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1. 发明申请

US20120244189A1 TREATMENT OF INFECTIONS 有权
标题翻译：治疗感染
公开(公告)号：US20120244189A1
公开(公告)日：2012-09-27
申请号：US13384234
申请日：2010-07-16
申请人： Timothy Foster , Judy Higgins , Elisabet Josefsson , Joan Geoghegan , Guy Dequesne , Andrej Tarkowski , Carlake Andersson
发明人： Timothy Foster , Judy Higgins , Elisabet Josefsson , Joan Geoghegan , Guy Dequesne , Andrej Tarkowski , Carlake Andersson
IPC分类号： A61K39/085 , C12N15/31 , C07K19/00 , C07K16/12 , A61P31/00 , A61P9/00 , A61P29/00 , A61P37/04 , C12N15/63 , C12N1/21 , A61P31/04 , C07K14/31 , A61P19/02
CPC分类号： C07K14/31 , A61K39/00
摘要： The present invention is directed to improved microbial antigen vaccines, pharmaceutical compositions, immunogenic compositions and antibodies and their use in the treatment of microbial infections, particularly those of bacterial origin, including Staphylococcal origin. Ideally, the present invention is directed to a recombinant staphylococcal MSCRAMM or MSCRAMM-like proteins, or fragment thereof, with reduced binding to its host ligand, for use in therapy.
摘要翻译：本发明涉及改进的微生物抗原疫苗，药物组合物，免疫原性组合物和抗体及其在治疗微生物感染，特别是包括葡萄球菌来源的细菌来源的微生物感染中的用途。理想地，本发明涉及与其宿主配体结合降低的重组葡萄球菌MSCRAMM或MSCRAMM样蛋白或其片段，用于治疗。

2. 发明授权

US07855272B2 SDRE protein from Staphylococcus aureus and diagnostic kits including same 有权
标题翻译：来自金黄色葡萄球菌的SDRE蛋白和包括其的诊断试剂盒
公开(公告)号：US07855272B2
公开(公告)日：2010-12-21
申请号：US12546322
申请日：2009-08-24
申请人： Joseph M. Patti , Timothy J. Foster , Elisabet Josefsson , Deidre Ni Eidhin , Magnus A. O. Hook , Samuel E. Perkins
发明人： Joseph M. Patti , Timothy J. Foster , Elisabet Josefsson , Deidre Ni Eidhin , Magnus A. O. Hook , Samuel E. Perkins
IPC分类号： C07K1/00
CPC分类号： G01N33/56938 , A61K38/00 , A61K39/00 , C07K14/31 , G01N2469/00 , Y10S435/975 , Y10S530/81 , Y10S530/825
摘要： An isolated extracellular matrix-binding protein, designated as SdrE and its corresponding amino acid and nucleic acid sequences and motifs are described. The proteins, peptides, fragments thereof or antigenic portions thereof are useful for the prevention, inhibition, treatment and diagnosis of S. aureus infection and as scientific research tools. Further, antibodies or antibody fragments to the proteins, peptides, fragments thereof or antigenic portions thereof are also useful for the prevention, inhibition, treatment and diagnosis of S. aureus infection. In particular, the proteins or antibodies thereof may be administered to wounds or used to coat biomaterials to act as blocking agents to prevent or inhibit the binding of S. aureus to wounds or biomaterials.
摘要翻译：描述了分离的细胞外基质结合蛋白，命名为SdrE及其相应的氨基酸和核酸序列和基序。蛋白质，肽，其片段或其抗原部分可用于预防，抑制，治疗和诊断金黄色葡萄球菌感染以及科学研究工具。此外，蛋白质，肽，其片段或其抗原部分的抗体或抗体片段也可用于预防，抑制，治疗和诊断金黄色葡萄球菌感染。特别地，其蛋白质或其抗体可以施用于伤口或用于涂覆生物材料以用作阻断剂以预防或抑制金黄色葡萄球菌与伤口或生物材料的结合。

