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1. 发明专利

IL284393D0 Claudin18.2 binding moieties and uses thereof 未知
公开(公告)号：IL284393D0
公开(公告)日：2021-08-31
申请号：IL28439321
申请日：2021-06-27
申请人： NANJING GENSCRIPT BIOTECH CO LTD , NANJING LEGEND BIOTECH CO LTD , YIN LIUSONG , ZHOU TIELIN , FANG ZHUO , LIU YONG , ZHUANG QIUCHUAN , WU BO , FAN XIAOHU , ZHANG QINGSHAN , ZHAO DAN , MAO JIE
发明人： YIN LIUSONG , ZHOU TIELIN , FANG ZHUO , LIU YONG , ZHUANG QIUCHUAN , WU BO , FAN XIAOHU , ZHANG QINGSHAN , ZHAO DAN , MAO JIE
IPC分类号： A61P35/00 , C07K14/725 , C07K16/28 , C07K16/30
摘要： Described herein are binding moieties, such as antibodies, that specifically bind Claudin18.2, and chimeric antigen receptors comprising such binding moieties. Further provided are engineered immune cells (such as T cells) comprising anti-Claudin 18.2 chimeric antigen receptors. Also disclosed are methods of treating Claudin18.2-expressing tumor or cancers using the binding moieties, chimeric antigen receptors and engineered immune cells.

2. 发明专利

IL293862A Single domain antibodies and chimeric antigen receptors targeting bcma and methods of use thereof 未知
公开(公告)号：IL293862A
公开(公告)日：2022-08-01
申请号：IL29386222
申请日：2022-06-13
申请人： NANJING LEGEND BIOTECH CO LTD , FAN XIAOHU , ZHUANG QIUCHUAN , ZHAO YUNCHENG , YANG LEI , FANG XU , XU CHANGMENG
发明人： FAN XIAOHU , ZHUANG QIUCHUAN , ZHAO YUNCHENG , YANG LEI , FANG XU , XU CHANGMENG
IPC分类号： A61K39/00 , A61P35/00 , A61P35/02 , C07K14/725 , C07K16/28
摘要： A chimeric antigen receptor (CAR) comprising a polypeptide comprising an extracellular antigen binding domain comprising a first BCMA binding moiety and a second BCMA binding moiety, wherein the first BCMA binding moiety is a first anti-BCMA single domain antibody, and the second BCMA binding moiety is a second anti-BCMA sdAb; and wherein each of the first and second sdAb is a VHH domain.

3. 发明专利

IL295774A Antibodies and chimeric antigen receptors targeting glypican-3 (gpc3) and methods of use thereof 未知
公开(公告)号：IL295774A
公开(公告)日：2022-10-01
申请号：IL29577422
申请日：2022-08-18
申请人： NANJING LEGEND BIOTECH CO LTD , FAN XIAOHU , MAO JIE , ZHUANG QIUCHUAN , WANG RUIXUE
发明人： FAN XIAOHU , MAO JIE , ZHUANG QIUCHUAN , WANG RUIXUE
IPC分类号： A61P35/00 , A61K39/00 , C07K14/52 , C07K14/54 , C07K14/725 , C07K16/30 , G01N33/53
摘要： Provided are anti-glypican-3 (GPC3) antibodies or antigen binding fragments thereof, and a chimeric antigen receptor (CAR) that binds glypican-3 (GPC3) containing an anti-GPC3 antibody in an extracellular domain, a transmembrane domain, and an intracellular signaling domain. Immune effector cells transduced with the disclosed CAR constructs can be used for cancer immunotherapy.

4. 发明专利

IL294096A Claudin18.2 binding moieties and uses thereof 未知
公开(公告)号：IL294096A
公开(公告)日：2022-08-01
申请号：IL29409622
申请日：2022-06-19
申请人： NANJING LEGEND BIOTECH CO LTD , FAN XIAOHU , ZHUANG QIUCHUAN , FANG XU , ZHANG QINGSHAN , XU MANMAN , FENG MENG
发明人： FAN XIAOHU , ZHUANG QIUCHUAN , FANG XU , ZHANG QINGSHAN , XU MANMAN , FENG MENG
IPC分类号： A61K39/00 , A61P35/00 , C07K14/525 , C07K14/725 , C07K16/28
摘要： Single domain antibodies that bind to Claudin18.2, and chimeric antigen receptors comprising same are provided. Further provided are engineered immune effector cells (such as T cells) comprising the chimeric antigen receptors. Pharmaceutical compositions, kits and methods of treating a disease or disorder are also provided.

