invention has found that a series of peptides having sequences that substantially correspond to specific regions of the C-terminus of IL-16 can inhibit the activity of IL-16. The present invention has demonstrated that such IL-16-inhibiting peptides can be as short as 4 amino acids in length. Based on these discoveries, the present invention provides IL-16 antagonist peptides and the use thereof for the treatment of IL-16-mediated disorders such as certain inflammatory diseases.
摘要翻译：本发明已经发现，具有基本上对应于IL-16的C末端的特定区域的序列的一系列肽可以抑制IL-16的活性。本发明已经证明这样的IL-16抑制肽的长度可以短至4个氨基酸。基于这些发现，本发明提供IL-16拮抗剂肽及其用于治疗IL-16介导的病症如某些炎性疾病的用途。

6. 发明授权

US5869263A Lymphocyte chemoattractant factor and uses thereof 失效
公开(公告)号：US5869263A
公开(公告)日：1999-02-09
申请号：US581094
申请日：1995-12-29
申请人： David M. Center , William W. Cruikshank , Hardy Kornfeld
发明人： David M. Center , William W. Cruikshank , Hardy Kornfeld
IPC分类号： A61K38/00 , A61K38/20 , C07K14/54 , C07K16/22 , C07K16/24 , G01N33/53 , A61K39/00 , C07K14/00 , G01N33/574
CPC分类号： C07K16/244 , A61K38/2013 , C07K14/5446 , C07K16/22 , C07K16/24 , C07K2317/73 , Y10S435/974 , Y10S435/975
摘要： Disclosed is a substantially pure antibody which specifically binds a LCF polypeptide and methods of using such antibodies.

7. 发明授权

US5766866A Lymphocyte chemoattractant factor and uses thereof 失效
公开(公告)号：US5766866A
公开(公告)日：1998-06-16
申请号：US580680
申请日：1995-12-29
申请人： David M. Center , William W. Cruikshank , Hardy Kornfeld
发明人： David M. Center , William W. Cruikshank , Hardy Kornfeld
IPC分类号： A61K38/00 , A61K38/20 , C07K14/54 , C07K16/22 , C07K16/24 , G01N33/53 , A61K45/05 , C07K1/00 , C07K16/00
CPC分类号： C07K16/244 , A61K38/2013 , C07K14/5446 , C07K16/22 , C07K16/24 , C07K2317/73 , Y10S435/974 , Y10S435/975
摘要： Disclosed is a substantially pure antibody which specifically binds a LCF polypeptide and methods of using such antibodies.

8. 发明申请

US20120213790A1 METHODS OF TREATMENT USING IL-16 ANTAGONIST PEPTIDES 审中-公开
标题翻译：使用IL-16拮抗剂肽治疗的方法
公开(公告)号：US20120213790A1
公开(公告)日：2012-08-23
申请号：US13424692
申请日：2012-03-20
申请人： David M. Center , William W. Cruikshank , Hardy Kornfeld
发明人： David M. Center , William W. Cruikshank , Hardy Kornfeld
IPC分类号： A61K38/07 , A61P29/00 , C07K16/00 , A61K39/395 , C07K5/10 , C07H21/04
CPC分类号： A61K38/13 , A61K31/00 , A61K38/00 , A61K39/395 , A61K45/06 , C07K14/5446 , A61K2300/00
摘要： The present invention has found that a series of peptides having sequences that substantially correspond to specific regions of the C-terminus of IL-16 can inhibit the activity of IL-16. The present invention has demonstrated that such IL-16-inhibiting peptides can be as short as 4 amino acid in length. Based on these discoveries, the present invention provides IL-16 antagonist peptides and the use thereof for the treatment of IL-16 mediated disorders such as certain inflammatory diseases.
摘要翻译：本发明已经发现，具有基本上对应于IL-16的C末端的特定区域的序列的一系列肽可以抑制IL-16的活性。本发明已经证明，这种IL-16抑制肽的长度可以短至4个氨基酸。基于这些发现，本发明提供IL-16拮抗剂肽及其用于治疗IL-16介导的病症例如某些炎性疾病的用途。

9. 发明授权

US07914778B2 Methods of treatment using IL-16 antagonist peptides 有权
标题翻译：使用IL-16拮抗剂肽治疗的方法
公开(公告)号：US07914778B2
公开(公告)日：2011-03-29
申请号：US11725090
申请日：2007-03-16
申请人： David M. Center , William W. Cruikshank , Hardy Kornfeld
发明人： David M. Center , William W. Cruikshank , Hardy Kornfeld
IPC分类号： A61K38/08 , C07K7/00 , C07K7/06
CPC分类号： A61K38/13 , A61K31/00 , A61K38/00 , A61K39/395 , A61K45/06 , C07K14/5446 , A61K2300/00
摘要： The present invention has found that a series of peptides having sequences that substantially correspond to specific regions of the C-terminus of IL-16 can inhibit the activity of IL-16. The present invention has demonstrated that such IL-16-inhibiting peptides can be as short as 4 amino acids in length. Based on these discoveries, the present invention provides IL-16 antagonist peptides and the use thereof for the treatment of IL-16 mediated disorders such as certain inflammatory diseases.
摘要翻译：本发明已经发现，具有基本上对应于IL-16的C末端的特定区域的序列的一系列肽可以抑制IL-16的活性。本发明已经证明这样的IL-16抑制肽的长度可以短至4个氨基酸。基于这些发现，本发明提供IL-16拮抗剂肽及其用于治疗IL-16介导的病症例如某些炎性疾病的用途。

10. 发明授权

US07608691B2 Antibodies against IL-16 antagonist peptides 有权
标题翻译：针对IL-16拮抗剂肽的抗体
公开(公告)号：US07608691B2
公开(公告)日：2009-10-27
申请号：US11544055
申请日：2006-10-06
申请人： David M. Center , William W. Cruikshank , Hardy Kornfeld
发明人： David M. Center , William W. Cruikshank , Hardy Kornfeld
IPC分类号： C07K16/24 , C07K7/06 , C07K7/08 , C07K5/00
CPC分类号： A61K38/13 , A61K31/00 , A61K38/00 , A61K39/395 , A61K45/06 , C07K14/5446 , A61K2300/00
摘要： The present invention has found that a series of peptides having sequences that substantially correspond to specific regions of the C-terminus of IL-16 can inhibit the activity of IL-16. The present invention has demonstrated that such IL-16-inhibiting peptides can be as short as 4 amino acid in length. Based on these discoveries, the present invention provides IL-16 antagonist peptides and the use thereof for the treatment of IL-16 mediated disorders such as certain inflammatory diseases.
摘要翻译：本发明已经发现，具有基本上对应于IL-16的C末端的特定区域的序列的一系列肽可以抑制IL-16的活性。本发明已经证明，这种IL-16抑制肽的长度可以短至4个氨基酸。基于这些发现，本发明提供IL-16拮抗剂肽及其用于治疗IL-16介导的病症例如某些炎性疾病的用途。

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