3. 发明申请

US20100113349A1 EXTRACELLULAR MATRIX-BINDING PROTEINS FROM STAPHYLOCOCCUS AUREUS 有权
标题翻译：来自ST FROM US US US US US US US US US US US US US US US US US US US US US
公开(公告)号：US20100113349A1
公开(公告)日：2010-05-06
申请号：US12546322
申请日：2009-08-24
申请人： Joseph M. PATTI , Timothy J. Foster , Elisabet Josefsson , Deidre Ni Eidhin , Magnus A.O. Hook , Samuel E. Perkins
发明人： Joseph M. PATTI , Timothy J. Foster , Elisabet Josefsson , Deidre Ni Eidhin , Magnus A.O. Hook , Samuel E. Perkins
IPC分类号： A61K38/16 , C07K14/315 , G01N33/566
CPC分类号： G01N33/56938 , A61K38/00 , A61K39/00 , C07K14/31 , G01N2469/00 , Y10S435/975 , Y10S530/81 , Y10S530/825
摘要： An isolated extracellular matrix-binding protein, designated as SdrE and its corresponding amino acid and nucleic acid sequences and motifs are described. The proteins, peptides, fragments thereof or antigenic portions thereof are useful for the prevention, inhibition, treatment and diagnosis of S. aureus infection and as scientific research tools. Further, antibodies or antibody fragments to the proteins, peptides, fragments thereof or antigenic portions thereof are also useful for the prevention, inhibition, treatment and diagnosis of S. aureus infection. In particular, the proteins or antibodies thereof may be administered to wounds or used to coat biomaterials to act as blocking agents to prevent or inhibit the binding of S. aureus to wounds or biomaterials.
摘要翻译：描述了分离的细胞外基质结合蛋白，命名为SdrE及其相应的氨基酸和核酸序列和基序。蛋白质，肽，其片段或其抗原部分可用于预防，抑制，治疗和诊断金黄色葡萄球菌感染以及科学研究工具。此外，蛋白质，肽，其片段或其抗原部分的抗体或抗体片段也可用于预防，抑制，治疗和诊断金黄色葡萄球菌感染。特别地，其蛋白质或其抗体可以施用于伤口或用于涂覆生物材料以用作阻断剂以预防或抑制金黄色葡萄球菌与伤口或生物材料的结合。

4. 发明申请

US20100081616A1 EXTRACELLULAR MATRIX-BINDING PROTEINS FROM STAPHYLOCOCCUS AUREUS 有权
标题翻译：来自ST FROM US US US US US US US US US US US US US US US US US US US US US
公开(公告)号：US20100081616A1
公开(公告)日：2010-04-01
申请号：US12546289
申请日：2009-08-24
申请人： Joseph M. Patti , Timothy J. Foster , Elisabet Josefsson , Deidre Ni Eidhin , Magnus A.O. Hook , Samuel E. Perkins
发明人： Joseph M. Patti , Timothy J. Foster , Elisabet Josefsson , Deidre Ni Eidhin , Magnus A.O. Hook , Samuel E. Perkins
IPC分类号： A61K38/16 , C07K14/31 , G01N33/569
CPC分类号： G01N33/56938 , A61K38/00 , A61K39/00 , C07K14/31 , G01N2469/00 , Y10S435/975 , Y10S530/81 , Y10S530/825
摘要： An isolated extracellular matrix-binding protein, designated as SdrD and its corresponding amino acid and nucleic acid sequences and motifs are described. The proteins, peptides, fragments thereof or antigenic portions thereof are useful for the prevention, inhibition, treatment and diagnosis of S. aureus infection and as scientific research tools. Further, antibodies or antibody fragments to the proteins, peptides, fragments thereof or antigenic portions thereof are also useful for the prevention, inhibition, treatment and diagnosis of S. aureus infection. In particular, the proteins or antibodies thereof may be administered to wounds or used to coat biomaterials to act as blocking agents to prevent or inhibit the binding of S. aureus to wounds or biomaterials.
摘要翻译：描述了分离的细胞外基质结合蛋白，称为SdrD及其相应的氨基酸和核酸序列和基序。蛋白质，肽，其片段或其抗原部分可用于预防，抑制，治疗和诊断金黄色葡萄球菌感染以及科学研究工具。此外，蛋白质，肽，其片段或其抗原部分的抗体或抗体片段也可用于预防，抑制，治疗和诊断金黄色葡萄球菌感染。特别地，其蛋白质或其抗体可以施用于伤口或用于涂覆生物材料以用作阻断剂以预防或抑制金黄色葡萄球菌与伤口或生物材料的结合。