5. 发明专利

IL275512D0 Multispecific chimeric receptors comprising an nkg2d domain and methods of use thereof 未知
公开(公告)号：IL275512D0
公开(公告)日：2020-08-31
申请号：IL27551220
申请日：2020-06-18
申请人： NANJING LEGEND BIOTECH CO LTD , FAN XIAOHU , WANG JUN , WANG PINGYAN , ZHUANG QIUCHUAN , MA LIAN
发明人： FAN XIAOHU , WANG JUN , WANG PINGYAN , ZHUANG QIUCHUAN , MA LIAN
IPC分类号： A61P35/00 , A61K35/17 , C07K14/705
摘要： Provided are chimeric receptors targeting NKG2D, and multispecific chimeric receptors comprising an NKG2D domain and a second antigen binding domain such as an IL-3 domain. Also provided are dual chimeric receptor systems comprising a first chimeric receptor comprising an NKG2D domain, and a second chimeric receptor comprising a second antigen binding domain such as an IL-3 domain. Further provided are engineered immune effector cells (such as T cells), pharmaceutical compositions, kits and methods of treating cancer.

6. 发明申请

WO2013003486A1 REACTOR SYSTEM 审中-公开
标题翻译：反应器系统
公开(公告)号：WO2013003486A1
公开(公告)日：2013-01-03
申请号：PCT/US2012/044440
申请日：2012-06-27
申请人： BURTON, Rachel , AUSTIC, Greg , FAN, Xiaohu
发明人： BURTON, Rachel , AUSTIC, Greg , FAN, Xiaohu
IPC分类号： B01J10/00
CPC分类号： B01J8/008 , B01J4/004 , B01J10/00 , B01J19/006 , B01J19/1881 , B01J2208/00796 , B01J2219/00006 , B01J2219/00094
摘要： A reactor tank is provided having an enzyme inlet, a heating jacket positioned around the exterior center of the tank, a gas outlet communicating with a vacuum apparatus and a condensing unit, a first gas inlet for receiving gas from a feed tank and a first liquid outlet for recirculating the liquid back to the feed tank. The tank further includes a sparged unit connected to the first gas inlet for receiving gas from the feed tank and a screen positioned between the sparged unit and the first liquid outlet. The reactor tank is utilized in a reactor system further including a condensing unit, vacuum pump or venturi valve, a first feed tank, a coalescer having at least one circulation pipe and a first circulation pump.
摘要翻译：提供了一种反应器罐，其具有酶入口，围绕罐的外部中心定位的加热套，与真空装置连通的气体出口和冷凝单元，用于从进料罐接收气体的第一气体入口和第一液体出口用于将液体再循环回进料罐。所述罐还包括连接到所述第一气体入口用于从所述进料罐接收气体的喷射单元和位于所述喷射单元和所述第一液体出口之间的筛子。反应器罐用于还包括冷凝单元，真空泵或文丘里阀的反应器系统，第一进料罐，具有至少一个循环管和第一循环泵的聚结器。

7. 发明申请

WO2012106701A1 FATTY ACID ESTERIFICATION PROCESS 审中-公开
标题翻译：脂肪酸酯化过程
公开(公告)号：WO2012106701A1
公开(公告)日：2012-08-09
申请号：PCT/US2012/023927
申请日：2012-02-06
申请人： NOVOZYMES A/S , PIEDMONT BIOFUELS , AUSTIC, Greg , BURTON, Rachel , FAN, Xiaohu
发明人： AUSTIC, Greg , BURTON, Rachel , FAN, Xiaohu
IPC分类号： C12P7/64
CPC分类号： C12P7/649 , C12M21/18 , C12M23/58 , Y02E50/13
摘要： The invention relates to the utilisation of fatty acid feedstocks with substantial free fatty acid content in the production of biodiesel by the use of microbial enzymes.
摘要翻译：本发明涉及通过使用微生物酶在生产生物柴油中利用具有大量游离脂肪酸含量的脂肪酸原料。

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