5. 发明申请

US20110150918A1 TREATMENT OF MICROBIAL INFECTIONS 审中-公开
标题翻译：治疗微生物感染
公开(公告)号：US20110150918A1
公开(公告)日：2011-06-23
申请号：US12865336
申请日：2009-01-29
申请人： Timothy Foster , Judy Higgins , Elisabet Josefsson , Joan Geoghegan , Carlake Andersson
发明人： Timothy Foster , Judy Higgins , Elisabet Josefsson , Joan Geoghegan , Carlake Andersson
IPC分类号： A61K39/085 , C12N15/63 , C12N1/00 , A61P37/04 , A61P31/04
CPC分类号： C07K14/31 , A61K38/00 , A61K39/00 , A61K39/085 , A61K2039/545 , A61K2039/55566 , C07K16/1271
摘要： The present invention is directed to improved microbial antigen vaccines, pharmaceutical compositions, immunogenic compositions and antibodies and their use in the treatment of microbial infections, particularly those of bacterial origin, including Staphylococcal origin. Ideally, the present invention is directed to a recombinant staphylococcal MSCRAMM or MSCRAMM-like proteins, or fragment thereof, with reduced binding to its host ligand, for use in therapy.
摘要翻译：本发明涉及改进的微生物抗原疫苗，药物组合物，免疫原性组合物和抗体及其在治疗微生物感染，特别是包括葡萄球菌来源的细菌来源的微生物感染中的用途。理想地，本发明涉及与其宿主配体结合降低的重组葡萄球菌MSCRAMM或MSCRAMM样蛋白或其片段，用于治疗。

6. 发明授权

US07834151B2 SDRD protein from Staphylococcus aureus and diagnostic kits including same 有权
标题翻译：来自金黄色葡萄球菌的SDRD蛋白和包括其的诊断试剂盒
公开(公告)号：US07834151B2
公开(公告)日：2010-11-16
申请号：US12546289
申请日：2009-08-24
申请人： Joseph M. Patti , Timothy J. Foster , Elisabet Josefsson , Deidre Ni Eidhin , Magnus A. O. Hook , Samuel E. Perkins
发明人： Joseph M. Patti , Timothy J. Foster , Elisabet Josefsson , Deidre Ni Eidhin , Magnus A. O. Hook , Samuel E. Perkins
IPC分类号： C07K1/00
CPC分类号： G01N33/56938 , A61K38/00 , A61K39/00 , C07K14/31 , G01N2469/00 , Y10S435/975 , Y10S530/81 , Y10S530/825
摘要： An isolated extracellular matrix-binding protein, designated as SdrD and its corresponding amino acid and nucleic acid sequences and motifs are described. The proteins, peptides, fragments thereof or antigenic portions thereof are useful for the prevention, inhibition, treatment and diagnosis of S. aureus infection and as scientific research tools. Further, antibodies or antibody fragments to the proteins, peptides, fragments thereof or antigenic portions thereof are also useful for the prevention, inhibition, treatment and diagnosis of S. aureus infection. In particular, the proteins or antibodies thereof may be administered to wounds or used to coat biomaterials to act as blocking agents to prevent or inhibit the binding of S. aureus to wounds or biomaterials.
摘要翻译：描述了分离的细胞外基质结合蛋白，称为SdrD及其相应的氨基酸和核酸序列和基序。蛋白质，肽，其片段或其抗原部分可用于预防，抑制，治疗和诊断金黄色葡萄球菌感染以及科学研究工具。此外，蛋白质，肽，其片段或其抗原部分的抗体或抗体片段也可用于预防，抑制，治疗和诊断金黄色葡萄球菌感染。特别地，其蛋白质或其抗体可以施用于伤口或用于涂覆生物材料以用作阻断剂以预防或抑制金黄色葡萄球菌与伤口或生物材料的结合。

7. 发明授权

US07381793B2 Extracellular matrix-binding proteins from Staphylococcus aureus 有权
标题翻译：来自金黄色葡萄球菌的细胞外基质结合蛋白
公开(公告)号：US07381793B2
公开(公告)日：2008-06-03
申请号：US10744672
申请日：2003-12-24
申请人： Joseph M. Patti , Timothy J. Foster , Elisabet Josefsson , Deidre Ni Eidhin , Magnus A. O. Hook , Samuel E. Perkins
发明人： Joseph M. Patti , Timothy J. Foster , Elisabet Josefsson , Deidre Ni Eidhin , Magnus A. O. Hook , Samuel E. Perkins
IPC分类号： C07K1/00
CPC分类号： G01N33/56938 , A61K38/00 , A61K39/00 , C07K14/31 , G01N2469/00 , Y10S435/975 , Y10S530/81 , Y10S530/825
摘要： Isolated extracellular matrix-binding proteins, designated ClfB, SdrC, SdrD and SdrE, and their corresponding amino acid and nucleic acid sequences and motifs are described. The proteins, peptides, fragments thereof or antigenic portions thereof are useful for the prevention, inhibition, treatment and diagnosis of S. aureus infection and as scientific research tools. Further, antibodies or antibody fragments to the proteins, peptides, fragments thereof or antigenic portions thereof are also useful for the prevention, inhibition, treatment and diagnosis of S. aureus infection. In particular, the proteins or antibodies thereof may be administered to wounds or used to coat biomaterials to act as blocking agents to prevent or inhibit the binding of S. aureus to wounds or biomaterials.ClfB is a cell-wall associated protein having a predicted molecular weight of approximately 88 kDa and an apparent molecular weight of approximately 124 kDa, which binds both soluble and immobilized fibrinogen. ClfB binds both the alpha and beta chains of fibrinogen and acts as a clumping factor. SdrC, SdrD and SdrE are cell-wall associated proteins that exhibit cation-dependent ligand binding to the extracellular matrix. It has been discovered that in the A region of SdrC, SdrD, SdrE, ClfA and ClfB, there is a highly conserved amino acid sequence that can be used to derive a consensus motif of TYTFTDYVD.
摘要翻译：描述了分离的细胞外基质结合蛋白，命名为ClfB，SdrC，SdrD和SdrE，以及它们相应的氨基酸和核酸序列和基序。蛋白质，肽，其片段或其抗原部分可用于预防，抑制，治疗和诊断金黄色葡萄球菌感染以及科学研究工具。此外，蛋白质，肽，其片段或其抗原部分的抗体或抗体片段也可用于预防，抑制，治疗和诊断金黄色葡萄球菌感染。特别地，其蛋白质或其抗体可以施用于伤口或用于涂覆生物材料以用作阻断剂以预防或抑制金黄色葡萄球菌与伤口或生物材料的结合。 ClfB是具有约88kDa的预测分子量和约124kDa的表观分子量的细胞壁相关蛋白，其结合可溶性和固定的纤维蛋白原。 ClfB结合纤维蛋白原的α链和β链，并作为聚集因子。 SdrC，SdrD和SdrE是表现出阳离子依赖性配体结合细胞外基质的细胞壁相关蛋白。已经发现，在SdrC，SdrD，SdrE，ClfA和ClfB的A区域中，存在可用于得到TYTFTDYVD的共有基序的高度保守的氨基酸序列。

8. 发明申请

US20050026170A1 Extracellular matrix-binding proteins from Staphylococcus aureus 审中-公开
标题翻译：来自金黄色葡萄球菌的细胞外基质结合蛋白
公开(公告)号：US20050026170A1
公开(公告)日：2005-02-03
申请号：US10744616
申请日：2003-12-24
申请人： Joseph Patti , Timothy Foster , Elisabet Josefsson , Deidre Eidhin , Magnus Hook , Samuel Perkins
发明人： Joseph Patti , Timothy Foster , Elisabet Josefsson , Deidre Eidhin , Magnus Hook , Samuel Perkins
IPC分类号： A61K38/00 , A61K39/00 , C07K14/31 , C12Q1/68 , C07K16/40
CPC分类号： G01N33/56938 , A61K38/00 , A61K39/00 , C07K14/31 , G01N2469/00 , Y10S435/975 , Y10S530/81 , Y10S530/825
摘要： Isolated extracellular matrix-binding proteins, designated ClfB, SdrC, SdrD and SdrE, and their corresponding amino acid and nucleic acid sequences and motifs are described. The proteins, peptides, fragments thereof or antigenic portions thereof are useful for the prevention, inhibition, treatment and diagnosis of S. aureus infection and as scientific research tools. Further, antibodies or antibody fragments to the proteins, peptides, fragments thereof or antigenic portions thereof are also useful for the prevention, inhibition, treatment and diagnosis of S. aureus infection. In particular, the proteins or antibodies thereof may be administered to wounds or used to coat biomaterials to act as blocking agents to prevent or inhibit the binding of S. aureus to wounds or biomaterials. ClfB is a cell-wall associated protein having a predicted molecular weight of approximately 88 kDa and an apparent molecular weight of approximately 124 kDa, which binds both soluble and immobilized fibrinogen. ClfB binds both the alpha and beta chains of fibrinogen and acts as a clumping factor. SdrC, SdrD and SdrE are cell-wall associated proteins that exhibit cation-dependent ligand binding to the extracellular matrix. It has been discovered that in the A region of SdrC, SdrD, SdrE, ClfA and ClfB, there is a highly conserved amino acid sequence that can be used to derive a consensus motif of TYTFTDYVD.
摘要翻译：描述了分离的细胞外基质结合蛋白，命名为ClfB，SdrC，SdrD和SdrE，以及它们相应的氨基酸和核酸序列和基序。蛋白质，肽，其片段或其抗原部分可用于预防，抑制，治疗和诊断金黄色葡萄球菌感染以及科学研究工具。此外，蛋白质，肽，其片段或其抗原部分的抗体或抗体片段也可用于预防，抑制，治疗和诊断金黄色葡萄球菌感染。特别地，其蛋白质或其抗体可以施用于伤口或用于涂覆生物材料以用作阻断剂以预防或抑制金黄色葡萄球菌与伤口或生物材料的结合。 ClfB是具有约88kDa的预测分子量和约124kDa的表观分子量的细胞壁相关蛋白，其结合可溶性和固定的纤维蛋白原。 ClfB结合纤维蛋白原的α链和β链，并作为聚集因子。 SdrC，SdrD和SdrE是表现出阳离子依赖性配体结合细胞外基质的细胞壁相关蛋白。已经发现，在SdrC，SdrD，SdrE，ClfA和ClfB的A区域中，存在可用于得到TYTFTDYVD的共有基序的高度保守的氨基酸序列。

9. 发明授权

US06680195B1 Extracellular matrix-binding proteins from staphylococcus aureus 有权
标题翻译：来自金黄色葡萄球菌的细胞外基质结合蛋白
公开(公告)号：US06680195B1
公开(公告)日：2004-01-20
申请号：US09200650
申请日：1998-11-25
申请人： Joseph M. Patti , Timothy J. Foster , Elisabet Josefsson , Deidre Ni Eidhin , Magnus A. O. Hook , Samuel E. Perkins
发明人： Joseph M. Patti , Timothy J. Foster , Elisabet Josefsson , Deidre Ni Eidhin , Magnus A. O. Hook , Samuel E. Perkins
IPC分类号： C07H2104
CPC分类号： G01N33/56938 , A61K38/00 , A61K39/00 , C07K14/31 , G01N2469/00 , Y10S435/975 , Y10S530/81 , Y10S530/825
摘要： Isolated extracellular matrix-binding proteins, designated ClfB, SdrC, SdrD and SdrE, and their corresponding amino acid and nucleic acid sequences and motifs are described. The proteins, peptides, fragments thereof or antigenic portions thereof are useful for the prevention, inhibition, treatment and diagnosis of S. aureus infection and as scientific research tools. Further, antibodies or antibody fragments to the proteins, peptides, fragments thereof or antigenic portions thereof are also useful for the prevention, inhibition, treatment and diagnosis of S. aureus infection. In particular, the proteins or antibodies thereof may be administered to wounds or used to coat biomaterials to act as blocking agents to prevent or inhibit the binding of S. aureus to wounds or biomaterials. ClfB is a cell-wall associated protein having a predicted molecular weight of approximately 88 kDa and an apparent molecular weight of approximately 124 kDa, which binds both soluble and immobilized fibrinogen. ClfB binds both the alpha and beta chains of fibrinogen and acts as a clumping factor. SdrC, SdrD and SdrE are cell-wall associated proteins that exhibit cation-dependent ligand binding to the extracellular matrix. It has been discovered that in the A region of SdrC, SdrD, SdrE, ClfA and ClfB, there is a highly conserved amino acid sequence that can be used to derive a consensus motif of TYTFTDYVD (SEQ ID NO: 16).
摘要翻译：描述了分离的细胞外基质结合蛋白，命名为ClfB，SdrC，SdrD和SdrE，以及它们相应的氨基酸和核酸序列和基序。蛋白质，肽，其片段或其抗原部分可用于预防，抑制，治疗和诊断金黄色葡萄球菌感染以及科学研究工具。此外，蛋白质，肽，其片段或其抗原部分的抗体或抗体片段也可用于预防，抑制，治疗和诊断金黄色葡萄球菌感染。特别地，其蛋白质或其抗体可以施用于伤口或用于涂覆生物材料以用作阻断剂以预防或抑制金黄色葡萄球菌与伤口或生物材料的结合。 ClfB是具有约88kDa的预测分子量和约124kDa的表观分子量的细胞壁相关蛋白，其结合可溶性和固定的纤维蛋白原。 ClfB结合纤维蛋白原的α链和β链，并作为聚集因子。 SdrC，SdrD和SdrE是表现出阳离子依赖性配体结合细胞外基质的细胞壁相关蛋白。已经发现，在SdrC，SdrD，SdrE，ClfA和ClfB的A区域中，存在可用于衍生TYTFTDYVD（SEQ ID NO：16）的共有基序的高度保守的氨基酸序列。

10. 发明授权

US09353160B2 Method of prophlactically treating infection using a recombinant fibrinogen binding protein clumping factor A (ClfA) or fragment thereof 有权
标题翻译：使用重组纤维蛋白原结合蛋白凝聚因子A（ClfA）或其片段前体治疗感染的方法
公开(公告)号：US09353160B2
公开(公告)日：2016-05-31
申请号：US13384234
申请日：2010-07-16
申请人： Timothy Foster , Judy Higgins , Elisabet Josefsson , Joan Geoghegan , Guy Dequesne , Andrej Tarkowski , Carlake Andersson
发明人： Timothy Foster , Judy Higgins , Elisabet Josefsson , Joan Geoghegan , Guy Dequesne , Andrej Tarkowski
IPC分类号： A61K39/00 , C07K14/31
CPC分类号： C07K14/31 , A61K39/00
摘要： The present invention is directed to improved microbial antigen vaccines, pharmaceutical compositions, immunogenic compositions and antibodies and their use in the treatment of microbial infections, particularly those of bacterial origin, including Staphylococcal origin. Ideally, the present invention is directed to a recombinant staphylococcal MSCRAMM or MSCRAMM-like proteins, or fragment thereof, with reduced binding to its host ligand, for use in therapy.
摘要翻译：本发明涉及改进的微生物抗原疫苗，药物组合物，免疫原性组合物和抗体及其在治疗微生物感染，特别是包括葡萄球菌来源的细菌来源的微生物感染中的用途。理想地，本发明涉及与其宿主配体结合降低的重组葡萄球菌MSCRAMM或MSCRAMM样蛋白或其片段，用于治疗。

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